LEVIPIL 500 Tablet 15's

Introduction About LEVIPIL 500 TABLET

Levipil 500 Tablet is an anti-seizure medication that helps in the management of epilepsy (seizures). Each tablet contains 500mg of levetiracetam, which is known for its effectiveness in controlling seizures.  It can be used alone or along with other medicines.

Levipil 500 Tablet helps control abnormal electrical activity in the brain. It can be taken with or without food, but it is best to take it at the same time each day for optimal effect. The dosage will vary based on your condition and response to the medication, and your doctor will determine the appropriate dose for you. This medication is typically used as a long-term treatment. It is important to continue taking it as prescribed, even if you feel fine. Stopping or missing doses could lead to a worsening of your seizures.

The most common side effects of this medicine include dizziness, fatigue, headaches, nausea, irritation, sleepiness, behavior changes, aggressive behavior, and decreases appetite. These effects are more frequent in the first few weeks and generally decrease as your body adjusts to the medication. While most side effects are not serious, some may require medical attention. A small number of individuals using this medication have experienced thoughts of self-harm or suicide. If you notice any worsening of your mood, reach out to your doctor.

Before starting this medication, it is important to inform your doctor if you have kidney issues, a history of depression or suicidal thoughts, or if you are pregnant, planning to get pregnant, or breastfeeding. Your doctor may recommend routine blood tests to check your kidney function during management.

Uses Of LEVIPIL 500 TABLET

• Epilepsy (seizures)

Benefits of LEVIPIL 500 TABLET

1. Effective in managing epilepsy- Levipil 500 is primarily used to manage epilepsy. It helps in controlling seizures and reduce their recurrence in patients with epilepsy.
2. Enhances management Compliance- Its once-daily dosage form makes it easy for patients to adhere to the prescribed management plan, improving overall compliance.
3. Well-Tolerated by Most Patients- Levipil 500 has a generally favorable safety profile and is well-tolerated by most individuals. It has a lower incidence of side effects compared to other anticonvulsants.
4. Useful for Both Adults and Children- Levipil 500 can be prescribed for both adult and pediatric patients with epilepsy, making it a versatile medication in managing a wide range of age groups.
5. Non-Sedative- This medication does not cause significant sedation or drowsiness, which means patients can go about their daily activities without being overly tired or impaired.

How LEVIPIL 500 TABLET Works

Levipil 500mg works by stabilizing electrical activity in the brain, reducing the occurrence of seizures. It is thought to bind to a specific protein in the brain that regulates the release of neurotransmitters, which helps prevent abnormal nerve activity that causes seizures.

How to use LEVIPIL 500 TABLET

How to Take Levipil 500 tablet?

• Take Levipil 500mg tablet as prescribed by your doctor. Swallow the tablet whole with a glass of water.
• Do not exceed the recommended daily dosage.

Dosage Recommendations for adults and children:

• For Adults: The initial dose is 500 mg once daily, which may be adjusted based on the response.
• For Children (2 years and older): The initial dose is starts at 10 mg/kg body weight per day, divided into one or two doses.
• Levipil can be taken with or without food. However, taking it with food may help reduce any potential stomach upset.
• It is important to take Levipil at the same time every day. This helps maintain stable levels of the medication in your blood and ensures the most effective management. Do not stop or adjust the dose without consulting your doctor.

Can It Be Split or Crushed?

• Can the tablet be split? Levipil tablets are generally not intended to be split. This is because splitting the tablet could lead to inaccurate dosing. Always check with your doctor before splitting the tablet.
• Can it be crushed? Crushing Levipil tablets is also not recommended, as this can affect the medication's effectiveness and could cause irritation in your mouth or throat.

How Long Does Levipil 500 tablet Take to Work?

• Levipil 500mg (levetiracetam) usually starts working within 1 to 2 hours after taking it. However, it may take a few days to a few weeks for the full effects to be noticeable, especially for controlling seizures. Always follow your doctor's instructions on dosage and timing for the best results.

What if I forgot to take LEVIPIL 500 TABLET

If you miss a dose of Levipil 500mg take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Side Effects Of LEVIPIL 500 TABLET

Like all medicines, Levipil 500 Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Levipil 500 Tablet are:

• Dizziness
• Fatigue
• Headaches
• Nausea
• Irritation
• Sleepiness
• Behavior changes
• Aggressive behavior
• Decreased appetite

When to consult your doctor?

• Severe allergic reactions symptoms may include rash, itching, swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.
• Mood or mental changes such as agitation, depression, anxiety, aggression, or even thoughts of suicide.
• Severe drowsiness or fatigue such as unusual tiredness, confusion, or loss of coordination
• Uncontrolled movements or tremors
• Chest pain or shortness of breath
• liver problems such as severe abdominal pain or yellowing of the skin/eyes

How To Manage Side Effects

Dizziness Or Drowsiness

• Sit or Lie Down: If you feel dizzy, sit down or lie down immediately to prevent falling. Keep your head still and close your eyes if needed.
• Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
• Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
• Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
• Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.

Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.

Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).

Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Warning & Precautions

Pregnancy

Monitoring required

Levipil 500 Tablet should be used with caution in pregnant women only if considered clearly necessary by the doctor. Most studies have shown low or no risk to the developing baby. Please consult your doctor before taking it.

Breastfeeding

Use with Caution

Levipil 500 Tablet should be used with caution in breastfeeding women. Although there is limited human data, it indicates that the medication poses little to no significant risk to the baby. However, it is recommended to monitor the baby for signs of drowsiness and ensure they are gaining weight properly. Please consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate machines if you experience dizziness or drowsiness.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking Levipil 500 Tablet since it may cause dizziness or drowsiness.

Kidney

Use with Caution

Levipil 500 Tablet should be used with caution in patients with kidney disease. Dosage adjustment and careful monitoring are required in such patients. Regular monitoring of kidney function is recommended while taking this medication. Please consult your doctor before taking it.

Liver

Consult your doctor

There is limited information available regarding the use of Levipil 500 Tablet in patients with liver disease, but it appears that dose adjustment may not be necessary for most individuals. However, patients with severe liver disease may require a reduced dose. Please consult your doctor before taking it.

Allergy

Contraindicated

Do not take this medication if you are allergic to levetiracetam and/or any other ingredients of this medicine.

Heart Disease

Use with Caution

Levipil 500 Tablet should be used with caution in patients with heart diseases such as family or medical history of irregular heart rhythm (visible on an electrocardiogram) or if you are prone to heartbeat irregularities. Please consult your doctor before taking it.

Use In Pediatrics

Use with Caution

Levipil 500 Tablet should be used with caution in children and adolescents. Consult your pediatrician before giving it.

Use In Geriatrics

Use with Caution

Levipil 500 Tablet should be used with caution in elderly patients. Dosage adjustment may be needed. Consult and inform your doctor before taking it.

Other Warnings for LEVIPIL 500 TABLET

Before taking Levipil 500 Tablet, inform your doctor if you have or had:

• Seizures or other neurological conditions
• Salt imbalance

Who should not take [GBNKEYWORD

• Severe depression or psychiatric problems such as mood changes, depression, and suicidal thoughts.

Safety Advice

• It is recommended to take Levipil 500mg tablet with food to reduce the risk of stomach upset.
• Let your doctor know If you are pregnant or planning to become pregnant or breastfeeding women or kidney problems.
• Do not suddenly stop taking the medication without consulting your doctor, stopping abruptly can increase the risk of seizures.
• Common side effects include dizziness, drowsiness, headache, or mood changes. If you experience more serious side effects like suicidal thoughts, unusual behavior, or severe allergic reactions, seek medical help immediately.
• Alcohol can increase side effects such as dizziness and drowsiness. Be sure to inform your doctor about any other medications (including over-the-counter and herbal products) you are taking to prevent harmful interactions.
• Some healthy tips to help reduce seizures such as maintain a balanced diet and engage in regular physical activity, incorporate daily yoga practice into your routine, ensure you get adequate sleep each night, reduce screen time, including mobile and laptop usage and take your medications as prescribed and on time.
• Levetiracetam can cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how the drug affects you.
• Keep up with regular doctor visits to monitor your progress and make any necessary adjustments to the dosage.

Diet and Lifestyle Advice

1. Dietary Recommendations:
   • Balanced Diet: Focus on whole grains, lean proteins, fruits, and vegetables to maintain overall health and reduce triggers.
   • Ketogenic Diet (Under Medical Supervision): A high-fat, low-carbohydrate diet may help control seizures in some people. Work with a dietitian to ensure safety and proper implementation.
   • Stay Hydrated: Dehydration can trigger seizures. Aim for adequate water intake daily.
   • Limit Stimulants: Reduce caffeine, alcohol, and processed foods that might interfere with seizure control.
2. Lifestyle Tips:
   • Adequate Sleep: Sleep deprivation is a common trigger for seizures. Aim for 7-8 hours of quality sleep each night.
   • Regular Exercise: Engage in moderate physical activity like walking or yoga to reduce stress and improve overall well-being. Avoid overly strenuous activities that might increase seizure risk.
   • Stress Management: Practice relaxation techniques such as meditation, deep breathing, or mindfulness to lower stress levels, a known seizure trigger.
   • Avoid Seizure Triggers: Identify and manage personal triggers, such as flashing lights, stress, or certain foods.
3. Medication Compliance:
   • Take prescribed anti-epileptic drugs (AEDs) consistently as directed by your doctor to maintain seizure control.
   • Avoid sudden discontinuation of medications, as this can increase seizure frequency.
4. Safety Measures:
   • Avoid risky activities like swimming alone or operating heavy machinery.
   • Use protective measures, such as wearing helmets during outdoor activities, to prevent injuries during a seizure.
5. Regular Medical Check-ups:
   • Maintain regular follow-ups with your neurologist to monitor and adjust treatment as necessary.
   • Inform your doctor about any changes in seizure patterns or side effects from medications.

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Levipil 500 Tablet:

1. Other Antiepileptic Drugs (AEDs)

• Interaction: When used in combination with other AEDs (such as phenytoin, valproate, carbamazepine), there may be changes in how well Levipil works or increased side effects.
• Effect: The effectiveness of Levipil may decrease, or the risk of CNS depression (such as drowsiness or dizziness) may increase.
• Management: Dose adjustments and close monitoring of serum drug levels are often necessary. Your doctor may need to adjust doses of both Levipil and the other AEDs to maintain optimal seizure control and minimize side effects.

2. Antacids (Containing Aluminum or Magnesium)

• Interaction: Antacids may reduce the absorption of Levipil when taken together, potentially leading to decreased blood levels of the drug.
• Effect: Reduced effectiveness of Levipil in controlling seizures.
• Management: If antacids are needed, they should be taken at least 2 hours apart from Levipil to minimize interaction.

3. Warfarin (Blood Thinner)

• Interaction: Levitiracetam may affect warfarin’s anticoagulant effects, though the interaction is not always significant.
• Effect: Potential for altered INR levels, either increasing the risk of bleeding or reducing anticoagulant effects.
• Management: Regular monitoring of INR (International Normalized Ratio) levels and dose adjustments for warfarin may be needed to maintain safe and effective anticoagulation.

4. NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)

• Interaction: Some studies suggest that taking NSAIDs (like ibuprofen) with Levitiracetam could increase the risk of kidney-related side effects or gastrointestinal issues.
• Effect: Increased risk of renal toxicity or gastrointestinal bleeding.
• Management: It is advisable to use NSAIDs with caution or under medical supervision. Alternatives like acetaminophen might be preferred for short-term pain relief.

5. Cimetidine (Stomach Acid Reducer)

• Interaction: Cimetidine may slightly increase the plasma levels of Levitiracetam, possibly leading to an increased risk of side effects like drowsiness or dizziness.
• Effect: Increased plasma levels and possible intensified side effects of Levitiracetam.
• Management: Monitoring for side effects, and possibly adjusting the dose of Levitiracetam if needed.

6. Oral Contraceptives

• Interaction: While Levitiracetam does not have a strong interaction with most oral contraceptives, some anticonvulsants can reduce the effectiveness of birth control pills. Levitiracetam’s impact on contraception is minimal, but it's still a good idea to use additional contraception methods.
• Effect: Potentially reduced effectiveness of oral contraceptives (though not significant for Levitiracetam).
• Management: Use additional forms of contraception if concerned about efficacy. 

More Information

Why Choose Levipil 500 tablet for epilepsy management?

1.Effective Control of Seizures: Levipil 500 Tablet (Levetiracetam) is known to be effective in controlling various types of seizures, including partial onset, generalized tonic-clonic seizures, and myoclonic seizures. This makes it a versatile option for many individuals with epilepsy.

2.Well-Established Safety Profile: Levetiracetam has been widely studied and used for a number of years, and its safety and efficacy are well-established. It is generally well-tolerated, and side effects are typically mild.

3.Convenient Dosage and Administration: Levipil 500 Tablet can be taken once or twice daily, depending on the doctor's prescription. The 500mg tablet allows for flexible dosing, making it easier for patients to stick to their management regimen.

4.Minimal Drug Interactions: Levetiracetam is known to have fewer drug interactions compared to other anti-epileptic medications. This can be especially important for patients who are taking other medications for different health conditions.

5.Fewer Side Effects: Compared to some other anti-epileptic drugs, Levipil has a relatively low incidence of cognitive side effects like drowsiness or memory issues, though individual responses vary.

6.Good for Long-Term Use: Levipil is often used as part of a long-term management plan for epilepsy, especially for individuals who need to take medication consistently over time.

FAQs About LEVIPIL 500 TABLET

References

1. K.D. Tripathi. Antiepileptic Drugs. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 420.

2. Bassel Abou-Khalil. Levetiracetam in the treatment of epilepsy. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. June 2008. [Accessed on 28th January 2025] 

3. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in June 2023] [Accessed on 28th January 2025] +

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Useful Diagnostic Tests

• Kidney Function test (KFT)
• Liver function test (LFT)

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 01 Feb 2025 | 10:44 AM(IST)