Granicip 1mg Injection 1ml
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Introduction About GRANICIP 1MG INJECTION
GRANICIP 1MG INJECTION contains a medicine Granisetron which belongs to a group of medicines called Anti-emetics. It is used to manage or manage nausea (feeling sick) and vomiting (being sick) caused by other medical managements such as chemotherapy or radiation management for cancer or by surgery.
Before receiving GRANICIP 1MG INJECTION inform your doctor if you have heart disease, blockage in your stomach or intestines, or electrolyte abnormalities.
GRANICIP 1MG INJECTION is not recommended for use in pregnant and breastfeeding women. Consult with your doctor before receiving it. GRANICIP 1MG INJECTION should not be given to children below 2 years of age. GRANICIP 1MG INJECTION can be used in elderly people (65 years and older). However, consult with your doctor before receiving it.
The most common side effects of receiving GRANICIP 1MG INJECTION are headache, constipation, problems sleeping (insomnia), and diarrhoea. Consult with your doctor if any of these worsen or doesn’t improve.
Uses Of GRANICIP 1MG INJECTION
Prevents or manages nausea and vomiting caused by,
- chemotherapy or radiotherapy for cancer
- surgery
How GRANICIP 1MG INJECTION Works
GRANICIP 1MG INJECTION acts by inhibiting a receptor called 5-HT3 receptor which is present both in the brain and gastrointestinal tract. This inhibition of 5-HT3 receptors in turn inhibits the stimulation of the vomiting centre, managing nausea and vomiting.
How to use GRANICIP 1MG INJECTION
GRANICIP 1MG INJECTION will be given as an injection into the veins (intravenous) by your doctor or nurse. Your doctor will give the right dose depending on your age, body weight and health condition.
Side Effects Of GRANICIP 1MG INJECTION
Common
- headache
- constipation
- problems sleeping (insomnia)
- changes in liver function tests (pain in the abdomen, nausea, vomiting, jaundice)
- diarrhoea
Rare
Stop receiving GRANICIP 1MG INJECTION and inform your doctor immediately if you experience any of the following side effects:
- changes in the heartbeat, chest pain, irregular heartbeat and changes seen on ECG readings (electrical recordings of the heart)
- swelling of the hands, feet, ankles, face, lips and mouth or throat, which may cause difficulty in swallowing or breathing
- rash or itching
- fainting
- serotonin syndrome symptoms such as diarrhoea, nausea, vomiting, high temperature and blood pressure, excessive sweating and rapid heartbeat, agitation, confusion, hallucination, shivering, muscle shakes, jerks or stiffness, loss of coordination and restlessness
How To Manage Side Effects
Diarrhoea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Ask for your doctor’s advice if diarrhoea doesn’t improve.
Headache:
Try to take rest and don’t involve yourself in exertive activities. Rest in a quiet and dark room. Apply a pain-relieving balm on your forehead. Ask for your doctor’s advice if the headache doesn’t improve.
Constipation:
Eat plenty of fiber-rich foods such as vegetables, fresh fruits, and cereals and drink plenty of water. Exercise more regularly. Ask for your doctor’s advice if constipation doesn’t improve.
Warning & Precautions
Pregnancy
GRANICIP 1MG INJECTION is not recommended for use in pregnant women. Consult your doctor before receiving it.
Breastfeeding
GRANICIP 1MG INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving it.
Driving and Using Machines
GRANICIP 1MG INJECTION is not likely to affect your ability to drive or use any tools or machines.
Allergy
Do not receive GRANICIP 1MG INJECTION if you are allergic (hypersensitive) to Granisetron or any other ingredients of this medicine.
Heart Disease
GRANICIP 1MG INJECTION should be used with caution in patients suffering from heart disease. Consult your doctor for advice before receiving this medicine.
Others
Before receiving GRANICIP 1MG INJECTION, inform your doctor if you have:
- blockage in the intestine (stomach-ache, wind, feeling or being sick, or difficulty passing stools)
- electrolyte abnormalities (potassium, sodium, or calcium)
- serotonin syndrome
- been or are being managed for cancer with a medicine that might cause damage to your heart
Use in pediatrics:
GRANICIP 1MG INJECTION is not recommended for use in children below 2 years of age. Consult with your child’s doctor before giving this to your child.
Use in geriatrics:
GRANICIP 1MG INJECTION can be used in elderly people (65 years and older). However, consult with your doctor before receiving.
Interactions
A. Drug - Drug interactions:
Before receiving GRANICIP 1MG INJECTION, inform your doctor if you are taking any of the following medicines:
- other 5-HT3 receptor antagonist such as dolasetron or ondansetron (used to manage nausea and vomiting)
- diltiazem, amlodipine (medicines used to manage an irregular heartbeat)
- phenobarbital (used to manage epilepsy)
- ketoconazole (used to manage fungal infections)
- paroxetine, sertraline, fluvoxamine, citalopram, venlafaxine, duloxetine, escitalopram (used to manage depression and/or anxiety)
- erythromycin (used to manage certain bacterial infections)
Overdosage:
GRANICIP 1MG INJECTION will be administered only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if there are any unusual symptoms such as headache.
Synopsis
| Drug | : | Granisetron |
| Pharmacological Category | : | 5-HT3 Receptor Antagonist |
| Therapeutic Indication | : | Nausea and vomiting caused by chemotherapy or radiotherapy |
| Dosage Forms | : | Tablet, Syrup, Suspension, Injection |
More Information
- Keep GRANICIP 1MG INJECTION out of reach of children
- Store GRANICIP 1MG INJECTION at room temperature below 30°C
FAQs About GRANICIP 1MG INJECTION
What is GRANICIP 1MG INJECTION and why is it prescribed?
GRANICIP 1MG INJECTION contains a medicine called Granisetron. It is used to manage or manage nausea (feeling sick) and vomiting (being sick) caused by other medical managements such as chemotherapy or radiation management for cancer or surgery.
Does GRANICIP 1MG INJECTION cause constipation?
Yes, GRANICIP 1MG INJECTION may cause constipation in some individuals. Eat plenty of fibre-rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. Ask for your doctor’s advice if constipation doesn’t improve
Can I receive GRANICIP 1MG INJECTION if I have heart disease?
GRANICIP 1MG INJECTION should be used with caution in patients suffering from heart disease. Consult your doctor for advice before receiving this medicine.
What are the common side effects of GRANICIP 1MG INJECTION?
The most common side effects of receiving GRANICIP 1MG INJECTION are headache, constipation, problems sleeping (insomnia), and diarrhoea. Consult your doctor if the symptoms worry you or persist for a longer duration. Your doctor will suggest ways to cope up with these side effects and manage them in future.
Can I stop receiving GRANICIP 1MG INJECTION on my own?
Do not stop receiving GRANICIP 1MG INJECTION unless your doctor tells you to. Stopping early may lead to a return of the symptoms. If you have any further questions on the use of GRANICIP 1MG INJECTION, ask your doctor.
How much time does it take administer GRANICIP 1MG INJECTION?
GRANICIP 1MG INJECTION will be given as injection into the veins (intravenous) by your doctor or nurse. The injection into your veins may take between 30 seconds and 5 minutes. Your doctor will give the right dose depends on your age, body weight and health condition.
References
1. KD. Tripathi. Antiemetic, Prokinetic and Digestant Drug. Essentials of medical pharmacology. Seventh edition. 2013. Page –669.
2. NIH National Library of Medicine, National center for biotechnology information. Granisetron. Pubchem. [Accessed on 26th November 2022]. https://pubchem.ncbi.nlm.nih.gov/compound/Granisetron-hydrochloride
3. Anh L. Ngo, Vwaire Orhurhu, Ivan Urits, Edwin O. Delfin, Medha Sharma, Mark R. Jones, Omar Viswanath, Richard D. Urman. Extended release granisetron: Review of pharmacologic considerations and clinical role in the perioperative setting. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. September 2019. [Accessed on 26th November 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625288/
4. Matti Aapro. Granisetron: an update on its clinical use in the management of nausea and vomiting. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. [Accessed on 26th November 2022]. https://pubmed.ncbi.nlm.nih.gov/15561811/
5. Siegfried Hameln GmbH: Electronic Medicines Compendium (EMC) [Revised on Apr 2020] [Accessed 09 Nov 2021] https://www.medicines.org.uk/emc/files/pil.6423.pdf
6. Atnahs Pharma UK Limited. Health Products Regulatory Authority (HPRA). [Revised in June 2020]. [Accessed on 26th November 2022]. http://www.hpra.ie/img/uploaded/swedocuments/276485a0-e462-4d1d-b47b-1b3a00f59273.pdf
7. Medsafe. Granirex (Granisetron). [Revised in January 2022]. [Accessed on 26th November 2022]. https://www.medsafe.govt.nz/Profs/Datasheet/g/granirexinj.pdf
8. Atnahs Pharma UK Limited. Kytril (Granisetron). Pharmanovia. [Accessed on 26th November 2022]. https://pharmanovia.com/product/kytril/
9. Drug Bank. Granisetron. [Accessed on 26th November 2022]. https://go.drugbank.com/drugs/DB00889
Useful Diagnostic Tests
- Complete Blood Count
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