Lornit 500mg Tablet 10'S

Introduction About LORNIT 500MG TABLET

LORNIT 500MG TABLET contains L-ornithine-L-aspartate, which belongs to the group of medicines called Hepatoprotective agents. It is used in the management of various liver disorders such as acute or chronic hepatitis, liver cirrhosis, fatty liver with hyperammonemia, or hepatic encephalopathy (a series of neuropsychiatric abnormalities in patients with liver dysfunction after exclusion of brain disease). It can also be used as an adjuvant therapy for all hepatotoxic drugs.

L-ornithine-l-aspartate is made up of two amino acids called ornithine and aspartic acid. Both l-ornithine and l-aspartic acid ensure hepatoprotective effects by decreasing the toxic load on the liver and by providing metabolic support for hepatic cells. Before taking this medicine, inform your doctor if you have severe liver disease, because your doctor might adjust the dose on an individual basis to avoid nausea and vomiting.

Always take this medicine as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. It is well tolerated with minimal side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor. Do not take this medicine if you have severe renal impairment. Ask your doctor for advice. Ask your doctor for advice before taking this medicine if you are pregnant or breastfeeding.

Uses Of LORNIT 500MG TABLET

• Manages acute or chronic hepatitis, liver cirrhosis, fatty liver with hyperammonemia, and hepatic encephalopathy
• Used as an adjuvant therapy with all hepatotoxic drugs

How LORNIT 500MG TABLET Works

L-ornithine converts toxic ammonia into non-toxic urea, which is eliminated via the kidneys. By doing this, it lowers the elevated level of toxic load (ammonia) in blood and helps the diseased liver to carry out its normal function smoothly (detoxification). L-aspartate is an important component of the citric acid cycle, which liberates energy in the form of ATP, which helps in the regeneration of damaged liver cells.

How to use LORNIT 500MG TABLET

Always take LORNIT 500MG TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine as long as your doctor tells you to do so to obtain better results.

Side Effects Of LORNIT 500MG TABLET

LORNIT 500MG TABLET is generally safe and does not cause any side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor.

Warning & Precautions

Pregnancy

Use with Caution

LORNIT 500MG TABLET should be used with caution in pregnant women. Consult your doctor before taking this medicine.

Breastfeeding

Use with Caution

LORNIT 500MG TABLET should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if your ability is affected by this medicine.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking this medicine, because alcohol can reduce the chances of healing and worsen liver damage.

Kidney

Contraindicated

Do not take LORNIT 500MG TABLET if you suffer from renal insufficiency (severely impaired kidney function). Consult your doctor for advice.

Liver

Use with Caution

LORNIT 500MG TABLET should be taken with caution in patients with severe liver disease. Consult your doctor for advice.

Allergy

Contraindicated

Do not take this medicine if you are allergic (hypersensitive) to l-ornithine-l-aspartate.

Interactions

Tell your doctor about all the medicines you use, including prescription and non-prescription medicines and herbal supplements.

Synopsis

More Information

FAQs About LORNIT 500MG TABLET

Q: How do I take LORNIT 500MG TABLET?

A: Always take this medicine as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.

Q: Can LORNIT 500MG TABLET be taken by pregnant women?

A: This medicine should be used with caution in pregnant women. Consult your doctor before taking it.

Q: Can I consume alcohol while taking LORNIT 500MG TABLET?

A: No. Avoid consumption of alcohol while taking this medicine, because alcohol can reduce the chances of healing and worsen liver damage.

Q: What is LORNIT 500MG TABLET used for?

A: LORNIT 500MG TABLET is used in the management of various liver disorders such as acute or chronic hepatitis, liver cirrhosis, fatty liver with hyperammonemia, or hepatic encephalopathy (a series of neuropsychiatric abnormalities in patients with liver dysfunction after exclusion of brain disease). It can also be used as an adjuvant therapy with all hepatotoxic drugs.

Q: What are the side effects of LORNIT 500MG TABLET?

A: LORNIT 500MG TABLET is generally safe and does not cause any side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor.

Q: How does LORNIT 500MG TABLET work?

A: L-ornithine converts toxic ammonia into non-toxic urea, which is eliminated via kidneys. By doing this, it lowers the elevated level of toxic load (ammonia) in blood and helps the diseased liver to carry out its normal function smoothly (detoxification). L-aspartate is an important component of the citric acid cycle, which liberates energy in the form of ATP, which helps in the regeneration of damaged liver cells.

Q: Who should not take LORNIT 500MG TABLET?

A: Do not take LORNIT 500MG TABLET if you suffer from renal insufficiency (severely impaired kidney function) and are allergic to l-ornithine-l-aspartate. Consult your doctor for advice.

Q: What precautions must be taken while using LORNIT 500MG TABLET?

A: LORNIT 500MG TABLET should be taken with caution in patients with severe liver disease. Consult your doctor for advice.

Q: Can I take other medicines along with LORNIT 500MG TABLET?

A: Tell your doctor about all the medicines you use, including prescription and non-prescription medicines and herbal supplements.

Q: What is the best time to take LORNIT 500MG TABLET?

A: Take LORNIT 500MG TABLET after meals or as advised by your doctor. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition. Continue to take this medicine as long as your doctor tells you to do so to obtain better results.

References

1. James M. Ritter, Lionel D. Lewis, Timothy GK Mant, and Albert Ferro. The alimentary system. Alimentary system and liver. A Textbook of Clinical Pharmacology and Therapeutics. Fifth edition. Hodder Arnold, an imprint of Hodden Education, part of Hachette Livre UK 2008. Page 260-264.

2. Centro Regional para el Estudio de las Enfermedades Digestivas. Efficacy of L-Ornithine L-Aspartate in Acute Hepatic Encephalopathy. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in September 2014] [Accessed on 29th August 2024] https://clinicaltrials.gov/ct2/show/NCT01041755

3. Aga Khan University. Efficacy of L-Ornithine-L-Aspartate in Cirrhotics with Hepatic Encephalopathy. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in February 2007] [Accessed on 29th August 2024] https://clinicaltrials.gov/ct2/show/NCT00433368

4. Gerald Kircheis and Stefan Lüth. Pharmacokinetic and Pharmacodynamic Properties of L-Ornithine L-Aspartate (LOLA) in Hepatic Encephalopathy. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2019. [Accessed on 29th August 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416235/

5. Ee Teng Goh, Caroline S Stokes, Sandeep S Sidhu, Hendrik Vilstrup, Lise Lotte Gluud, and Marsha Y Morgan. L-ornithine L-aspartate for prevention and management of hepatic encephalopathy in people with cirrhosis. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2018. [Accessed on 29th August 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494563/

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Urine Routine & Microscopy
• Serum Electrolytes/ Electrolytes Profile
• Liver Function Test (LFT)
• Hepatitis Panel
• Hepatitis B Profile
• Hepatitis C Antibody (Hcvab) Rapid Test
• Hepatitis B Virus (Qualitative)
• Hepatitis E Virus Antibody Igm (Hevm) Rapid Test

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 31 Aug 2024 | 11:07 AM(IST)