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Introduction About LINOSPAN INJECTION
LINOSPAN INJECTION contains Linezolid which belongs to the group of medicines called Antibiotics. It is used to manage bacterial infections like pneumonia (nosocomial and community-acquired pneumonia), complicated and uncomplicated skin and soft tissue infections caused by susceptible bacteria. It is also used to manage vancomycin-resistant enterococcus faecium infections, including cases with concurrent bacteremia (viable bacteria in the blood).
Bacterial infections are caused by multiplication of specific harmful strain of bacteria anywhere in the body. It is generally characterized by fever, child and sweats, swollen lymph nodes, sudden pain or its worsening, unexplained tiredness, headache, skin flushing or discomfort, nausea, vomiting, diarrhea or stomach pain.
Before receiving LINOSPAN INJECTION, inform your doctor if you have liver, kidney or heart problems, mental health problems (such as maniac depression, schizoaffective disorder) overactive thyroid, anemia or low blood sodium levels (hyponatremia), history of seizures, diarrhea or if you are prone to get infection.
During management with LINOSPAN INJECTION, your doctor might perform regular blood tests to monitor your blood count and your eyesight if you receive LINOSPAN INJECTION for more than 28 days.
LINOSPAN INJECTION is not recommended for use in pregnant women unless advised by the doctor and it is not recommended for use in breastfeeding women. LINOSPAN INJECTION is not recommended for use in children and adolescents (under 18 years of age) and it should be used with caution in elderly patients (aged 65 years and above).
The most common side effects of receiving LINOSPAN INJECTION are headache, dizziness, nausea, vomiting, diarrhea, metallic taste in the mouth and indigestion. Inform your doctor if any of the side effect worsens.
Uses Of LINOSPAN INJECTION
Manages bacterial infections like:
- pneumonia (nosocomial and community-acquired)
- complicated and uncomplicated skin and soft tissue infections
- vancomycin-resistant enterococcus faecium infections
How LINOSPAN INJECTION Works
LINOSPAN INJECTION works by binding to and inhibiting bacterial enzymes required in DNA synthesis, thus interrupting DNA replication and managing bacterial cell multiplication.
How to use LINOSPAN INJECTION
LINOSPAN INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration of LINOSPAN INJECTION for you depending on your age, body weight, severity and type of the infection.
Side Effects Of LINOSPAN INJECTION
Common
- vaginal or oral thrush (fungal infection)
- headache, dizziness
- metallic taste in the mouth
- diarrhea, nausea, vomiting, localized or general stomach pain, constipation, indigestion
- difficulty in sleeping
- increased blood pressure
- anaemia (low red blood cells)
- altered sugar levels
Uncommon
- tingling sensation or feeling numb
- swollen, sore or discoloured tongue
- dry mouth
- frequent urination
- chills
- feeling thirsty
- increased sweating
- kidney failure
- abdominal bloating
- increased or decreased heart rate
- pain and inflammation at injection site and around
- weakness, sensory changes
- inflammation of the vagina or genital area (women)
Rare
- superficial tooth discolouration
Inform your doctor immediately if you experience any of the following side effects while receiving LINOSPAN INJECTION:
- severe skin disorder and allergic reactions (sign includes swelling particularly around the face and neck, wheezing, difficulty breathing, raised purple rash due to inflammation of blood vessels, red sore skin and flaking, rash and itching)
- vision problems (like blurred vision, changes in color vision, difficulty in seeing detail, or restricted field of vision)
- severe diarrhea with blood or mucus (it may develop into complications which are life-threatening)
- repeated nausea or vomiting, abdominal pain or rapid breathing
- fits or seizures or serotonin syndrome (signs include agitation, confusion, mental disturbance, rigidity, shaking, incoordination, seizure, rapid heart rate and severe breathing problems)
- unexplained bleeding or bruising
- changes in the numbers of certain blood cells which may lead to infection (signs of infection include fever, sore throat, mouth ulcers and tiredness)
- inflammation of the pancreas
- transient ischaemic attacks (temporary disturbance of the flow of blood to the brain causing short-term symptoms such as loss of vision, leg and arm weakness, slurring of speech and loss of consciousness)
- ringing in the ears (tinnitus)
- new or worsening myelosuppression (fewer blood cells due to bone marrow suppression)
- syndrome of inappropriate antidiuretic hormone secretion (SIADH) causing confusion, sleepiness, generalized weakness and respiratory failure
How To Manage Side Effects
Constipation
Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and drink plenty of water. If this does not help, inform your doctor for receiving alternate management for constipation.
Diarrhea
Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Inform your doctor if the symptom gets worse.
Dizziness Or Drowsiness
Lie down until the dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid intake of caffeine and its related products. If dizziness does not improve or worsen, inform your doctor.
Headache
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.
Nausea And Vomiting
Stick to simple meals while receiving this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.
Stomach Pain
Try to rest and relax. Eat and drink slowly or try to eat smaller meals more frequently. Keep a heat pad on your stomach. Inform your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
Monitoring requiredLINOSPAN INJECTION is not recommended for use in pregnant women unless advised by the doctor. Consult your doctor before receiving LINOSPAN INJECTION.
Breastfeeding
ContraindicatedLINOSPAN INJECTION is not recommended for use in breastfeeding women as it passes into the breast milk and may affect the baby. Consult your doctor before receiving LINOSPAN INJECTION.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you experience dizziness or problems with your eyesight after receiving LINOSPAN INJECTION.
Alcohol
Consult your doctorAvoid consumption of alcohol (especially draught beers and wine) while receiving LINOSPAN INJECTION.
Kidney
Use with CautionLINOSPAN INJECTION should be used with caution in patients with kidney problems especially if the patient is on dialysis. Consult your doctor before receiving LINOSPAN INJECTION.
Liver
Use with CautionLINOSPAN INJECTION should be used with caution in patients with liver problems. Consult your doctor before receiving LINOSPAN INJECTION.
Allergy
ContraindicatedDo not receive LINOSPAN INJECTION if you are allergic to Linezolid or any other ingredients of this medicine.
Heart Disease
Use with CautionLINOSPAN INJECTION should be used with caution in patients with high blood pressure. Consult your doctor before receiving LINOSPAN INJECTION.
Use In Pediatrics
ContraindicatedLINOSPAN INJECTION is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionLINOSPAN INJECTION should be used with caution in elderly patients (aged 65 years and above) due to greater risk of developing blood dyscrasias (condition which affects the blood, bone marrow or lymph tissue). Consult your doctor before receiving it.
Others
Before receiving LINOSPAN INJECTION, inform your doctor if you:
- have an overactive thyroid
- have adrenal glands tumor (phaeochromocytoma) or carcinoid syndrome (tumors of the hormone system causing diarrhoea, flushing of the skin and wheezing)
- have mental disorders such as manic depression, schizoaffective disorder, mental confusion or other mental problems
- bruise and bleed easily
- have history of low blood sodium levels
- are anemic (low red blood cells)
- are prone to getting infections
- have a history of seizures
- have diarrhea
Interactions
A. Drug-Drug interactions:
Before receiving LINOSPAN INJECTION, inform your doctor if you are taking any of the following medicines:
- medicines used to manage cold or flu (Ex. pseudoephedrine, phenylpropanolamine)
- medicines used to manage asthma (Ex. salbutamol, terbutaline, fenoterol)
- medicines used to manage depression (Ex. clomipramine, amitriptyline, doxepin, citalopram, dosulepin, fluoxetine, fluvoxamine, imipramine, lofepramine, paroxetine and sertraline), monoamine oxidase inhibitors (MAOIs) (used to manage depression or parkinson’s disease) (Ex. phenelzine, isocarboxazid, selegiline, moclobemide)
- medicines used to manage migraines (Ex. sumatriptan, zolmitriptan)
- medicines used to manage sudden, severe allergic reactions (Ex. adrenaline (epinephrine))
- medicines that increase blood pressure (Ex. noradrenaline (norepinephrine), dopamine and dobutamine)
- pethidine (used to manage moderate to severe pain)
- buspirone (used to manage anxiety disorders)
- warfarin (used to stop blood clotting)
- rifampicin (used to manage bacterial infections)
B. Drug-Food interaction:
Avoid eating large amounts of mature cheese, yeast extracts or soya bean extracts (Ex. soy sauce) while receiving LINOSPAN INJECTION as it may react with a substance called tyramine which is naturally present in some foods and cause an increase in the blood pressure.
Overdosage:
LINOSPAN INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Linezolid |
| Pharmacological Category | : | Oxazolidinone antibiotic |
| Therapeutic Indication | : | Pneumonia, Skin infections, Vancomycin-resistant enterococcus faecium infections |
| Dosage Forms | : | Tablet, Dispersible Tablet, Injection, Infusion, Dry Syrup, Syrup, Oral suspension |
More Information
- StoreLINOSPAN INJECTION below 25°C
FAQs About LINOSPAN INJECTION
Q: Can LINOSPAN INJECTION be used in infants?
A: No, LINOSPAN INJECTION is used for adults and it is not recommended for children and adolescents below 18 years of age. Your child’s doctor will select a suitable alternative therapy for your child to manage the specific infection.
Q: Can LINOSPAN INJECTION be used during pregnancy?
A: LINOSPAN INJECTION is not recommended for use in pregnant women unless advised by the doctor. Consult your doctor before receiving LINOSPAN INJECTION if you are pregnant or planning to get pregnant.
Q: Is LINOSPAN INJECTION safe to use in patients with kidney problems?
A: LINOSPAN INJECTION should be used with caution in patients with kidney problems especially if the patient is on dialysis. Your doctor may monitor your kidney function test regularly to manage any unusual effects. Consult your doctor before receiving LINOSPAN INJECTION.
Q: What are the common side effects of LINOSPAN INJECTION?
A: The most common side effects of receiving LINOSPAN INJECTION are headache, dizziness, nausea, vomiting, diarrhea, metallic taste in the mouth, localized or general stomach pain, constipation, altered sugar levels, vaginal or oral fungal infection, indigestion, etc. Inform your doctor if any of the side effect worsens.
Q: How is LINOSPAN INJECTION administered?
A: LINOSPAN INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion over a period of 30 to 120 minutes. Your doctor will decide the correct dose and duration of LINOSPAN INJECTION for you depending on your age, severity and type of the infection.
References
1. KD. Tripathi. Macrolide, Lincosamide, Glycopeptide and Other Antibacterial Antibiotics; Urinary Antiseptics. Essentials of Medical Pharmacology. Eighth edition. 2019. Page – 807.
2. Seyed Mohammad Reza Hashemian, Tayebeh Farhadi, and Mojdeh Ganjparvar. Linezolid: a review of its properties, function, and use in critical care. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. June 2018 [Accessed on 29th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014438/
3. Abed Zahedi Bialvaei, Mohammad Rahbar, Mehdi Yousefi, Mohammad Asgharzadeh, Hossein Samadi Kafil. Linezolid: a promising option in the treatment of Gram-positives. Journal of Antimicrobial Chemotherapy. February 2017 [Accessed on 29th August 2022] https://academic.oup.com/jac/article/72/2/354/2629138
4. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 29th August 2022] https://www.medicines.org.uk/emc/files/pil.12567.pdf
5. Pfizer Limited. Zyvox (Linezolid). [Revised in November 2021] [Accessed on 29th August 2022] https://labeling.pfizer.com/ShowLabeling.aspx?format=PDF&id=649
Useful Diagnostic Tests
- Completed Blood Count (CBC)
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