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Introduction About GYNOGEN HP 75IU INJECTION
GYNOGEN HP 75IU INJECTION contains Menotrophin which belongs to the group of medicines called Gonadotropins. It is used to manage infertility in both men and women. In women, it helps in egg (ovum) growth and stimulates the release of the matured eggs from the ovaries into the uterus. This helps in managing ovulation problems in women with polycystic ovarian disease (PCOD) especially in those who are not responding appropriately with other medicines (Ex. clomiphene citrate).
It also helps in the growth and development of several egg follicles in women undergoing fertility managements. In men, it improves sperm count and corrects fertility problems.
Before receiving GYNOGEN HP 75IU INJECTION inform your doctor if you have thyroid problems, adrenal gland problems, high blood prolactin levels, fibroids in uterus, any tumours in the breasts, uterus, testes, prostate, pituitary gland or hypothalamus, heavy vaginal bleeding, or blood clots. Your doctor may also ask you to reduce body weight to achieve better results.
You must also inform your doctor if you have any damage in the fallopian tubes, as management with GYNOGEN HP 75IU INJECTION may cause ectopic pregnancy (pregnancy outside of the womb) in such cases.
GYNOGEN HP 75IU INJECTION is not recommended for use in pregnant or breastfeeding women. The most common side effects of receiving GYNOGEN HP 75IU INJECTION are stomach pain or swelling, nausea, headache, and injection site reactions (such as pain, redness, and swelling). Consult your doctor if they worsen.
Uses Of GYNOGEN HP 75IU INJECTION
- Manage infertility in men and women
- Promotes egg growth and release in women with PCOD
- Helps women to produce multiple eggs prior to fertility managements
- Improves sperm count in men
How GYNOGEN HP 75IU INJECTION Works
GYNOGEN HP 75IU INJECTION stimulates your body to release sufficient amount of sex hormones (Estrogen and Progesterone in females and Testosterone in males) to maintain normal reproductive functions. In women, it helps in the growth and maturation of the eggs followed by their release from the ovaries into the uterus (ovulation). This improves the chances of pregnancy among women facing difficulties in becoming pregnant. In men, it improves the levels of testosterone (male hormone) which in turn improves sperm count and reduces fertility problems.
How to use GYNOGEN HP 75IU INJECTION
GYNOGEN HP 75IU INJECTION will be given to you only by a doctor or a nurse into the muscles (intramuscularly) or under the skin (subcutaneously). It can also be self-administered by the patient if instructed by the doctor. Carefully follow the instructions given by your doctor in case of self-administration.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of GYNOGEN HP 75IU INJECTION
Common
- injection site reactions (pain, redness, itching or swelling)
- headache
- nausea
- stomach pain or swelling
- pelvic pain
Uncommon
- vomiting, stomach discomfort, diarrhoea
- tiredness, dizziness
- hot flushes
- breast enlargement and pain, nipple discharge
Rare
- skin rash, acne
Contact your doctor immediately if you experience any of the following side effects after receiving GYNOGEN HP 75IU INJECTION:
- signs of ovarian hyperstimulation syndrome (such as lower abdominal pain with sensation of nausea or vomiting, weight gain, difficulty in breathing, difficulty in passing urine, enlarged ovaries and fluid build-up in chest or abdomen)
- signs of allergic reactions (such as skin rash, itching, swelling of the eyes, face, lips, tongue or throat leading to difficulty in breathing or swallowing)
How To Manage Side Effects
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Injection Site Reactions
Place an ice pack on the affected area. Do not frequently move the injection site. Consult your doctor if the symptom did not improve.
Nausea And Vomiting
Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your symptom worsens.
Warning & Precautions
Pregnancy
ContraindicatedGYNOGEN HP 75IU INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.
Breastfeeding
ContraindicatedGYNOGEN HP 75IU INJECTION is not recommended for use in breastfeeding women. Therefore, consult your doctor before receiving it.
Driving and Using Machines
Use with CautionGYNOGEN HP 75IU INJECTION does not affect your ability to drive or operate machinery. However, do not drive or handle any heavy tools or machines if your ability is affected by GYNOGEN HP 75IU INJECTION.
Alcohol
Consult your doctorAvoid consumption of alcohol before receiving GYNOGEN HP 75IU INJECTION.
Allergy
ContraindicatedTalk to your doctor before receiving GYNOGEN HP 75IU INJECTION if you are allergic to Menotrophin.
Use In Pediatrics
ContraindicatedGYNOGEN HP 75IU INJECTION is not intended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before receiving it.
Use In Geriatrics
Use with CautionGYNOGEN HP 75IU INJECTION should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before receiving it.
Others
GYNOGEN HP 75IU INJECTION is not recommended for use if you:
- have any tumours in the breasts, uterus, pituitary gland or hypothalamus
- have polycystic ovarian disease or enlarged ovaries
- have undiagnosable vaginal bleeding
- had an early menopause
- have any malformation of sex organs that hinders pregnancy
- have fibroids in the uterus
- had uterus removal
- have cancer in testicles or in prostate gland
Before receiving GYNOGEN HP 75IU INJECTION, inform your doctor if you:
- have an underactive thyroid gland
- have an underactive adrenal gland (glands responsible for regulating sex hormones)
- have hyperprolactinemia (high levels of a hormone called prolactin in blood)
- have blood clots in the body or have a family history of blood clots
- are overweight
- have damaged fallopian tubes
Interactions
A. Drug-Drug interactions:
Before receiving GYNOGEN HP 75IU INJECTION, inform your doctor if you are taking any of the following medicines:
- Clomiphene citrate (another medicine used in the management of female infertility)
Overdosage:
GYNOGEN HP 75IU INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Menotrophin |
| Pharmacological Category | : | Gonadotrophins |
| Therapeutic Indication | : | Infertility |
| Dosage Forms | : | Injection, Pre-filled syringes |
More Information
- Keep GYNOGEN HP 75IU INJECTION out of reach of children
- Store GYNOGEN HP 75IU INJECTION at room temperature
FAQs About GYNOGEN HP 75IU INJECTION
Q: What is the use of GYNOGEN HP 75IU INJECTION?
A: GBNKEYWORD] is used to manage infertility in both men and women. It helps in egg (ovum) growth and egg release from the ovaries into the uterus. This helps in managing ovulation problems in women with polycystic ovarian disease (PCOD) and other reproductive problems. In men, improves sperm count and corrects fertility problems.
Q: How GYNOGEN HP 75IU INJECTION works?
A: GYNOGEN HP 75IU INJECTION stimulates your body to release sufficient amount of sex hormones (Estrogen and Progesterone in females and Testosterone in males) to maintain normal reproductive functions. In women, it helps in the growth and maturation of the eggs followed by their release from the ovaries into the uterus (ovulation). This improves the chances of pregnancy among women facing difficulties in becoming pregnant. In men, it improves the levels of testosterone (male hormone) which in turn improves sperm count and reduces fertility problems.
Q: How GYNOGEN HP 75IU INJECTION is administered?
A: GYNOGEN HP 75IU INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously) or under the skin (subcutaneously). It can also be self-administered by the patients if advised by the physician. Carefully, follow the instructions given by the doctor in case of self-administration.
Q: What precautions must be followed while receiving GYNOGEN HP 75IU INJECTION?
A: Before receiving GYNOGEN HP 75IU INJECTION inform your doctor if you have any unexplained vaginal bleeding, blood clot problems or any tumours in the testes, prostate, brain, breast, uterus or ovaries. You must also inform your doctor if you have any damage in the fallopian tubes, as management with GYNOGEN HP 75IU INJECTION may cause ectopic pregnancy (pregnancy outside of the womb) in such cases. GYNOGEN HP 75IU INJECTION should not be used in pregnant women after successful conception. Regularly visit your doctor and perform all blood tests and ultrasounds recommended by him/her without fail.
Q: Is GYNOGEN HP 75IU INJECTION safe?
A: GYNOGEN HP 75IU INJECTION is considered safe at the doses administered by the physician. However, consult your doctor if you experience any unusual side effects
Q: What are the common side effects of receiving GYNOGEN HP 75IU INJECTION?
A: The most common side effects of receiving GYNOGEN HP 75IU INJECTION are stomach pain, nausea, headache and injection site reactions (such as pain, redness, and swelling). Consult your doctor if they worsen.
Q: Can I stop receiving GYNOGEN HP 75IU INJECTION once my symptoms subside?
A: Do not stop taking GYNOGEN HP 75IU INJECTION without consulting your doctor. You need to receive GYNOGEN HP 75IU INJECTION for the duration recommended by your doctor to achieve better results.
Q: Can I use GYNOGEN HP 75IU INJECTION during pregnancy?
A: GYNOGEN HP 75IU INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.
Q: Can GYNOGEN HP 75IU INJECTION be used in children?
A: GYNOGEN HP 75IU INJECTION is not intended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before receiving it.
References
1. KD. Tripathi. Anterior Pituitary Hormones. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 241.
2. Jared C. Robins, M.D., Andrew F. Khair, Ph.D., M.B.A.,,∗ Eric A. Widra, M.D.,c Michael M. Alper, M.D.,d Winnie W. Nelson, Pharm.D., M.S., M.B.A.,b Eric D. Foster, Ph.D.,b Anshul Sinha, B.Tech.,b Masakazu Ando, Ph.D.,b Patrick W. Heiser, Ph.D.,b and Gaurang S. Daftary, M.D., M.B.A. Economic evaluation of highly purified human menotropin or recombinant follicle-stimulating hormone for controlled ovarian stimulation in high-responder patients: analysis of the Menopur in Gonadotropin-releasing Hormone Antagonist Single Embryo Transfer–High Responder (MEGASET-HR) trial. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2020. [Accessed on 10th February 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244378/
3. Ferring Pharmaceuticals Ltd. Menopur 75IU. Electronics Medicines Compendium. [Revised in August 2019]. [Accessed on 10th February 2023] https://www.medicines.org.uk/emc/files/pil.1294.pdf
4. Ferring Pharmaceuticals Ltd. Menopur 150IU. Electronics Medicines Compendium. [Revised in August 2019]. [Accessed on 10th February 2023] https://www.medicines.org.uk/emc/files/pil.4260.pdf
5. Ferring Pharmaceuticals Ltd. Menopur 600IU. Electronics Medicines Compendium. [Revised in March 2022]. [Accessed on 10th February 2023] https://www.medicines.org.uk/emc/files/pil.4595.pdf
6. Ferring Pharmaceuticals Ltd. REPRONEXÒ (MENOTROPINS FOR INJECTION, USP) FOR SUBCUTANEOUS INJECTION AND INTRAMUSCULAR INJECTION. U.S. Food and Drug Administration. [Accessed on 10th February 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21047lbl.pdf
Useful Diagnostic Tests
- Anti-Mullerian Hormone
- Glycosylated Haemoglobin
- Testosterone Total
- Thyroid Stimulating Hormone
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