New Revised MRP, 100% GST benefit passed Glyxambi 25/5mg Tablet 10'S
Netmeds First Membership
Quick Links
Introduction About GLYXAMBI 25/5MG TABLET
GLYXAMBI 25/5MG TABLET is a combination of Empagliflozin and Linagliptin which belongs to the group of medicines called Antidiabetic agents. It is used to manage type II diabetes mellitus among adult patients when diet, exercise and management with other conventional medicines does not result in adequate sugar control. It is used as an adjunct therapy along with proper diet and exercise to achieve better results.
GLYXAMBI 25/5MG TABLET can also be used in the management of heart complications among patients having both diabetes and heart problems. Follow proper hygiene and regular foot care as instructed by your doctor while taking GLYXAMBI 25/5MG TABLET. Regularly monitor your blood glucose levels as instructed by your doctor.
Before taking GLYXAMBI 25/5MG TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you are severely dehydrated due to excessive vomiting or diarrhea recently as a precaution.
GLYXAMBI 25/5MG TABLET is not recommended for use in patients with Type I diabetes. It is also not suitable for use in patients with alcoholism and in patients with diabetic ketoacidosis.
Consult your doctor before taking GLYXAMBI 25/5MG TABLET if you are pregnant or breastfeeding. The most common side effects of taking GLYXAMBI 25/5MG TABLET are vaginal infection, sore throat or nose, cough, passing more urine than normal, thirst and constipation. Consult your doctor if any of these side effects trouble you.
Uses Of GLYXAMBI 25/5MG TABLET
It is used to manage:
- type II diabetes mellitus in adults along with proper diet and exercise
- heart problems among patients having both diabetes and heart problems
How GLYXAMBI 25/5MG TABLET Works
GLYXAMBI 25/5MG TABLET is an antidiabetic medicine. It contains two medicines namely Empagliflozin and Linagliptin. Empagliflozin eliminates the excess sugars from the body via urine. Whereas linagliptin makes the pancreas to secrete more insulin (a hormone that digests glucose in the body). Collectively, these actions controls blood sugar levels and improve glycemic control in patients with type II diabetes.
How to use GLYXAMBI 25/5MG TABLET
Take GLYXAMBI 25/5MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. GLYXAMBI 25/5MG TABLET can be taken with or without meals.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking GLYXAMBI 25/5MG TABLET unless your doctor advice you to stop.
Side Effects Of GLYXAMBI 25/5MG TABLET
Common
- vaginal infection (such as vaginal thrush)
- sore throat or nose, cough
- passing more urine than normal
- increased urge to pass urine
- skin rash or itching
- increased amylase/lipase levels in blood
- thirst
- constipation
Uncommon
- pain or strain while passing urine
- changes in blood fat levels
- increase in the amount of red blood cells
- kidney problems
Rare
- sore mouth
Stop taking GLYXAMBI 25/5MG TABLET and consult your doctor immediately if you experience any of the following side effects:
- signs of severe decrease in blood sugar levels (such as increased sweating, feeling shaky, anxiety, blurred vision, increased hunger, headache, mood changes or confusion)
- serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- severe skin rashes with redness and blistering of the skin
- inflammation of the pancreas causing severe persistent stomach pain which radiates towards your back along with nausea and vomiting
- signs of diabetic ketoacidosis (such as nausea, vomiting, sudden weight loss, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, metallic taste, smelly urine or sweat)
- infection of kidneys or urinary tract with fever (such as burning sensation while passing urine, mid-back pain or pelvic pain, cloudy urine, urge to pee)
- signs of Fournier’s gangrene (such as pain, tenderness, redness, or swelling of the genitals or the area between the genitals and/or anus combined with fever or general weakness)
- signs of dehydration (such as excessive thirst, dizziness upon standing, fainting)
How To Manage Side Effects
Constipation
Taking GLYXAMBI 25/5MG TABLET with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Warning & Precautions
Pregnancy
Consult your doctorIt is not known whether the use of GLYXAMBI 25/5MG TABLET could affect the unborn baby. Therefore, it should not be used during pregnancy unless recommended by your doctor.
Breastfeeding
Consult your doctorIt is not known whether the use of GLYXAMBI 25/5MG TABLET could pass through the breast milk. Therefore, it should not be used in breastfeeding unless considered necessary by the physician.
Driving and Using Machines
Use with CautionGLYXAMBI 25/5MG TABLET has no influence on your ability to drive or handle heavy tools or machines. However, do not drive or operate any machines if your ability is affected by GLYXAMBI 25/5MG TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking GLYXAMBI 25/5MG TABLET as it may increase the risk of unwanted side effects.
Kidney
Use with CautionGLYXAMBI 25/5MG TABLET should be used with caution in in patients with serious kidney problems. Therefore, consult your doctor before taking it.
Liver
ContraindicatedGLYXAMBI 25/5MG TABLET is not recommended for use in patients with severe liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take GLYXAMBI 25/5MG TABLET if you are allergic to Empagliflozin or Linagliptin.
Use In Pediatrics
ContraindicatedGLYXAMBI 25/5MG TABLET is not generally recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use In Geriatrics
Use with CautionGLYXAMBI 25/5MG TABLET should be used with caution among the elderly patients (aged 75 years or above). Therefore, consult your doctor before taking it.
Others
GLYXAMBI 25/5MG TABLET is not recommended for use if you:
- have type I diabetes mellitus
- have diabetic ketoacidosis (buildup of ketones in the body)
- are an alcoholic
Before taking GLYXAMBI 25/5MG TABLET, inform your doctor if you:
- are on fasting
- suddenly increase or decrease the dose of insulin
- have or previously had any problems in pancreas
- have dehydration or at risk of becoming dehydrated (such as due to excessive vomiting, diarrhea, fever, or if you are not able to eat or drink)
- have high RBC in blood
Interactions
A. Drug - Drug interactions:
Before taking GLYXAMBI 25/5MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to manage diabetes (Ex. glimepiride, glyburide, gliclazide, rosiglitazone, pioglitazone, insulin)
- medicines used to manage epilepsy (Ex. carbamazepine, phenytoin)
- diuretics (used to reduce edema and to manage hypertension) Ex. furosemide, hydrochlorothiazide
- lithium (a medicine used to manage mental illness)
- rifampicin (a medicine used to manage tuberculosis)
Overdosage:
If you or anyone else accidentally took more GLYXAMBI 25/5MG TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Empagliflozin, Linagliptin |
| Pharmacological Category | : | SGLT2 inhibitors, DPP-4 Inhibitors |
| Therapeutic Indication | : | Type II Diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
- Keep GLYXAMBI 25/5MG TABLET out of the sight and reach of children
- Store GLYXAMBI 25/5MG TABLET below 30°C
FAQs About GLYXAMBI 25/5MG TABLET
Q: What is Glyxambi 25/5 mg Tablet used for?
A: Glyxambi 25/5 mg Tablet is an antidiabetic medicine used to manage type II diabetes mellitus, in addition to proper diet and exercise.
Q: How Glyxambi 25/5 mg Tablet works?
A: Glyxambi 25/5 mg Tablet contains two medicines namely Empagliflozin and Linagliptin. Empagliflozin eliminates the excess sugars from the body via urine. Whereas linagliptin makes the pancreas to secrete more insulin (a hormone that digests glucose in the body). Collectively, these actions control blood sugar levels and improve glycemic control in patients with type II diabetes.
Q: Is Glyxambi 25/5 mg Tablet better than metformin?
A: Glyxambi (empagliflozin/linagliptin) 25/5 mg tablet and metformin are both medications used to manage type 2 diabetes, but they work differently and may be used in different circumstances. Metformin is a first-line medication for type 2 diabetes and is often prescribed as an initial management. It works primarily by decreasing the amount of glucose produced by the liver and improving insulin sensitivity in the body.
Glyxambi, on the other hand, is a combination medication that contains empagliflozin and linagliptin which works by lowering blood sugar levels through different mechanisms, such as increasing glucose excretion in the urine and stimulating insulin release in response to meals.
Whether Glyxambi is better than metformin depends on various factors, including the individual's specific health conditions, other medications they are taking, and their response to management. In some cases, Glyxambi may be prescribed when metformin alone is not sufficient to control blood sugar levels or when an individual cannot tolerate metformin due to side effects.
It's important to consult with a healthcare professional to determine the most appropriate management for managing type 2 diabetes based on individual circumstances and medical history.
Q: What is the best time to take Glyxambi 25/5 mg Tablet?
A: Glyxambi 25/5 mg Tablet can be taken with or without meals and at any time of the day. Take this medicine at the same time each day.
Q: How long should I take Glyxambi 25/5 mg Tablet?
A: As diabetes is a chronic condition, you need to take Glyxambi 25/5 mg Tablet as long as your doctor prescribes you the medicine. Do not stop taking this medicine without consulting your doctor.
Q: What to do if I forgot to take a dose of Glyxambi 25/5 mg Tablet?
A: If a dose is forgotten and more than 12 hours remain until the next scheduled dose, the missed dose should be taken promptly when remembered, with the subsequent dose taken at the regular time. If a dose is missed and less than 12 hours remain until the next scheduled dose, it should be skipped, and the following dose should be taken at the usual time. It's important not to take a double dose to make up for a missed one.
Q: What are the most common side effects of taking Glyxambi 25/5 mg Tablet?
A: The most common side effects of taking Glyxambi 25/5 mg Tablet are vaginal infection, sore throat or nose, cough, passing more urine than normal, thirst and constipation. Consult your doctor if any of these side effects trouble you.
Q: Can I stop taking Glyxambi 25/5 mg Tablet without consulting your doctor?
A: No. You should not stop taking Glyxambi 25/5 mg Tablet without consulting your doctor because it may lead to reversal of symptoms. However, if you wish to stop using this medicine, consult your doctor for advice.
Q: Will taking a higher dose of Glyxambi 25/5 mg Tablet be more effective?
A: No, taking a higher dose of Glyxambi 25/5 mg Tablet will not be effective rather it can lead to unpleasant reactions. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with Glyxambi 25/5 mg Tablet?
A: It is not advisable to take medicines to control blood pressure while taking Glyxambi 25/5 mg Tablet without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive medications along with Glyxambi 25/5 mg Tablet as they have known interactions with Glyxambi 25/5 mg Tablet.
Q: Can I take Glyxambi 25/5 mg Tablet in combination with metformin?
A: Consult your doctor before taking metformin along with Glyxambi 25/5 mg Tablet. In some cases, your doctor will prescribe taking metformin along with Glyxambi 25/5 mg Tablet, while at few times it is not advisable. Therefore, check with your doctor.
Q: What should I do if I experience low blood sugar after taking Glyxambi 25/5 mg Tablet?
A: Low blood sugar is a common side effect of taking Glyxambi 25/5 mg Tablet. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if your condition did not improve.
Q: Can Glyxambi 25/5 mg Tablet be taken with insulin?
A: Co-administration of Glyxambi 25/5 mg Tablet with insulin is considered risky as they increase the chance of hypoglycemia (decreased blood sugar levels). Therefore, consult your doctor before taking it.
Q: Can Glyxambi 25/5 mg Tablet be used in pregnant women?
A: Glyxambi 25/5 mg Tablet should not be used in pregnant women unless recommended by the physician. Therefore, consult your doctor for advice.
Q: Can Glyxambi 25/5 mg Tablet cause constipation?
A: Yes. Constipation is a common side effect of using Glyxambi 25/5 mg Tablet. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly while taking this medicine. Contact your doctor if this side effect bothers you.
Q: Can Glyxambi 25/5 mg Tablet cause kidney problems?
A: This medication may cause you to become dehydrated. This can lead to serious kidney damage. Drink plenty of fluids to manage dehydration. Tell your doctor or pharmacist right away if you are not able to drink fluids as usual, or losing fluid (such as due to vomiting, diarrhea, or heavy sweating).
Q: Can Glyxambi 25/5 mg Tablet increases creatinine levels?
A: Studies have shown that empagliflozin may cause increased creatinine levels in the body, as it primarily acts on the kidneys and eliminates excess glucose from the body via urine. To avoid this, your doctor will prescribe regular tests to analyse how your kidney performs as a precaution and adjust the dose accordingly.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.
2. V. Woo. Empagliflozin/linagliptin single-tablet combination: first-in-class treatment option. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2015. [Accessed on 27th November 2023]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049636/
3. Rottendorf Pharma GmbH. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 27th November 2023]. https://www.medicines.org.uk/emc/files/pil.10317.pdf
4. Boehringer Ingelheim Pharmaceuticals, Inc. GLYXAMBI- empagliflozin and linagliptin tablet, film coated. Dailymed.com. [Revised in July 2022] [Accessed on 27th November 2023] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ddbab689-f76c-488c-9613-4168d41dd730
5. Cipla Ltd. TIPTENGIO ® Tablets (FDC of Empagliflozin and Linagliptin). Ciplamed.com. [Revised in July 2021] [Accessed on 27th November 2023] file:///C:/Users/50062978/Downloads/TIPTENGIO%20%C2%AE%20Tablets.pdf
6. Central Drugs Standard Control Organization. Each film coated tablet contains: Empagliflozin 10mg/ 25mg Linagliptin 5mg / 5 mg. October 2017. [Accessed on 27th November 2023] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin Glucose - Postprandial Blood
- Blood Glucose Fasting (FBS)
- Random Blood Sugar (Rbs)
- Post Prandial Blood Sugar (PPBS)
- Advance Diabetes Care
- Diabetes Screening
- Diabetic Profile – Basic
- Diabetes Care Package - Essential
Author Details
