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Introduction About LINAPIL 5 TABLET
LINAPIL 5 TABLET contains Linagliptin which belongs to the group of medicines called Oral Anti-diabetics. It is used in the management of type 2 diabetes in adults, if the disease cannot be adequately controlled with one oral anti-diabetic medicine (such as metformin or sulphonylureas (Ex. glimepiride)) or diet and exercise alone. This medicine may be used together with other anti-diabetic medicines such as metformin, sulphonylureas (Ex. glimepiride, glipizide), empagliflozin or insulin. During management with LINAPIL 5 TABLET, follow regular exercise and diet plan as advised by your doctor to achieve better glucose control.
Type 2 diabetes is a chronic medical condition in which the body does not make enough insulin or the produced insulin does not work well. When this happens, glucose levels rise in the blood and can lead to serious medical problems like heart or kidney disease and blindness. Symptoms include excessive urination, excessive thirst, hunger, fatigue and blurred vision. Before taking LINAPIL 5 TABLET, inform your doctor if you have any disease of the pancreas, heart or kidney problems, type-1 diabetes, gallstones or history of alcoholism.
LINAPIL 5 TABLET is generally not recommended for use in pregnant women as it is unknown if it is harmful to the unborn child and it is not known if LINAPIL 5 TABLET passes through breast milk, hence consult your doctor before taking this medicine if you are pregnant or breast-feeding women. LINAPIL 5 TABLET is not recommended for use in children and adolescents (under 18 years of age). The most common side effects of taking LINAPIL 5 TABLET are stuffy or runny nose, sore throat, cough and diarrhea. Consult your doctor if any of the symptoms worsen.
Uses Of LINAPIL 5 TABLET
- Manage type 2 diabetes in adults
How LINAPIL 5 TABLET Works
LINAPIL 5 TABLET works by increasing the amount of insulin produced by the body which effectively controls your blood sugar. Also, it reduces the amount of substance called glucagon which is produced by the pancreas (glucagon causes liver to produce more sugar) resulting in reduced levels of sugar in your blood.
How to use LINAPIL 5 TABLET
Take LINAPIL 5 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you according to your age, body weight and disease condition. Do not stop taking this medicine unless your doctor advices you to stop.
Side Effects Of LINAPIL 5 TABLET
Common
- Stuffy or runny nose
- Sore throat
- Cough
- Diarrhoea
Uncommon
- Inflamed nose or throat (nasopharyngitis)
Stop taking LINAPIL 5 TABLET and contact your doctor immediately if you experience any of the following side effects:
- Signs of low blood sugar (hypoglycaemia) (such as trembling, sweating, anxiety, blurred vision, tingling lips, paleness, mood change or confusion, headache, drowsiness, weakness, dizziness, irritability, hunger, fast heartbeat, shaking or feeling jittery)
- Signs of serious allergic reactions (such as swelling of your face, lips, tongue, throat, and other areas on skin, difficulty with swallowing or breathing, raised red areas on the skin (hives), skin rash, itching, flaking or peeling of the skin)
- Signs of inflamed pancreas (pancreatitis) (such as severe and persistent stomach pain, nausea and vomiting)
- Bullous pemphigoid (blisters or breakdown of the outer skin layer (erosion))
- Heart failure symptoms (such as increasing shortness of breath or trouble breathing, especially when you lie down, swelling or fluid retention, especially in the feet, ankles or legs, an unusually fast increase in weight, unusual tiredness)
How To Manage Side Effects
Diarrhea
Drink lot of fluids, such as water to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Consult your doctor if the symptom has not improved.
Nasal Block
Drink sufficient amount of fluids. Use humidifier and rinse inside the nose with saline solution to relieve congestion after consulting the doctor. Consult your doctor if the symptoms has not improved.
Sore Throat
Try to gargle with warm salt water which can help to soothe a throat and break down secretions. Drink a lot of fluids to keep the throat moist and manage dehydration. Avoid drinking alcohol or caffeine and smoking cigarettes. Consult your doctor if the symptom has not improved.
Warning & Precautions
Pregnancy
ContraindicatedLINAPIL 5 TABLET is generally not recommended for use in pregnant women as it is unknown if it is harmful to the unborn child. Consult your doctor before taking it.
Breastfeeding
Consult your doctorIt is not known if LINAPIL 5 TABLET passes though breast milk. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionLINAPIL 5 TABLET has no or negligible effect on the ability to drive or use machines. Consult your doctor if you feel any side effects during management that may stop you from driving or using machines.
Alcohol
Consult your doctorLINAPIL 5 TABLET should be used with caution in patients with a history of alcoholism. Consult your doctor before taking it.
Kidney
Use with CautionLINAPIL 5 TABLET should be taken with caution in patients with kidney problems. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take LINAPIL 5 TABLET if you are allergic to Linagliptin. Inform your doctor if you had an allergic reaction to any other medicines that you take to control blood sugar levels.
Heart Disease
Use with CautionLINAPIL 5 TABLET should be taken with caution in patients with a history of heart failure. Consult your doctor before taking it.
Use In Pediatrics
ContraindicatedLINAPIL 5 TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionLINAPIL 5 TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.
Others
Before taking LINAPIL 5 TABLET, inform your doctor if you:
- Have type 1 diabetes (body does not produce any insulin)
- Have diabetic ketoacidosis (complication of diabetes with high blood sugar, rapid weight loss, nausea or vomiting)
- Have or have had a disease of the pancreas
- Have diabetic skin lesions
Interactions
A. Drug-Drug interactions:
Before taking LINAPIL 5 TABLET inform your doctor if you are taking any of the following medicines:
- Carbamazepine, phenobarbital or phenytoin (used to control fits or chronic pain)
- Antibiotic such as rifampicin (used to manage tuberculosis)
- Insulin or other medicines that can lower your blood sugar
Overdosage:
If you or anyone else accidentally take too much of LINAPIL 5 TABLET consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Linagliptin |
| Pharmacological Category | : | Oral anti-diabetics |
| Therapeutic Indication | : | Type-2 Diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep LINAPIL 5 TABLET out of reach of children
- Store at room temperature
FAQs About LINAPIL 5 TABLET
Q: Can LINAPIL 5 TABLET be used in children?
A: No, LINAPIL 5 TABLET is used for adults and not recommended for use in children and adolescents under 18 years of age. Child’s doctor will decide the correct dose or select a suitable alternative therapy for your child.
Q: Is LINAPIL 5 TABLET safe to use during pregnancy?
A: LINAPIL 5 TABLET is generally not recommended for use in pregnant women as it is unknown if it is harmful to the unborn child. Consult your doctor before taking this medicine if you are pregnant or planning to become pregnant.
Q: Can I stop taking LINAPIL 5 TABLET on my own?
A: Do not stop taking LINAPIL 5 TABLET unless your doctor advice you to stop. If you have type 2 diabetes mellitus, your blood sugar levels may rise when you stop taking this medicine suddenly and increase the risk of other complications.
Q: How does LINAPIL 5 TABLET work?
A: LINAPIL 5 TABLET works by increasing the amount of insulin produced by the body which effectively controls your blood sugar. Also, it reduces the amount of substance called glucagon which is produced by the pancreas (glucagon causes liver to produce more sugar) resulting in reduced levels of sugar in your blood.
Q: Is LINAPIL 5 TABLET safe to use in patients with kidney disease?
A: LINAPIL 5 TABLET should be taken with caution in patients with kidney problems. Your doctor may monitor your kidney function test before and during management with this medicine to assess the risk of any unusual effects. Consult your doctor before taking this medicine.
References
1.KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. seventh edition.2013. Page-275.
2.Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th edition. Philadelphia, PA: Wolters Kluwer Health; 2015. Page 2247-2248.
3.Rachael Aletti, Angela Cheng-Lai. Linagliptin: the newest dipeptidyl peptidase-4 inhibitor for type 2 diabetes mellitus. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. February 2012. [Accessed on 27th November 2023] https://pubmed.ncbi.nlm.nih.gov/22143285/
4.Boehringer Ingelheim Hellas Single Member S.A. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 27th November 2023] https://www.medicines.org.uk/emc/files/pil.4762.pdf
5.Boehringer Ingelheim Pharmaceuticals, Inc. U.S. Food & Drug Administration. [Revised in June 2023] [Accessed on 27th November 2023] https://docs.boehringer-ingelheim.com/Prescribing%20Information/PIs/Tradjenta/Tradjenta.pdf
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Random Blood Sugar (Rbs)
- Post Prandial Blood Sugar (PPBS)
- Vital Diabetes Care
- Comprehensive Diabetes Care
- Netmeds Diabetic Checkup
- Routine Diabetes Care
- Diabetes Care Package
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