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Introduction About LUPRORIN 4MG INJECTION
LUPRORIN 4MG INJECTION contains Leuprolide which belongs to the group of medicines called Gonadotropin Releasing Hormone (GnRH) agonist. It is used for palliative management (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer.
Advanced prostatic cancer is the cancer (abnormal cell multiplication and differentiation) that originates in the prostate gland and spreads to the other parts of the body. It is characterized by the symptoms such as painful urination, decreased urine pressure, blood in the semen, bone pain, leg swelling, and weakness.
Do not receive LUPRORIN 4MG INJECTION if you are allergic to Leuprolide and other GnRH, GnRH agonist analogs.
Before receiving this medicine, inform your doctor if you have liver impairment, kidney failure, metastatic vertebral lesions, urinary tract obstruction, diabetes or if you have history of orchiectomy (surgical removal of testes) or have been managed with an LH-RH agonist analog previously also.
LUPRORIN 4MG INJECTION is not recommended for use in pregnant and breastfeeding women. It should be used with caution in children and elderly patients (aged above 65 years). Consult your doctor before receiving.
The common side effects associated with the use of LUPRORIN 4MG INJECTION are hot flashes, impotence, anaemia, bone pain, muscle pain, dizziness, light-headedness, general pain, headache, sleeplessness, sleep disorders, and shortness of breath. Consult your doctor if any of these side effects worsens.
Uses Of LUPRORIN 4MG INJECTION
- Used for palliative management (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer
How LUPRORIN 4MG INJECTION Works
LUPRORIN 4MG INJECTION helps in palliative management of advanced prostatic cancer where leuprolide works by initial stimulation followed by blocking of secretion of gonadotropin releasing hormone (GnRH), resulting in suppression of production of ovarian and testicular hormones. This thus helps to relieve the symptoms associated with increased testosterone levels in advanced prostatic cancer.
How to use LUPRORIN 4MG INJECTION
LUPRORIN 4MG INJECTION will be administered to you only by a doctor or a nurse subcutaneously (under the skin). Keep changing the site of injection periodically if taken for long term. Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LUPRORIN 4MG INJECTION
Common
- constipation
- nausea/vomiting
- shrinking of testicles
- gynecomastia (breast enlargement in men)
- ECG changes
- ischemia (poor blood supply to heart muscles)
- high blood pressure
- abnormal heart sounds
- peripheral oedema (swelling in legs and hands due to excessive water retention)
- phlebitis (swelling in blood vessels)
- thrombosis (blood clot formation inside the blood vessels)
- anorexia (eating disorder causing weight loss or weight gain)
- breast tenderness
- hot flashes
- impotence
- anaemia (reduced red blood cell count)
- bone and muscle pain
- dizziness, light-headedness
- headache
- sleep disorders
- shortness of breath
- sinus congestion
- dermatitis (swelling in skin)
- increased urinary frequency and urgency
- blood in urine
- urinary tract infections
- extreme weakness
Rare
Stop receiving LUPRORIN 4MG INJECTION and contact your doctor if you experience any of the following side effects:
- signs of pituitary apoplexy such as sudden headache, visual changes, vomiting, weakened eye muscles, altered mental status, sudden loss of heart function
How To Manage Side Effects
Headache:
Take rest and plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching screen for long time. Consult your doctor if the condition persists for long or gets worsened.
Dizziness:
Lie down until the dizziness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for long or gets worsened.
Constipation:
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.
Warning & Precautions
Pregnancy
LUPRORIN 4MG INJECTION is not recommended for use during pregnancy. Consult your doctor before receiving.
Breastfeeding
LUPRORIN 4MG INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving.
Kidney
LUPRORIN 4MG INJECTION should be used with caution in patients with kidney failure. Consult your doctor before receiving.
Liver
There is no dose adjustment of LUPRORIN 4MG INJECTION is required in patients with hepatic impairment. Consult your doctor before receiving.
Allergy
Do not receive LUPRORIN 4MG INJECTION if you are allergic to Leuprolide, GnRH, GnRH agonist analogs, or to any of the other ingredients of this medicine.
Heart Disease
LUPRORIN 4MG INJECTION should be used with caution in patients under high cardiovascular risk factors. Consult your doctor before receiving.
Others
Before receiving LUPRORIN 4MG INJECTION, inform your doctor if you:
- have metastatic vertebral lesions
- have urinary tract obstruction
- have diabetes
- had orchiectomy (surgical removal of testes)
- have been managed with an LH-RH agonist analog previously also
Use in pediatrics:
LUPRORIN 4MG INJECTION should be used with caution in children. Your doctor will administer the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before receiving.
Use in geriatrics:
LUPRORIN 4MG INJECTION should be used with caution in elderly patients (above 65 years of age). Consult your doctor before receiving.
Interactions
A. Drug-Drug Interactions:
Before receiving LUPRORIN 4MG INJECTION, inform your doctor if you are taking any prescription, non-prescription and herbal supplements.
Overdosage:
LUPRORIN 4MG INJECTION will be administered to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are shortness of breath, decreased activity, and irritation at the site of injection.
Synopsis
| Drug | : | Leuprolide |
| Pharmacological Category | : | Gonadotropin Releasing Hormone (GnRH) Agonist |
| Therapeutic Indication | : | Palliative management for advanced prostatic cancer |
| Dosage Forms | : | Injection, Injection depot |
More Information
- Keep LUPRORIN 4MG INJECTION out of reach of children
- Store between 2-8°C
FAQs About LUPRORIN 4MG INJECTION
What LUPRORIN 4MG INJECTION is used for?
LUPRORIN 4MG INJECTION for palliative management (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer. Consult your doctor before receiving.
What side effects are seen with LUPRORIN 4MG INJECTION?
The common side effects associated with the use of LUPRORIN 4MG INJECTION are hot flashes, impotence, anaemia, bone pain, muscle pain, dizziness, light-headedness, general pain, headache, sleeplessness, sleep disorders, and shortness of breath. Consult your doctor if any of these side effects worsens.
Who should avoid receiving LUPRORIN 4MG INJECTION?
Do not receive LUPRORIN 4MG INJECTION if you are allergic to Leuprolide, GnRH, GnRH agonist analogs. It is not recommended for use in pregnant women, breastfeeding women, and children. Consult your doctor before receiving.
Is LUPRORIN 4MG INJECTION safe to use in children?
LUPRORIN 4MG INJECTION should be used with caution in children. Your doctor will administer the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before receiving.
Is LUPRORIN 4MG INJECTION safe to use in pregnant and breastfeeding women?
LUPRORIN 4MG INJECTION is not recommended for use during pregnancy as it may increase the risk for pregnancy loss. It is also not recommended for use in breastfeeding women as it is not known whether it can pass through milk. Consult your doctor before receiving.
What is the method of receiving LUPRORIN 4MG INJECTION?
LUPRORIN 4MG INJECTION will be given to you only by a doctor or a nurse subcutaneously (under the skin). Keep changing the site of injection periodically if taken for long term. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Is LUPRORIN 4MG INJECTION safe to use in heart patients?
LUPRORIN 4MG INJECTION should be used with caution in patients under high cardiovascular risk factors. Consult your doctor before receiving.
References
1. KD. Tripathi. Anterior Pituitary Hormones. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 243.
2. Bethesda, National Institute of Diabetes and Digestive and Kidney Diseases. Leuprolide. NIH. National Library of Medicine. National Centre for Biotechnology Information. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. March 2018. [Accessed on 29th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK548676/
3. K Saruki, T Sekihara, M Mashimo, H Matsuo, H Sekiguchi. Leuprorelin acetate blood levels and dialysance after the administration of sustained release leuprorelin acetate in a dialysis case complicated by prostate cancer. NIH. National Library of Medicine. National Centre for Biotechnology Information. PubMed.gov. February 1998. [Accessed on 29th November 2022] https://pubmed.ncbi.nlm.nih.gov/9492847/
4. Ben Venue Laboratories, Inc. FDA (Food and Drug Administration). [Revised in August 2011] [Accessed on 29th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/074728s011lbl.pdf
5. Intas Pharmaceuticals Ltd. LUPRORIN 4. [Accessed on 29th November 2022] https://www.intaspharma.com/products/
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