Gonal F 900IU Injection(Pfs) 1's
Netmeds First Membership
Quick Links
Introduction About GONAL F 900IU INJECTION(PFS)
GONAL F 900IU INJECTION(PFS) contains Follitropin Alfa which belongs to the group of medicines called Gonadotropins. It is used in the management of infertility in men and women. It can promote ovulation (release of matured egg from the ovaries) in women who do not produce eggs. It also helps in the growth and development of several egg follicles in women undergoing fertility managements. It can also be used to improve sperm production among infertile men.
Prior to the management, your doctor may evaluate your and your partner’s fertility status thoroughly as a precaution. During management with GONAL F 900IU INJECTION(PFS), your doctor will closely monitor your health condition through several blood tests and ultrasounds to avoid the risk of side effects.
Before receiving GONAL F 900IU INJECTION(PFS) inform your doctor if you have any unexplained vaginal bleeding, blood clot problems or any tumours in the brain, breast, uterus or ovaries. You must also inform your doctor if you have any damage in the fallopian tubes, as management with GONAL F 900IU INJECTION(PFS) may cause ectopic pregnancy (pregnancy outside of the womb) in such cases.
GONAL F 900IU INJECTION(PFS) should not be used in pregnant women after successful conception. It is also not recommended for use in breastfeeding women and in children or adolescents (aged below 18 years) due to lack of safety data.
The most common side effects of receiving GONAL F 900IU INJECTION(PFS) are hot flushes, stomach pain, headache and injection site reactions (such as pain, redness, and swelling). Consult your doctor if they worsen.
Uses Of GONAL F 900IU INJECTION(PFS)
- Manage infertility in men and women
- Promotes ovulation and stimulate the growth of egg follicles among infertile women
- Improves sperm production among infertile men
How GONAL F 900IU INJECTION(PFS) Works
GONAL F 900IU INJECTION(PFS) is a hormonal medicine. In women, it stimulates the body to secrete sufficient amount of a female sex hormone called estrogen that is required for the normal growth and development of the ovarian (egg) follicles. This action stimulates egg growth and maturation. It also promotes the release of matured eggs from the ovaries (ovulation) in women facing problems in becoming pregnant.
In men, it stimulates the release of a male sex hormone called testosterone that is required for sperm production. This action improves sperm production among infertile men.
How to use GONAL F 900IU INJECTION(PFS)
GONAL F 900IU INJECTION(PFS) will be given to you only by a doctor or a nurse into the muscles (intramuscularly) or under the skin (subcutaneously). It can also be self-administered by the patient if instructed by the doctor. Carefully follow the instructions given by your doctor in case of self-administration.
Your doctor will decide the correct dose and duration of therapy depending upon your age, body weight and disease condition.
Side Effects Of GONAL F 900IU INJECTION(PFS)
Common
- injection site reactions (pain, redness, itching or swelling)
- headache
- stomach pain, bloated stomach
- hot flushes
- nausea, vomiting, stomach discomfort, diarrhoea, constipation
- fluid filled cysts in ovaries
- breast enlargement in men
- acne
- weight gain
Rare
Contact your doctor immediately if you experience any of the following side effects after receiving GONAL F 900IU INJECTION(PFS):
- signs of ovarian hyperstimulation syndrome (such as lower abdominal pain with sensation of nausea or vomiting, weight gain, difficulty in breathing, difficulty in passing urine, enlarged ovaries and fluid build-up in chest or abdomen)
- signs of allergic reactions (such as skin rash, itching, swelling of the eyes, face, lips, tongue or throat leading to difficulty in breathing or swallowing)
- skin blistering/peeling especially after sun exposure
- stomach pain, arm pain or leg pain
- signs of blood clots (such as chest pain, difficulty in breathing, heart attack, stroke)
How To Manage Side Effects
Injection site reactions:
Place an ice pack on the affected area. Do not frequently move the injection site. Consult your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Constipation:
Taking GONAL F 900IU INJECTION(PFS) with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Nausea and Vomiting
Take GONAL F 900IU INJECTION(PFS) with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your symptom worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
GONAL F 900IU INJECTION(PFS) is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.
Breastfeeding
GONAL F 900IU INJECTION(PFS) is not recommended for use in breastfeeding women. Therefore, consult your doctor before receiving it.
Driving and Using Machines
GONAL F 900IU INJECTION(PFS) does not affect your ability to drive or operate machinery. However, do not drive or handle any heavy tools or machines if your ability is affected by GONAL F 900IU INJECTION(PFS).
Alcohol
Avoid consumption of alcohol before receiving GONAL F 900IU INJECTION(PFS).
Allergy
Talk to your doctor before receiving GONAL F 900IU INJECTION(PFS) if you are allergic to Follitropin Alfa or to Follicle Stimulating Hormone (FSH).
Others
GONAL F 900IU INJECTION(PFS) is not recommended for use if you:
- have primary ovarian failure (ovaries that do not produce eggs)
- have any tumours in the pituitary gland or hypothalamus
- have breasts cancer, uterine cancer or ovarian cancer
- have polycystic ovarian disease or enlarged ovaries
- have any malformation of sex organs that hinders pregnancy
- had an early menopause
- are a man with damages testis
Before receiving GONAL F 900IU INJECTION(PFS), inform your doctor if you:
- have porphyria
- have overactive thyroid gland
- have hyperprolactinemia (high levels of a hormone called prolactin in blood)
- have undiagnosable vaginal bleeding
- have fibroids in the uterus
- have blood clots in the body or have a family history of blood clots
- have or had stroke
- are overweight
Use in pediatrics:
GONAL F 900IU INJECTION(PFS) is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice.
Use in geriatrics:
GONAL F 900IU INJECTION(PFS) should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before receiving it.
Interactions
A. Drug-Drug interactions:
Before receiving GONAL F 900IU INJECTION(PFS), inform your doctor if you are taking any of the following medicines such as:
- other medicine used in the management of female infertility (such as HCG, clomiphene citrate)
- medicines used to manage cancers of prostate, breast or ovaries (such as leuprolide, goserelin, triptorelin and histrelin)
Overdosage:
GONAL F 900IU INJECTION(PFS) will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Follitropin Alfa |
| Pharmacological Category | : | Ovulation stimulators |
| Therapeutic Indication | : | Infertility |
| Dosage Forms | : | Injection, Pre-filled syringes (PFS), Cartridge |
More Information
- Keep GONAL F 900IU INJECTION(PFS) out of reach of children
- Store GONAL F 900IU INJECTION(PFS) at room temperature
FAQs About GONAL F 900IU INJECTION(PFS)
What is the use of GONAL F 900IU INJECTION(PFS)?
GONAL F 900IU INJECTION(PFS) is used in the management of infertility in men and women. It can promote ovulation (release of matured egg from the ovaries) in women who do not produce eggs. It also helps in the growth and development of several egg follicles in women undergoing fertility managements. It can also be used to improve sperm production among infertile men.
How GONAL F 900IU INJECTION(PFS) works?
GONAL F 900IU INJECTION(PFS) is a hormonal medicine. In women, it stimulates the body to secrete sufficient amount of a female sex hormone called estrogen that is required for the normal growth and development of the ovarian (egg) follicles. This action stimulates egg growth and maturation. It also promotes the release of matured eggs from the ovaries (ovulation) in women facing problems in becoming pregnant. In men, it stimulates the release of a male sex hormone called testosterone that is required for sperm production. This action improves sperm production among infertile men.
How GONAL F 900IU INJECTION(PFS) is administered?
GONAL F 900IU INJECTION(PFS) will be given to you only by a doctor or a nurse into the muscle (intravenously) or under the skin (subcutaneously). It can also be self-administered by the patients if advised by the physician. Carefully, follow the instructions given by the doctor in case of self-administration.
What precautions must be followed while receiving GONAL F 900IU INJECTION(PFS)?
Before receiving GONAL F 900IU INJECTION(PFS) inform your doctor if you have any unexplained vaginal bleeding, blood clot problems or any tumours in the brain, breast, uterus or ovaries. You must also inform your doctor if you have any damage in the fallopian tubes, as management with GONAL F 900IU INJECTION(PFS) may cause ectopic pregnancy (pregnancy outside of the womb) in such cases. GONAL F 900IU INJECTION(PFS) should not be used in pregnant women after successful conception. Regularly visit your doctor and perform all blood tests and ultrasounds recommended by him/her without fail.
Is GONAL F 900IU INJECTION(PFS) safe?
GONAL F 900IU INJECTION(PFS) is considered safe at the doses administered by the physician. However, consult your doctor if you experience any unusual side effects
What are the common side effects of receiving GONAL F 900IU INJECTION(PFS)?
The most common side effects of receiving GONAL F 900IU INJECTION(PFS) are hot flushes, stomach pain, headache and injection site reactions (such as pain, redness, and swelling). Consult your doctor if they worsen.
Can I stop receiving GONAL F 900IU INJECTION(PFS) once my symptoms subside?
Do not stop receiving GONAL F 900IU INJECTION(PFS) without consulting your doctor. You need to receive GONAL F 900IU INJECTION(PFS) for the duration recommended by your doctor to achieve better results.
Can I use GONAL F 900IU INJECTION(PFS) during pregnancy?
GONAL F 900IU INJECTION(PFS) should not be used in pregnant women after successful conception. Therefore, consult your doctor for advice.
Can GONAL F 900IU INJECTION(PFS) be used in children?
GONAL F 900IU INJECTION(PFS) is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice.
References
1. KD. Tripathi. Anterior pituitary Hormones. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 240-241.
2. Peter Sydow, Norbert Gmeinwieser, Katrin Pribbernow, Christoph Keck and Inka Wiegratz. Effectiveness and safety of follitropin alfa (Ovaleap®) for ovarian stimulation using a GnRH antagonist protocol in real-world clinical practice: a multicenter, prospective, open, non-interventional assisted reproductive technology study. Reproductive biology and endocrinology. BMC. May 2020. [Accessed on 8th November 2022] https://rbej.biomedcentral.com/articles/10.1186/s12958-020-00610-2
3. Merck Serono S.p.A. Electronic Medicines Compendium (EMC). [Revised in December 2019]. [Accessed on 8th November 2022] https://www.medicines.org.uk/emc/files/pil.6801.pdf
4. EMD Serono, Inc. U.S. Food and Drug Administration. [Revised in December 2020]. [Accessed on 8th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020378s045,s067,s075lbl.pdf
5. Merck Serono S.p.A. Health Products Regulatory Authority. [Accessed on 8th November 2022] https://www.ema.europa.eu/en/documents/product-information/gonal-f-epar-product-information_en.pdf
6. Cipla Ltd. Newmon-R PFSTM injection (Recombinant Human Follicle Stimulating Hormone). [Revised in January 2018]. [Accessed on 7th November 2022] https://ciplamed.com/content/newmon-r-pfstm-injection
7. Indian Fertility Society. Gonadotropins in ART. August 2018. [Accessed on 8th November 2022] https://www.indianfertilitysociety.org/pdf/Gonadotropins%20in%20ART.pdf
Useful Diagnostic Tests
- Anti-Mullerian Hormone
- Glycosylated Haemoglobin
- Testosterone Total
- Thyroid Stimulating Hormone
Author Details
