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Introduction About KOLIBITOR INFUSION
KOLIBITOR INFUSION is a combination of Sulphamethoxazole and Trimethoprim which belongs to the group of medicines called Antibiotics. It is used to manage lung infections (pneumonia or Pneumocystis jiroveci pneumonia) caused by a bacteria called Pneumocystis jirovecii and toxoplasmosis (an infection with the Toxoplasma gondii parasite).
It can also be used to manage urinary tract infections, respiratory tract infections (such as bronchitis), ear infections (such as otitis media) and an infection called nocardiosis which can affect the lungs, skin and brain. KOLIBITOR INFUSION is suitable for use both in adults and in children (including infants aged 6 weeks or more).
KOLIBITOR INFUSION should be used under careful medical supervision. It is important to receive this medicine for the stipulated duration as instructed by your doctor even if you feel better during the midway of the therapy to achieve better results. Failing to complete the full course of the therapy or skipping doses in between the therapy may not result in adequate infection control.
Before receiving KOLIBITOR INFUSION inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have asthma, any allergic conditions, genetic disorders, blood-related disorders, folic acid deficiency, high blood potassium levels or if you are malnourished as a precaution.
Consult your doctor before receiving this medicine if you are pregnant or breastfeeding. The most common side effects of receiving KOLIBITOR INFUSION are headache, nausea, diarrhea, high blood potassium levels, fungal infections of mouth or vagina and skin rashes. Consult your doctor if any of these side effect troubles you.
Uses Of KOLIBITOR INFUSION
It is used in adults and in children (including infants aged 6 weeks or above) to manage the following bacterial infections:
- Lung infections (Ex. Pneumonia or Pneumocystis jiroveci pneumonia) caused by a bacteria called Pneumocystis jirovecii
- Toxoplasmosis (infection with the Toxoplasma gondii parasite)
- Urinary tract infections
- Respiratory tract infections (Ex. bronchitis)
- Ear infections (Ex. otitis media)
- Nocardiosis (a bacterial infection that affects the lungs, skin and brain)
How KOLIBITOR INFUSION Works
KOLIBITOR INFUSION is a powerful antibiotic. It kills the susceptible bacteria by blocking the production of certain essential vitamins (folate) that is necessary for the bacteria to grow, multiply and survive. Therefore, it destroys the susceptible bacteria and manage their further growth and multiplication within the body which helps in reducing the severity of the infection.
How to use KOLIBITOR INFUSION
KOLIBITOR INFUSION will be administered to you only by a doctor or a nurse into the vein (intravenously).
Your doctor will decide the correct dose for you depending upon your age, body weight and health condition.
Side Effects Of KOLIBITOR INFUSION
Common
- high potassium levels in blood causing abnormal heart beats
- fungal infection (thrush or candidiasis) of mouth or vagina
- headache, nausea, diarrhoea
- skin rashes
Uncommon
- vomiting
How To Manage Side Effects

Diarrhea
Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens, contact your doctor immediately.

Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Nausea And Vomiting
Stick to simple meals. Avoid eating oil-rich or spicy foods. Please consult your doctor immediately if you experience severe nausea and vomiting.
Warning & Precautions

Pregnancy
Use with CautionKOLIBITOR INFUSION should be used with caution in pregnant women. Therefore, consult your doctor for advice before receiving it.

Breastfeeding
Use with CautionKOLIBITOR INFUSION should be used with caution in breastfeeding women. Therefore, consult your doctor for advice before receiving it.

Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by KOLIBITOR INFUSION.

Alcohol
Consult your doctorAvoid consumption of alcohol while receiving KOLIBITOR INFUSION.

Kidney
Consult your doctorKOLIBITOR INFUSION is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before receiving it.

Liver
ContraindicatedKOLIBITOR INFUSION is not recommended for use in patients with severe liver problems. Therefore, consult your doctor before receiving it.

Allergy
ContraindicatedTalk to your doctor before receiving KOLIBITOR INFUSION if you are allergic to Sulphamethoxazole, trimethoprim, sulphonamide medicines (such as gliclazide, glibenclamide) or to thiazide diuretics (such as Bendroflumethiazide).

Lungs
Use with CautionKOLIBITOR INFUSION should be used with caution in patients with asthma. Therefore, consult your doctor before receiving it.

Use In Pediatrics
Consult your doctorKOLIBITOR INFUSION is suitable for use in infants and in children (aged between 6 weeks to 18 years). It is not recommended for use in infants aged less than 6 weeks. Therefore, consult your doctor before administering it to your child.

Use In Geriatrics
Use with CautionKOLIBITOR INFUSION should be used with caution in elderly patients. Therefore, consult your doctor for advice before receiving it.
Others
KOLIBITOR INFUSION is not recommended for use if you:
- ever had bleeding problems (such as thrombocytopenia)
- have porphyria (a rare blood disorder)
Before receiving KOLIBITOR INFUSION, consult your doctor if you:
- have any allergic conditions (such as watery eyes, itchy nose, repeated sneezing)
- have anemia or vitamin B9 (folic acid) deficiency
- have G6PD deficiency (a genetic disorder that affect metabolism)
- have phenylketonuria (build-up of an amino acid called phenylalanine in the body)
- are underweight or malnourished
- have high blood potassium levels
- have very low RBC, WBC and platelet counts in blood
Interactions
A. Drug-Drug Interactions:
Before receiving KOLIBITOR INFUSION, inform your doctor if you are taking any of the following medicines such as:
- diuretics (medicines used to remove excess water from the body) such as furosemide, hydrochlorothiazide
- pyrimethamine (a medicine used to manage malaria)
- medicines used for blood thinning (such as warfarin)
- phenytoin (a medicine used to manage epilepsy)
- medicines used to manage diabetes (such as glibenclamide, glipizide, tolbutamide or repaglinide)
- rifampicin (an antibiotic used to manage tuberculosis)
- medicines used to manage heart problems (such as digoxin or procainamide)
- amantadine (a medicine used to manage Parkinson’s disease)
- medicines used to manage HIV infections (such as zidovudine or lamivudine)
- medicines that can increase the amount of potassium in blood, such as potassium-sparging diuretics (Ex. spironolactone, acetazolamide), certain steroids (like prednisolone) or ACE inhibitors (Ex. captopril, enalapril, lisinopril)
- medicines used to suppress immune function and to manage graft rejection (such as ciclosporin, azathioprine)
- methotrexate (a medicine used to manage certain cancers or joint pain)
- folinic acid (a type of vitamin B9 supplement)
- contraceptive medicines (birth control pills) Ex. ethinylestradiol, dydrogesterone
B. Drug-Food Interaction:
KOLIBITOR INFUSION is preferably taken with meals to avoid unwanted stomach problems. However, it can also be taken on an empty stomach. Avoid consuming foods rich in potassium while receiving this medicine.
Overdosage:
KOLIBITOR INFUSION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, contact your doctor if you experience any unusual side effects. Symptoms of overdose might include dizziness, nausea, vomiting or confusion.
Synopsis
Drug | : | Sulphamethoxazole, Trimethoprim |
Pharmacological Category | : | Sulphonamides, Diaminopyrimidine |
Therapeutic Indication | : | Bacterial Infections |
Dosage Forms | : | Tablet, Syrup, Suspension, Injection, Infusion, Eye drops |
More Information
- Keep KOLIBITOR INFUSION out of reach of children
- Store KOLIBITOR INFUSION at room temperature
FAQs About KOLIBITOR INFUSION
Q: What is the use of KOLIBITOR INFUSION?
A: KOLIBITOR INFUSION is used to manage severe bacterial infections including lung infections, toxoplasmosis (an infection with the Toxoplasma gondii parasite), urinary tract infections, respiratory tract infections (such as bronchitis), ear infections (such as otitis media) and an infection called nocardiosis which can affect the lungs, skin and brain.
Q: How KOLIBITOR INFUSION works in my body?
A: KOLIBITOR INFUSION is a powerful antibiotic. It kills the susceptible bacteria by blocking the production of certain essential vitamins (folate) that is necessary for the bacteria to grow, multiply and survive. Therefore, it destroys the susceptible bacteria and manage their further growth and multiplication within the body which helps in reducing the severity of the infection.
Q: How KOLIBITOR INFUSION is administered?
A: KOLIBITOR INFUSION will be administered to you only by a doctor or a nurse into the vein (intravenously).
Q: For how long should I take KOLIBITOR INFUSION?
A: Take KOLIBITOR INFUSION for the stipulated duration as prescribed by your doctor. Do not skip the medicine or stop receiving it on your own as it can cause the infection to reappear.
Q: Can KOLIBITOR INFUSION be given to pregnant women?
A: KOLIBITOR INFUSION should be used with caution in pregnant women. Therefore, consult your doctor for advice before receiving it.
Q: What precautions should I follow while receiving KOLIBITOR INFUSION?
A: Before receiving KOLIBITOR INFUSION inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have asthma, any allergic conditions, genetic disorders, blood-related disorders or if you are malnourished as a precaution. Consult your doctor before receiving this medicine if you are pregnant or breastfeeding. Regularly visit your doctor for check-up and perform all medical tests recommended by your doctor without fail. Take KOLIBITOR INFUSION for the stipulated duration recommended by your doctor to achieve better results. Failing to do so may cause the symptom to re-occur.
Q: What are the common side effects of receiving KOLIBITOR INFUSION?
A: The most common side effects of receiving KOLIBITOR INFUSION are headache, nausea, diarrhea, high blood potassium levels, fungal infections of mouth or vagina and skin rashes. Consult your doctor if any of these side effect troubles you.
Q: Can I stop receiving KOLIBITOR INFUSION once my symptoms subside?
A: Do not stop receiving this medicine once your symptom subsides. It is important to take the full course of KOLIBITOR INFUSION to achieve better results. Failing to complete the full course of the therapy or skipping doses in between the therapy may not result in adequate infection control. It may also cause your symptoms to reappear.
Q: Can the use of KOLIBITOR INFUSION cause diarrhea?
A: KOLIBITOR INFUSION may cause diarrhea in some individuals. If you experience diarrhea, drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens contact your doctor immediately.
References
1. KD. Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 689, 705 & 706.
2. Tyler R. Kemnic, Meghan Coleman. Trimethoprim Sulfamethoxazole. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2022. [Accessed on 16th February 2023]. https://www.ncbi.nlm.nih.gov/books/NBK513232/#:~:text=Trimethoprim%2Fsulfamethoxazole%2C%20also%20known%20as,for%20many%20types%20of%20illnesses.
3. Aspen Pharma Trading Limited. Co-Trimoxazole 16 mg/80 mg per ml for Infusion. Electronic Medicines Compendium. [Revised in July 2021]. [Accessed on 16th February 2023]. https://www.medicines.org.uk/emc/files/pil.4669.pdf
Useful Diagnostic Tests
- Complete blood count