New Revised MRP, 100% GST benefit passed Letroz 2.5mg Tablet 5'S
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Introduction About LETROZ 2.5MG TABLET
LETROZ 2.5MG TABLET contains Letrozole which belongs to the group of medicines called Hormonal Chemotherapeutic agents. It works by suppressing the release of excessive estrogen in the body that is responsible for causing various health conditions in women like breast cancer.
Before taking Letroz 2.5 mg tablet inform your doctor if you have any problems in your kidneys or liver. You must also inform your doctor before taking Letroz 2.5 mg tablet if you have a history of any bone problems such as osteoporosis or joint pain.
Tab Letroz 2.5 mg is only intended for use in women who have reached their menopause. It is strictly not recommended for use in pregnant women as it may cause serious harm to the growing baby. The most common side effects of taking Tab Letroz 2.5 mg are hot flushes, fatigue, increased sweating, joint pain, hair loss, vaginal bleeding, and high blood cholesterol levels. Talk to your doctor if any of these above side effect bothers you.
Uses Of LETROZ 2.5MG TABLET
- Used for breast cancer in postmenopausal women
How LETROZ 2.5MG TABLET Works
LETROZ 2.5MG TABLET acts by blocking the actions of an enzyme called aromatase in the body which is involved in the production of estrogen. This action suppresses the release of excessive estrogen in the body that triggers breast cancer.
How to use LETROZ 2.5MG TABLET
Take LETROZ 2.5MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of LETROZ 2.5MG TABLET
Serious
Stop taking Letroz 2.5 mg Tablet and contact your doctor immediately if you experience any of the following side effects:
- Signs of blood clot (such as difficulty in breathing, fainting, rapid heart rate, chest pain, bluish skin discoloration, leg, or foot pain)
- Tendon rupture causing bone pain, inflammation of the tendons
- Severe persistent blurred vision
- Severe fever, chills, or mouth ulcers due to infections
- Swelling and redness along a vein which is tender painful when touched
- Sudden onset of oppressive chest pain
- Signs of a brain disorder or a stroke (weakness, paralysis, or numbness in any part of the body, loss of coordination, nausea, or difficulty in speaking or breathing)
- Signs of allergic reactions (such as swelling of the face and throat)
- Hepatitis (symptoms include loss of appetite, dark-colored urine, yellow skin and eyes, nausea)
- Signs of serious skin reactions (such as skin rash, red skin, blistering and peeling of the skin, accompanied with fever)
Common
- Hot flushes
- Feeling weak or tired
- Increased sweating
- Joint pain, muscle pain
- Skin rash
- Headache, dizziness
- Nausea, vomiting
- Indigestion
- Constipation
- Diarrhoea
- loss of appetite
- Swelling of arms, hands, feet, ankles
- weight gain
- Depression
- Hair loss, dry skin
- Vaginal bleeding
- Palpitations (rapid heartbeat)
Uncommon
- Feeling anxious, nervous or irritated
- Drowsiness
- Memory problems, insomnia (lack of sleep)
- Pain or burning sensation in the hands or wrist (carpal tunnel syndrome)
- Impaired sensation of touch, tingling or numbness
- Vaginal discharge or dryness
- Breast pain
- Thirst, taste disorder, dry mouth
- Weight loss
- Urinary tract infection, increased frequency of urination
- Cough
- Inflammation of the mouth and lips (stomatitis)
How To Manage Side Effects
Constipation
To manage constipation, lifestyle changes and dietary adjustments can be beneficial. Increase your fiber intake by incorporating more fruits, vegetables, and whole grains into your diet. Ensure you are drinking an adequate amount of water throughout the day, as hydration is crucial for proper digestion. Regular physical activity can also promote bowel movements. Establish a consistent toilet routine and take your time during bowel movements. If needed, over-the-counter fiber supplements or stool softeners may offer relief, but it's advisable to consult with a healthcare professional before using them regularly. If constipation persists or is accompanied by severe symptoms, seeking medical advice is recommended for a comprehensive evaluation and appropriate> management.
Dizziness Or Drowsiness
To manage dizziness, it's crucial to identify and address potential causes. Ensure you stay hydrated, as dehydration can contribute to dizziness. If you experience sudden changes in position, like standing up quickly, do so gradually to avoid postural hypotension. If dizziness is linked to stress or anxiety, consider relaxation techniques such as deep breathing or meditation. Avoid alcohol and limit caffeine intake, as they can affect balance and coordination. If dizziness persists or is severe, consult with a healthcare professional to rule out underlying medical conditions, adjust medications if necessary, and receive appropriate guidance on managing symptoms. In cases of sudden or severe dizziness, accompanied by other concerning symptoms, seek medical attention promptly.
Headache
To manage a headache, consider some simple strategies. Ensure you are well-hydrated by drinking enough water throughout the day. Take short breaks if you spend long periods in front of a screen, and practice good posture. Applying a cold or warm compress to your forehead or neck can provide relief. Over-the-counter pain relievers, such as acetaminophen or ibuprofen, may help, but it's essential to follow recommended dosages and consult a healthcare professional if headaches persist or worsen. Additionally, practicing relaxation techniques, such as deep breathing or meditation, can help alleviate stress-related headaches. If headaches become chronic or severe, seeking medical advice is advisable for a more comprehensive evaluation and appropriate> management.
Nausea And Vomiting
To manage nausea, consider several lifestyle adjustments. Stay hydrated by sipping small amounts of clear liquids, and opt for bland, easy-to-digest foods like crackers and bananas. Ginger, whether in tea, candies, or supplements, may help alleviate symptoms. Eat small, frequent meals to manage an empty stomach, and avoid strong odors that can trigger nausea. Acupressure wristbands, deep breathing, and staying upright after meals are additional strategies. Peppermint, known for its soothing effect, can be consumed through tea or candies. Identify and avoid triggers, and if nausea persists, consult with a healthcare professional for further evaluation and potential medication options.
Warning & Precautions
Pregnancy
ContraindicatedLetroz 2.5 mg Tablet is not recommended for use during pregnancy. Therefore, consult your doctor for advice.
Breastfeeding
ContraindicatedLetroz 2.5 mg Tablet is not recommended for use in breast-feeding women. Therefore, consult your doctor for advice.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy, tired, drowsy or generally unwell after taking LETROZ 2.5MG TABLET.
Alcohol
ContraindicatedAvoid consumption of alcohol while taking LETROZ 2.5MG TABLET to avoid unwanted reactions.
Kidney
Use with CautionLETROZ 2.5MG TABLET should be used with caution in patients with severe kidney diseases. Therefore, consult your doctor before taking it.
Liver
Use with CautionLETROZ 2.5MG TABLET should be used with caution in patients with severe liver diseases. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take LETROZ 2.5MG TABLET if you are allergic to Letrozole.
Use In Pediatrics
ContraindicatedLETROZ 2.5MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use In Geriatrics
Use with CautionLETROZ 2.5MG TABLET should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before taking it.
Others
LETROZ 2.5MG TABLET is not recommended for use if you:
- have not gone through menopause
Before taking LETROZ 2.5MG TABLET, inform your doctor if you have:
- a history of bone fractures or osteoporosis
- osteoporosis (weak bones) or joint inflammation
Interactions
A. Drug-Drug interactions:
Before taking LETROZ 2.5MG TABLET inform your doctor if you are taking any of the following medicines such as:
- Other medicines used for cancer (Ex. tamoxifen, anastrozole)
- Cimetidine (medicine used to manage stomach ulcer)
- Warfarin (medicine used for blood thinning)
Over dosage:
If you or anyone else accidentally took more of LETROZ 2.5MG TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
|
Drug |
: |
Letrozole |
|
Pharmacological Category |
: |
Aromatase inhibitor |
|
Therapeutic Indication |
: |
Breast cancer in postmenopausal women |
|
Dosage Forms |
: |
Tablet, Capsule |
More Information
- Keep LETROZ 2.5MG TABLET out of reach of children
- Store LETROZ 2.5MG TABLET at room temperature
FAQs About LETROZ 2.5MG TABLET
Q: How does LETROZ 2.5MG TABLET works?
A: LETROZ 2.5MG TABLET contains Letrozole is an aromatase inhibitor which acts by blocking the actions of an enzyme called aromatase in the body involved in the production of Estrogen. This suppresses the release of excessive estrogen in the body that triggers breast cancer. As a result, it slows down from growing and spreading to other parts of the body.
Q: Can I take LETROZ 2.5MG TABLET during breastfeeding?
A: No. LETROZ 2.5MG TABLET is not recommended for use in breast-feeding women. Therefore, consult your doctor before taking the medicine.
Q: Can LETROZ 2.5MG TABLET cause headache?
A: Yes. LETROZ 2.5MG TABLET may cause headache in some individuals. If you experience headache, take rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Consult your doctor if your headache worsens.
Q: Can LETROZ 2.5MG TABLET increase the risk of infections?
A: LETROZ 2.5MG TABLET may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at greater risk of getting infected while taking LETROZ 2.5MG TABLET. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.
Q: Can the use of LETROZ 2.5MG TABLET make me feel tired?
A: Yes. LETROZ 2.5MG TABLET may make you feel tired easily. This is because, it reduces the levels of red blood cells in the blood and makes anaemic. Consult your doctor if you experience tiredness after taking LETROZ 2.5MG TABLET. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while taking this medicine.
Q: Can I drive a car after taking LETROZ 2.5MG TABLET?
A: LETROZ 2.5MG TABLET may make you feel tired, dizzy, or drowsy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by LETROZ 2.5MG TABLET.
Q: How to take LETROZ 2.5MG TABLET?
A: Take LETROZ 2.5MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Q: What should I do if I forget to take a dose of LETROZ 2.5MG TABLET?
A: If you forget to take a dose of LETROZ 2.5MG TABLET, or vomited immediately after taking the dose, take it as soon as you remember. Do not take the medicine twice to make up for the forgotten dose.
Q: How to control nausea caused due to LETROZ 2.5MG TABLET?
A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with LETROZ 2.5MG TABLET. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-manage nausea.
References
1. K.D. Tripathi, Essentials of medical pharmacology, Primary and secondary prevention of breast cancer. Chapter - Hormones and related drugs. Seventh Edition. 2013. Page – 314.
2. Dong-xu He Xin Ma, Clinical utility of letrozole in the treatment of breast cancer: a Chinese perspective. Onco Targets and Therapies. March 2016. [Accessed on 3rd January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780194/pdf/ott-9-1077.pdf
3. Ajay S. Bhatnagar. The discovery and mechanism of action of letrozole. NIH: National Library of Medicine, National Center for Biotechnology Information. PMC, PubMed Central. 3 Oct 2007. [Accessed on 3rd January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001216/
4. Accord Healthcare Ltd. Electronic Medicines Compendium (EMC). [Revised in Jan 2020] [Accessed on 3rd January 2024] https://www.medicines.org.uk/emc/files/pil.6054.pd
Useful Diagnostic Tests
- Breast Cancer (CA 15.3/ ER/ PR)
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