New Revised MRP, 100% GST benefit passed IT MAC Oral Solution 100ml
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Introduction About IT MAC ORAL SOLUTION
IT MAC ORAL SOLUTION contains Itraconazole which belongs to a group of medicines called Antifungals. It is used to manage fungal infections in patients (with poor immune systems), which include yeast infections of the mouth, throat, or gullet. It is also used to manage fungal infections in patients with poor immunity systems that occur due to major blood disorders or bone marrow transplantation.
Yeast infection is a type of fungal infection that occurs when excess yeast (fungi) grows on the skin or other areas. It is generally characterized by symptoms such as white patches on the tongue, redness, soreness, or difficulty swallowing.
IT MAC ORAL SOLUTION is not recommended for use in patients who are allergic to Itraconazole. Before taking IT MAC ORAL SOLUTION, inform your doctor if you have heart problems (including congestive heart failure), kidney disorders, or liver problems (such as jaundice).
IT MAC ORAL SOLUTION is not recommended for use in pregnant women unless it is clearly advised by the doctor, and it is not recommended for use in breast-feeding women. It is also not recommended for use in children and adolescents (aged below 18 years) or elderly patients unless it is clearly advised by the doctor.
The most common side effects of taking IT MAC ORAL SOLUTION are headache, stomachache, nausea, vomiting, diarrhea, unpleasant taste, and rash. Consult your doctor if any of the side effects worsen.
How IT MAC ORAL SOLUTION Works
IT MAC ORAL SOLUTION works by inhibiting ergosterol synthesis (an organic compound responsible for maintaining cell membrane integrity of fungi cells) that leads to fungal cell membrane abnormalities (marked with increased permeability and disruption of fungi cells), thus causing destruction to the fungi cell and managing the occurrence of fungal infections in affected individuals.
How to use IT MAC ORAL SOLUTION
- Take IT MAC ORAL SOLUTION as advised by your physician.
- Shake well before use.
- Use a graduated measuring cup to properly measure the dose.
- Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Side Effects Of IT MAC ORAL SOLUTION
Common Side Effects of IT MAC ORAL SOLUTION:
- headache
- stomach-ache
- nausea, vomiting, diarrhea
- unpleasant taste
- rash
- fever/high temperature
- shortness of breath
Stop taking IT MAC ORAL SOLUTION and contact your doctor immediately if you experience any of the following side effects:
- have signs of severe liver problems (such as severe lack of appetite, nausea, vomiting, unusual tiredness, abdominal/stomach pain, unusually dark urine, and/or pale stools)
- experience any hearing loss symptoms that can become temporary or permanent hearing loss
- have signs of serious allergic reactions such as sudden wheeziness, difficulty breathing, swelling of the face, rash, and itching (especially affecting the whole body)
Warning & Precautions
Pregnancy
Monitoring requiredIT MAC ORAL SOLUTION is generally not recommended for use during pregnancy and in women planning for pregnancy unless it is considered clearly necessary. Women with childbearing potential should use contraceptives to avoid pregnancy during management with this medicine.
Breastfeeding
ContraindicatedIT MAC ORAL SOLUTION is not recommended for use in breastfeeding women since it may pass through the breast milk.
Driving and Using Machines
Use with CautionDo not drive or operate any machines after taking IT MAC ORAL SOLUTION since it may cause dizziness, blurred/double vision, and/or hearing loss.
Alcohol
Use with CautionAvoid consumption of alcohol while taking IT MAC ORAL SOLUTION since it may reduce the absorption of this medicine.
Kidney
Use with CautionIT MAC ORAL SOLUTION should be used with caution in patients with kidney disorders.
Liver
Use with CautionIT MAC ORAL SOLUTION should be used with caution in patients with liver problems such as jaundice (yellowing of the skin).
Allergy
ContraindicatedDo not take IT MAC ORAL SOLUTION if you are allergic to Itraconazole or any other ingredients of this medicine.
Heart Disease
Use with CautionIT MAC ORAL SOLUTION should be used with caution in patients with heart problems, including congestive heart failure.
Use In Pediatrics
Monitoring requiredIT MAC ORAL SOLUTION is generally not recommended for use in children and adolescents (aged below 18 years) unless it is considered clearly necessary.
Use In Geriatrics
Monitoring requiredIT MAC ORAL SOLUTION is generally not recommended for use in elderly patients unless it is considered clearly necessary.
Others
Before taking IT MAC ORAL SOLUTION, inform your doctor if you:
- had an allergic reaction to any other antifungal medicines
Interactions
A. Drug-Drug interactions:
Before taking IT MAC ORAL SOLUTION, inform your doctor if you are taking any of the following medicines:
- terfenadine, astemizole, mizolastine, and ebastine (antihistaminic medicines used for allergies)
- bepridil (used to manage angina)
- nisoldipine (used for high blood pressure)
- cisapride (used for stomach upsets)
- midazolam, alprazolam, brotizolam, triazolam, and buspirone (used to help you sleep or for anxiety)
- lovastatin, simvastatin, and atorvastatin (used to lower cholesterol)
- pimozide, sertindole (antipsychotic medicines used to manage conditions affecting thoughts, feelings, and behavior)
- levacetylmethadol (used to manage opioid drug abuse)
- dihydroergotamine, ergotamine, and eletriptan (used for migraine headaches)
- ergometrine, methyl-ergometrine (medicines used after giving birth)
- quinidine, dofetilide (medicine used for irregular heartbeat rhythms)
- clarithromycin, erythromycin (antibiotics used to manage infections)
- medicines that act on the heart and blood vessels Ex. digoxin, calcium channel-blockers (Ex. dihydropyridines, verapamil), cilostazol, disopyramide
- drugs that slow down blood clotting/thin the blood (Ex. warfarin)
- methylprednisolone, budesonide, fluticasone, and dexamethasone (medicines used to manage inflammation, asthma, and allergies)
- ciclosporin, tacrolimus, and rapamycin (medicines that are given after an organ transplantation to manage rejection)
- medicines used in HIV-infected patients (Ex. ritonavir, indinavir, saquinavir)
- medicines for cancer (Ex. busulphan, docetaxel, vinca alkaloids (Ex. vinblastine, vinorelbine), trimetrexate
- alfentanil, fentanyl (medicines used for pain)
- reboxetine (used for depression)
- loperamide (used for diarrhea)
- halofantrine (medicine used to manage malaria)
- repaglinide (medicine used to manage diabetes)
B. Drug-Food interaction:
Avoid taking IT MAC ORAL SOLUTION with food since it reduces the absorption of this medicine. Consult your doctor before taking IT MAC ORAL SOLUTION.
Overdosage:
If you or anyone else accidentally takes too much of IT MAC ORAL SOLUTION, consult your doctor immediately or visit the nearby hospital to manage the overdosage symptoms.
Synopsis
| Drug | : | |
| Pharmacological Category | : |
Triazole antifungals |
| Therapeutic Indication | : |
Fungal infection (which includes infections of mouth, fingernails, vagina and toenails) |
| Dosage Forms | : |
Oral Solution, Suspension, Capsule, Tablet, Cream, Dusting Powder, Eye Drops, Eye Ointment, Gel, Ointment, Powder, Soap |
More Information
FAQs About IT MAC ORAL SOLUTION
Q: What is IT MAC ORAL SOLUTION used for?
A: IT MAC ORAL SOLUTION is used to manage fungal infections in patients (with poor immune systems), which include yeast infections of the mouth, throat, or gullet. It is also used to manage fungal infections in patients with poor immunity systems that occur due to major blood disorders or bone marrow transplantation.
Q: What are the common side effects of IT MAC ORAL SOLUTION?
A: The most common side effects of taking IT MAC ORAL SOLUTION are headache, stomach-ache, nausea, vomiting, diarrhea, unpleasant taste, rash, and/or shortness of breath. Consult your doctor if any of these side effects worsen.
Q: Can IT MAC ORAL SOLUTION be used in pregnant and breastfeeding women?
A: No, IT MAC ORAL SOLUTION is generally not recommended for use during pregnancy or in women planning for pregnancy unless it is clearly advised by the doctor. It is also not recommended for use in breastfeeding women since it may pass through the breast milk. Consult your doctor before taking IT MAC ORAL SOLUTION.
Q: How does IT MAC ORAL SOLUTION work?
A: IT MAC ORAL SOLUTION works by inhibiting ergosterol synthesis (an organic compound responsible for maintaining cell membrane integrity of fungi cells) that leads to fungal cell membrane abnormalities (marked with increased permeability and disruption of fungi cells), thus causing destruction to the fungi cell and managing the occurrence of fungal infections in affected individuals.
Q: Is IT MAC ORAL SOLUTION safe to use in patients with heart problems?
A: IT MAC ORAL SOLUTION should be used with caution in patients with heart problems, including congestive heart failure, as this medicine could make it worse. During management with this medicine, if you experience any symptoms related to the heart (such as shortness of breath, unexpected weight gain, swelling of the legs or stomach, unusual tiredness, etc.), inform your doctor immediately.
Q: Who should not use IT MAC ORAL SOLUTION?
A: Do not take IT MAC ORAL SOLUTION if you are allergic to Itraconazole or any other ingredients of this medicine.
Q: What precautions must be taken while using IT MAC ORAL SOLUTION?
A: IT MAC ORAL SOLUTION should be used with caution in patients with kidney disorders, liver problems such as jaundice (yellowing of the skin), heart problems including congestive heart failure, or had an allergic reaction to any other antifungal medicines.
Q: Is IT MAC ORAL SOLUTION safe for kids?
A: IT MAC ORAL SOLUTION is generally not recommended for use in children and adolescents (aged below 18 years) unless it is considered clearly necessary.
Q: Can I consume alcohol while using IT MAC ORAL SOLUTION?
A: Avoid consumption of alcohol while taking IT MAC ORAL SOLUTION since it may reduce the absorption of this medicine.
Q: How long does it take for IT MAC ORAL SOLUTION to work?
A: You may notice improvement in a few days, but the treatment duration depends on the type and severity of the infection. Complete the full course as prescribed by your doctor.
Q: What should I do if I miss a dose?
A: If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and continue your regular schedule. Do not double the dose.
References
1. K.D. Tripathi. Antifungal Drugs. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page 794.
2. Heidi Kurn; Roopma Wadhwa. Itraconazole. NIH National Library of Medicine. National Center for Biotechnology Information. Stat Pearls [Internet]. April 2022. [Accessed on 4th October 2024] click here
3. Janssen Pharmaceuticals. Randomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis. ClinicalTrials.gov. [Revised in June 2005] [Accessed on 4th October 2024] click here
4. SyriMed. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 4th October 2024] click here
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