Name: Glycomet Gp2 Forte Tablet 10'S
Brand: Netmeds
SKU: 8351992
Price: 101.64 INR
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Glycomet Gp2 Forte Tablet 10'S - Diabetes-Ant

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Introduction About GLYCOMET GP2 FORTE TABLET

Glycomet GP2 Forte Tablet is a combination medication that contains two active ingredients such as Glimepiride and Metformin. This medication is primarily used to manage blood sugar levels in individuals with type 2 diabetes. Glimepiride works by stimulating the pancreas to produce more insulin, while Metformin improves the body’s response to insulin. Together, they help lower blood sugar levels and improve overall glycemic control.

Glycomet GP2 Forte Tablet should be taken with food. To get the best results, take it consistently at the same time every day. Your doctor will determine the appropriate dose for you, which may be adjusted over time based on your blood sugar levels.

Continue taking this medicine, even if you are feeling fine or your blood sugar levels are under control. Stopping it without consulting your doctor could cause your blood sugar levels to rise, increasing the risk of kidney damage, blindness, nerve issues, and limb loss. Keep in mind that this medication is just one part of your management plan, which should also include a healthy diet, regular exercise, and weight loss as recommended by your doctor. Your lifestyle is crucial in managing diabetes.

The most common side effect of this medication include nausea, dizziness, low blood sugar, taste disturbance, diarrhea, stomach pain, loss of appetite and upper respiratory tract infection. It is important to recognize the signs of low blood sugar symptoms such as sweating, dizziness, headache, and shaking, and know how to manage it. To reduce low blood sugar, make sure to eat regularly and carry a quick source of glucose, like sugary food or fruit juice. Be cautious with alcohol, as it can increase the risk of low blood sugar. Some people may also experience weight gain while taking this medicine.

Before taking this medication, make sure to tell your doctor if you have any type 1 diabetes, diabetic ketoacidosis (high blood acid levels), or severe kidney or liver disease or heart problems. Pregnant or breastfeeding women should consult their doctor before taking it. It is important to regularly check your blood sugar levels, and your doctor may recommend blood tests to monitor your blood cell counts and liver function.

Uses Of GLYCOMET GP2 FORTE TABLET

Type 2 diabetes mellitus

Benefits of GLYCOMET GP2 FORTE TABLET

01.Helps manage blood sugar levels in Type 2 Diabetes: Designed to assist in controlling blood sugar, helping maintain healthy glucose levels.

02.Combines the power of Glimepiride and Metformin for effective results: The combination of two active ingredients works synergistically to improve blood sugar regulation.

03.Reduces the risk of complications associated with high blood sugar: Helps lower the chance of developing complications like nerve damage, kidney disease, and cardiovascular issues.

04. Supports better glycemic control: Offers improved management of blood sugar spikes, contributing to overall health and well-being.

How GLYCOMET GP2 FORTE TABLET Works

Glimepiride stimulates the pancreas to release more insulin. Insulin is the hormone that helps lower blood sugar by allowing cells to take up glucose from the bloodstream. Metformin primarily works by reducing the amount of glucose produced by the liver. It also helps increase the sensitivity of muscle cells to insulin, making it easier for them to absorb glucose.

This combination therapy helps manage blood sugar levels more effectively in people with Type 2 diabetes.

How to use GLYCOMET GP2 FORTE TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

How to Take Glycomet GP2 Forte Tablet?

Typically, take once daily with food to avoid gastrointestinal discomfort.
It is recommended to take Glycomet GP2 Forte Tablet during your evening meal. This helps minimize any potential stomach discomfort and ensures better absorption of the medication.
Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
For best results, take the tablet at the same time each day.

What if I forgot to take GLYCOMET GP2 FORTE TABLET

If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose, do not double up to make up for a missed one.
Set a reminder: To avoid forgetting doses, consider setting an alarm on your phone or using a medication reminder app.

Overdose

If you or anyone else accidentally take too much of Glycomet GP2 Forte Tablet, consult and inform your doctor immediately or visit the nearby hospital. Symptoms of overdose are Low blood sugar levels, Lactic acidosis symptoms include vomiting, bellyache with muscle cramps, general feeling of not being well with severe tiredness, reduced body temperature, low heartbeat, and difficulty in breathing.

Side Effects Of GLYCOMET GP2 FORTE TABLET

Like all medicines, Glycomet GP2 Forte Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Glycomet GP2 Forte Tablet are:

Nausea
Dizziness
Low blood sugar
Taste disturbance
Diarrhea
Stomach pain
Loss of appetite
Upper respiratory tract infection

When to consult your doctor?

Severe Low blood sugar (hypoglycemia) symptoms such as shaking, sweating, rapid heartbeat, dizziness, confusion, blurred vision
Lactic acidosis symptoms such as weakness, tiredness, unusual muscle pain, difficulty breathing, abdominal discomfort, slow or irregular heartbeat, feeling cold or dizzy, loss of appetite, nausea, or vomiting
Severe allergic reactions symptoms such as rash, itching, or swelling (especially on the face/tongue/throat), severe dizziness or trouble breathing
Liver problems symptoms such as jaundice (yellowing of the skin or eyes)
Stomach problems symptoms such as severe abdominal pain or persistent nausea or vomiting
Heart problems symptoms such as chest pain or shortness of breath

How To Manage Side Effects

Diarrhea

Drink Fluids: Drink clear fluids such as water, broths, and oral rehydration solutions (ORS).
Electrolytes: If you are losing a lot of fluids (for example, from frequent diarrhea), consider drinking an electrolyte solution to help replenish lost minerals like potassium and sodium.
BRAT Diet: Try to take Bananas, Rice (white rice), Apple sauce and Toast (plain, without butter) to control diarrhoea management.
Avoid Certain Foods: While recovering avoid the following food items such as fatty, greasy, or fried foods, spicy foods, dairy products (especially if you have a temporary lactose intolerance), caffeinated drinks and alcohol and artificial sweeteners like sorbitol.
Over-the-Counter Medications: You can take over-the-counter anti-diarrheal medications such as loperamide, Bismuth subsalicylate if appropriate for you. Follow the recommended dosage.

Dizziness Or Drowsiness

Sit or Lie Down: If you feel dizzy, sit down or lie down immediately to prevent falling. Keep your head still and close your eyes if needed.
Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.

Hypoglycemia

Act Quickly: If you notice symptoms of hypoglycemia, you need to raise your blood sugar immediately.
Consume Fast-Acting Carbohydrates: Eat or drink something containing 15-20 grams of fast-acting carbs (e.g., glucose tablets, fruit juice, regular soda). Avoid foods with fat, as they can slow down the absorption of sugar.
Recheck in 15 Minutes: After consuming carbs, check your blood sugar. If it is still low, repeat the process.
Avoid Overeating: Once blood sugar is normalized, avoid overconsumption of food, which can cause a rebound effect.

Nausea And Vomiting

Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Glycomet GP2 Forte is not recommended for use in elderly patients (aged 75 years or above) and it should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may assess your kidney function more frequently during management with Glycomet GP2 Forte tablet.

Other Warnings for GLYCOMET GP2 FORTE TABLET

Before taking Glycomet GP2 Forte, inform your doctor if you:

are recovering from injury, operation, infections with fever, or from other forms of stress
have glucose-6-phosphate dehydrogenase (G6PD) deficiency
have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take [GBNKEYWORD

Glycomet GP2 Forte tablet is generally not recommended for use if you have:

type 1 diabetes mellitus
diabetic ketoacidosis
uncontrolled diabetes or ketoacidosis
dehydration
severe infection

Safety Advice

Follow your doctor's instructions regarding the exact dosage
Do not exceed the recommended daily dosage.
Typically, take once daily with food to avoid gastrointestinal discomfort.
It is recommended to take Glycomet GP2 Forte Tablet during your evening meal. This helps minimize any potential stomach discomfort and ensures better absorption of the medication.
Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
For best results, take the tablet at the same time each day.
Follow the prescribed diet and exercise plan along with taking this medication for best results.
Monitor your blood sugar levels regularly while taking this medicine.
Avoid alcohol while taking this medication, as it can increase the risk of hypoglycemia or lactic acidosis.
Your doctor might regularly monitor your kidney and liver function.
Let your doctor know if you have kidney disease or any history of kidney problems, liver disease or a history of liver problems or heart problems.
Let your doctor know If you are pregnant or planning to become pregnant or breastfeeding women.
Do not suddenly stop taking the medication without consulting your doctor, as this can lead to uncontrolled blood sugar levels.

Diet and Lifestyle Advice

Category	Tip	Details
Dietary Tips	Balanced Diet	Include a variety of foods like vegetables, fruits, whole grains, lean proteins, and healthy fats. Focus on portion control to avoid blood sugar spikes.
	Low-Glycemic Foods	Choose foods with a low glycemic index (GI) like oats, legumes, sweet potatoes, and non-starchy vegetables to help regulate blood sugar levels.
	Fiber-Rich Foods	Include high-fiber foods like whole grains, beans, lentils, and vegetables to help stabilize blood sugar and improve digestion.
	Avoid Processed Foods and Sugary Drinks	Minimize processed foods, refined sugars, and sugary beverages, which can cause rapid blood sugar fluctuations. Opt for water or herbal teas instead.
	Small, Frequent Meals	Eating smaller, more frequent meals throughout the day helps maintain steady blood sugar levels and prevents overeating.
Exercise Routines	Regular Physical Activity	Aim for at least 150 minutes of moderate-intensity exercise (e.g., brisk walking) per week to improve insulin sensitivity and help control blood sugar.
	Strength Training	Include strength training exercises (e.g., resistance bands, weight lifting) 2-3 times per week to build muscle and support blood sugar management.
	Aerobic Exercise	Incorporate activities like swimming, cycling, or dancing to improve cardiovascular health and overall blood sugar control.
	Stretching and Flexibility	Include daily stretching or yoga to improve circulation, reduce stress, and enhance flexibility.
Other Lifestyle Tips	Regular Monitoring	Check blood sugar levels regularly to track changes and make necessary adjustments to diet or medication.
	Stress Management	Practice stress-relieving techniques like deep breathing, meditation, or mindfulness to avoid blood sugar spikes caused by stress.
	Adequate Sleep	Aim for 7-9 hours of quality sleep per night, as poor sleep can affect insulin sensitivity and overall blood sugar control.
	Hydration	Stay hydrated with water to help maintain kidney function and flush out excess glucose from the body.
	Weight Management	Maintaining a healthy weight through a balanced diet and exercise can significantly improve insulin sensitivity and overall diabetes management.

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Glycomet GP2 Forte:

1.Antidiabetic Drugs:

Interaction: Combining Glycomet GP2 Forte with other antidiabetic medications, such as insulin, may increase the risk of hypoglycemia (low blood sugar levels).
Effect: Elevated risk of hypoglycemia, which can lead to symptoms like dizziness, sweating, and confusion.
Management: Monitor blood glucose levels regularly. Adjust dosages of antidiabetic medications as needed under medical supervision.

2.Thiazide Diuretics:

Interaction: Medications like hydrochlorothiazide and chlorthalidone may reduce the glucose-lowering effect of Glycomet GP2 Forte.
Effect: Potentially less effective blood sugar control.
Management: Regularly monitor blood glucose levels. Consider alternative diuretics or adjust diabetes medication dosages as advised by a healthcare provider.

3.Corticosteroids:

Interaction: Drugs such as prednisone and dexamethasone may reduce the effectiveness of Glycomet GP2 Forte in controlling blood sugar levels.
Effect: Elevated blood sugar levels, potentially leading to hyperglycemia.
Management: Monitor blood glucose levels more frequently. Adjust diabetes medication dosages as necessary under medical guidance.

4.Estrogens and Oral Contraceptives:

Interaction: Hormonal medications, including ethinyl estradiol and levonorgestrel, may increase blood sugar levels, reducing the effectiveness of Glycomet GP2 Forte.
Effect: Potential for hyperglycemia.
Management: Regularly monitor blood glucose levels. Discuss alternative contraceptive methods or diabetes medication adjustments with a healthcare provider.

5.Alcohol:

Interaction: Consuming alcohol while taking Glycomet GP2 Forte may increase the risk of lactic acidosis, a rare but serious condition.
Effect: Lactic acidosis, characterized by symptoms such as muscle pain, difficulty breathing, and fatigue.
Management: Avoid alcohol consumption while on this medication.

Synopsis

Drug	:	Glimepiride, Metformin
Pharmacological Category	:	Sulfonylureas, Biguanides
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet

More Information

1. How effective is Glycomet GP2 Forte Tablet in managing blood sugar, and why is it preferred over other similar medications?

Effectiveness in Managing Blood Sugar

Metformin (1000mg):

Mechanism: It helps in reducing liver glucose production, improves insulin sensitivity in muscle cells, and decreases intestinal glucose absorption.
Effectiveness: Metformin is a cornerstone in managing type 2 diabetes as it helps in lowering blood sugar levels and is known to reduce A1c (a measure of blood sugar levels over time) effectively.

Glimepiride (2mg):

Mechanism: Glimepiride is a sulfonylurea that stimulates the pancreas to release more insulin, especially after meals.
Effectiveness: It helps in lowering blood glucose by promoting insulin secretion. Glimepiride works faster in reducing post-meal blood sugar spikes and can be effective in managing high blood sugar levels.

Why Glycomet GP2 Forte is Preferred:

Combination Therapy: The combination of Glimepiride and Metformin offers a dual approach to controlling blood sugar. While Metformin primarily works by reducing the production of glucose from the liver and improving insulin sensitivity, Glimepiride directly stimulates insulin production from the pancreas. Together, they are more effective than either drug alone, especially for people whose blood sugar is not controlled with Metformin alone.
Lower Risk of Hypoglycemia: Compared to other sulfonylureas, Glimepiride has a relatively lower risk of causing hypoglycemia (low blood sugar), especially when taken as prescribed and in combination with Metformin.
Weight Management: Metformin has a neutral or weight-lowering effect, which is an advantage for many individuals with type 2 diabetes who may be overweight. Glimepiride may have a mild weight-gaining effect, but in combination with Metformin, this is often balanced.
Convenience: Glycomet GP2 Forte, with its fixed combination of Glimepiride and Metformin, simplifies the medication regimen, making it easier for patients to adhere to their treatment plan compared to taking two separate pills.
Well-Studied and Cost-Effective: Both Metformin and Glimepiride are well-researched and have been widely used for years. They have a solid evidence base supporting their effectiveness in managing blood sugar. This makes Glycomet GP2 Forte a trusted and cost-effective choice for many healthcare providers and patients.

Comparing with Other Medications:

Other medications, like insulin or DPP-4 inhibitors (e.g., sitagliptin), may also be used to manage blood sugar, but they have different mechanisms of action, and their choice depends on individual factors such as disease severity, comorbidities, and patient preferences.
GLP-1 agonists and SGLT2 inhibitors are newer classes with additional benefits, but they may come with higher costs or additional side effects that some patients may prefer to avoid.

Conclusion

Glycomet GP2 Forte is effective because it combines two different mechanisms to target blood sugar levels: improving insulin sensitivity and stimulating insulin secretion. It is preferred for its dual action, relative safety, ease of use (in a single tablet), and cost-effectiveness compared to other medications. However, the choice of management should always be individualized, taking into account the patient's specific condition, potential side effects, and lifestyle. Always consult your doctor to determine the best management option.

FAQs About GLYCOMET GP2 FORTE TABLET

Q: What is Glycomet GP2 Forte Tablet used for?

A: Glycomet GP2 Forte Tablet is primarily used to manage type 2 diabetes by helping to control blood sugar levels.

Q: How does Glycomet GP2 Forte Tablet help in managing diabetes?

A: Glycomet GP2 Forte Tablet helps in managing diabetes by improving the body’s sensitivity to insulin and decreasing the amount of sugar produced by the liver, thus reducing blood sugar levels.

Q: Can I take Glycomet GP2 Forte Tablet with other diabetes medications?

A: Yes, Glycomet GP2 Forte Tablet can be taken with other diabetes medications. However, it is important to consult your doctor before combining it with other medications to avoid any potential drug interactions.

Q: Is Glycomet GP2 Forte Tablet suitable for type 1 diabetes patients?

A: Glycomet GP2 Forte Tablet is typically not used for type 1 diabetes, as this type of diabetes is characterized by little or no insulin production. It is mainly used for managing type 2 diabetes.

Q: What should I do if I miss a dose of Glycomet GP2 Forte Tablet?

A: If you miss a dose of Glycomet GP2 Forte Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not take two doses at once to make up for the missed dose.

Q: Is Glycomet GP2 Forte Tablet suitable for pregnant women?

A: Glycomet GP2 Forte Tablet is generally not recommended for pregnant women unless prescribed by a doctor, as it may not be safe during pregnancy. Always consult your doctor for advice.

Q: What are the side effects of Glycomet GP2 Forte Tablet?

A: Common side effects of Glycomet GP2 Forte Tablet include nausea, stomach upset, diarrhea, and a metallic taste. Serious side effects are rare but can include lactic acidosis. Contact a doctor if you experience severe symptoms.

Q: How does Glycomet GP2 Forte Tablet work for type 2 diabetes?

A: For type 2 diabetes, Glycomet GP2 Forte Tablet works by improving insulin sensitivity and reducing the amount of glucose produced by the liver, thus helping to control blood sugar levels.

Q: What should I avoid while taking Glycomet GP2 Forte Tablet?

A: Avoid consuming alcohol in excess, as it can increase the risk of lactic acidosis. Also, avoid skipping meals and make sure to follow your doctor’s dietary recommendations.

Q: How long does it take for Glycomet GP2 Forte Tablet to work?

A: Glycomet GP2 Forte Tablet typically starts working within a few days to a week. However, it may take longer to achieve full control over blood sugar levels, depending on individual circumstances.

Q: Can I take Glycomet GP2 Forte Tablet with food?

A: Yes, it is generally recommended to take Glycomet GP2 Forte Tablet with food to help reduce the risk of gastrointestinal side effects, such as nausea or upset stomach.

Q: How to store Glycomet GP2 Forte Tablet properly?

A: Store Glycomet GP2 Forte Tablet in a cool, dry place at room temperature, away from direct sunlight. Keep it out of reach of children.

Q: How should I take Glycomet GP2 Forte Tablet?

A: Take Glycomet GP2 Forte Tablet exactly as prescribed by your doctor. It is usually taken orally with meals to minimize gastrointestinal upset.

Q: What is the recommended dosage for Glycomet GP2 Forte Tablet?

A: The dosage of Glycomet GP2 Forte Tablet is determined by your doctor based on your individual health needs and condition. Typically, it is taken once or twice a day, but your doctor will adjust the dose as needed.

Q: Are there any food or drink restrictions while taking Glycomet GP2 Forte?

A: There are no specific food restrictions while taking Glycomet GP2 Forte. However, maintaining a healthy diet and regular monitoring of blood glucose levels is essential for managing diabetes effectively.

Q: Can I stop taking Glycomet GP2 Forte if I feel better?

A: You should never stop taking Glycomet GP2 Forte without consulting your doctor, even if you feel better. Diabetes management is an ongoing process that requires medical supervision.

Q: Where can I buy Glycomet GP2 Forte tablet online?

A: You can buy Glycomet GP2 Forte tablet online at Netmeds. Just visit their website and search for the product, and you will find options to purchase it directly from there.

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on 14th Feb 2025]

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on 14th Feb 2025]

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on 14th Feb 2025]

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on 14th Feb 2025]

Useful Diagnostic Tests

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 14 Feb 2025 | 05:02 PM(IST)

Lab updated