Lanoxin 0.25mg Tablet 10'S

Introduction About LANOXIN 0.25MG TABLET

Lanoxin 0.25mg Tablet contains the active ingredient digoxin, which is classified as a cardiac glycoside. This medication is primarily used to manage certain heart conditions, including heart failure and specific types of irregular heartbeats (arrhythmias), such as atrial fibrillation. By improving the strength and efficiency of the heart, Lanoxin helps restore and maintain a normal, steady heartbeat, making it easier for the heart to pump blood throughout the body.

Lanoxin 0.25mg Tablet should be taken exactly as prescribed by your doctor. It can be taken with or without food, but it is best to take the medicine at the same time each day to maintain consistent levels in your body. Do not stop taking this medication suddenly without consulting your doctor, as abrupt discontinuation may worsen your heart condition. Regular follow-up appointments are important to monitor your response to management and adjust the dose if necessary.

Some common side effects of Lanoxin 0.25mg Tablet include nausea, vomiting, diarrhea, dizziness, visual disturbances (such as blurred vision or seeing halos), rash or skin reactions and weakness and headache. If any of these side effects become bothersome, inform your doctor. Prompt medical attention is needed if you experience serious symptoms like an irregular or slow heartbeat, severe dizziness, or vision changes.

Lanoxin should be used with caution in certain individuals. Inform your doctor if you have kidney disease (dose adjustments may be necessary), recently suffered a heart attack, vitamin B1 deficiency (Beri-beri disease) and are taking diuretics or other medications that may interact with digoxin. Additionally, let your doctor know if you are pregnant or  breastfeeding, or planning to become pregnant. Regular monitoring of kidney function and electrolyte levels (potassium, magnesium, calcium) is often recommended while on this medication.

Uses Of LANOXIN 0.25MG TABLET

• Arrhythmia (Atrial fibrillation)
• Heart failure

Benefits of LANOXIN 0.25MG TABLET

1) Helps Regulate Heart Rhythm: Lanoxin 0.25mg (digoxin) is effective in managing arrhythmias, particularly atrial fibrillation, by helping to restore and maintain a steady and regular heartbeat. It slows the heart rate and improves its rhythm, which is especially beneficial for patients with irregular or fast heartbeats.

2) Improves Heart Pumping Efficiency: Lanoxin increases the force of heart muscle contractions by affecting the movement of ions in heart cells, resulting in stronger and more efficient pumping of blood throughout the body. This action helps the heart work more effectively, especially in patients with heart failure.

3)Reduces Symptoms of Heart Problems: By improving heart function, Lanoxin can help alleviate common symptoms of heart failure such as fatigue, shortness of breath, and swelling in the legs, ankles, or feet. These improvements contribute to a better quality of life for patients with chronic heart conditions.

4) Enhances Exercise Capacity: Patients with heart failure who take Lanoxin often experience improved exercise tolerance and physical activity levels, as the medication supports more efficient heart function and circulation.

5) Manages Atrial Fibrillation: Lanoxin is widely used to control the heart rate in atrial fibrillation, helping to prevent dangerously fast or irregular heartbeats and reducing the risk of complications like blood clots and stroke.

6) Provides Symptomatic Relief: When used under medical supervision, Lanoxin helps ease symptoms associated with heart failure and arrhythmias, providing symptomatic relief and improving overall well-being.

7) Supports Overall Heart Health: By maintaining heart function and rhythm, Lanoxin plays a crucial role in the long-term management of chronic heart conditions, supporting overall cardiovascular health during management.

How LANOXIN 0.25MG TABLET Works

Lanoxin (digoxin) is a cardiac glycoside used to manage heart failure and certain types of irregular heart rhythms (arrhythmias). Its primary mechanism involves increasing the strength and efficiency of the heart’s contractions and helping regulate heart rhythm.

Key Mechanisms in the Heart:

Increases Heart Contractility (Positive Inotropic Effect): Lanoxin inhibits the sodium-potassium ATPase (Na-K ATPase) enzyme in heart muscle cells. This inhibition leads to an increase in intracellular sodium, which in turn promotes increased calcium influx into the cells via the sodium-calcium exchanger. The higher calcium levels inside the heart muscle cells enhance the force of each contraction, making the heart pump more effectively.

Regulates Heart Rhythm (Negative Chronotropic Effect): By boosting parasympathetic (vagal) activity, Lanoxin slows down the heart rate and reduces conduction through the atrioventricular (AV) node. This effect is especially beneficial in conditions like atrial fibrillation, where controlling a rapid or irregular heartbeat is crucial.

Improves Blood Flow: The increased contractile strength and regulated rhythm support better circulation, ensuring that blood is pumped more efficiently to vital organs, which can relieve symptoms such as fatigue and shortness of breath.

Cellular Actions:

At the cellular level, Lanoxin’s inhibition of the Na-K ATPase pump causes:

• Increased intracellular sodium.
• Enhanced calcium entry into heart muscle cells.
• Stronger heart muscle contractions and improved cardiac output

Additional Effects

Neurohormonal Modulation: Lanoxin decreases sympathetic nervous system activity and reduces activation of the renin-angiotensin system, which can further benefit heart failure patients by lowering vascular resistance and venous tone.

Improved Baroreceptor Sensitivity: This leads to better autonomic regulation of blood pressure and heart function.

How to use LANOXIN 0.25MG TABLET

How to Take Lanoxin 0.25mg Tablet:

• Take Lanoxin 0.25mg Tablet exactly as prescribed by your doctor. Do not change your dose or stop taking the medication without consulting your doctor.
• You may take Lanoxin with or without food, but it is best to take it at the same time each day to maintain consistent blood levels.

Dosage Guidelines for Lanoxin 0.25mg Tablet:

• The typical maintenance dose for adults with heart failure is 0.125 mg to 0.25 mg (125 to 250 micrograms) once daily.
• Dosage may vary based on your age, body weight, kidney function, and other medications you are taking. Your doctor will determine the most appropriate dose for you.
• In some cases, a loading dose may be given initially to achieve therapeutic levels more quickly, followed by a maintenance dose.
• For most adults, the total loading dose is 750 to 1250 micrograms, given in divided doses, but maintenance is usually 125 to 250 micrograms daily.

Administration Instructions for Lanoxin:

• Swallow the tablet whole with a glass of water.
• Try to take it at the same time each day for best results.
• If you have trouble swallowing tablets, discuss alternative formulations with your doctor.

Dose Adjustment and Monitoring:

• Your doctor may adjust your dose based on your response, kidney function, and blood levels of digoxin.
• Regular monitoring of kidney function, potassium, magnesium, and calcium levels is recommended while taking Lanoxin, as these can affect the drug's safety and effectiveness.
• Dose reductions may be necessary in elderly patients, those with impaired kidney function, or those taking certain other medications.

Important Precautions During Use:

• Do not stop taking Lanoxin suddenly without medical advice, as this can worsen your condition.
• Inform your doctor about all other medications you are taking, as Lanoxin can interact with many drugs, potentially increasing the risk of side effects or toxicity.
• Be aware of possible side effects such as nausea, vomiting, dizziness, visual disturbances, and diarrhea. Contact your doctor if these occur or worsen.
• Notify your doctor if you have kidney disease, as dose adjustments and close monitoring may be required.
• Regular follow-up appointments are important to monitor your response and adjust your management as needed.

What if I forgot to take LANOXIN 0.25MG TABLET

• If you miss a dose, take it as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose. Do not take two doses at the same time to make up for a missed one.

Side Effects Of LANOXIN 0.25MG TABLET

Like all medicine, Lanoxin 0.25mg Tablet may cause certain side effects in some individuals, although not everybody gets them,

Common Side Effects of Lanoxin 0.25mg Tablet are:

• Nausea
• Vomiting
• Diarrhea
• Dizziness
• Visual disturbances (such as blurred vision or seeing halos)
• Rash or skin reactions
• Weakness
• Headache

When To Seek Medical Attention

• Severe allergic reactions symptoms such as swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, severe rash, itching, or hives
• Serious skin reactions symptoms such as blistering, peeling, or severe rash, redness or swelling of the skin, signs of Stevens-Johnson Syndrome (such as flu-like symptoms followed by a painful red or purplish rash that spreads and blisters)
• Mood and behavioral changes symptoms such as new or worsening depression, aggression, agitation, or irritability, thoughts of self-harm or suicide, extreme anxiety or panic attacks
• Neurological symptoms such as unusual tiredness or weakness, loss of coordination or balance, hallucinations or confusion, seizures or worsening in frequency or intensity
• Respiratory or cardiovascular problems symptoms such as shortness of breath, chest pain, irregular heartbeat (fast, slow, pounding, or skipping beats)

How To Manage Side Effects

Dizziness Or Drowsiness

• Sit or Lie Down: If you feel dizzy, sit or lie down right away to prevent falls. Remain seated until you feel better.
• Hydrate: Drink water or electrolyte drinks, as dehydration can worsen dizziness3.
• Avoid Sudden Movements: Stand up or sit down slowly to avoid triggering dizziness1.
• Eat Small, Regular Meals: Reduce low blood sugar by eating small, frequent meals and not skipping meals.
• Get Fresh Air: Take slow, deep breaths in a well-ventilated area if you feel dizzy.

Headache

• Rest in a Quiet, Dark Room: Lie down in a calm, dark space to help relieve headache symptoms.
• Hydrate: Drink plenty of fluids, as dehydration can contribute to headaches.
• Apply a Cold or Warm Compress: Use a cold pack on your forehead or a warm compress on your neck/shoulders to ease pain.
• Use Over-the-Counter Pain Relief: If approved by your doctor, take medications like acetaminophen or ibuprofen as directed.
• Practice Relaxation Techniques: Deep breathing, meditation, or gentle stretching can help reduce stress-related headaches.

Warning & Precautions

Pregnancy

Consult your doctor

Lanoxin should be used during pregnancy only if clearly needed and prescribed by your doctor. Most evidence suggests no increased risk of birth defects, but dose adjustments and close monitoring may be necessary. If used during pregnancy, your doctor may monitor your baby for signs of toxicity after birth. Always consult your doctor before starting or continuing Lanoxin during pregnancy.

Breastfeeding

Consult your doctor

Digoxin passes into breast milk in very small amounts and is generally considered safe during breastfeeding. However, monitor your baby for unusual sleepiness, poor feeding, or other symptoms. Discuss with your doctor before breastfeeding while taking Lanoxin.

Driving and Using Machines

Use with Caution

Lanoxin can cause dizziness, drowsiness, or vision changes. Avoid driving or operating heavy machinery until you know how Lanoxin affects you.

Alcohol

Contraindicated

Avoid alcohol while taking Lanoxin. Alcohol can worsen side effects such as dizziness and increase the risk of toxicity.

Kidney

Use with Caution

Lanoxin is mainly excreted by the kidneys. Dose adjustments may be needed in patients with kidney problems. Use with caution and under medical supervision. Regular monitoring of kidney functiXon and digoxin blood levels is recommended.

Liver

Use with Caution

No major dose adjustments are typically needed for mild to moderate liver impairment, but caution is advised in severe liver disease. Consult your doctor if you have liver problems.

Allergy

Contraindicated

Do not take Lanoxin if you are allergic to digoxin or digitalis or any ingredients in the formulation. Signs of allergy include rash, swelling, or difficulty breathing. Seek immediate medical help if these occur.

Heart Disease

Consult your doctor

Lanoxin is not recommended for people with certain abnormal heart rhythms (e.g., ventricular fibrillation). Patients with other heart conditions should be used with caution. close monitoring is required. Always inform your doctor about your full cardiac history. Consult your doctor before taking this medication.

Use In Pediatrics

Use with Caution

Lanoxin Tablet should be used with caution in children and adolescents (below 18 years of age). Consult your pediatrician before giving it.

Use In Geriatrics

Use with Caution

Lanoxin Tablet should be used with caution in elderly patients (aged above 65 years). Elderly patients may be more sensitive to the effects of Lanoxin, including the risk of toxicity. Dose adjustments and regular monitoring are recommended.

Other Warnings for LANOXIN 0.25MG TABLET

Before taking Lanoxin 0.25mg Tablet, inform your doctor if you:

• have beri-beri disease (disease that occurs due to vitamin B1 deficiency)
• have signs of low levels of oxygen in the body (such as low blood pressure and tiredness)
• have signs of low levels of potassium in the blood (such as constipation, fatigue, muscle damage)
• have signs of low levels of magnesium in the blood (such as abnormal eye movements, fatigue and numbness)
• have signs of high levels of calcium in the blood (such as excessive thirst and frequent urination)
• have signs of over/under active thyroid disease (such as nervousness, mood swings, sensitivity to heat and muscle weakness)
• have signs of malabsorption syndrome (such as abdominal pain, bloating, nausea/vomiting)
• had or have gastro-intestinal reconstruction surgery
• have an intolerance to certain sugars (such as lactose)

Drug - Drug interaction

Inform your physician if you are taking any of the following medications before starting Lanoxin 0.25mg Tablet:

1. Antiarrhythmic Drugs (e.g., Amiodarone, Quinidine, Propafenone, Dronedarone, Sotalol)
   • Interaction: These can significantly increase digoxin (Lanoxin) blood levels or alter its effects.
   • Effects: Higher risk of digoxin toxicity, irregular heart rhythms, or sudden cardiac events.
   • Management: Measure serum digoxin concentrations before starting or stopping these drugs. Dose reduction of Lanoxin (by 30–50%) and close monitoring are often required.
2. Calcium Channel Blockers (e.g., Verapamil, Diltiazem, Nifedipine)
   • Interaction: May increase digoxin levels and have additive effects on slowing heart rate.
   • Effects: Increased risk of bradycardia (slow heart rate) or heart block.
   • Management: Monitor heart rate and digoxin levels; adjust dose if necessary.
3. Beta Blockers (e.g., Metoprolol, Carvedilol, Atenolol)
   • Interaction: Can have additive effects with digoxin on slowing the heart.
   • Effects: Risk of excessive slowing of the heart or heart block.
   • Management: Monitor heart rate and rhythm; adjust doses as needed.
4. Certain Antibiotics (e.g., Erythromycin, Clarithromycin, Tetracycline)
   • Interaction: May increase digoxin absorption and blood levels.
   • Effects: Higher risk of toxicity (nausea, vomiting, visual changes, irregular heartbeat).
   • Management: Monitor for toxicity and digoxin blood levels; dose adjustment may be necessary.
5. Diuretics (Water Pills, e.g., Furosemide, Hydrochlorothiazide, Spironolactone)
   • Interaction: Can cause electrolyte imbalances (low potassium/magnesium) that increase digoxin toxicity risk.
   • Effects: Arrhythmias, muscle weakness, or confusion.
   • Management: Regularly monitor electrolytes and digoxin levels.
6. Drugs Affecting Kidney Function (e.g., ACE inhibitors, NSAIDs)
   • Interaction: May impair digoxin excretion.
   • Effects: Increased risk of toxicity.
   • Management: Monitor kidney function and digoxin levels closely.
7. Other Notable Interactions
   • Antacids, Cholestyramine, St. John’s Wort, Rifampin, Phenytoin: Can decrease digoxin absorption or blood levels, reducing effectiveness.
   • Management: Take Lanoxin at a different time of day, or adjust the dose as advised by your doctor.

Drug - Food interaction

1. High-Fiber Foods (e.g., bran, whole grains, fiber supplements)
   • Interaction: High-fiber foods can reduce the absorption of Lanoxin (digoxin) from the digestive tract.
   • Effects: Lower digoxin blood levels, potentially reducing its effectiveness.
   • Management: Take Lanoxin at least 1 hour before or 2 hours after eating high-fiber foods or taking fiber supplements.
2. Bananas and Potassium-Rich Foods
   • Interaction: Bananas and other potassium-rich foods can increase potassium levels in the body.
   • Effects: High potassium may lead to irregular heartbeat or reduce Lanoxin’s effectiveness.
   • Management: Avoid excessive intake of potassium-rich foods; consult your doctor regarding your diet1.
3. Salt Substitutes (containing potassium)
   • Interaction: Salt substitutes often contain potassium, which can interact with Lanoxin.
   • Effects: Increased risk of heart rhythm problems or reduced drug effectiveness.
   • Management: Avoid salt substitutes with potassium unless approved by your doctor
4. Herbal Supplements (e.g., St. John’s Wort, Senna, Black Licorice, Hawthorn, Siberian Ginseng, Milkweed)
   • Interaction: These herbs can either reduce Lanoxin levels (St. John’s Wort, Senna) or increase its activity and risk of toxicity (black licorice, hawthorn, Siberian ginseng, milkweed).
   • Effects: Reduced effectiveness or increased risk of side effects and toxicity.
   • Management: Avoid these herbal supplements while taking Lanoxin
5. Alcohol
   • Interaction: Alcohol can make you more drowsy and may decrease the amount of Lanoxin in your bloodstream.
   • Effects: Abnormalities in heart function, increased risk of high blood pressure and heart failure.
   • Management: Avoid alcohol while taking Lanoxin
6. Multivalent Ion Supplements (e.g., calcium, magnesium, aluminum-containing antacids)
   • Interaction: These can interfere with Lanoxin absorption.
   • Effects: Reduced drug absorption and effectiveness.
   • Management: Separate administration of Lanoxin and these supplements by several hours

Synopsis

More Information

1) Why Choose Lanoxin 0.25mg Tablet?

Lanoxin 0.25mg Tablet is a trusted medication for managing heart failure and certain irregular heart rhythms (arrhythmias), such as atrial fibrillation. Here are the key reasons to consider Lanoxin 0.25mg Tablet:

• Proven Efficacy in Heart Failure and Arrhythmias:
  Lanoxin strengthens the force of each heartbeat and helps regulate heart rhythm, making it effective for treating heart failure and controlling abnormal heart rates.
• Improves Heart Function and Symptoms:
  By increasing the heart’s pumping efficiency, Lanoxin can improve blood circulation, reduce symptoms like fatigue, swelling, and shortness of breath, and help patients feel more energetic and active.
• Restores and Maintains Normal Heartbeat:
  Lanoxin helps slow down and regularize a fast or irregular heartbeat, restoring a steady rhythm that is vital for overall cardiovascular health.
• Well-Studied and Widely Used:
  Lanoxin has been used for decades, with a well-understood safety profile and dosing guidelines. Its benefits and risks are well-documented in both clinical practice and medical literature.
• Can Be Used in Combination Therapy:
  Lanoxin is often prescribed alongside other heart medications (such as diuretics and ACE inhibitors) to achieve optimal management of heart failure and arrhythmias.
• Flexible Dosing and Monitoring:
  The tablet comes in standardized doses, and your doctor can tailor the dosage based on your individual needs, kidney function, and blood levels, ensuring safe and effective management.

Lanoxin 0.25mg Tablet is a reliable choice for patients needing better heart function and rhythm control, with decades of clinical use supporting its effectiveness and safety when prescribed and monitored by your doctor.

02) What lifestyle changes or dietary considerations are recommended while taking Lanoxin?

FAQs About LANOXIN 0.25MG TABLET

References

1. K.D. Tripathi. Cardiac Glycosides and Drugs for Heart Failure. Essentials of medical pharmacology. Seventh edition. 2013. Page 515.

2. Rim Charfi, Mouna Ben Sassi, Emna Gaies, Nadia Jebabli, Riadh Daghfous, Sameh Trabelsi. Digoxin therapeutic drug monitoring: age influence and adverse events. NIH National Library of medicine. National Center for Biotechnology Information. PubMed.gov. [Revised in January 2020] [Accessed on 16th June 2025] 

3. University Medical Center Groningen. Digoxin Evaluation in Chronic Heart Failure: Investigational Study in Outpatients in the Netherlands (DECISION). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in February 2022] [Accessed on 16th June 2025] 

4. Aspen Bad Oldesloe GmbH. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 16th June 2025]

Useful Diagnostic Tests

• Echocardiogram (ECG)
• Kidney function test

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 16 Jun 2025 | 03:34 PM(IST)