Jalra-M 50/500mg Tablet 15's

Introduction About JALRA-M 50/500 MG TABLET

The Jalra-M 50/500 Tablet is a combination medication containing Vildagliptin (50 mg) and Metformin (500 mg), designed for effective blood sugar control in adults with type 2 diabetes. It helps improve glycemic control while minimizing side effects.

Jalra-M 50/500 Tablet works by making your pancreas secrete more insulin, a hormone used to digest glucose and makes your body cells efficiently utilise circulating blood sugars.

Take Jalra-M 50/500 Tablet with meals once or twice daily as directed by your doctor. Your doctor will decide the correct dose of the medicine based on its effects in controlling your blood sugar. Try to take the medicine at the same time each day to have optimum levels of medicine in the blood to have better control on blood sugar throughout the day.

Before taking Jalra-M 50/500 Tablet inform your doctor if you have any liver, kidney or heart problems or if you are pregnant or breastfeeding as a precaution. The most common side effects of taking jalra-M 50/500 Tablet are nausea, vomiting, abdominal discomfort, dyspepsia, indigestion, headache and dizziness. Consult your doctor if any of these side effects trouble you.

Key Composition

The active ingredients present in Jalra-M 50/500 Tablet are:

• Metformin: A Biguanide
• Vildagliptin: A Dipeptidyl peptidase-4 (DPP-4) inhibitor.

Uses Of JALRA-M 50/500 MG TABLET

• Helps manage blood sugar levels in type 2 diabetes.
• Improves insulin sensitivity and reduces glucose production in the liver.

Benefits of JALRA-M 50/500 MG TABLET

1. Jalra-M for blood sugar control:

Jalra-M contains Vildagliptin and Metformin, which work together to effectively control blood sugar levels. Vildagliptin improves insulin sensitivity, while Metformin reduces the amount of sugar produced by the liver, helping maintain stable blood glucose levels.

2. Reduces Insulin Resistance:

The combination of Vildagliptin and Metformin enhances the body's response to insulin, making it effective in lowering insulin resistance, which is a key factor in Type 2 Diabetes.

3. Weight Management Support:

Unlike some other diabetes medications, Jalra-M is weight-neutral, which means it does not cause weight gain. In some cases, it may even assist in modest weight loss, making it beneficial for those with Type 2 Diabetes who need to manage their weight.

4. Decreases the Risk of Hypoglycemia:

Jalra-M has a lower risk of causing hypoglycemia (low blood sugar) compared to some other diabetes medications, especially when used alone or in combination with other agents like diet and exercise.

5. Benefits on Jalra-M on Long-term use:

Long-term use of Jalra-M 50/500 Tablet helps in maintaining consistent blood glucose levels, preventing spikes and crashes, which reduces the risk of diabetes-related complications like neuropathy and retinopathy. Over time, Jalra-M 50/500 Tablet may help improve lipid profiles (reducing triglycerides and LDL cholesterol), lowering the risk of heart disease, which is particularly beneficial for individuals with Type 2 Diabetes who are at higher cardiovascular risk.

How JALRA-M 50/500 MG TABLET Works

Jalra-M 50/500 Tablet combines two active ingredients: Vildagliptin and Metformin, which work together to help control blood sugar levels in people with Type 2 Diabetes.

How Jalra-M Controls Blood Sugar Levels:

• Vildagliptin stimulates the pancreas to release more insulin when blood sugar levels are high, especially after meals. It also helps to reduce the release of glucagon, a hormone that increases blood sugar. This combined effect helps keep blood glucose levels under control throughout the day.
• Metformin reduces the amount of sugar produced by the liver and decreases the absorption of sugar from food in the intestines. By working on both these fronts, it helps maintain stable blood sugar levels.

How Jalra-M Reduces Insulin Resistance:

• Metformin improves the body’s sensitivity to insulin, allowing the cells to better absorb glucose from the bloodstream. This helps the body use insulin more effectively and reduces insulin resistance, which is often a major issue in Type 2 Diabetes.
• Vildagliptin complements this action by helping the pancreas work more efficiently, further reducing the need for the body to produce excessive amounts of insulin. Together, they make the body's insulin more effective, addressing insulin resistance.

How Jalra-M Improves Overall Glycemic Control:

• The combination of Vildagliptin and Metformin offers dual-action: Metformin works to reduce glucose production and improve insulin sensitivity, while Vildagliptin boosts insulin secretion when needed and prevents excessive glucose production. This helps provide comprehensive control over blood sugar levels, improving overall glycemic control and reducing fluctuations in blood glucose.

By targeting different mechanisms in the body, Jalra-M helps individuals with Type 2 Diabetes manage their condition more effectively and maintain healthier blood sugar levels in the long term.

How to use JALRA-M 50/500 MG TABLET

Jalra-M 50/500 Tablet should be used as advised by your physician. Strictly follow the dosing schedule provided by your doctor for best results.

How to Use Jalra-M 50/500mg Tablet:

• Take Jalra-M 50/500mg Tablet with meals to help improve absorption and reduce stomach discomfort.
• Swallow the medicine with a glass of water. Do not chew or crush the tablet.
• It is important to take Jalra-M 50/500mg at the same time each day to help remember the dose and maintain stable blood sugar levels.

Recommended Dosage For Adults:

• Starting Dose: Typically, the starting dose of Jalra-M 50/500mg is one tablet once a day, taken with food, to reduce the risk of gastrointestinal side effects. The dosage may be adjusted by the healthcare provider depending on individual needs and response to the medication.
• Maximum Dose: The maximum recommended dose is two tablets (100mg/1000mg) daily, taken in divided doses (morning and evening), depending on your blood sugar levels and response to the medication.

Jalra-M Dosage Adjustments for Liver Disease Patients:

• Liver disease patients should use Jalra-M with caution. Dosage adjustments are necessary, and a lower dose of Metformin (500mg) should be considered, or the medication might be avoided altogether depending on the severity of liver function impairment. Close monitoring of liver function is recommended.

Jalra-M Dosage Adjustments for Heart Patients:

• Patients with heart conditions should use Jalra-M with care, especially if they have congestive heart failure or other cardiovascular issues. Dose adjustments may be necessary based on the individual’s health status and heart function, as Metformin can sometimes worsen heart failure symptoms. Consult a healthcare provider for personalized recommendations.

Jalra-M Dosage Adjustments for Kidney Patients:

• Kidney disease patients may require dose adjustments. In patients with moderate to severe renal impairment, Jalra-M should be avoided, or the dose should be reduced significantly, depending on kidney function. Kidney function must be regularly monitored during treatment.

Jalra-M Dosage Adjustments Based on Blood Sugar Levels:

• Dosage adjustments of Jalra-M are often made based on regular blood glucose monitoring. If blood sugar levels are not well controlled, your doctor may increase the dose or adjust the medication. Regular monitoring is crucial for maintaining appropriate blood sugar control.

Stopping Jalra-M Safely:

• Stopping Jalra-M should only be done under the guidance of your doctor. Abruptly stopping the medication may lead to poor blood sugar control. The doctor may gradually decrease the dosage to avoid complications and ensure blood glucose levels remain stable.

What if I forgot to take JALRA-M 50/500 MG TABLET

• If you forget to take a dose of Jalra-M 50/500mg Tablet, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose. Do not double the dose to make up for the missed dose.

Overdose

• In case of overdose, seek immediate medical attention. Symptoms of overdose may include severe low blood sugar (hypoglycemia), nausea, vomiting, dizziness, and weakness. The healthcare provider may initiate treatment to reverse the effects, which may include intravenous glucose or other emergency measures depending on the severity of the overdose.

Side Effects Of JALRA-M 50/500 MG TABLET

Like all medicines, Jalra-M may cause certain side effects in some individuals, although not everybody gets them.

Common Side Effects of Jalra-M Includes:

• Nausea, Vomiting
• Diarrhea, Indigestion, Abdominal pain or discomfort
• Constipation
• Headache, Dizziness
• Dyspepsia, heartburn, flatulence
• Taste disturbance
• Tiredness and loss of appetite

Side Effects in Liver Patients:

• Increased risk of lactic acidosis with Metformin.
• Liver dysfunction if not monitored properly

Side Effects in Kidney Patients:

• Higher risk of lactic acidosis due to Metformin accumulation.
• Reduced kidney function may affect Jalra-M’s effectiveness.
• Regular kidney function monitoring is essential.

When To Seek Medical Attention:

Stop taking Jalra-M 50/500 Tablet  and contact your doctor immediately if you experience any of the following side effects:

• symptoms of lactic acidosis (such as vomiting, stomach pain, decreased heartbeat, difficulty breathing, muscle cramps, general weakness with severe tiredness, or reduced body temperature)
• signs of an inflamed pancreas (severe and persistent pain in the abdomen with or without nausea or vomiting)

Warning & Precautions

Other Warnings for JALRA-M 50/500 MG TABLET

Before taking Jalra M 50/500mg Tablet, inform your doctor if you have or had:

• pancreatic disease
• Vitamin B12 deficiency
• Malnutrition with adrenal or pituitary insufficiency

Who should not take [GBNKEYWORD

Jalra M 50/500mg Tablet is not recommended for you if you have:

• Type 1 diabetes mellitus
• Uncontrolled diabetes
• Severe infection or seriously dehydrated
• are going to have a contrast x-ray (a specific type of x-ray involving an injectable dye)

Safety Advice

Expert Advice to Follow While Taking Jalra-M Tablet:

• Take with Food: Always take Jalra-M with meals to reduce stomach discomfort and help with better absorption.
• Monitor Blood Sugar: Regularly check your blood sugar levels to ensure the medication is working effectively.
• Stay Hydrated: Drink plenty of water to prevent dehydration, especially if you're prone to gastrointestinal issues.
• Avoid Alcohol: Limit alcohol intake as it can increase the risk of low blood sugar and other side effects.
• Consult Your Doctor Regularly: Keep your doctor informed about your progress and any side affects you may experience.

Diet and Lifestyle Advice

Best Foods to Eat For Diabetes Management:

• Focus on low glycemic index (GI) foods like leafy greens, whole grains, and lean proteins (chicken, fish).
• Include non-starchy vegetables (broccoli, cauliflower) and fruits (berries, apples) in moderation.
• Add healthy fats (avocado, nuts) and fiber-rich foods (beans, legumes) to improve blood sugar control.
• Limit sugary snacks and processed carbs to prevent spikes in glucose levels.

Exercise Routines to Manage Blood Sugar Levels:

• Aerobic exercises like walking, cycling, or swimming can help improve insulin sensitivity and reduce blood sugar levels.
• Incorporate strength training (using weights or resistance bands) at least twice a week to build muscle, which helps regulate glucose.
• Aim for at least 150 minutes of moderate-intensity exercise each week to maintain healthy blood sugar levels.

How to Monitor Blood Sugar at Home:

• Use a glucometer to check your blood sugar levels before and after meals to understand how your body reacts to different foods.
• Record your readings regularly to track patterns and share with your doctor for adjustments to your treatment plan.
• Continuous glucose monitoring (CGM) devices are available for more detailed tracking of your blood sugar throughout the day.

Synopsis

Drug	:	Metformin, Vildagliptin
Pharmacological Category	:	Biguanides, Dipeptidyl peptidase 4 inhibitors
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet

More Information

Jalra-M vs. Januvia 50/500 vs. Glucophage:

Aspect	Jalra-M	Januvia 50/500	Glucophage
Active Ingredients	Vildagliptin + Metformin	Sitagliptin + Metformin	Metformin
Mechanism of Action	Vildagliptin stimulates insulin release and reduces glucagon; Metformin decreases liver sugar production	Sitagliptin increases insulin release and reduces glucagon; Metformin decreases liver sugar production	Metformin decreases liver sugar production and enhances insulin sensitivity
Indication	Type 2 diabetes mellitus	Type 2 diabetes mellitus	Type 2 diabetes mellitus
Side Effects	Nausea, vomiting, diarrhea, dizziness	Headache, upper respiratory infection, hypoglycemia	Stomach upset, diarrhea, lactic acidosis (rare)
FDA Approval	Not FDA approved for combination	FDA approved	FDA approved
Use in Pregnancy	Not recommended	Not recommended	Caution, consult doctor
Use in Kidney Impairment	Dose adjustment required	Dose adjustment required	Dose adjustment required
Use in Liver Impairment	Caution, monitor liver function	Caution, monitor liver function	Caution, contraindicated in severe liver disease

Relevant Health Articles

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Diabetes Diet: 5 Power-Packed Snacks To Manage Blood Sugar Levels- Infographic

FAQs About JALRA-M 50/500 MG TABLET

References

1. Jalra-M. SajaPharma. Product Leaflet Summary. [Accessed on 31st January 2025].
2. Jalra 50mg Tablet. Summary of Product Characteristics. [Accessed on 31st January 2025].
3. Metformin + vildagliptin. Package Insert. [Accessed on 31st January 2025].
4. Metformin + vildagliptin. Prescribing Information. [Accessed on 31st January 2025].

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

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