MEFZEST FORTE Tablet 10's

Introduction About MEFZEST FORTE TABLET

MEFZEST FORTE TABLET is a combination of Mefenamic acid and Paracetamol, which belongs to a group of medicines called Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Analgesics and Antipyretics. It is used to manage fever. It is also used for the management of mild to moderate pain, such as headaches, toothaches, joint or muscle pains, and period pain.

MEFZEST FORTE TABLET is not recommended for use in patients with asthma or aspirin-sensitive asthma, kidney or liver disease, or heart failure. Contact your doctor before taking.

Pregnant women should generally avoid using MEFZEST FORTE TABLET. Contact your doctor before taking.

MEFZEST FORTE TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Contact your doctor before taking it.

MEFZEST FORTE TABLET is not recommended for use in children. Contact your doctor before taking.

MEFZEST FORTE TABLET should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking.

The most common side effects of this medicine are nausea, vomiting, abdominal pain, diarrhea, constipation, indigestion, flatulence, anorexia, dry mouth, heartburn, peptic ulcers, perforation or GI bleeding, and ulcerative stomatitis. Contact your doctor if any of the above side effects worsen.

Uses Of MEFZEST FORTE TABLET

It is used to manage:

• fever
• mild to moderate pain (headache, toothache, joint or muscle pains, and period pains)

How MEFZEST FORTE TABLET Works

MEFZEST FORTE TABLET helps to relieve fever and pain, where paracetamol acts on the hypothalamus (heat regulating center) of the brain, resulting in peripheral vasodilation, sweating, and loss of body heat, and it also increases the pain threshold by inhibiting COX-1 and COX-2 enzymes, and mefenamic acid works by inhibiting COX-1 and COX-2 enzymes, which are involved in prostaglandin synthesis (responsible for pain and inflammation).

How to use MEFZEST FORTE TABLET

Take MEFZEST FORTE TABLET as advised by your physician. It can be taken with or without food.

For Tablet, Capsule: Swallow MEFZEST FORTE TABLET with a glass of water. Do not crush or chew the medicine.

For Dispersible Tablet: Disperse the medicine in the specified quantity of water as mentioned in the label. Consume the medicine immediately after reconstitution.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Side Effects Of MEFZEST FORTE TABLET

How To Manage Side Effects

Constipation

Eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals. Drink plenty of water and exercise more regularly. Consult your doctor if constipation persists.

Dehydration

Drink lots of fluids, such as water or fruit juices, to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the diarrhea does not improve.

Indigestion

Eat smaller meals but take them frequently. Eat and exercise regularly. Contact your doctor if the digestion does not improve.

Nausea And Vomiting

Take this medicine with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if the nausea and vomiting do not improve.

Stomach Pain

Try to rest and relax. Eat small meals but take them frequently. Keep a heating pad on your stomach. Contact your doctor if the stomach pain does not improve.

Warning & Precautions

Pregnancy

Contraindicated

MEFZEST FORTE TABLET is not recommended for use in pregnant women. Contact your doctor before taking the medicine.

Breastfeeding

Contraindicated

MEFZEST FORTE TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizziness, drowsiness, fatigue, and visual disturbances after taking MEFZEST FORTE TABLET.

Alcohol

Contraindicated

Avoid consumption of alcohol while taking MEFZEST FORTE TABLET, as it increases the risk of liver injury and stomach bleeding.

Kidney

Contraindicated

MEFZEST FORTE TABLET is not recommended for use in patients with kidney disease. Contact your doctor before taking.

Liver

Contraindicated

MEFZEST FORTE TABLET is not recommended for use in patients with liver disease. Contact your doctor before taking it.

Allergy

Contraindicated

Do not take MEFZEST FORTE TABLET if you are allergic to mefenamic acid, paracetamol, or any other ingredients of this medicine.

Lungs

Contraindicated

MEFZEST FORTE TABLET is not recommended for use in patients with lung diseases such as asthma, sinusitis with or without nasal polyps (aspirin triad), or aspirin-sensitive asthma. Contact your doctor before taking it.

Heart Disease

Contraindicated

MEFZEST FORTE TABLET is not recommended for use in patients with heart disease such as heart failure or hypertension. Contact your doctor before taking it. 

Use In Pediatrics

Consult your doctor

MEFZEST FORTE TABLET is not recommended for use in children below 6 months. Your doctor will give the right dose depending on your child’s age, body weight, and disease condition. Contact your doctor before taking.

Use In Geriatrics

Use with Caution

MEFZEST FORTE TABLET should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking.

Interactions

A. Drug-Drug interactions:

Inform your physician if you are taking,

• cholestyramine (medicines used to decrease high cholesterol levels)
• metoclopramide and domperidone (medicine used to manage nausea and vomiting)
• warfarin (medicine used for managing blood clots)
• phenytoin (medicine used to manage seizures)
• isoniazid (medicines used for tuberculosis)
• medicine used for high blood pressure (captopril and diuretics like chlorthiazide, chlorthalidone)
• ibuprofen, ketoprofen (medicine used to manage pain)
• lithium (medicine used to manage depression and mania)
• methotrexate (medicines used to manage cancer)
• antacids (medicines used for heartburn or indigestion)
• medicine used to manage bacterial infections (Ex. chloramphenicol, aminoglycosides like amikacin, tobramycin, gentamicin, and quinolone antibiotics like ciprofloxacin)
• digoxin (medicine used for heart failure)
• medicines used to manage diabetes mellitus (Ex. glimepiride, metformin)
• antiplatelet like aspirin (medicine used to manage platelet aggregation)
• cyclosporine (medicines acting on the immune system)
• corticosteroids (medicines used to manage inflammation)
• mifepristone (medicines used to terminate pregnancy)
• tacrolimus (medicines used to manage atopic dermatitis)
• zidovudine (medicines used for HIV infection)

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdose are pallor, nausea, vomiting, anorexia, abdominal pain or epigastric pain, lethargy, drowsiness, liver damage, abnormalities of glucose metabolism, and metabolic acidosis may occur.

Synopsis

More Information

FAQs About MEFZEST FORTE TABLET

Q: For what conditions MEFZEST FORTE TABLET is used?

A: MEFZEST FORTE TABLET is indicated for the management of fever. It is also used for the management of mild to moderate pain, such as headaches, toothaches, joint or muscle pains, and period pains. Contact your doctor before taking it.

Q: What are the side effects of taking MEFZEST FORTE TABLET?

A: The most common side effects of this medicine are nausea, vomiting, abdominal pain, diarrhea, constipation, indigestion, flatulence, anorexia, dry mouth, heartburn, peptic ulcers, perforation or GI bleeding, and ulcerative stomatitis. Contact your doctor if any of the symptoms worsen.

Q: How does MEFZEST FORTE TABLET work?

A: MEFZEST FORTE TABLET helps to relieve fever and pain, where paracetamol acts on the hypothalamus (heat-regulating center) of the brain, resulting in peripheral vasodilation, sweating, and loss of body heat, and it also increases the pain threshold by inhibiting COX-1 and COX-2 enzymes, and mefenamic acid works by inhibiting COX-1 and COX-2 enzymes, which are involved in prostaglandin synthesis (responsible for pain and inflammation).

Q: Can I use MEFZEST FORTE TABLET in children?

A: No. MEFZEST FORTE TABLET is not recommended for use in children below 6 months. Contact your doctor before taking it.

Q: Can I drink alcohol while using MEFZEST FORTE TABLET?

A: No. Avoid consumption of alcohol while taking MEFZEST FORTE TABLET, as it increases the risk of liver injury and stomach bleeding.

Q: Who should avoid taking MEFZEST FORTE TABLET?

A: MEFZEST FORTE TABLET is not recommended for use in patients with an allergic history to mefenamic acid, paracetamol, and with asthma or aspirin-sensitive asthma, sinusitis with or without nasal polyps (aspirin triad), kidney or liver disease or heart failure, hypertension, active ulceration/bleeding, or chronic inflammation of the upper or lower gastrointestinal (GI) tract, obstructive uropathy, or coronary artery bypass graft (CABG) surgery. Contact your doctor before taking it.

Q: Is MEFZEST FORTE TABLET safe during pregnancy?

A: MEFZEST FORTE TABLET is not recommended for use in pregnant women. Contact your doctor before taking the medicine.

Q: What precautions must be taken while using MEFZEST FORTE TABLET?

A: Before taking MEFZEST FORTE TABLET, inform your doctor if you have fluid retention or edema, poor general health, previous anaphylactic reactions to NSAIDs, anemia, or are scheduled for a blood test for prothrombin time.

Q: How should I take MEFZEST FORTE TABLET?

A: Take MEFZEST FORTE TABLET as advised by your physician. It can be taken with or without food.

For Tablet, Capsule: Swallow MEFZEST FORTE TABLET with a glass of water. Do not crush or chew the medicine.

For Dispersible Tablet: Disperse the medicine in the specified quantity of water as mentioned in the label. Consume the medicine immediately after reconstitution.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Q: Is MEFZEST FORTE TABLET safe for fever?

A: Yes, MEFZEST FORTE TABLET is a combination of mefenamic acid and paracetamol, which belongs to a group of medicines called Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Analgesics and Antipyretics. It is used to manage fever and mild to moderately painful conditions.

References

1. Rowa. Pharmaceuticals Ltd. Health Products Regulatory Authority (HPRA). [Revised in March 2019] [Accessed on 10th August 2024] https://www.hpra.ie/img/uploaded/swedocuments/eec4b0f8-a82a-4ba9-8e04-d411ee4d7b95.pdf

2. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in July 2023] [Accessed on 10th August 2024]https://www.medicines.org.uk/emc/files/pil.5164.pdf

3. Lelypharma B.V. Electronic Medicines Compendium (EMC). [Revised in April 2020] [Accessed on 10th August 2024] https://www.medicines.org.uk/emc/files/pil.12890.pdf

4. Mefenamic acid and Paracetamol. Mepromax Life Sciences Pvt. Ltd. [Revised in January 2021] [Accessed on 10th August 2024] https://bluecrosslabs.com/wp-content/uploads/2021/01/MEFTAGESIC-P-DT.pdf

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Kidney Function Test (KFT)
• Liver Function Test (LFT)
• Serum Electrolytes/ Electrolytes Profile
• Healthy Midlife Checkup
• Men Health Checkup - Advanced
• Complete Women Checkup
• Full Body Checkup - Gold
• Full Body Checkup – Silver

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 12 Aug 2024 | 04:59 PM(IST)