Name: Glycomet GP 3/850mg Tablet 10'S
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Glycomet GP 3/850mg Tablet 10'S - Diabetes-Ant

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Introduction About GLYCOMET GP 3/850MG TABLET

Glycomet GP 3/850mg Tablet 10's is a combination medicine containing Glimepiride and Metformin, designed for adults with type 2 diabetes whose blood sugar remains uncontrolled with diet, exercise, or single-agent therapy. This medicine is particularly suitable for patients who require a dual approach to manage elevated blood glucose and reduce the risk of long-term complications such as kidney damage, nerve issues, and vision loss. It works by stimulating the pancreas to produce more insulin (Glimepiride) and improving the body's sensitivity to insulin while decreasing glucose production in the liver (Metformin).

This tablet is best suited for adults with type 2 diabetes, especially those who have not achieved adequate control with either Glimepiride or Metformin alone, or who are already taking both medicines separately. It is not intended for type 1 diabetes, diabetic ketoacidosis, or patients with severe kidney or liver disease. Before starting treatment, patients should inform their doctor about all existing health conditions and other medications they are using.

Glycomet GP 3/850mg should be taken with food to minimize gastrointestinal side effects and maximize effectiveness. It is important to take the tablet at the same time each day, as prescribed by your doctor. Do not crush or chew the tablet. Regular blood sugar monitoring is essential, and patients should avoid alcohol, which increases the risk of lactic acidosis and low blood sugar. Patients must also avoid prolonged fasting and should always carry a quick source of sugar to manage potential hypoglycemic episodes.

This medicine is not recommended during pregnancy or breastfeeding, as it may harm the unborn baby or be excreted in breast milk. Common side effects include hypoglycemia (low blood sugar), nausea, diarrhea, stomach pain, headache, and a metallic taste in the mouth. If any side effects persist or worsen, or if you become pregnant or plan to breastfeed, consult your doctor immediately.

Uses Of GLYCOMET GP 3/850MG TABLET

Used to treat type 2 diabetes mellitus in adults
Helps control high blood sugar when diet and exercise alone are not enough
Improves the body’s response to insulin and reduces glucose production by the liver

Benefits of GLYCOMET GP 3/850MG TABLET

Benefits of Glycomet GP 3/850 Tablet for diabetes

Glycomet GP 3/850 Tablet is a combination of glimepiride and metformin, widely used for the management of type 2 diabetes in adults. It helps regulate blood sugar levels when diet, exercise, or single-agent therapy are not sufficient. Consistent use of this medication, along with lifestyle modifications, can significantly reduce the risk of diabetes-related complications such as kidney damage, nerve problems, and vision loss. By maintaining optimal glycemic control, patients can lead healthier, more active lives

Improves Insulin Sensitivity

Metformin, a key component of Glycomet GP 3/850 Tablet, enhances the body’s sensitivity to insulin. This means the body’s cells are better able to respond to insulin, allowing glucose to be used more efficiently for energy rather than accumulating in the bloodstream. Improved insulin sensitivity is crucial for effective blood sugar management in type 2 diabetes.

Stimulates Insulin Secretion

Glimepiride in this combination stimulates the pancreas to produce and release more insulin. Increased insulin secretion helps lower blood glucose levels, particularly after meals. This action is especially beneficial for patients whose bodies do not produce enough insulin on their own, helping to maintain more stable blood sugar levels throughout the day.

Reduces Hepatic Glucose Production

Metformin also works by reducing the amount of glucose produced by the liver. By limiting hepatic glucose output, the medicine prevents excessive sugar from entering the bloodstream, especially during fasting periods. This dual action—reducing liver glucose production and improving insulin sensitivity—makes Glycomet GP 3/850 Tablet highly effective in comprehensive diabetes management.

How GLYCOMET GP 3/850MG TABLET Works

Mechanism of Action of Glycomet GP 3/850 Tablet in diabetes management

Glycomet GP 3/850 Tablet combines glimepiride and metformin, two oral antidiabetic agents that work together to effectively lower and control blood sugar in adults with type 2 diabetes. Glimepiride stimulates the pancreas to release more insulin, allowing the body to move glucose from the blood into the cells for energy. Metformin targets multiple pathways: it reduces the amount of glucose produced by the liver, decreases glucose absorption from the intestine, and improves how the body uses insulin. This dual mechanism helps maintain stable blood glucose levels and reduces the risk of diabetes-related complications when combined with proper diet and exercise.

How Glycomet GP 3/850 Tablet reduce glucose from the liver

Metformin, a key component of Glycomet GP 3/850 Tablet, acts directly on the liver to lower blood sugar levels. It inhibits two major processes: gluconeogenesis (the production of new glucose) and glycogenolysis (the breakdown of stored glycogen into glucose). By suppressing these pathways, metformin significantly decreases the amount of glucose released into the bloodstream, especially during fasting periods, helping to prevent spikes in blood sugar

How Glycomet GP 3/850 Tablet improve insulin sensitivity

Both glimepiride and metformin contribute to improved insulin sensitivity, but metformin is particularly effective in this regard. It enhances the body’s response to insulin, enabling muscle and fat cells to absorb and utilize glucose more efficiently. This action helps lower blood sugar levels and reduces insulin resistance, a core problem in type 2 diabetes. By making the cells more responsive to insulin, Glycomet GP 3/850 Tablet supports better overall glycemic control and long-term diabetes management.

How to use GLYCOMET GP 3/850MG TABLET

Dosage and Administration Guidelines of Glycomet GP 3/850 Tablet

Take Glycomet GP 3/850 Tablet exactly as prescribed by your doctor; the dose may be adjusted based on your blood sugar response and health status.
Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
Do not take more than the prescribed dose.
Continue taking the medicine for the entire duration recommended, even if you feel well or your blood sugar is controlled.
Regular monitoring of blood sugar is essential during treatment.

When and How to Take Glycomet GP 3/850 Tablet

Always take Glycomet GP 3/850 Tablet with food, ideally at the same time each day for best results.
Take it immediately before or during breakfast, unless your doctor advises otherwise.
Do not skip meals while on this medication to avoid the risk of low blood sugar.
If you miss a dose, take it as soon as you remember, but skip it if your next dose is due soon—never double up doses.

What if I forgot to take GLYCOMET GP 3/850MG TABLET

If you forget to take a dose of Glycomet GP 3/850 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing routine. Do not take two doses at the same time or double up to make up for a missed dose, as this can increase the risk of side effects such as hypoglycemia. Maintaining a consistent schedule for your medication is important for effective blood sugar control.

Overdose

Accidentally taking more than the prescribed dose of Glycomet GP 3/850 Tablet can lead to severe hypoglycemia (low blood sugar), which may present as sweating, dizziness, shakiness, confusion, or even loss of consciousness. In some cases, metformin overdose can also cause a rare but serious condition called lactic acidosis, characterized by rapid breathing, persistent nausea, vomiting, and stomach pain. If an overdose is suspected, consume a fast-acting source of sugar, such as glucose tablets or fruit juice, and seek immediate medical attention. Prompt treatment is essential to prevent serious complications.

Side Effects Of GLYCOMET GP 3/850MG TABLET

Common side effects of GLYCOMET GP 3/850MG TABLET:

taste disturbance
diarrhea
stomach pain
loss of appetite

Stop taking GLYCOMET GP 3/850MG TABLET and contact your doctor immediately if you experience any of the following side effects:

lactic acidosis
inflammation of the liver which may result in jaundice (yellowing of skin or eyes)
severe allergic reactions (such as skin rash, hives, and increased sensitivity to sun, inflammation of blood vessels which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock)
severe low blood sugar levels

GLYCOMET GP 3/850MG TABLET is not recommended for use in elderly patients (aged 75 years or above) and it should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may assess your kidney function more frequently during management with GLYCOMET GP 3/850MG TABLET.

Other Warnings for GLYCOMET GP 3/850MG TABLET

Before taking GLYCOMET GP 3/850MG TABLET inform your doctor if you:

are recovering from injury, operation, infections with fever, or from other forms of stress
have glucose-6-phosphate dehydrogenase (G6PD) deficiency
have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take [GBNKEYWORD

GLYCOMET GP 3/850MG TABLET is not recommended for use, if you have:

type 1 diabetes mellitus
diabetic ketoacidosis
uncontrolled diabetes or ketoacidosis
dehydration
severe infection

Safety Advice

Importance of Regular Medical Follow-Up

Regular medical follow-up is crucial for effective diabetes management. These routine check-ups with your healthcare provider help monitor your overall health and track the progression of diabetes. During these visits, your doctor can detect potential complications early, such as heart disease, kidney issues, nerve damage, or vision problems, allowing for timely intervention. Regular appointments also provide an opportunity to review and adjust your medications, receive updated lifestyle guidance, and address any concerns you may have. By attending scheduled follow-ups, you help ensure your treatment plan remains effective, risk factors are managed promptly, and you receive the support needed to maintain a healthy lifestyle and prevent future complications.

Monitoring Blood Sugar and Recognizing Hypoglycemia

Monitoring your blood sugar regularly is a fundamental part of diabetes care. Checking your levels helps you understand how your diet, physical activity, medications, and stress affect your blood sugar, enabling you to make better daily decisions. Consistent monitoring allows you to spot patterns, quickly detect high or low blood sugar episodes, and take action before they become serious. Recognizing the signs of hypoglycemia—such as sweating, shakiness, dizziness, confusion, and a rapid heartbeat—is especially important, as untreated low blood sugar can be dangerous. Always carry a source of fast-acting glucose, like glucose tablets or fruit juice, to manage hypoglycemia if it occurs. Regular monitoring also assists your healthcare provider in assessing your blood sugar control and making necessary adjustments to your treatment plan for optimal health.

Diet and Lifestyle Advice

Glycomet GP 3/850mg Tablet 10'S is prescribed to help manage type 2 diabetes, but its effectiveness is greatly enhanced when combined with the right dietary and lifestyle habits. Here are key recommendations to support optimal blood sugar control and overall health:

Dietary Advice

Follow a Balanced Diet: Focus on meals rich in whole grains, lean proteins (such as fish, poultry, tofu, and legumes), fresh vegetables, and fruits. Limit processed foods, sugary snacks, and high-fat items.
Control Carbohydrate Intake: Choose complex carbohydrates (brown rice, oats, whole wheat) over simple sugars. Spread carbohydrate consumption evenly throughout the day to prevent blood sugar spikes.
Limit High-Sodium and Unhealthy Fats: Reduce intake of salty foods, fried items, and foods high in saturated and trans fats.
Avoid Grapefruit Juice: Grapefruit juice may interfere with the metabolism of glimepiride, potentially increasing side effects.
Moderate Dairy Consumption: If you are lactose intolerant, opt for lactose-free dairy products to avoid gastrointestinal discomfort, which can be aggravated by metformin.
Avoid Alcohol: Alcohol increases the risk of hypoglycemia and lactic acidosis, especially when combined with metformin.
Regular Meal Times: Eat meals and snacks at consistent times each day to help regulate blood sugar and avoid hypoglycemia.

Lifestyle Advice

Engage in Regular Physical Activity: Aim for at least 30 minutes of moderate exercise (such as brisk walking, cycling, or swimming) most days of the week. Physical activity improves insulin sensitivity and helps control blood sugar.
Monitor Blood Sugar Regularly: Keep track of your blood glucose levels as advised by your doctor to assess how your body responds to medication, diet, and activity.
Maintain a Healthy Weight: Achieving and maintaining a healthy body weight can improve blood sugar control and reduce the risk of diabetes complications.
Manage Stress: Practice stress-reducing techniques such as yoga, meditation, or deep breathing, as stress can affect blood sugar levels.
Stay Hydrated: Drink plenty of water throughout the day and avoid sugary beverages.
Carry Fast-Acting Glucose: Always have a source of fast-acting sugar (like glucose tablets or fruit juice) in case of hypoglycemic episodes.

1. Glycomet GP 3/850mg vs Sulfonylurea-Only Therapy: Advantages of Combination Therapy

Parameter	Glycomet GP 3/850mg (Glimepiride + Metformin)	Sulfonylurea-Only Therapy	Advantage of Combination Therapy
Mechanism	Improves insulin sensitivity + increases insulin secretion	Increases insulin secretion only	Dual mechanism offers better glucose control
Glycemic Control (HbA1c reduction)	~1.5–2.0%	~1.0–1.5%	Greater HbA1c reduction
Weight Impact	Neutral to mild gain	Moderate weight gain	Less weight gain with metformin
Hypoglycemia Risk	Moderate	High	Lower risk compared to high-dose sulfonylurea
Beta-cell Function Preservation	Yes (via metformin)	No	Slower β-cell decline
Insulin Resistance	Addressed (metformin)	Not addressed	Improved insulin sensitivity
Cardiovascular Impact	Modest benefit (metformin)	Neutral or negative	Better metabolic profile
Overall Benefit	Broader metabolic effect, better long-term control	Limited to short-term glucose lowering	Combination is more effective and sustainable

2. Glycomet GP 3/850mg vs Other Regimens for Rapid Blood Sugar Control

Regimen	Onset of Action	HbA1c Reduction	Speed of Effectiveness	Remarks
Glycomet GP 3/850mg	Moderate (days to 1 week)	~1.5–2.0%	Moderate	Suitable for gradual control
Insulin Therapy	Immediate (hours)	>2.0%	Fastest	Best for acute hyperglycemia
GLP-1 Receptor Agonists	Few days	~1.0–1.5%	Fast	Also promotes weight loss
SGLT2 Inhibitors	1–2 weeks	~0.5–1.0%	Moderate	Useful in early combination
DPP-4 Inhibitors	~1 week	~0.5–0.8%	Moderate	Gentle effect, fewer side effects
Sulfonylurea Alone	1–2 days	~1.0–1.5%	Moderate-fast	May cause hypoglycemia
Conclusion	Glycomet is not the fastest, but provides balanced, sustained control	Insulin is fastest; GLP-1 and sulfonylureas also rapid

Drug - Drug interaction

Glycomet GP 3/850 Tablet, which contains glimepiride and metformin, can interact with several other medications, potentially affecting blood sugar control or increasing the risk of side effects. It is important to inform your doctor about all medicines you are taking before starting this tablet. Below are some common drug-drug interactions and recommended management strategies:

1. Other Antidiabetic Medicines (e.g., insulin, sulfonylureas)

Interaction: Using multiple glucose-lowering drugs together can increase the risk of hypoglycemia.
Management: Monitor blood sugar levels closely and adjust dosages as advised by your doctor. Always carry a source of fast-acting glucose.

2. Beta-blockers (e.g., propranolol, atenolol)

Interaction: Beta-blockers can mask the symptoms of hypoglycemia, making it harder to recognize low blood sugar.
Management: Be extra vigilant about routine blood glucose monitoring and educate yourself about non-obvious signs of hypoglycemia.

3. Diuretics and Corticosteroids

Interaction: These medications can increase blood sugar levels, counteracting the effects of Glycomet GP 3/850.
Management: Your doctor may need to adjust your diabetes medication dosage and monitor your blood glucose more frequently.

4. Certain Antibiotics and Antifungals (e.g., fluconazole, chloramphenicol)

Interaction: Some antibiotics and antifungals can increase the effect of glimepiride, raising the risk of hypoglycemia.
Management: Inform your doctor if you are prescribed these medications. Blood sugar monitoring and dose adjustments may be necessary.

5. NSAIDs and Salicylates (e.g., aspirin)

Interaction: These can enhance the blood sugar-lowering effect of Glycomet GP 3/850, increasing hypoglycemia risk.
Management: Use under medical supervision and monitor blood sugar levels regularly.

6. Thyroid Medications and Oral Contraceptives

Interaction: These may reduce the effectiveness of Glycomet GP 3/850 Tablet, leading to higher blood sugar.
Management: Your doctor may adjust your diabetes medication and will monitor your blood sugar more closely.

7. Cimetidine

Interaction: Cimetidine can increase the risk of metformin-related side effects, including lactic acidosis.
Management: Alternative medications may be recommended, or additional monitoring may be required.

Drug - Food interaction

Glycomet GP 3/850 Tablet, a combination of glimepiride and metformin, is generally safe with most foods when taken as prescribed. However, some foods and dietary habits can affect how well the medication works or increase the risk of side effects. Here are the main drug-food interactions to be aware of, along with management tips for each:

1. Grapefruit Juice

Interaction: Grapefruit juice may interfere with the metabolism of certain medications, including glimepiride, potentially altering its effectiveness or increasing side effects.
Management: It is best to avoid grapefruit juice while taking Glycomet GP 3/850 Tablet.

2. High-Sodium and Unhealthy Foods

Interaction: Diets high in sodium, processed foods, or unhealthy fats can worsen blood sugar control and reduce the effectiveness of your diabetes medication.
Management: Follow a healthy, balanced diet as recommended by your doctor or dietitian. Focus on whole grains, lean proteins, vegetables, and fruits, and limit processed and high-sodium foods.

3. Dairy Products

Interaction: Dairy does not directly interact with Glycomet GP 3/850 Tablet, but people who are lactose intolerant may experience increased gastrointestinal discomfort, which can be worsened by metformin.
Management: If you notice increased stomach upset with dairy, consider lactose-free options or consult your doctor.

4. Alcohol

Interaction: Alcohol can increase the risk of hypoglycemia and lactic acidosis, particularly when combined with metformin.
Management: Avoid alcohol while taking Glycomet GP 3/850 Tablet.

Synopsis

Drug	:	Glimepiride, Metformin
Pharmacological Category	:	Sulfonylureas, Biguanides
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet

More Information

Storage

Keep Glycomet GP 3/850mg tablet out of the sight and reach of children
Store Glycomet GP 3/850mg tablet below 30°C

FAQs About GLYCOMET GP 3/850MG TABLET

Q: What is Glycomet GP 3/850mg Tablet used for?

A: Glycomet GP 3/850mg Tablet is primarily prescribed to manage type 2 diabetes in adults. It helps control blood sugar levels when diet, exercise, or single-agent therapy are not sufficient. The tablet contains a combination of glimepiride and metformin, which work together to improve insulin sensitivity and reduce glucose production in the liver.

Q: How does Glycomet GP 3/850mg Tablet work?

A: This medication combines two antidiabetic agents: glimepiride, which stimulates the pancreas to release more insulin, and metformin, which reduces glucose production by the liver and improves the body’s response to insulin. Together, they help maintain stable blood sugar levels and reduce the risk of diabetes complications.

Q: Can Glycomet GP 3/850mg Tablet be taken on an empty stomach?

A: It is recommended to take Glycomet GP 3/850mg Tablet with food. Taking it on an empty stomach may increase the risk of gastrointestinal side effects and low blood sugar. Always follow your doctor’s instructions regarding meal timing.

Q: What should I do if I experience hypoglycemia?

A: If you notice symptoms of low blood sugar—such as sweating, shakiness, dizziness, or confusion—consume a fast-acting source of glucose like fruit juice, glucose tablets, or candies. Inform your doctor if hypoglycemic episodes are frequent or severe.

Q: How long should I take Glycomet GP 3/850mg Tablet?

A: Continue taking the medicine for the duration prescribed by your doctor, even if you feel well or your blood sugar is controlled. Stopping suddenly can lead to uncontrolled diabetes and complications.

Q: Is Glycomet GP 3/850mg Tablet habit-forming?

A: No, Glycomet GP 3/850mg Tablet is not habit-forming or addictive. It is a prescription medication used for chronic disease management.

Q: What dietary precautions should I follow?

A: Eat a balanced diet rich in whole grains, lean proteins, vegetables, and fruits. Avoid high-sugar, high-fat, and processed foods. Do not skip meals, as this increases the risk of low blood sugar.

Q: Can Glycomet GP 3/850mg Tablet cause weight gain?

A: Some people may experience weight gain, mainly due to the glimepiride component. Maintaining a healthy diet and regular exercise can help manage your weight.

Q: What lifestyle changes should I adopt with this medicine?

A: Along with taking your medication, engage in regular physical activity, follow a balanced diet, monitor your blood sugar regularly, maintain a healthy weight, and manage stress for optimal diabetes control.

Q: Can I stop taking Glycomet GP 3/850mg Tablet if my sugar is controlled?

A: Do not stop taking the medication without consulting your doctor. Blood sugar may rise again, increasing the risk of complications. Your doctor will guide you on any changes to your treatment plan.

Q: How often should I monitor my blood sugar?

A: Your doctor will advise how often to check your blood sugar, but regular monitoring is important, especially when starting a new medication or adjusting your dose. Keeping a log helps your doctor tailor your treatment.

Q: Does Glycomet GP 3/850mg Tablet affect kidney or liver function?

A: Prolonged use can affect kidney and liver function, especially in those with pre-existing conditions. Your doctor may recommend periodic blood tests to monitor organ health.

Q: What precautions should I take before surgery?

A: Inform your doctor or surgeon if you are taking Glycomet GP 3/850mg Tablet before any planned surgery or medical procedure. Temporary discontinuation may be necessary to reduce the risk of complications.

Q: What are the benefits of Glycomet GP 3/850mg Tablet over single-agent therapy?

A: This combination tablet targets multiple pathways: it increases insulin secretion and improves insulin sensitivity, offering better blood sugar control for those not responding to single-agent therapy.

Q: What should I do if I experience a metallic taste in my mouth?

A: A metallic taste is a common side effect of metformin. It is usually temporary and mild. If it becomes bothersome, discuss with your doctor for possible solutions.

Q: Can Glycomet GP 3/850mg Tablet be used for prediabetes?

A: This medication is not typically prescribed for prediabetes. It is meant for managing established type 2 diabetes. Your doctor will recommend the best treatment for prediabetes if needed.

Q: What regular tests should I undergo while on this medication?

A: Your doctor may advise regular blood sugar tests, kidney and liver function tests, and sometimes blood cell counts to monitor your health and the medication’s effects.

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on 11th July 2025]

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on 11th July 2025]

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on 11th July 2025]

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on 11th July 2025]

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Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 11 Jul 2025 | 03:00 PM(IST)

Lab updated