Glynase MF Tablet 10'S

Introduction About GLYNASE MF TABLET

Glynase MF Tablet is a combination medication used to manage type 2 diabetes mellitus. It contains Glipizide (a sulfonylurea), which helps the pancreas release more insulin, and Metformin (a biguanide), which reduces excess sugar production in the liver and improves insulin sensitivity. Together, they help control blood sugar levels and reduce diabetes-related complications such as nerve damage, kidney problems, and heart disease. This medicine is most effective when combined with a healthy diet and regular exercise.

Glynase MF should be taken exactly as prescribed by your doctor, usually once or twice daily before meals to prevent low blood sugar (hypoglycemia). Do not skip meals after taking this medicine.

Patients with kidney, liver, or heart problems should use it with caution, as it may increase the risk of lactic acidosis and low blood sugar. Alcohol should be avoided while on this medication, as it can further increase these risks. Regular blood sugar monitoring is essential to ensure safe and effective use.

Glynase MF is not recommended during pregnancy and breastfeeding, as Glipizide can cross the placenta and may affect the baby. Pregnant women should discuss alternative medications with their doctor.

Common side effects include low blood sugar (shakiness, dizziness, sweating), nausea, stomach upset, diarrhea, and mild weight gain. In rare cases, it may cause serious allergic reactions or lactic acidosis, which requires immediate medical attention. If any severe side effects occur, consult a doctor promptly.

Uses Of GLYNASE MF TABLET

• Type II diabetes mellitus when diet, exercise and lifestyle changes does not result in adequate response

Benefits of GLYNASE MF TABLET

Glynase MF Tablet for type 2 diabetes Treatment:

• Helps lower blood sugar levels in diabetic patients
• Improves insulin sensitivity and reduces insulin resistance
• Prevents diabetes-related complications like nerve damage, kidney issues, and heart disease
• Works best when combined with a healthy diet and regular exercise

Glynase MF for Weight Loss: Can It Help?

• Metformin in Glynase MF is known to aid in weight management by reducing appetite and lowering glucose absorption
• Glipizide may lead to weight gain in some cases, so lifestyle changes are important
• Supports better metabolism and fat utilization when paired with proper diet and activity

How GLYNASE MF TABLET Works

Glynase MF Tablet helps people with type 2 diabetes control their blood sugar levels. It contains two medicines:

1. Glipizide – Helps the pancreas release more insulin, which lowers blood sugar.
2. Metformin – Reduces the amount of sugar the liver makes and helps the body use insulin more effectively.

Together, these ingredients help keep blood sugar stable, prevent sudden spikes, and reduce diabetes-related risks. For best results, take it before meals, follow a healthy diet, and stay active.

How to use GLYNASE MF TABLET

How to Take Glynase MF Tablet

• Take Glynase MF exactly as prescribed by your doctor.
• Swallow the tablet whole with water, preferably before meals to maximize its effect.
• Avoid crushing or chewing the tablet, as it may alter the release of the medicine.

Best Time to Take Glynase MF Tablet

Glynase MF Tablet is best taken before meals, usually 30 minutes before breakfast or the first main meal of the day. This helps the medicine work effectively by stimulating insulin release right when food increases blood sugar levels.

For those taking multiple doses, doctors may recommend splitting the dose before breakfast and dinner. Always follow your doctor's instructions for the best results and to avoid low blood sugar (hypoglycemia).

Glynase MF – Dosage Instructions

• The usual starting dose is based on your doctor’s recommendation.
• It is important to take the tablet at the same time every day to maintain consistent blood sugar levels.
• Do not skip doses, as it may lead to fluctuations in blood sugar levels.

Glynase MF Maximum Dosage Per Day

• The maximum dose depends on individual patient needs.
• Generally, Glipizide (up to 20 mg/day) and Metformin (up to 2000 mg/day) are used.
• Always follow your doctor’s prescription to avoid side effects.

Glynase MF Dosage Adjustments in Elderly Patients

• Lower starting doses may be needed for elderly patients due to a higher risk of low blood sugar (hypoglycemia).
• Close monitoring of blood sugar levels is essential to prevent complications.

Glynase MF Dosage Guidelines for Patients with Liver Impairment

• Patients with liver problems should take lower doses or an alternative medication as prescribed by a doctor.
• Metformin use may be restricted in severe liver disease due to the risk of lactic acidosis.

What if I forgot to take GLYNASE MF TABLET

What If I Forget to Take a Dose of Glynase MF?

• If you miss a dose, take it as soon as you remember.
• If it’s almost time for your next dose, skip the missed dose and continue as usual.
• Do not double the dose, as it may cause low blood sugar.

Glynase MF – Missed Dosage: What to Do?

• Missing doses may cause high blood sugar (hyperglycemia).
• Watch for symptoms like increased thirst, frequent urination, and tiredness.
• If you frequently forget doses, consider setting a reminder or alarm.

Overdose

Glynase MF – Overdosage: What Happens?

• Taking too much Glynase MF can cause severe low blood sugar (hypoglycemia).
• Symptoms include dizziness, confusion, sweating, shaking, and fainting.
• In case of overdose, consume sugar (like glucose tablets, fruit juice) and seek immediate medical attention.

Side Effects Of GLYNASE MF TABLET

Like all medicines, GLYNASE MF TABLET may cause certain side effects in some individuals, although not everybody gets them.

Common Side Effects of Glynase MF Tablet:

• hypoglycemia (low blood sugar levels)
• nausea, vomiting
• diarrhea, stomach pain, loss of appetite
• changes in taste, metallic taste 
• dizziness, drowsiness
• feeling shaky
• blurred vision
• eczema (skin inflammation)

When to Seek Medical Attention?

Stop taking GLYNASE MF TABLET and contact your doctor immediately if you experience any of the following side effects:  

• severe allergic reaction (such as skin rash, swelling of the face, eyelids, lips, tongue, or throat which causes difficulty in breathing or swallowing)
• signs of severe decrease in blood sugar level (such as confusion, headache, excessive sweating, clammy skin, trembling, weakness, double vision, excessive hunger, nausea, vomiting, problems in sleeping, feeling agitated, unable to concentrate, drowsiness, loss of consciousness, slowed reactions, depression, trouble seeing or speaking, paralysis, numbness, dizziness, hallucinations, difficulty in breathing, slowed or faster heartbeat with chest pain)
• signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)
• signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)

Glynase MF Side Effects in Elderly Patients:

Elderly patients taking Glynase MF are at a higher risk of hypoglycemia (low blood sugar) due to reduced metabolism and kidney function. Common side effects include:

• Dizziness, weakness, or confusion due to low blood sugar
• Increased sensitivity to the medication, requiring dosage adjustments
• Gastrointestinal issues like nausea, bloating, or diarrhea
• Risk of falls or fractures due to sudden blood sugar drops

Regular blood sugar monitoring and cautious dosing are essential for elderly patients.

Glynase MF and Weight Gain

Glynase MF contains Glipizide, which may cause weight gain in some individuals by increasing insulin production. However, Metformin in the tablet helps control weight by improving insulin sensitivity and reducing appetite. To prevent weight gain:

• Follow a balanced diet with portion control
• Engage in regular physical activity
• Monitor weight changes and consult a doctor for adjustments if needed

How To Manage Side Effects

Hypoglycemia

Hypoglycemia (low blood sugar) can occur if Glynase MF lowers blood sugar too much, especially in elderly patients or those who skip meals. Here’s how to manage it:

1. Recognize Symptoms Early

Common signs of low blood sugar include:

• Dizziness, shakiness, or sweating
• Hunger, irritability, or confusion
• Fast heartbeat or blurred vision

2. Take Quick Sugar Sources

If you experience symptoms, immediately consume:

• Glucose tablets or gel (fastest option)
• Half a glass of fruit juice or regular soda
• 1 tablespoon of honey or sugar
• Hard candy (not sugar-free)

3. Follow Up with a Snack

After stabilizing blood sugar, eat a small snack like a banana, nuts, or a sandwich to prevent another drop.

4. Prevent Future Episodes

• Never skip meals; eat at regular times.
• Avoid excessive alcohol as it can trigger low blood sugar.
• Carry glucose tablets or sugary snacks when outside.
• Monitor blood sugar levels regularly and adjust medication with your doctor if needed.

Seek immediate medical help if symptoms are severe or persist.

Warning & Precautions

Pregnancy

Risky

There is insufficient information regarding the use of Glipizide and metformin in pregnant women. Animal studies have not indicated any side effects on the growing baby. But, a risk to the growing baby cannot be excluded. Therefore, Glynase MF Tablet should not be used in pregnant women unless considered necessary by the physician

Breastfeeding

Contraindicated

Glynase MF Tablet should not be used in breastfeeding women due to lack of safety data. Therefore, inform your doctor before taking Galvus Met, if you are breastfeeding.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you experience dizziness after taking this medicine.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking Glynase MF Tablet as it may increase the risk of side effects.

Kidney

Consult your doctor

Glynase MF Tablet is not recommended in patients with severely reduced kidney function. It should be used with caution in patients with mild to moderate kidney problems. Proper dose adjustments and careful monitoring are required in such patients.

Liver

Consult your doctor

Glynase MF Tablet is not recommended for use in patients with severe liver diseases. It should be used with caution in patients with mild to moderate liver problems. Therefore, inform your doctor before taking Galvus Met, if you have any pre-existing liver conditions as a precaution.

Allergy

Contraindicated

Do not take this medicine if you are allergic (hypersensitive) to metformin or vildagliptin.

Lungs

Contraindicated

GLYNASE MF TABLET is not recommended for use in patients with breathing problems (such as asthma or COPD) or lung infections. Therefore, consult your doctor before taking it

Heart Disease

Contraindicated

Glynase MF Tablet is not recommended in patients who recently had a heart attack or heart failure or any signs of heart problems such as serious blood circulation problems or difficulty breathing.

Use In Pediatrics

Contraindicated

Glynase MF Tablet is not recommended for use in children and adolescents less than 18 years of age due to a lack of safety and effectiveness. Your doctor will decide whether it should be prescribed for your child or not based on your child’s health status.

Use In Geriatrics

Use with Caution

Glynase MF Tablet should be used with caution in elderly patients above 65 years of age, especially in patients with impaired kidney function.

Other Warnings for GLYNASE MF TABLET

Before taking Glynase MF Tablet, inform your doctor if you have or had:

• Disease of the pancreas
• Going to undergo any surgery
• Vitamin B12 deficiency
• Malnutrition with adrenal or pituitary insufficiency

Who should not take [GBNKEYWORD

Who Should Not Take Galvus Met:

Glynase MF Tablet is not recommended for you if you have:

• Type 1 diabetes mellitus
• Uncontrolled diabetes (with severe low blood sugar levels, nausea, vomiting, diarrhea, rapid weight loss, ketoacidosis, or lactic acidosis)
• Severe infection or seriously dehydrated
• Are going to have a contrast x-ray (a specific type of x-ray involving an injectable dye)

Safety Advice

• Take Glynase MF exactly as prescribed to avoid low blood sugar (hypoglycemia).
• Do not skip meals, as it may cause sudden blood sugar drops.
• Monitor blood sugar levels regularly to track effectiveness and prevent complications.
• Avoid alcohol, as it can increase the risk of low blood sugar and lactic acidosis.
• Patients with liver or kidney disease should use Glynase MF cautiously and under medical supervision.

Doctor’s Opinion on Glynase MF for Type 2 Diabetes

Doctors recommend Glynase MF for type 2 diabetes patients who need both insulin stimulation (Glipizide) and improved insulin sensitivity (Metformin). It effectively:

• Lowers blood sugar levels
• Reduces diabetes-related complications
• Helps maintain long-term blood sugar control
   

However, it may not be suitable for elderly patients, those with severe kidney/liver issues, or pregnant women without doctor’s advice.

Diet and Lifestyle Advice

Diet and Lifestyle Advice for Glynase MF Users

• Eat a balanced diet rich in fiber, whole grains, lean proteins, and healthy fats.
• Avoid processed foods, sugary drinks, and excessive carbs to prevent blood sugar spikes.
• Drink plenty of water and limit alcohol intake.
• Maintain a consistent meal schedule to prevent low blood sugar.
• Exercise regularly but avoid overexertion, as it may trigger hypoglycemia.

Best Foods to Eat While Taking Glynase MF

• High-Fiber Foods – Whole grains, vegetables, lentils, and beans to control blood sugar.
• Lean Proteins – Chicken, fish, eggs, tofu, and paneer to maintain muscle and control hunger.
• Healthy Fats – Nuts, seeds, olive oil, and avocados for heart health.
• Low-Glycemic Fruits – Apples, berries, oranges in moderation.
• Avoid Sugary, Processed Foods & White Bread/Rice to prevent sugar spikes.

Exercise Tips for People on Glynase MF

• Do at least 30 minutes of moderate exercise daily (walking, yoga, cycling).
• Strength training 2-3 times per week improves insulin sensitivity.
• Avoid intense workouts on an empty stomach, as it may cause low blood sugar.
• Keep glucose tablets handy if exercising for long periods.
• Monitor blood sugar levels before and after exercise.

Glynase MF and Weight Loss: What You Should Know

• Metformin in Glynase MF may help with weight loss by improving insulin function.
• Glipizide, however, may cause mild weight gain by increasing insulin levels.
• Following a low-carb diet, regular exercise, and portion control can help manage weight effectively.

Drug - Drug interaction

1.With Other Antidiabetic Drugs (Insulin, Sulfonylureas, DPP-4 Inhibitors, SGLT2 Inhibitors)

• Can cause severe hypoglycemia (low blood sugar).
• Close blood sugar monitoring is required.

2.With Beta-Blockers (Metoprolol, Propranolol, Atenolol)

• Can mask low blood sugar symptoms like rapid heartbeat, making hypoglycemia harder to detect.

3.With Corticosteroids (Prednisolone, Dexamethasone)

• May increase blood sugar levels, reducing Glynase MF’s effectiveness.

4.With Diuretics (Hydrochlorothiazide, Furosemide)

• Can worsen dehydration and kidney issues, increasing the risk of lactic acidosis (a rare but serious condition).

5.With Antibiotics (Rifampicin, Ciprofloxacin, Clarithromycin)

• Some antibiotics can increase or decrease Glynase MF’s effect, leading to blood sugar fluctuations.

6.With NSAIDs (Ibuprofen, Diclofenac, Aspirin)

• May enhance the blood sugar-lowering effect, increasing the risk of hypoglycemia.

Drug - Food interaction

1. Alcohol
   • Can cause severe low blood sugar (hypoglycemia) and increase the risk of lactic acidosis.
   • Avoid excessive alcohol consumption.
2. High-Carbohydrate Meals (White Bread, Sugary Drinks, Rice, Potatoes)
   • May spike blood sugar, making Glynase MF less effective.
   • Opt for fiber-rich and low-GI foods instead.
3. Grapefruit Juice
   • Can interfere with drug metabolism, potentially increasing side effects.
4. Caffeine (Coffee, Tea, Energy Drinks)
   • May increase blood sugar fluctuations, especially in sensitive individuals.
5. Vitamin B12-Deficient Diet
   • Long-term Metformin use in Glynase MF may reduce Vitamin B12 levels, leading to weakness and nerve issues.
   • Include B12-rich foods like eggs, dairy, and fish or consider supplements if needed.

Synopsis

More Information

Glynase MF vs Glycomet – Which is better?

Which One is Better?

Glynase MF – Best for patients needing stronger blood sugar control but requires careful monitoring due to hypoglycemia risk.

Glycomet – Best for overweight patients or those with insulin resistance, with a lower risk of hypoglycemia.

Consult your doctor to choose the best medication based on your health needs.Bottom of Form

FAQs About GLYNASE MF TABLET

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270 & 275.
2. Glipizide. Prescribing information. U.S. Food and Drug Administration.
3. Metformin. Prescribing information. U.S. Food and Drug Administration.
4. Glipizide + Metformin. Prescribing information. U.S. Food and Drug Administration.
5. Dietary Advice for Individuals with Diabetes. Last updated April 2024. NIH.
6. Diabetic Diet. Medlineplus.

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Glucose - Fasting Urine

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 21 Mar 2025 | 11:50 AM(IST)