New Revised MRP, 100% GST benefit passed Levipil 1gm Tablet 10'S
Netmeds First Membership
Quick Links
Introduction About LEVIPIL 1GM TABLET
LEVIPIL 1GM TABLET is used to manage epilepsy (seizures). It contains Levetiracetam, an anticonvulsant medication that helps control seizures by altering the release of specific brain chemicals involved in seizure activity.
It can take it with or without food, but try to take it at the same time each day for the best results. The dosage will be based on your specific condition and how you respond to the management, your doctor will determine the most appropriate dose for you. It is usually prescribed for long-term use, and you should continue taking it exactly as directed, even if you feel fine. Stopping the medication or missing doses can increase the risk of seizures.
Common side effects of this medicine include drowsiness, dizziness, headache, fatigue, decreased appetite, behavioral changes such as aggression or irritability, sleepiness. Side effects are more common during the first few weeks of management and often decrease as your body adjusts to the medication. Most side effects are mild and do not require medical attention. However, in rare cases, some people may experience serious effects, including thoughts of self-harm or suicide. If you notice any worsening in your mood or behavior, contact your doctor immediately.
Before taking this medication, inform your doctor if you have any kidney problems, experience depression or suicidal thoughts, or if you are pregnant, planning to become pregnant, or breastfeeding. Your doctor may recommend regular blood tests to monitor your kidney function during management.
Uses Of LEVIPIL 1GM TABLET
- Epilepsy (seizures)
Benefits of LEVIPIL 1GM TABLET
- Supports Electrical Stability in the Brain: Levetiracetam helps maintain balanced neuronal activity, offering support in conditions involving episodes of sudden brain electrical shifts.
- Suitable for Long-Term Neurological Support: Designed for ongoing neurological health management, Levipil 1gm is often part of a sustained care plan advised by specialists.
- Extended-Release Formulation: The once-daily tablet offers convenience with sustained effects, minimizing the need for multiple doses throughout the day.
- Can Be Used Alongside Other Neurological Medications: Levetiracetam is commonly prescribed in combination with other medications, providing flexibility in comprehensive care routines.
- Non-Sedating for Most Users: Compared to older-generation alternatives, levetiracetam is less likely to cause excessive drowsiness, helping patients maintain daily functionality (though individual responses may vary).
- Backed by Clinical Use: Levetiracetam has been widely studied and is commonly included in neurological care strategies across various age groups under professional guidance.
How LEVIPIL 1GM TABLET Works
Levipil 1gm Tablet works by stabilizing abnormal electrical activity in the brain to control seizures. Its active ingredient, levetiracetam, binds selectively to synaptic vesicle protein 2A (SV2A), which is involved in the regulation of neurotransmitter release at nerve endings. This binding modulates the release of excitatory neurotransmitters, helping to prevent the excessive neuronal firing that leads to seizures. Levetiracetam does not directly interact with common neurotransmitter receptors like GABA or glutamate but indirectly balances excitatory and inhibitory signaling in the brain. This action reduces the spread of seizure activity without disrupting normal brain function. Additionally, levetiracetam may have neuroprotective effects by decreasing neuronal hyperexcitability and oxidative stress. Its rapid absorption and penetration into the central nervous system ensure effective seizure control with a favorable safety profile.
Key Actions of Levipil 1gm Tablet:
Selective Binding to SV2A Protein:
Levetiracetam binds to the synaptic vesicle protein 2A (SV2A), modulating neurotransmitter release at the synapse.
Reduction of Excessive Neuronal Firing:
By regulating neurotransmitter release, it prevents abnormal hyperexcitability and spread of seizure activity.
Indirect Modulation of Neurotransmitters:
Levetiracetam does not directly affect GABA or glutamate receptors but balances excitatory and inhibitory signals in the brain.
Potential Neuroprotective Effects:
It may reduce oxidative stress and protect neurons from damage caused by excessive excitation.
Efficient Brain Penetration:
The drug rapidly reaches the central nervous system, ensuring timely seizure control with minimal side effects.
How to use LEVIPIL 1GM TABLET
Recommended Dosage of Levipil 1gm Tablet:
The recommended dosage of Levipil 1gm Tablet depends on your doctor’s prescription. Always follow your doctor’s advice and do not alter the dosage without consulting them.
How to Take Levipil 1gm for Best Effectiveness:
For best results, swallow the tablet whole with a full glass of water. You may take Levipil with or without food, depending on your comfort.
When to Take Levipil 1gm Tablet:
Levipil can be taken either in the morning or at night. The most important thing is to take it at the same time every day to maintain steady levels in your body.
Levipil 1gm Dosage for Adults:
Adults should take Levipil exactly as prescribed. Do not exceed the prescribed dose, and avoid missing doses to ensure effective seizure control.
How to Make Levipil 1gm Tablet Part of Your Daily Routine:
Incorporate Levipil into your daily routine by taking it at the same time each day, with or without food. This helps maintain consistent medication levels and improves management effectiveness.
Precautions When Taking Levipil 1gm:
Levipil should be swallowed whole and not crushed, chewed, or broken, as this can affect how the medicine works. Inform your doctor about any other medications you are taking, and any pre-existing conditions.
What if I forgot to take LEVIPIL 1GM TABLET
If you forget to take a dose, take it as soon as you remember. If it is nearly time for your next dose, skip the missed one. Do not double up to make up for a missed dose.
Overdose
Symptoms of overdose may include drowsiness, agitation, or difficulty breathing. If you suspect an overdose, seek emergency medical attention immediately.
Side Effects Of LEVIPIL 1GM TABLET
Like all medicine, Levipil 1gm tablet may cause certain side effects in some individuals, although not everybody gets them,
Common Side Effects of Levipil 1gm tablet are:
- Drowsiness
- Dizziness
- Headache
- Fatigue
- Decreased appetite
- Behavioral changes such as aggression or irritability
- Sleepiness
When To Seek Medical Attention
- Severe allergic reactions (Anaphylaxis) symptoms such as swelling of face, lips, tongue, or throat, difficulty breathing or swallowing, severe rash, itching, or hives
- Serious Skin Reactions symptoms such as blistering, peeling, or severe rash, Redness or swelling of the skin, Signs of Stevens-Johnson Syndrome
- Mood and behavioral changes symptoms such as new or worsening depression, aggression, agitation, or irritability, thoughts of self-harm or suicide, extreme anxiety, or panic attacks
- Neurological symptoms such as unusual tiredness or weakness, loss of coordination or balance, hallucinations or confusion, seizures worsening in frequency or intensity
- Respiratory or cardiovascular problems symptoms such as shortness of breath, chest pain, irregular heartbeat
How To Manage Side Effects
Dizziness Or Drowsiness
- Sit or Lie Down: If you feel dizzy, sit down, or lie down immediately to prevent falling. Keep your head still and close your eyes if needed.
- Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
- Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
- Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
- Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.
Headache
- Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
- Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
- Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
- Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
- Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.
Warning & Precautions
Pregnancy
Consult your doctorLevipil 1gm Tablet should be used during pregnancy only if clearly needed and prescribed by your doctor. While some studies suggest it may be relatively safe, seizure control is crucial during pregnancy. Consult your doctor before taking this medication.
Breastfeeding
Consult your doctorLevetiracetam passes into breast milk in small amounts. Levipil 1gm Tablet is generally considered compatible with breastfeeding, but monitor the baby for signs of sleepiness or poor feeding. Consult your doctor before taking this medication.
Driving and Using Machines
Use with CautionLevipil can cause drowsiness, dizziness, and coordination problems, especially at the beginning of management. Avoid driving or operating machinery until you know how the medicine affects you.
Alcohol
ContraindicatedAvoid alcohol while taking Levipil 1gm Tablet. Alcohol can increase side effects such as drowsiness, dizziness, and may also worsen seizure control.
Kidney
Consult your doctorLevipil is mainly excreted through the kidneys. Dose adjustments may be needed in patients with kidney problems. Use with caution and under medical supervision. Consult your doctor before taking this medication.
Liver
Consult your doctorLevipil 1gm is generally safe for the liver, but caution is advised in patients with severe liver disease. Discuss with your doctor if you have liver conditions. Consult your doctor before taking this medication.
Allergy
ContraindicatedDo not take Levipil if you are allergic to levetiracetam or any other ingredients in the formulation. Signs of allergy include rash, swelling, or breathing difficulty, seek immediate medical help if these occur.
Lungs
Consult your doctorNo specific pulmonary risks are directly associated with Levipil, but seek medical advice if you have breathing disorders and are starting this medication. Consult your doctor before taking this medication.
Heart Disease
Consult your doctorThere are no major known heart-related restrictions, but patients with pre-existing cardiovascular conditions should be monitored, especially if taking other CNS depressants. Consult your doctor before taking this medication.
Use In Pediatrics
ContraindicatedLevipil is generally not recommended for children under 16 years of age when used alone. Consult your pediatrician before giving it.
Use In Geriatrics
Consult your doctorLevipil 1gm tablet should be used with caution in elderly patients. Elderly patients may be more sensitive to the side effects of Levipil, such as sedation or confusion. Regular monitoring is recommended. Dose adjustments may be needed. Consult your doctor before taking this medication.
Other Warnings for LEVIPIL 1GM TABLET
Before taking Levipil 1gm Tablet, inform your doctor if you:
- Have a history of depression, mood disorders, or suicidal thoughts
- Have a history of drowsiness, dizziness, or coordination problems
- Have any condition that affects drug metabolism or clearance, including certain genetic conditions.
- Have salt imbalance
Who should not take [GBNKEYWORD
Levipil 1gm Tablet is not recommended for use if you:
- Have experienced serious psychiatric reactions (e.g., psychosis)
Drug - Drug interaction
Inform your physician if you are taking any of the following medications before starting Levipil 1gm Tablet:
1. Other Antiepileptic Drugs (e.g., Carbamazepine, Phenytoin, Phenobarbital)
- Interaction: May alter Levetiracetam blood levels or be affected by it.
- Effects: Reduced seizure control or increased side effects.
- Management: Monitor seizure frequency and drug levels. Dosage adjustments may be needed.
2. Methotrexate
- Interaction: Levetiracetam may decrease the clearance of methotrexate.
- Effects: Increased risk of methotrexate toxicity (e.g., liver damage, bone marrow suppression).
- Management: Monitor methotrexate levels and toxicity signs closely.
3. CNS Depressants (e.g., Benzodiazepines, Alcohol, Opioids)
- Interaction: Additive sedative effects.
- Effects: Increased drowsiness, dizziness, and risk of respiratory depression.
- Management: Use with caution; avoid alcohol. Monitor for excessive sedation.
4. Oral Contraceptives
- Interaction: No known direct interaction, but seizure medications can sometimes reduce contraceptive efficacy.
- Effects: Risk of unintended pregnancy in some cases.
- Management: Consider additional contraceptive methods if on multiple AEDs. Discuss with your doctor.
5. Digoxin or Warfarin
- Interaction: Minimal direct interaction, but co-administration should be monitored.
- Effects: Potential changes in therapeutic levels.
- Management: Monitor INR (for warfarin) or digoxin levels regularly.
Synopsis
|
Drug |
: |
Levetiracetam |
|
Pharmacological Category |
: |
Anticonvulsants |
|
Therapeutic Indication |
: |
Epilepsy |
|
Dosage Forms |
: |
Tablet, Injection, Infusion, Syrup, Suspension, Oral Suspension, Solution |
More Information
01.Recommended Diet & Lifestyle Considerations While Taking Levipil 1gm Tablet?
|
Category |
Recommendation |
Reason/Benefit |
|
Alcohol |
Avoid or limit alcohol consumption |
Alcohol can worsen drowsiness and reduce seizure control |
|
Sleep |
Maintain a consistent sleep schedule |
Poor sleep can trigger seizures |
|
Hydration |
Stay well-hydrated |
Helps manage dizziness and fatigue |
|
Diet |
No strict restrictions, but a balanced diet is recommended |
Supports overall brain and body health |
|
Caffeine |
Limit excessive intake |
High doses may increase nervousness or affect sleep |
|
Stress Management |
Practice relaxation techniques (e.g., meditation, yoga) |
Stress is a known seizure trigger |
|
Driving/Operating Machinery |
Avoid if experiencing drowsiness or dizziness |
Levipil may impair alertness, especially during initial use |
|
Medication Adherence |
Take at the same time every day |
Maintains steady drug levels for effective seizure control |
|
Vitamin B6/Folate |
May be helpful if recommended by a doctor |
Supports nerve health; sometimes considered in epilepsy management |
|
Recreational Drugs |
Avoid all recreational drugs |
They can lower seizure threshold and interact with medication |
02. Product Comparison
a) Levipil 1gm vs Levipil 500
|
Feature |
Levipil 500 |
Levipil 1gm |
Levipil 1gm Stands Out By |
|
Active Ingredient |
Levetiracetam 500 mg |
Levetiracetam 1000 mg (1gm) |
Double the dose in one tablet |
|
Dosing Frequency |
Typically taken 2–3 times a day |
Often taken 1–2 times a day |
Fewer tablets needed per day |
|
Tablet Count per Dose |
May require multiple tablets per dose |
Usually, 1 tablet per dose |
Simplifies dosing and improves adherence |
|
Use in Severe Cases |
Suitable for mild to moderate seizures |
Preferred in moderate to severe seizure cases |
Delivers higher dose in single tablet for better seizure control |
|
Convenience |
Less convenient due to multiple dosing |
More convenient, especially for long-term use |
Easier regimen, particularly for elderly or non-compliant patients |
|
Formulation Type |
Immediate-release |
Often available in extended-release form |
Potential for steadier drug levels with fewer side effects |
|
Prescription Preference |
Commonly prescribed for dose titration |
Used when stable higher dose is established |
Ideal for maintenance phase once optimal dose is determined |
b) Levetiracetam vs Valproate – Which is better?
|
Criteria |
Levetiracetam (Levipil) |
Valproate (Valproic Acid / Divalproex) |
Which is Better? |
|
Mechanism of Action |
Modulates neurotransmitter release |
Increases GABA levels (inhibitory neurotransmitter) |
Both are effective but act via different pathways |
|
Seizure Types Treated |
Focal, generalized tonic-clonic, myoclonic seizures |
Broad-spectrum: all types including absence, myoclonic, GTC |
Valproate is broader-spectrum |
|
Monotherapy Use |
Approved for monotherapy in some types |
Widely used as monotherapy across many seizure types |
Valproate is more versatile in monotherapy |
|
Common Side Effects |
Drowsiness, dizziness, mood changes |
Weight gain, hair loss, tremor, GI upset |
Levetiracetam has fewer systemic effects |
|
Serious Risks |
Psychiatric symptoms (irritability, depression, aggression) |
Liver toxicity, pancreatitis, thrombocytopenia, teratogenicity |
Valproate carries more serious systemic risks |
|
Use in Pregnancy |
Safer option (Category B or C; not strongly teratogenic) |
High teratogenic risk (Category D/X) |
Levetiracetam is preferred in pregnancy |
|
Drug Interactions |
Minimal drug interactions |
Many drug interactions (enzyme inhibitor) |
Levetiracetam is better for polypharmacy patients |
|
Monitoring Requirements |
No routine blood monitoring needed |
Requires regular liver function, platelets, and drug level checks |
Levetiracetam is lower maintenance |
|
Mood/Behavior Effects |
May cause aggression or depression |
May cause sedation, rarely psychiatric issues |
Valproate may be better tolerated in some with mood disorders |
Conclusion:
- Valproate is more effective for generalized and mixed seizure types but has more side effects and requires close monitoring.
- Levetiracetam is often preferred for its cleaner safety profile, especially in pregnancy, elderly, or those with polypharmacy concerns.
FAQs About LEVIPIL 1GM TABLET
Q: What is Levipil 1gm Tablet used for?
A: Levipil 1gm tablet is primarily used to manage epilepsy. It is prescribed for both focal (partial-onset) and generalized seizures in adults and certain pediatric patients.
Q: How does Levipil 1gm Tablet work?
A: Levipil contains levetiracetam, which works by stabilizing electrical activity in the brain and reducing abnormal nerve signals that cause seizures.
Q: Can Levipil 1gm be taken on an empty stomach?
A: Yes, Levipil 1gm can be taken with or without food. However, taking it with food may help reduce nausea in some individuals.
Q: Is Levipil 1gm Tablet safe for long-term use?
A: Yes, Levipil 1gm is generally safe for long-term use under medical supervision. Regular follow-up with your doctor is important to monitor for side effects and adjust dosing if needed.
Q: Does Levipil 1gm cause drowsiness or sleepiness?
A: Drowsiness is a common side effect, especially when starting the medication. Avoid driving or using machinery until you know how Levipil affects you.
Q: Can I stop taking Levipil 1gm if my seizures are controlled?
A: No, do not stop taking Levipil without consulting your doctor. Abrupt discontinuation may lead to seizure recurrence or worsening.
Q: What should I do if I miss a dose of Levipil 1gm?
A: Take the missed dose as soon as you remember. If it is close to the next dose, skip the missed one. Never take two doses at once.
Q: Is Levipil 1gm safe during pregnancy or breastfeeding?
A: Levipil may be used during pregnancy if the benefits outweigh the risks. It is also considered relatively safe during breastfeeding. Always consult your doctor.
Q: Can Levipil 1gm interact with other medications?
A: Yes, although Levipil has fewer drug interactions compared to other antiepileptics, always inform your doctor about any other medications you are taking.
Q: How is Levipil 1gm different from Levipil 500?
A: Levipil 1gm contains double the dose of Levipil 500, allowing for fewer tablets per day. It is often prescribed when higher doses are required for seizure control.
References
1. K.D. Tripathi. Antiepileptic Drugs. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 420.
2. Bassel Abou-Khalil. Levetiracetam in the treatment of epilepsy. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. June 2008. [Accessed on 3rd June 2025] 
3. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in June 2023] [Accessed on 3rd June 2025] 
Useful Diagnostic Tests
Author Details
