Glycomet Trio 2mg Tablet 10'S

Introduction About GLYCOMET TRIO 2MG TABLET

What is Glycomet Trio 2mg Tablet?

Glycomet Trio 2mg is a prescription medication used to control blood sugar levels in people with type 2 diabetes. It contains a combination of Metformin, Glimepiride and Voglibose.

Glycomet Trio 2mg is a prescription medicine used for diabetes management. Take Glycomet Trio 2mg as prescribed by your doctor, usually once daily with food to avoid stomach upset.

Before taking Glycomet Trio 2mg, inform your doctor if you recently had trauma and/or have febrile infections, fever, uncontrolled diabetes, hypothyroidism, chronic intestinal disease, fever, or other kidney or liver problems.

The most common side effects include nausea, dizziness, and digestive issues. Consult your doctor if symptoms persists for a longer duration.

Key Composition

Active Ingredients of Glycomet Trio 2mg:

The active ingredients in Glycomet Trio 2mg Tablet are:

• Glimepiride (2 mg) – A sulfonylurea that helps the pancreas release more insulin, lowering blood sugar levels
• Metformin (500 mg) – A biguanide that reduces glucose production in the liver and improves insulin sensitivity
• Voglibose (0.2 mg) – An alpha-glucosidase inhibitor that delays glucose absorption in the intestine, helps in reducing post-meal sugar spikes

Uses Of GLYCOMET TRIO 2MG TABLET

• Type II Diabetes mellitus

Benefits of GLYCOMET TRIO 2MG TABLET

1. Helps manage Type 2 Diabetes – controls blood sugar levels effectively in diabetic patients

2. Improves insulin sensitivity - Metformin enhances the body's response to insulin, reducing insulin resistance

3. Reduces blood sugar spikes after meals - Voglibose slows carbohydrate absorption, reducing sudden sugar surges

How GLYCOMET TRIO 2MG TABLET Works

How Glycomet Trio 2mg Tablet works: A complete guide:

1. Glimepiride (2 mg): Stimulates insulin release

• Class: Sulfonylurea
• Function: Increases insulin production from the pancreas
• Effect: Helps reduce blood sugar levels by promoting glucose uptake into cells
• Benefit: More insulin helps in better glucose regulation, especially in insulin-deficient individuals

2. Metformin (500 mg): Reduces glucose production & improves sensitivity

• Class: Biguanide
• Function 1: Reduces glucose production in the liver
• Function 2: Enhances insulin sensitivity in muscle cells, helping them absorb glucose efficiently
• Effect: Lowers fasting blood sugar levels and improves overall glycemic control
• Benefit: Reduces excessive sugar release from the liver and ensures better insulin utilization

3. Voglibose (0.2 mg): Delays carbohydrate absorption

• Class: Alpha-glucosidase inhibitor
• Function: Slows down the breakdown and absorption of carbohydrates in the intestine
• Effect: Reduces sudden spikes in blood sugar levels after meals (postprandial hyperglycemia)
• Benefit: Helps maintain steady blood sugar levels throughout the day

How the three ingredients work together:

• Before a meal: Metformin and Glimepiride help keep blood sugar under control
• During a meal: Voglibose slows down carbohydrate absorption, reducing sugar spikes
• After a meal: Insulin secretion is enhanced by Glimepiride, and glucose utilization is optimized by Metformin

How to use GLYCOMET TRIO 2MG TABLET

Glycomet Trio 2mg Tablet is a prescription medicine which needs to be taken under medical supervision. Always consult your doctor or pharmacist if you have any questions or concerns about taking this medication.

Recommended dosage of Glycomet Trio 2mg:

• Usual dose: 1 tablet per day (or as prescribed by a doctor)
• When to take: With or after meals (usually breakfast or dinner) to reduce low blood sugar (hypoglycemia)
• Maximum dose: Based on your doctor’s instructions, do not exceed the recommended amount
• Since Glimepiride stimulates insulin release, make sure to eat meals regularly to avoid hypoglycemia (low blood sugar)

How to take of Glycomet Trio 2mg:

• Take Glycomet Trio 2mg as prescribed by your doctor, usually once daily with food to avoid stomach upset
• Taking Glycomet Trio 2mg with food helps reduce stomach upset and ensures proper absorption of the medication
• Always follow your doctor's specific instructions, and regularly monitor your blood sugar levels as advised

Can I split or crush Glycomet Trio 2mg Tablet?

• Glycomet Trio 2mg should be swallowed whole with water. Do not crush, chew, or break the tablet as this can affect how the medication is absorbed

What if I forgot to take GLYCOMET TRIO 2MG TABLET

• Take Glycomet Trio 2mg Tablet as soon as you remember
• Skip it if it is close to the next scheduled dose
• Do not double the dose to make up for a missed one

Overdose

1. If conscious & experiencing low blood sugar:

• Immediately consume fast-acting sugar (fruit juice, glucose tablets, candy)
• Follow with a balanced meal to stabilize blood sugar

2. If severe symptoms appear (e.g., fainting, breathing trouble):

• Call emergency services or rush to the nearest hospital
• Do not self-medicate or delay medical attention

Side Effects Of GLYCOMET TRIO 2MG TABLET

Common side effects:

• nausea
• dizziness
• digestive issues

When to seek medical attention?

• severe hypoglycemia
• signs of lactic acidosis (lactic acid built up in the bloodstream) such as exhaustion or extreme fatigue, body weakness, diarrhea, and/or headache

How To Manage Side Effects

Dizziness Or Drowsiness

• Drink plenty of water throughout the day to reduce dehydration
• Sit for a few seconds before standing to reduce dizziness from blood pressure changes
• Ensure you get enough sleep (7-8 hours per night)

Indigestion

• Always take Glycomet Trio with a meal to reduce stomach irritation
• Probiotics (good bacteria) found in yogurt or supplements can help improve gut health
• Light physical activity (like walking) after meals can aid digestion

Nausea And Vomiting

• Always take Glycomet Trio with a meal (preferably breakfast or dinner)
• Sip on herbal teas (ginger, peppermint, or chamomile) to soothe the stomach
• Stick to light, bland foods like crackers, toast, or bananas

Warning & Precautions

Pregnancy

Consult your doctor

There is no well-controlled human studies exist for the combination of Glycomet Trio in pregnant women. Pregnant women should not take Glycomet Trio unless prescribed by a specialist.

Breastfeeding

Consult your doctor

There are no specific human studies exist for the combination of Glycomet Trio in lactating mothers. Metformin is excreted in breast milk in small amounts, but studies suggest it is generally safe for breastfeeding infants. Glimepiride and Voglibose have unknown safety profiles in breastfeeding and may pose a risk of hypoglycemia in infants. Breastfeeding mothers should avoid Glycomet Trio unless advised by a doctor.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you experience impaired alertness or reactions (due to hypoglycemia) while taking Glycomet Trio Tablet.

Alcohol

Contraindicated

Do not consume alcohol while taking Glycomet Trio 2mg since it may reduce your blood sugar level.

Kidney

Consult your doctor

Glycomet Trio 2mg is not recommended in patients with severe renal failure. It should be used with caution in patients with other kidney diseases.

Liver

Consult your doctor

Glycomet Trio 2mg is not recommended for use in patients with severe liver disease. It should be used with caution in patients with other liver diseases.

Allergy

Contraindicated

Do not take Glycomet Trio 2mg if you are allergic to Glimepiride, Metformin, Voglibose or any other ingredients of this medicine.

Lungs

Contraindicated

Glycomet Trio 2mg is not recommended for use in patients with lung problems such as acute or chronic respiratory failure.

Heart Disease

Contraindicated

Glycomet Trio 2mg is not recommended in patients with heart problems such as acute or chronic cardiac failure or recent myocardial infarction.

Use In Pediatrics

Contraindicated

Glycomet Trio 2mg is not recommended for use in children and adolescents (aged below 18 years) since the safety and effectiveness of the medicine are not established

Use In Geriatrics

Use with Caution

Glycomet Trio 2mg should be used with caution in elderly patients (aged 65 years and above).

Other Warnings for GLYCOMET TRIO 2MG TABLET

Before taking Glycomet Trio 2mg, inform your doctor if you:

• recently had trauma
• had or scheduled for any surgery
• suffer from febrile infections, fever or uncontrolled diabetes
• are undernourished and/or have irregular mealtimes or skipped meals
• suffer from an imbalance between physical exertion and carbohydrate intake
• have hypothyroidism
• have a history of laparotomy
• suffer from chronic intestinal disease
• suffer from fever

Who should not take [GBNKEYWORD

Glycomet Trio 2mg is not recommended for use if you:

• suffer from any acute type of metabolic acidosis
• suffer from acute conditions such as dehydration, severe infection, and shock
• have severe ketosis
• are in a state of diabetic coma
• had severe infections before or after the operation
• had severe trauma
• have gastrointestinal obstruction

Diet and Lifestyle Advice

Best foods to eat while taking Glycomet Trio 2mg:

1. High-fiber foods (slow sugar absorption)

• whole grains (oats, quinoa, brown rice, whole wheat bread)
• leafy greens (spinach, kale, lettuce, broccoli)
• legumes (lentils, chickpeas, beans)
• nuts and seeds (flaxseeds, chia seeds, almonds, walnuts)

2. Lean proteins (keeps you full & stabilizes blood sugar)

• skinless chicken, turkey
• fish rich in omega-3 (salmon, tuna, mackerel)
• eggs (boiled or scrambled)
• tofu, paneer, or greek yogurt

3. Low-glycemic index (GI) fruits (safe for blood sugar)

• berries (strawberries, blueberries, blackberries)
• apples and pears  
• oranges, guava, and pomegranate
• avocados (rich in healthy fats)

4. Healthy fats (supports insulin sensitivity)

• olive oil, avocado oil
• nuts (almonds, walnuts, pistachios)
• seeds (flaxseeds, sunflower seeds, pumpkin seeds)
• fatty fish (rich in omega-3)

5. Dairy products (choose low-fat options)

• low-fat or greek yogurt
• low-fat milk or almond milk
• cottage cheese (paneer)

The best exercises for diabetes control – Expert tips:

• walking - 30 minutes, 5 days a week
• strength training - 2-3 times a week
• cycling - 30–45 minutes, 3-5 times a week
• swimming (gentle & effective for joints) - 30–45 minutes, 3 times a week
• high-intensity interval training (HIIT) - 15–20 minutes, 3 times a week

Dietary guidelines for diabetes:

• Maintain stable blood sugar levels
• Improve insulin sensitivity
• Support weight management
• Reduce the risk of diabetes-related complications

Balanced meal plans? – Key guidelines:

• Eat every 3-4 hours to maintain stable blood sugar
• Include fiber-rich carbs (whole grains, vegetables)
• Prioritize lean proteins (chicken, fish, legumes)
• Limit processed foods, sugar, and unhealthy fats
• Drink plenty of water and stay active

Recommended carbohydrate intake:

• 45-60 grams per meal (depends on individual needs)
• 15-30 grams per snack
• Prioritize complex carbs (whole grains, legumes, fiber-rich foods)
• Limit refined and processed carbs (white bread, sugar, sodas)
• Total daily intake: 45-50% of total calories should come from carbohydrates

Managing Hypoglycemia:

1. Recognizing low blood sugar symptoms:

• Mild symptoms: shakiness, dizziness, sweating, chills, hunger, nausea, irritability, nervousness, rapid heartbeat
• Moderate symptoms: confusion, difficulty concentrating, blurred vision, weakness, fatigue, mood swings
• Severe symptoms (emergency – seek help immediately): loss of consciousness, seizures, inability to swallow

2. Immediate corrective actions (hypoglycemia management):

• consume 15g of fast-acting carbs (glucose tablets, fruit juice, honey, candy)
• wait 15 minutes and check blood sugar levels

Best quick sugar sources (15g carbs each):

• 4 glucose tablets or 1 tube of glucose gel
• ½ cup (120ml) fruit juice (orange/apple)
• 1 tbsp honey or sugar
• 3-4 pieces of hard candy
• ½ can of regular soda (not diet)

Strategies to avoid hypoglycemia:

• Eat regular meals and snacks
• Balance carbs with protein & healthy fats
• Monitor blood sugar levels regularly
• Adjust insulin/medications as per doctor’s advice
• Carry glucose tablets or sugary snacks when outside
• Limit alcohol intake (can cause delayed hypoglycemia)
• Exercise safely (check sugar levels before and after)

Step-by-Step guide to using Glycomet Trio 2mg safely:

Step 1: Consult your doctor first

• Get a proper diagnosis and prescription before starting the medication
• Inform your doctor about allergies, existing health conditions, and other medications you take

Step 2: Follow the correct dosage

• Recommended Dosage: Usually 1 tablet per day (or as prescribed)
• When to take with or after meals (preferably breakfast or dinner)
• Do not crush, chew, or break the tablet, swallow it whole with water

Step 3: Maintain a balanced diet

• Eat fiber-rich foods, whole grains, and proteins to help stabilize blood sugar
• Limit sugary and high-carb foods to avoid blood sugar spikes
• Stay hydrated by drinking enough water throughout the day

Step 4: Monitor blood sugar levels regularly

• Track fasting and post-meal blood sugar levels
• Report any unusual highs or lows to your doctor for dosage adjustments

Step 5: Be aware of potential side effects

• Common side effects: mild nausea, dizziness, bloating, or diarrhea
• Serious side effects: severe hypoglycemia (excessive sweating, confusion, fainting) or lactic acidosis (breathing difficulty, muscle pain)

Step 6: Take precautions

• Avoid alcohol
• Do not skip meals
• Limit heavy physical exertion

Step 7: Know what to do in case of overdose or missed dose

• Missed dose: Take it as soon as you remember. if it is close to the next dose, skip it, do not double the dose
• Overdose can cause severe hypoglycemia or lactic acidosis. seek emergency medical help immediately

Step 8: Lifestyle adjustments for best results

• Engage in regular physical activity like walking to improve insulin sensitivity
• Manage stress levels as it can impact blood sugar fluctuations
• Get regular health check-ups for diabetes management

Drug - Drug interaction

Medications that should not be taken with Glycomet Trio 2mg:

1. Blood Sugar-Lowering Medications  

• Combining Glycomet Trio with other diabetes medications can cause dangerously low blood sugar (hypoglycemia)
• Examples: Insulin, Other sulfonylureas (e.g., Gliclazide, Glibenclamide), DPP-4 inhibitors (e.g., Sitagliptin, Vildagliptin)

2. Beta-Blockers  

• Examples: Atenolol, Metoprolol, Propranolol
• Risk: Beta-blockers can mask warning signs of hypoglycemia (such as increased heart rate)

3. NSAIDs & Pain Relievers  

• Examples: Ibuprofen, Diclofenac, Naproxen
• Risk: Can increase insulin sensitivity, leading to low blood sugar and worsen kidney function in diabetics

4. Diuretics:

• Examples: Hydrochlorothiazide, Furosemide
• Risk: May increase blood sugar and cause dehydration, worsening diabetes symptoms

5. Corticosteroids

• Examples: Prednisone, Dexamethasone
• Risk: Can raise blood sugar levels significantly, requiring medication adjustments

6. Antibiotics

• Examples: Rifampicin, Fluoroquinolones
• Solution: Use alternative antibiotics if necessary & monitor sugar levels

Synopsis

More Information

Glycomet Trio 2mg vs. Other Diabetes Medications – Which Is Best?

Debunking common myths about diabetes medications:

Myth 1: "Once you start diabetes medication, you are stuck for life."

Fact: Many people can reduce or stop medication with proper diet, exercise, and weight management. However, diabetes is progressive, and medication may be necessary for long-term control.

Myth 2: "Natural remedies can replace diabetes medications."

Fact: Herbal supplements like bitter gourd, cinnamon, or fenugreek may help support blood sugar control but cannot replace prescribed diabetes medications. Unmonitored use may even cause dangerous sugar fluctuations.

Myth 3: "Metformin causes kidney damage."

Fact: Metformin does not damage kidneys. However, in people with pre-existing kidney disease, metformin dosage must be adjusted to avoid complications.

Myth 4: "Insulin is only for severe diabetes cases."

Fact: Insulin is not just for end-stage diabetes. Some people may need insulin early if their blood sugar is uncontrolled despite oral medications.

Myth 5: "Skipping medication occasionally does not harm me."

Fact: Even one missed dose can lead to uncontrolled blood sugar, increasing the risk of complications like nerve damage, kidney disease, and heart issues.

FAQs About GLYCOMET TRIO 2MG TABLET

References

1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2019. Page – 270, 275, 277.

2. Kalra S, Das AK, Priya G, Ghosh S, Mehrotra RN, Das S, Shah P, Bajaj S, Deshmukh V, Sanyal D, Chandrasekaran S, Khandelwal D, Joshi A, Nair T, Eliana F, Permana H, Fariduddin MD, Shrestha PK, Shrestha D, Kahandawa S, Sumanathilaka M, Shaheed A, Rahim AA, Orabi A, Al-Ani A, Hussein W, Kumar D, Shaikh K. Fixed-dose combination in management of type 2 diabetes mellitus. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. [Revised in November 2020] [Accessed on 6th March 2025] 

3. Windlas Biotech Private Limited. Amaryl MV 1mg, Amaryl MV 2mg. [Revised in March 2021] [ [Accessed on 6th March 2025] 

4. Primus Remedies Pvt. Ltd. Voglow GM1 Fort. [Accessed on 6th March 2025] 

5. Eris Lifesciences. Glimisave MV 1.3 F, Glimisave MV 2 forte, Glimisave MV 3.3, Glimisave MV 3.3 F. [Accessed on 6th March 2025] 

6. Leeford Healthcare Ltd. VOGLIMET-GM FORTE. [Accessed on 6th March 2025] 

7. Ikon Remedies Pvt. Ltd. Voglicon-GM Tablets. [Accessed on 6th March 2025] 

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin-Fasting
• Insulin Postprandial (PP)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 07 Mar 2025 | 12:03 PM(IST)