Hepcinat Plus 60/400mg Tablet 10'S
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Introduction About HEPCINAT PLUS 60/400MG TABLET
HEPCINAT PLUS 60/400MG TABLET is a combination of Sofosbuvir and Daclatasvir which belongs to the group of medicines called Antiviral agents. It is used to manage chronic (long-term) Hepatitis C infection.
Hepatitis C infection is a viral infection caused due to hepatitis C virus. It predominantly affects the liver and causes severe liver damage. It spreads mostly through contact with blood from an infected person (such as through sharing needles).
HEPCINAT PLUS 60/400MG TABLET is suitable for use both in adults and in children (aged 3 years or above). Before taking HEPCINAT PLUS 60/400MG TABLET inform your doctor if you have diabetes, kidney problems or any other liver problems apart from hepatitis C infection (such as liver transplant or hepatitis B infection).
Do not take HEPCINAT PLUS 60/400MG TABLET without consulting your doctor if you are pregnant or breastfeeding. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy during management with this medicine and until 5 weeks after stopping the management.
The most common side effects of taking HEPCINAT PLUS 60/400MG TABLET are fever, flu-like symptoms, migraine headache, dizziness, hair thinning, dry skin, muscle pain, back pain, tiredness, weakness, lack of sleep, stomach discomfort and loss of appetite. Consult your doctor if they trouble you.
Uses Of HEPCINAT PLUS 60/400MG TABLET
- Manage chronic Hepatitis C infection
How HEPCINAT PLUS 60/400MG TABLET Works
HEPCINAT PLUS 60/400MG TABLET is an antiviral agent. It acts by blocking the actions of certain viral proteins that is required for the viral cell to grow and multiply. As a result, it controls the multiplication of harmful viral cells within the body which reduces the severity of the infection.
How to use HEPCINAT PLUS 60/400MG TABLET
Take HEPCINAT PLUS 60/400MG TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. HEPCINAT PLUS 60/400MG TABLET can be taken with or without meals.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the infection. Do not stop taking HEPCINAT PLUS 60/400MG TABLET without consulting your doctor as it may reduce its effectiveness.
Side Effects Of HEPCINAT PLUS 60/400MG TABLET
Common
- fever, chills, cold, flu-like symptoms
- nausea, vomiting, diarrhoea, loss of appetite
- lack of sleep (insomnia)
- tiredness, weakness, irritability
- headache, migraine, dizziness
- skin rash or itching
- muscle aches and pains, joint pain
- low RBC, WBC and platelet count in blood
- mouth ulcers
- mood changes, depression, anxiety, agitation
- blurred vision
- loss of memory or concentration
- weight loss
- stomach discomfort, constipation, dry mouth, indigestion, acid reflux
- hair loss and thinning hair, dry skin
- back pain
Rare
Stop taking HEPCINAT PLUS 60/400MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, nose, throat which causes difficulty in breathing or swallowing)
- severe skin reactions causing widespread skin rashes with severe itching, blistering and peeling of skin, accompanied with fever, flu-like symptoms and ulcers in the mouth, eyes and/or genitals)
- shortness of breath, slow or irregular heartbeat or problems in heart rhythm problems
How To Manage Side Effects
Nausea and Vomiting:
Take HEPCINAT PLUS 60/400MG TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
HEPCINAT PLUS 60/400MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it. Women undergoing therapy with medicine, must use a suitable contraceptive method to avoid pregnancy during and until 5 weeks after stopping the therapy.
Breastfeeding
HEPCINAT PLUS 60/400MG TABLET may pass through the breast milk. Therefore, it is not recommended for use in breastfeeding women. Consult your doctor for advice before taking it.
Driving and Using Machines
Do not drive or handle any machines if your ability is affected by HEPCINAT PLUS 60/400MG TABLET.
Kidney
HEPCINAT PLUS 60/400MG TABLET should be used with caution in patients with kidney problems (such as dialysis). Therefore, consult your doctor before taking it.
Liver
HEPCINAT PLUS 60/400MG TABLET should be used with caution in patients with other liver problems apart from hepatitis C infection such as awaiting a liver transplant or hepatitis B infection. Therefore, consult your doctor before taking it.
Allergy
Do not take HEPCINAT PLUS 60/400MG TABLET if you are allergic to Daclatasvir or Sofosbuvir.
Heart Disease
HEPCINAT PLUS 60/400MG TABLET should be used with caution if you have heart problems. Consult your doctor for advice.
Others
Before taking HEPCINAT PLUS 60/400MG TABLET, inform your doctor if you:
- are taking medicines for any on-going viral infections
- have diabetes
Use in Paediatrics:
HEPCINAT PLUS 60/400MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use in Geriatrics:
HEPCINAT PLUS 60/400MG TABLET should be used with caution in elderly people. Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking HEPCINAT PLUS 60/400MG TABLET inform your doctor if you are taking any of the following medicines such as:
- rifampicin, rifabutin, rifapentine (used to manage tuberculosis)
- St. John’s wort (a medicine used to manage depression)
- medicines used to manage epilepsy (such as carbamazepine, phenobarbital, phenytoin, oxcarbazepine)
- rosuvastatin (a medicine used to manage high blood cholesterol levels)
- amiodarone, digoxin (used to manage irregular heart rate)
- modafinil (a medicine used to manage narcolepsy)
- warfarin, dabigatran, vitamin k antagonists (used for blood thinning)
- medicines used to suppress your immune system (such as tacrolimus, cyclosporine)
- medicines used to manage HIV infection (such as atazanavir/ritonavir, atazanavir/cobicistat, elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate combination tablet, etravirine, nevirapine or efavirenz)
- medicines used to manage bacterial infection (such as clarithromycin, telithromycin or erythromycin)
- medicines used to manage fungal infection (such as ketoconazole, itraconazole, posaconazole or voriconazole)
- medicines used to manage heart problems (such as verapamil, diltiazem, nifedipine or amlodipine)
- medicines used to control blood cholesterol levels (such as rosuvastatin, atorvastatin, fluvastatin, simvastatin, pitavastatin or pravastatin)
- oral contraceptives (birth control pills) Ex. ethinylestradiol, drospirenone
- medicines used to manage stomach ulcers or heartburn (such as aluminium hydroxide, omeprazole, lansoprazole, rabeprazole, pantoprazole, esomeprazole, famotidine, cimetidine, nizatidine or ranitidine)
- dexamethasone (a steroid medicine used to manage allergic or autoimmune reactions)
Overdosage:
If you or anyone else accidentally took more HEPCINAT PLUS 60/400MG TABLET, consult your doctor immediately.
Synopsis
| Drug | : | Daclatasvir, Sofosbuvir |
| Pharmacological Category | : | HCV NS5A inhibitors, Nucleotide polymerase inhibitors |
| Therapeutic Indication | : | Hepatitis C infection |
| Dosage Forms | : | Tablet |
More Information
- Keep HEPCINAT PLUS 60/400MG TABLET out of reach of children
- Store HEPCINAT PLUS 60/400MG TABLET at room temperature
FAQs About HEPCINAT PLUS 60/400MG TABLET
Q: What is HEPCINAT PLUS 60/400MG TABLET?
A: HEPCINAT PLUS 60/400MG TABLET is an antiviral medicine used to manage Hepatitis C infection.
Q: Is HEPCINAT PLUS 60/400MG TABLET safe?
A: HEPCINAT PLUS 60/400MG TABLET is safe at doses prescribed by the physician.
Q: How does HEPCINAT PLUS 60/400MG TABLET work in our body?
A: HEPCINAT PLUS 60/400MG TABLET acts by blocking the actions of certain viral proteins that is required for the viral cell to grow and multiply. This reduces multiplication of viral cells and manages the spread of infection.
Q: Can I stop taking HEPCINAT PLUS 60/400MG TABLET if I feel unwell?
A: No. Do not stop taking HEPCINAT PLUS 60/400MG TABLET without consulting your doctor. Take HEPCINAT PLUS 60/400MG TABLET regularly, because if you miss a dose of HEPCINAT PLUS 60/400MG TABLET or take it at irregular intervals, you may experience some unpleasant reactions.
Q: What to do if I forget to take a dose of HEPCINAT PLUS 60/400MG TABLET?
A: If you miss a dose of HEPCINAT PLUS 60/400MG TABLET take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular time. Do not take a double dose of HEPCINAT PLUS 60/400MG TABLET to compensate the missed dose.
Q: Can HEPCINAT PLUS 60/400MG TABLET manage Hepatitis C completely?
A: Yes. HEPCINAT PLUS 60/400MG TABLET acts by reducing the number of viral cells within the body. Eventually, it can eliminate the virus from the body and can manage hepatitis C completely.
Q: What are the precautions to be followed while taking HEPCINAT PLUS 60/400MG TABLET?
A: Before taking HEPCINAT PLUS 60/400MG TABLET inform your doctor if you have diabetes, kidney problems or any other liver problems apart from hepatitis C infection (such as liver transplant or hepatitis B infection). Do not take HEPCINAT PLUS 60/400MG TABLET without consulting your doctor if you are pregnant or breastfeeding. Regularly visit your doctor and take all the blood tests recommended for you. Do not stop taking HEPCINAT PLUS 60/400MG TABLET without consulting your doctor.
Q: Can HEPCINAT PLUS 60/400MG TABLET be used in children?
A: HEPCINAT PLUS 60/400MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Q: How to take HEPCINAT PLUS 60/400MG TABLET?
A:Take HEPCINAT PLUS 60/400MG TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. HEPCINAT PLUS 60/400MG TABLET can be taken with or without meals. Continue to take HEPCINAT PLUS 60/400MG TABLET regularly as advised by your physician for maximum benefits.
References
1. Harsh Mohan. Viral Hepatitis. The Liver, Biliary Tract and 592 Exocrine Pancreas. Textbook of Pathology. 6th Edition. Page – 605.
2. Seyed Ali, Dehghan Manshadi, Shahin Merat, Minoo Mohraz, Mehrnaz Rasoolinejad, Shanaz Sali, Masoud Mardani, Payam Tabarsi, Mohammad-Hossein Somi, Roya Sedghi, Katayoun Tayeri, Mehri Nikbin, Jalal Karimi, Amir-Houshang Sharifi, Saeed Kalantari, Alireza Norouzi, Dorsa Merat, Zeinab Malekzadeh, Babak Mirminachi, Hossein Poustchi, Reza Malekzadeh. Single pill sofosbuvir and daclatasvir for treating hepatis C in patients co-infected with human immunodeficiency virus. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. August 2021. [Accessed on 5th January 2023] https://pubmed.ncbi.nlm.nih.gov/33930223/
3. Gilead Sciences Ireland UC. Sovaldi 400 mg film-coated tablets sofosbuvir. Electronic Medicines Compendium (EMC) [Revised in June 2021] [Accessed on 4th January 2023] https://www.medicines.org.uk/emc/files/pil.12361.pdf
4. Bristol-Myers Squibb S.r.l. Daklinza 30 mg and 60 mg film-coated tablets. European Medicines Agency. [Accessed on 5th January 2023] https://www.ema.europa.eu/en/documents/product-information/daklinza-epar-product-information_en.pdf
5. Central Drugs Standard Control Organization. Each film coated tablet contains : Daclatasvir Dihydrochloride Eq to Daclatasvir………..60 mg Sofosbuvir……………....400 mg. June 2018. [Accessed on 5th January 2023] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
Useful Diagnostic Tests
- Complete Blood Count
- Bilirubin Total
- Hepatitis B s (Surface) Antigen
- Hepatitis C Virus Total Antibody
- Liver Function Test
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