Ketosteril Tablet 20'S

Introduction About KETOSTERIL TABLET

KETOSTERIL TABLET is a combination of L-Histidine, L-Lysine, L-Threonine, L-Tryptophan, and L-Tyrosine which belongs to the group of medicines called Amino acids. It is used to manage the damages caused by faulty or deficient protein metabolism in chronic kidney diseases in association with limited dietary protein intake.

Chronic kidney diseases are long-standing conditions that lead to impairment of kidney functions, resulting in impaired excretion of toxins from the body. It is characterized by symptoms such as nausea, vomiting, loss of appetite, fatigue, weakness, and sleep problems.

KETOSTERIL TABLET is not recommended for use if you are allergic to L-histidine, L-lysine, L Threonine, L Tryptophan, and L-tyrosine. It is also not recommended for use in patients with hypercalcaemia (high blood calcium levels) or disturbed amino acid metabolism.

KETOSTERIL TABLET should be used with caution in patients with liver diseases (particularly liver cirrhosis), chronic kidney diseases, renal hyperphosphatemia (excess blood phosphate levels), renal osteodystrophy (metabolic renal disease), and renal insufficiency.

KETOSTERIL TABLET should be used with caution in pregnant and breastfeeding women. It should be used with caution with children (aged 13 years or older) and elderly patients (above 60 years). Consult your doctor before taking it.

The common side effects associated with the use of KETOSTERIL TABLET are signs of increased levels of alanine, glutamine, and glutamate (anxiety and restlessness) and signs of decreased levels of glycine and BCAA (impaired growth and protein wasting). Contact your doctor or a nearby hospital if any of the conditions worsen.

Uses Of KETOSTERIL TABLET

• Prevent and manage the damages caused by faulty or deficient protein metabolism in chronic kidney diseases in association with limited dietary protein intake

How KETOSTERIL TABLET Works

KETOSTERIL TABLET helps in managing chronic kidney diseases where L Histidine, L Lysine, L Threonine, L Tryptophan, and L Tyrosine after getting absorbed get converted into corresponding essential amino acids by taking nitrogen from non-essential amino acids, thereby decreasing the formation of excessive urea and toxins in the body. These amino acids also put a positive effect on bone health by optimizing the phosphate and parathyroid hormone levels in the body.

How to use KETOSTERIL TABLET

Take KETOSTERIL TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Side Effects Of KETOSTERIL TABLET

Warning & Precautions

Pregnancy

Use with Caution

KETOSTERIL TABLET should be used with caution in pregnant women. Consult and inform your doctor before taking it.

Breastfeeding

Use with Caution

KETOSTERIL TABLET should be used with caution in breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

Safe

KETOSTERIL TABLET has no or negligible effect on your ability to drive or use machines.

Kidney

Use with Caution

KETOSTERIL TABLET should be used with caution in patients with chronic kidney diseases, renal hyperphosphatemia (excess blood phosphate levels), renal osteodystrophy (metabolic renal disease), and renal insufficiency. Consult your doctor for advice before taking it.

Liver

Use with Caution

KETOSTERIL TABLET should be used with caution in patients with liver diseases, particularly liver cirrhosis. Consult your doctor before taking it.

Allergy

Contraindicated

KETOSTERIL TABLET is not recommended for use if you are allergic to L Histidine, L Lysine, L Threonine, L Tryptophan, L Tyrosine, or any other ingredient of this medicine. Consult your doctor before taking it.

Use In Pediatrics

Use with Caution

KETOSTERIL TABLET should be used with caution in children (aged 13 years or below). Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

KETOSTERIL TABLET should be used with caution in elderly patients (above aged 60 years). Consult your doctor before taking it.

Interactions

A. Drug-Drug Interactions:

Before taking KETOSTERIL TABLET, inform your doctor, if you are taking any of the following medicine:

• medicines used to manage bacterial infection such as tetracyclines (Ex. doxycycline), quinolines (Ex. ciprofloxacin, norfloxacin)
• medicines containing iron, fluoride, estramustine
• medicines used to manage arrhythmias such as cardioactive glycosides Ex. digoxin
• aluminium hydroxide (a medicine used to manage acidity)

Overdosage:

If you or anyone else accidentally takes too much of KETOSTERIL TABLET, consult your doctor immediately or visit the nearby hospital. However, no case of overdose has been reported.

Synopsis

More Information

• Keep the medicine out of reach of children
• Store KETOSTERIL TABLET at room temperature

FAQs About KETOSTERIL TABLET

Q: What is KETOSTERIL TABLET used for?

A: KETOSTERIL TABLET is used to manage the damages caused by faulty or deficient protein metabolism in chronic kidney diseases in association with limited dietary protein intake.

Q: What happens if you take more KETOSTERIL TABLET than your required dose?

A: If you or anyone else accidentally takes too much KETOSTERIL TABLET, consult your doctor immediately or visit the nearby hospital. However, no cases of overdose have been reported.

Q: What side effects are seen with KETOSTERIL TABLET?

A: The common side effects associated with the use of KETOSTERIL TABLET are signs of increased levels of alanine, glutamine, and glutamate (anxiety and restlessness) and signs of decreased levels of glycine and BCAA (impaired growth and protein wasting). Contact your doctor or a nearby hospital if any of the conditions worsen.

Q: Who should avoid taking KETOSTERIL TABLET?

A: KETOSTERIL TABLET is not recommended for use if you are allergic to L-histidine, L-lysine, L Threonine, L Tryptophan, and L-tyrosine. It is also not recommended for use in patients with hypercalcaemia (high blood calcium levels) or disturbed amino acid metabolism. Consult your doctor before taking it.

Q: Is KETOSTERIL TABLET safe to use in children or elderly patients?

A: KETOSTERIL TABLET should be used with caution with children (aged 13 years or above) and elderly patients (above 60 years). Consult your doctor before taking it to avoid any harm.

Q: How does KETOSTERIL TABLET work?

A: KETOSTERIL TABLET helps in managing chronic kidney diseases where L-histidine, L-lysine, L Threonine, L Tryptophan, and L-tyrosine, after getting absorbed, get converted into corresponding essential amino acids by taking nitrogen from non-essential amino acids, thereby decreasing the formation of excessive urea and toxins in the body. These amino acids also have a positive effect on bone health by optimizing the phosphate and parathyroid hormone levels in the body.

Q: What is the method of taking KETOSTERIL TABLET?

A: Take KETOSTERIL TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will determine the correct dose and duration for you depending on your age, body weight, and disease condition.

Q: Is KETOSTERIL TABLET safe to use in kidney patients?

A: KETOSTERIL TABLET should be used with caution in patients with chronic kidney diseases, renal hyperphosphatemia (excess blood phosphate levels), renal osteodystrophy (metabolic renal disease), and renal insufficiency. Consult your doctor for advice before taking it.

Q: Is KETOSTERIL TABLET safe to use in liver patients?

A: KETOSTERIL TABLET should be used with caution in patients with liver diseases, particularly liver cirrhosis (late-stage scarring of the liver tissue, or fibrosis). Consult your doctor before taking it.

Q: Is KETOSTERIL TABLET safe for pregnant women to use?

A: KETOSTERIL TABLET should be used with caution in pregnant women as it may harm foetal development, the childbirth process, or the development of the child after birth. Consult and inform your doctor before taking it.

References

1. Bharat V Shah. Nutritional Requirements in Health. Kidney Disease and Nutrition. 2013. Page - 2.

2. Milan HOLECEK. Side Effects of Amino Acid Supplements. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. January 2022. [Assessed on 29th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997670/

3. Subcommittee on the Tenth Edition of the RDAs, Food and Nutrition Board, Commission on Life Sciences, National Research Council, Protein and Amino Acids; Recommended Dietary Allowances: 10th Edition. NIH National Library of Medicine. National Centre for Biotechnology Information. Bookshelf. 1989. [Assessed on 29th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK234922/

4. Serena del Favero, Hamilton Roschel, Marina Y. Solis, Ana P. Hayashi, Guilherme G. Artioli,1 Maria Concepción Otaduy, Fabiana B. Benatti, Roger C. Harris, John A. Wise,4 Cláudia C. Leite, Rosa M. Pereira, Ana L. de Sá-Pinto, Antonio Herbert Lancha-Junior, Bruno Gualano. Beta-alanine (Carnosyn™) supplementation in elderly subjects (60–80 years): effects on muscle carnosine content and physical capacity. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. December 2011. [Assessed on 29th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374124/

5. Ketosteril_corporate SPC. Ketosteril®. [Revised in March 2009] [Assessed on 29th August 2022] https://www1.ndmctsgh.edu.tw/pharm/pic/medinsert/005KET06E.pdf

Useful Diagnostic Tests

• Blood Tests

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Narayanasetty Sai Swaroop - Pharm.D

Last updated on 25 Mar 2023 | 02:41 PM(IST)