LINASHINE 5 Tablet 10's

Introduction About LINASHINE 5 TABLET

LINASHINE 5 TABLET contains Linagliptin, an anti-diabetic medication used to manage type 2 diabetes mellitus. It works by inhibiting the DPP-4 enzyme, which helps increase incretin hormone levels in the body. This enhances insulin secretion and reduces excess glucose production in the liver, helping to control blood sugar levels effectively. LINASHINE 5 TABLET is usually prescribed along with a proper diet and exercise routine to achieve better glycemic control.

This tablet is typically taken once daily, with or without food, as directed by the doctor. It is suitable for patients with kidney impairment as it does not require dose adjustments based on kidney function. However, it should not be used in individuals with type 1 diabetes or diabetic ketoacidosis. Regular monitoring of blood sugar levels is recommended to prevent the risk of hyperglycemia (high blood sugar) or hypoglycemia (low blood sugar), especially if combined with other diabetes medications like sulfonylureas or insulin.

Common side effects of LINASHINE 5 TABLET include stuffy nose, sore throat, headache, and mild hypoglycemia when used with other antidiabetic drugs. Serious side effects, though rare, may include pancreatitis (severe abdominal pain) or allergic reactions. It is important to inform the doctor about any pre-existing medical conditions and ongoing medications before starting this treatment. Maintaining a healthy lifestyle with a balanced diet and regular physical activity can enhance the effectiveness of this medication in managing diabetes.

Uses Of LINASHINE 5 TABLET

• Manage type 2 diabetes mellitus in adults

Benefits of LINASHINE 5 TABLET

1. Effective Blood Sugar Control

LINASHINE 5 TABLET (Linagliptin) helps to lower blood glucose levels by inhibiting the DPP-4 enzyme, which increases insulin production and reduces glucagon secretion, thereby controlling blood sugar levels more effectively

2. No Dose Adjustment for Renal Impairment

Unlike many other diabetes medications, LINASHINE 5 TABLET does not require dose adjustment for patients with kidney disease, making it a safer choice for those with compromised kidney function

3. Minimal Risk of Hypoglycemia

When used alone, LINASHINE 5 TABLET carries a lower risk of causing hypoglycemia compared to other diabetes medications like sulfonylureas or insulin

How LINASHINE 5 TABLET Works

LINASHINE 5 TABLET contains Linagliptin, which helps lower blood sugar in people with type 2 diabetes. It works by blocking an enzyme called DPP-4, which normally breaks down hormones called incretins. Incretins help the body release more insulin when blood sugar is high and reduce sugar production in the liver. By preventing their breakdown, Linagliptin increases insulin levels and decreases sugar release from the liver, keeping blood sugar stable. Unlike some other diabetes medicines, it has a lower risk of causing dangerously low blood sugar (hypoglycemia) and is safe for people with kidney problems.

How to use LINASHINE 5 TABLET

How To Take LINASHINE 5 TABLET ?

• Take one tablet (5mg) once daily, or as directed by your doctor.
• You can take it with or without food at any time of the day, but try to take it at the same time each day for the best results.
• Swallow the tablet whole with water; do not crush, chew, or break it.

What is the correct dosage of LINASHINE 5 TABLET ?

1. Adult Dosage:

• Standard Dosage: The typical dosage for LINASHINE 5 TABLET (Linagliptin) is 5 mg once daily.
• It can be taken with or without food

2. Special Populations:

• Elderly Patients: The dosage remains the same for elderly individuals unless there is a specific medical condition requiring changes

What if I forgot to take LINASHINE 5 TABLET

If a dose of LINASHINE 5 TABLET  is missed, the patient should take it as soon as they remember, unless it is close to the time for the next dose. In that case, they should skip the missed dose and continue with their regular schedule. Do not double up on doses

Overdose

In case of an overdose, symptoms of hypoglycemia may occur, though LINASHINE 5 TABLET is not typically associated with causing significant hypoglycemia. Immediate medical attention should be sought if an overdose is suspected

Side Effects Of LINASHINE 5 TABLET

Like all medicines, LINASHINE 5 TABLET  may cause certain side effects, although not everybody gets them.

What are the common side effects of LINASHINE 5 TABLET ?

• Stuffy or runny nose
• Sore throat
• Cough
• Diarrhoea

What are the rare but serious side effects of LINASHINE 5 TABLET ?

Stop taking LINASHINE 5 TABLET and contact your doctor immediately if you experience any of the following side effects:

• Signs of low blood sugar (hypoglycaemia) (such as trembling, sweating, anxiety, blurred vision, tingling lips, paleness, mood change or confusion, headache, drowsiness, weakness, dizziness, irritability, hunger, fast heartbeat, shaking or feeling jittery)
• Signs of serious allergic reactions (such as swelling of your face, lips, tongue, throat, and other areas on skin, difficulty with swallowing or breathing, raised red areas on the skin (hives), skin rash, itching, flaking or peeling of the skin)
• Signs of inflamed pancreas (pancreatitis) (such as severe and persistent stomach pain, nausea and vomiting)
• Bullous pemphigoid (blisters or breakdown of the outer skin layer (erosion))
• Heart failure symptoms (such as increasing shortness of breath or trouble breathing, especially when you lie down, swelling or fluid retention, especially in the feet, ankles or legs, an unusually fast increase in weight, unusual tiredness)

Does LINASHINE 5 TABLET cause hypoglycemia?

LINASHINE 5 TABLET (Linagliptin) generally does not cause hypoglycemia when used alone, as it works by increasing insulin production in response to elevated blood glucose levels without directly lowering blood sugar in the absence of food or insulin. However, when used in combination with other medications like insulin or sulfonylureas, which can increase insulin levels, there is a risk of hypoglycemia (low blood sugar)

Can LINASHINE 5 TABLET cause skin reactions?

Skin reactions are a rare side effect of LINASHINE 5 TABLET . Common side effects include symptoms like nasopharyngitis or respiratory issues. Though not very common, allergic reactions, including skin rashes or itching, can occur in some individuals. If you notice any unusual skin reactions, it's important to seek medical advice immediately

How To Manage Side Effects

Warning & Precautions

Other Warnings for LINASHINE 5 TABLET

Before taking LINASHINE 5 TABLET , inform your doctor if you:

• Have type 1 diabetes (body does not produce any insulin)
• Have diabetic ketoacidosis (complication of diabetes with high blood sugar, rapid weight loss, nausea or vomiting)
• Have or have had a disease of the pancreas
• Have diabetic skin lesions

Drug - Drug interaction

1. Insulin and Insulin Secretagogues (e.g., Sulfonylureas):

• LINASHINE 5 TABLET (Linagliptin) can be used in combination with insulin or insulin secretagogues like sulfonylureas, but this combination may increase the risk of hypoglycemia (low blood sugar). If these medications are used together, your healthcare provider may need to adjust the insulin or sulfonylurea dose to reduce this risk

2. Metformin:

• LINASHINE 5 TABLET can be safely combined with metformin, a common medication for Type 2 diabetes, as there are no significant interactions between the two. In fact, this combination is often used for enhanced glycemic control

3. Other Antidiabetic Medications:

• LINASHINE 5 TABLET does not interact significantly with other antidiabetic agents like glyburide, pioglitazone, or sitagliptin

4. CYP Enzyme Interaction:

• LINASHINE 5 TABLET (Linagliptin) is a weak inhibitor of CYP3A4, an enzyme involved in the metabolism of many medications. However, LINASHINE 5 TABLET does not significantly interfere with the activity of other CYP enzymes, meaning it is less likely to cause significant drug interactions compared to other drugs that strongly inhibit CYP enzymes

5. Warfarin (Coumadin):

• LINASHINE 5 TABLET does not cause significant interactions with warfarin, an anticoagulant. However, when combining any drug with warfarin, it is crucial to monitor the International Normalized Ratio (INR) to ensure blood clotting levels remain stable

6. Digoxin:

• Similarly, LINASHINE 5 TABLET does not interact significantly with digoxin, a heart medication. However, any changes in kidney function should be closely monitored

7. Other Medications:

• There are no major interactions between LINASHINE 5 TABLET and common drugs like statins (e.g., atorvastatin), antihypertensives, or oral contraceptives

Drug - Food interaction

1. Alcohol:

• Alcohol consumption should be avoided or limited while taking LINASHINE 5 TABLET , as alcohol can lead to hypoglycemia (low blood sugar), especially if consumed on an empty stomach or after exercise. Chronic alcohol use may also affect glucose tolerance. Therefore, it's advised that individuals with diabetes restrict alcohol intake to one drink per day for women and two for men

2. High-Fat Meals:

• While LINASHINE 5 TABLET can be taken with or without food, high-fat meals may slightly reduce its peak concentration in the bloodstream but not to a clinically significant extent. Therefore, it's generally safe to take LINASHINE 5 TABLET with meals, but individuals should avoid excessively fatty or greasy foods

3. Foods Impacting Glucose Levels:

• As LINASHINE 5 TABLET works by improving insulin response, it's important to maintain a balanced diet to optimize its effectiveness. Foods rich in simple sugars or carbs may increase blood sugar, so these should be limited. A consistent low glycemic index (GI) diet is recommended to support overall diabetes management

Synopsis

Drug	:	Linagliptin
Pharmacological Category	:	Oral anti-diabetics
Therapeutic Indication	:	Type-2 Diabetes mellitus
Dosage Forms	:	Tablet

More Information

Alternatives to LINASHINE 5 TABLET

• Januvia 100mg Tablet (Sitagliptin)
• Trajenta 5mg Tablet (Linagliptin)
• Glyxambi 25mg/5mg Tablet (Empagliflozin + Linagliptin)

Linagliptin Vs. Other Antidiabetic Agents

Medication	Mechanism of Action	Risk of Hypoglycemia	Weight Impact	Side Effects	Special Considerations
LINASHINE 5 TABLET (Linagliptin)	Increases insulin secretion, decreases glucagon	Low	Neutral	Mild headache, rare pancreatitis	Safe for kidney patients; No dose adjustment required
Metformin	Reduces liver glucose production, increases insulin sensitivity	Low	Neutral or mild weight loss	GI upset, diarrhea, lactic acidosis (rare)	First-line therapy, affordable
Glimepiride, Glibenclamide (Sulfonylureas)	Increases insulin release from pancreas	High	Weight gain	Hypoglycemia, weight gain	Risk of long-term beta-cell failure
Liraglutide, Semaglutide (GLP-1 Agonists)	Mimics GLP-1 hormone, increases insulin secretion, slows digestion	Low	Weight loss	Nausea, vomiting	Reduces cardiovascular risk, given via injection
Empagliflozin, Dapagliflozin (SGLT-2 Inhibitors)	Prevents kidney glucose reabsorption, increases glucose excretion	Low	Weight loss	UTI, dehydration, ketoacidosis	Heart and kidney protective benefits
Insulin	Directly lowers blood glucose by increasing uptake in cells	High	Weight gain	Hypoglycemia, injection site reactions

 

FAQs About LINASHINE 5 TABLET

Q: Can I take LINASHINE 5 TABLET t while breastfeeding?

A: LINASHINE 5 TABLET (Linagliptin) is considered safe for breastfeeding, as only small amounts are likely to pass into breast milk. However, there are no definitive human studies on the impact on infants. Therefore, breastfeeding mothers should consult their healthcare provider to weigh the potential risks and benefits before starting this medication.

Q: What are the warnings for LINASHINE 5 TABLET in kidney or liver disease?

Kidney Disease: One of the advantages of LINASHINE 5 TABLET (Linagliptin) is that it does not require dose adjustment in patients with mild to moderate renal impairment. This makes it a preferred option for people with kidney disease compared to other diabetes medications. However, it should be used with caution in patients with severe renal impairment or end-stage renal disease

Liver Disease: LINASHINE 5 TABLET has not shown significant interactions in patients with liver disease, and no dose adjustment is required in cases of mild or moderate liver impairment. As always, it's essential for individuals with liver conditions to consult their healthcare provider before using any medication

Q: Is LINASHINE 5 TABLET safe for elderly patients?

A: LINASHINE 5 TABLET is generally safe for elderly patients and does not require dose adjustments based on age alone. However, the elderly are more likely to experience conditions such as renal impairment, so kidney function should be monitored in older patients, especially those with underlying kidney issues

Q: Can LINASHINE 5 TABLET be used for type 1 diabetes?

A: LINASHINE 5 TABLET is specifically approved for the management of Type 2 diabetes and should not be used for Type 1 diabetes. In Type 1 diabetes, the body does not produce insulin at all, whereas LINASHINE 5 TABLET enhances insulin secretion in response to meals, which is more relevant to Type 2 diabetes management.

Q: Is LINASHINE 5 TABLET habit-forming?

A: LINASHINE 5 TABLET (Linagliptin) is not habit-forming. It does not have any addictive properties, and its use does not lead to dependence or withdrawal symptoms

Q: Is LINASHINE 5 TABLET safe for long-term use?

A: Yes, when used as prescribed, LINASHINE 5 TABLET is considered safe for long-term use in diabetes management

Q: Can I take LINASHINE 5 TABLET with insulin?

A: Yes, but it should be taken under a doctor’s supervision to prevent low blood sugar

Q: Does LINASHINE 5 TABLET cause weight gain?

A: No, it does not typically cause weight gain.

Q: Can I take LINASHINE 5 TABLET with alcohol?

A: It is recommended to limit alcohol consumption while taking LINASHINE 5 TABLET . Alcohol can interfere with blood sugar control and may increase the risk of hypoglycemia (low blood sugar), particularly if consumed in excess or on an empty stomach. It’s best to consult with your doctor for specific recommendations regarding alcohol use.

Q: What drugs should not be taken with LINASHINE 5 TABLET ?

A: While LINASHINE 5 TABLET has few significant drug interactions, caution is needed when combining it with:

Insulin or insulin secretagogues (e.g., sulfonylureas) as these may increase the risk of hypoglycemia.

CYP3A4 inhibitors (such as certain antifungals and antibiotics) can theoretically increase LINASHINE 5 TABLET concentration, although interactions are typically minimal

Q: Are there any food restrictions while taking LINASHINE 5 TABLET ?

A: There are no specific food restrictions while taking LINASHINE 5 TABLET. However, it is advisable to maintain a balanced diet and avoid excessive consumption of high-sugar or high-fat foods to ensure optimal blood glucose control.

Q: Can LINASHINE 5 TABLET be taken with metformin or insulin?

A: Yes, LINASHINE 5 TABLET can be safely combined with metformin and insulin to provide comprehensive blood sugar control. In fact, this combination is often prescribed for better glucose management in people with Type 2 diabetes. However, if insulin or sulfonylureas are used alongside LINASHINE 5 TABLET , hypoglycemia may occur, and dose adjustments may be necessary.

Q: Can LINASHINE 5 TABLET be used in children?

A: No, LINASHINE 5 TABLET is used for adults and not recommended for use in children and adolescents under 18 years of age. Child’s doctor will decide the correct dose or select a suitable alternative therapy for your child.

Q: Is LINASHINE 5 TABLET safe to use during pregnancy?

A: LINASHINE 5 TABLET is generally not recommended for use in pregnant women as it is unknown if it is harmful to the unborn child. Consult your doctor before taking this medicine if you are pregnant or planning to become pregnant.

Q: Can I stop taking LINASHINE 5 TABLET  on my own?

A: Do not stop taking LINASHINE 5 TABLET unless your doctor advice you to stop. If you have type 2 diabetes mellitus, your blood sugar levels may rise when you stop taking this medicine suddenly and increase the risk of other complications.

Q: How does LINASHINE 5 TABLET work?

A: LINASHINE 5 TABLET works by increasing the amount of insulin produced by the body which effectively controls your blood sugar. Also, it reduces the amount of substance called glucagon which is produced by the pancreas (glucagon causes liver to produce more sugar) resulting in reduced levels of sugar in your blood.

Q: Is LINASHINE 5 TABLET safe to use in patients with kidney disease?

A: LINASHINE 5 TABLET should be taken with caution in patients with kidney problems. Your doctor may monitor your kidney function test before and during management with this medicine to assess the risk of any unusual effects. Consult your doctor before taking this medicine.

Q: Can I take LINASHINE 5 TABLET with or without food?

A: LINASHINE 5 TABLET  (Linagliptin) can be taken with or without food. There is no specific dietary requirement, making it convenient for users to take it at any time of the day as per their routine. However, it’s recommended to take the tablet consistently at the same time every day for the best results. Although high-fat meals may slightly affect the absorption of Linagliptin, this effect is not clinically significant.

References

1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. seventh edition.2013. Page-275.
2. Rachael Aletti, Angela Cheng-Lai. Linagliptin: the newest dipeptidyl peptidase-4 inhibitor for type 2 diabetes mellitus. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. February 2012. [Accessed on 27th March 2025] 
3. Boehringer Ingelheim Hellas Single Member S.A. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 27th March 2025] 
4. Boehringer Ingelheim Pharmaceuticals, Inc. U.S. Food & Drug Administration. [Revised in June 2023] [Accessed on 27th March 2025] 

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