Name: IVANODE C 3.125 Tablet 10's - Netmeds
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Introduction About IVANODE C 3.125 TABLET

IVANODE C 3.125 TABLET is a combination of Carvedilol and Ivabradine, which belongs to the group of medicines called Antiarrhythmics. It is indicated for symptomatic management of chronic stable angina pectoris in coronary artery disease patients and to manage chronic heart failure (II-IV NYHA-Class) with systolic dysfunction.

Along with the management, your doctor will monitor your heart rate to know if there are any irregularities in your heart rate. Your doctor may also check your blood glucose levels to know any variations. Avoid grapefruit juice while taking IVANODE C 3.125 TABLET, as it may increase the side effects.

Before taking IVANODE C 3.125 TABLET, inform your doctor if you have retina pigmentosa, diabetes, psoriasis, or hyperthyroidism (increased thyroid hormone in the body). IVANODE C 3.125 TABLET is not recommended in patients having metabolic acidosis, unmanaged phaeochromocytoma, and stroke. Consult your doctor before taking it.

IVANODE C 3.125 TABLET is not recommended in patients having lung, liver, and heart diseases. Patients with kidney disease should use it with caution. IVANODE C 3.125 TABLET is not recommended during pregnancy and lactation. Contact your doctor before taking it. IVANODE C 3.125 TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking it.

The most common side effects of taking IVANODE C 3.125 TABLET are headache, dizziness, nausea, diarrhea, abdominal pain, and vomiting. Consult your doctor if any of the side effects worsen or persist for a longer duration.

Uses Of IVANODE C 3.125 TABLET

It is used to manage:

Stable angina pectoris (which causes chest pain)
Chronic heart failure

How IVANODE C 3.125 TABLET Works

IVANODE C 3.125 TABLET is a combination of carvedilol and ivabradine. Carvedilol is a beta-blocker that slows the heartbeat, lessens the force with which the heart muscle contracts, and reduces the blood vessel contraction in the heart, brain, and throughout the body. Ivabradine works mainly by reducing the heart rate by a few beats per minute. This lowers the heart’s need for oxygen, especially in situations when an angina attack is more likely to happen. Thus IVANODE C 3.125 TABLET helps to control and reduce the number of angina attacks.

How to use IVANODE C 3.125 TABLET

Take IVANODE C 3.125 TABLET as advised by your physician. Swallow IVANODE C 3.125 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Side Effects Of IVANODE C 3.125 TABLET

Common

Luminous visual phenomena (brief moment of increased brightness, most often caused by sudden changes in light intensity)
Headache
Dizziness
Shortness of breath or swelling of the feet or legs due to fluid buildup (heart failure)
Low blood pressure (feeling dizzy or light-headed), generalized weakness, feeling of tiredness
Lung or chest infections
Infections of the urinary tract
Decreased number of red blood cells
Increased levels of cholesterol in the blood
Increased levels of blood sugar (diabetes)
Weight gain
Being or feeling depressed
Lacrimation decreased (dry eyes), impaired vision, eye irritation, blurred vision (cloudy vision)
Fluid retention
Buildup of fluid in the lungs
Modification in the heart functioning (slowing down of the heart rate)
Heart block (irregular heartbeats)
Irregular rapid contraction of the heart
Dizzy, light-headed, or faint when you stand or sit up quickly
Cold hands and feet, obstruction of the large arteries in the arms and legs, worsening of symptoms in patients with Raynaud’s disease, claudication (pain in the leg that gets worse when you walk)
Uncontrolled blood pressure
Shortness of breath, asthma
Nausea, vomiting
Stomach pain
Indigestion
Diarrhoea
Pain in the extremities
Disease with painful
Swollen joints caused by uric acid crystals (gout)
Problems with your kidneys, including problems starting, passing, and stopping urination or altered frequency of urination

Uncommon

Increased level of some white blood cells
Increased level of uric acid in the blood
Sleep disturbances, including nightmares, confusion
Fainting (syncope), light-headedness, muscular weakness, blurred vision, and feeling faint (pre-syncope), tingling or numbness of the hands or feet
Double vision, spinning sensation (vertigo)
A pain or uncomfortable feeling in the chest, palpitations, changes in heart rate (fast, slow, or irregular)
Low blood pressure (possibly related to slow heart rate)
Constipation
Certain skin reactions (such as skin rash, hives, itching, increased sweating, or psoriatic or lichen planus-like skin lesions)
Hair loss
Swelling of the face, lips, tongue, or throat, which may cause difficulty breathing or swallowing (angioedema), rash
Muscle cramps
Sexual dysfunction, impotence (inability to get or maintain an erection)

Rare

Bleeding or bruising more easily than normal (low blood platelet count)
Stuffy nose
Wheezing
Dry mouth
Redness of the skin
Feeling unwell

How To Manage Side Effects

Constipation

Eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals, and drink plenty of water. Exercise more regularly. Consult your doctor if constipation persists.

Diarrhea

Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.

Dizziness Or Drowsiness

Try to lie down or sit immediately if you feel dizzy. Drink enough water to get hydrated. Consult your doctor if the dizziness does not improve.

Dry Mouth

Try chewing sugar-free gum or sugar-free candies to stimulate the flow of saliva. Avoid caffeine-containing drinks. Drink plenty of water to avoid dehydration. Consult your doctor if the dry mouth is not improving.

Headache

Use a cold pack or hot pads to reduce the pressure on your head. Reduce looking into bright light and try to get adequate sleep. Consult your doctor if the headache is not improving.

Nausea And Vomiting

Take this medicine with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if nausea and vomiting worsen.

Skin rash Or Itching

Avoid hot baths because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if the symptom worsens.

Stomach Pain

Try to rest and relax. Eat and drink slowly, or try to have smaller and more frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.

Warning & Precautions

Pregnancy

Contraindicated

IVANODE C 3.125 TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.

Breastfeeding

Contraindicated

IVANODE C 3.125 TABLET is not recommended for use by breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

Contraindicated

Do not drive or operate any machines if you feel dizziness, fatigue, or decreased alertness while taking IVANODE C 3.125 TABLET.

Alcohol

Contraindicated

Consumption of alcohol is not recommended while taking IVANODE C 3.125 TABLET. Consult your doctor for advice.

Kidney

Use with Caution

IVANODE C 3.125 TABLET should be used with caution in patients having renal insufficiency. Consult your doctor before taking.

Liver

Contraindicated

IVANODE C 3.125 TABLET is not recommended in patients having severe liver impairment. Consult your doctor before taking.

Allergy

Contraindicated

Do not take IVANODE C 3.125 TABLET if you are allergic to carvedilol, ivabradine, or any other ingredients of this medicine.

Lungs

Contraindicated

IVANODE C 3.125 TABLET is not recommended in patients having chronic obstructive pulmonary disorder associated with bronchial obstruction and a history of bronchospasm or asthma. Consult your doctor before taking.

Heart Disease

Consult your doctor

IVANODE C 3.125 TABLET is not recommended in patients with acute or unstable or decompensated heart failure, pacemaker dependent (heart rate imposed exclusively by the pacemaker), with a pre-management resting heart rate below 50 beats per minute, severe hypotension, or congenital QT syndrome. It should be used with caution in patients with ischaemic heart disease. Consult your doctor before taking.

Use In Pediatrics

Consult your doctor

The safety and efficacy of IVANODE C 3.125 TABLET in children and adolescents have not been established. Consult your doctor before taking.

Use In Geriatrics

Use with Caution

IVANODE C 3.125 TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking.

Others

IVANODE C 3.125 TABLET is not recommended for use if you:

Have metabolic acidosis (accumulation of acid in the body due to kidney problems)
Have unmanaged phaeochromocytoma (a non-cancerous tumour in the adrenal glands)
Have stroke

Before taking IVANODE C 3.125 TABLET, inform your doctor if you:

Have retinitis pigmentosa (a rare eye disease affecting the retina of the eye)
Have diabetes
Have hyperthyroidism
Wear contact lenses
Have a family history of psoriasis

Interactions

A. Drug-Drug interactions:

Before taking IVANODE C 3.125 TABLET, inform your doctor if you are taking any of the following medicines:

Medicines used to manage fungal infections (Ex. ketoconazole, itraconazole)
Medicines used to manage bacterial infections (Ex. clarithromycin, erythromycin, josamycin, telithromycin)
HIV protease inhibitors (Ex. nelnavir, ritonavir, and nefazodone)
Diltiazem, amlodipine, and verapamil (medicines used to manage heart diseases)
Cimetidine (medicine used to manage acidity)
Fluoxetine (medicine used to manage depression)
Cardiac glycosides (Ex. digoxin digitoxin)
Cyclosporine (medicine used to manage organ rejection during organ transplantation)
Anti-diabetic medicines (Ex. insulin, oral hypoglycaemics)
Clonidine (medicine used to manage high blood pressure)
Anaesthetics (Ex. ketamine, etomidate)
Medicines used to manage asthma (Ex levalbuterol, albuterol)
Medicine used to manage water retention (Ex. chlorthalidone, frusemide)
Medicine used to manage pain and inflammation (Ex. diclofenac, ibuprofen)
Medicines used to manage high blood pressure (Ex. captopril, enalapril)
Medicines used to manage inflammation (Ex. prednisolone)
Warfarin (medicine used to manage clotting of blood)
Ergotamine (medicine used to manage headaches)
Nitrates (medicines used to manage angina)
Medicine used to manage neural problems (Ex. doxepin, amitriptyline)
Medicines used to manage eye diseases (Ex. betaxolol)
Medicines used to manage fits (Ex. phenobarbital, primidone)

B. Drug-Food interaction:

Avoid drinking grapefruit juice while taking IVANODE C 3.125 TABLET, as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally takes too much of IVANODE C 3.125 TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

Drug	:	Carvedilol, Ivabradine
Pharmacological Category	:	Beta blockers, Hyperpolarization-activated cyclic nucleotide gated (HCN) channel blockers
Therapeutic Indication	:	Chronic heart failure, Chronic stable angina pectoris
Dosage Forms	:	Tablet

More Information

Storage

Keep IVANODE C 3.125 TABLET out of reach of children
Store at a temperature not exceeding 30°C

FAQs About IVANODE C 3.125 TABLET

Q: What is IVANODE C 3.125 TABLET used for?

A: IVANODE C 3.125 TABLET is indicated for symptomatic management of chronic stable angina pectoris in coronary artery disease patients and to manage chronic heart failure (II-IV NYHA-Class) with systolic dysfunction.

Q: How IVANODE C 3.125 TABLET works on my body?

A: IVANODE C 3.125 TABLET is a combination of Carvedilol and Ivabradine. Carvedilol is a beta-blocker that slows the heartbeat, lessens the force with which the heart muscle contracts, and reduces the blood vessel contraction in the heart, brain, and throughout the body. Ivabradine works mainly by reducing the heart rate by a few beats per minute. This lowers the heart’s need for oxygen, especially in situations when an angina attack is more likely to happen. Thus IVANODE C 3.125 TABLET helps to control and reduce the number of angina attacks.

Q: What are the dietary modifications I should follow while taking IVANODE C 3.125 TABLET?

A: Avoid drinking grapefruit juice and alcohol while taking IVANODE C 3.125 TABLET, as it may increase the side effects. Consult your doctor for advice.

Q: Can IVANODE C 3.125 TABLET lower your blood sugar?

A: IVANODE C 3.125 TABLET may impair the glucose tolerance, whereas hypoglycaemia may occur in diabetic patients under insulin and anti-diabetic therapy. So it is essential to monitor the blood glucose levels in these patients undergoing management with IVANODE C 3.125 TABLET.

Q: Is IVANODE C 3.125 TABLET suitable for elderly patients?

A: IVANODE C 3.125 TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking.

Q: Is IVANODE C 3.125 TABLET safe during pregnancy?

A: IVANODE C 3.125 TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.

Q: What are the side effects of IVANODE C 3.125 TABLET?

A: The most common side effects of taking IVANODE C 3.125 TABLET are headache, dizziness, nausea, diarrhea, abdominal pain, vomiting. Consult your doctor if any of the side effects worsen or persist for a longer duration.

Q: Who should not take IVANODE C 3.125 TABLET?

A: IVANODE C 3.125 TABLET is not recommended for use if you have metabolic acidosis (accumulation of acid in the body due to kidney problems), unmanaged phaeochromocytoma (non-cancerous tumour in the adrenal glands), stroke, severe liver impairment, chronic obstructive pulmonary disorder associated with bronchial obstruction and a history of bronchospasm or asthma, acute or unstable or decompensated heart failure, pacemaker dependent (heart rate imposed exclusively by the pacemaker), with a pre-management resting heart rate below 50 beats per minute, severe hypotension, congenital QT syndrome, or if you are allergic to Carvedilol, Ivabradine, or any other ingredients of this medicine.

Q: What precautions must be taken while using IVANODE C 3.125 TABLET?

A: Before taking IVANODE C 3.125 TABLET, inform your doctor if you have renal insufficiency, ischaemic heart disease, retinitis pigmentosa (a rare eye disease affecting the retina of the eye), diabetes, hyperthyroidism, or if you wear contact lenses or have a family history of psoriasis.

Q: Can IVANODE C 3.125 TABLET be used with children?

A: The safety and efficacy of IVANODE C 3.125 TABLET in children and adolescents have not been established. Consult your doctor before taking.

References

1. KD Tripathi. Antiadrenergic drugs and drugs for glaucoma. Cardiovascular drugs. Essentials of Medical Pharmacology. Eighth Edition, 2019. Page – 165, 600.

2. Yue-Chun L, Teng Z, Na-Dan Z, Li-Sha G, Qin L, Xue-Qiang G, Jia-Feng L. Comparison of effects of ivabradine versus carvedilol in murine model with the Coxsackievirus B3-induced viral myocarditis. NIH National Library of Medicine, National Center for Biotechnology Information. [Accessed on 11th July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386276/

3. Ciplamed. CARLOC-1 Tablets. [Revised in 30th June 2021] [Accessed on 11th July 2024] https://www.ciplamed.com/product-index/carloc-i-tablets

4. Les Laboratoires Servier. [Accessed on 11th July 2024] https://file.wuxuwang.com/hma/NL_H_3546_001_FinalPI.pdf

Useful Diagnostic Tests

Complete Blood Count (CBC)/ Hemogram
Kidney Function Test (KFT)
Cardiac Risk Profile
Basic Heart Care
Extended Heart Care
Advance Heart Care
Comprehensive Heart Care
Lipid Profile Test/Cholesterol-Total, Serum
Netmeds Healthy Heart
Cardiac Risk Markers – Advanced

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 12 Jul 2024 | 05:29 PM(IST)

Lab updated