Glyciphage SR 1gm Tablet 10'S

Introduction About GLYCIPHAGE SR 1GM TABLET

Glyciphage SR 1gm Tablet is a sustained-release oral medication used in the management of type 2 diabetes mellitus. It makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose, thereby reducing blood sugar levels. Additionally, it also manages glucose production by the liver and reduces its absorption in the body. This action helps in managing the insulin resistance and weight gain in patients with poly cystic ovarian disease.

Along with the therapy, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption. Before taking Glyciphage SR inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently.

Glyciphage Sis not recommended for use in patients with severe uncontrollable diabetes. It is also not suitable for use in patients with shock or problems with breathing or blood circulation. Consult your doctor before taking Glyciphage Sif you are pregnant or breastfeeding.

The most common side effects are stomach upset and diarrhea. These side effects can be controlled when the medicine is taken along with meals. However, if these side effect bothers you or worsens contact your doctor.

Uses Of GLYCIPHAGE SR 1GM TABLET

• Type 2 Diabetes Mellitus
• Insulin resistance in Polycystic Ovary Syndrome (off-label)
• Improves insulin sensitivity

Benefits of GLYCIPHAGE SR 1GM TABLET

• Glyciphage SR 1gm Tablet is a sustained-release formulation of Metformin, a trusted first-line medication for managing type 2 diabetes and insulin resistance.
• It helps regulate blood sugar levels, improves insulin sensitivity, supports healthy weight management, and may also offer benefits for conditions like PCOS.
• The SR (sustained-release) technology ensures gradual absorption, minimizing gastric discomfort and providing consistent glucose control throughout the day.
• It is ideal for patients looking for a reliable, once-daily diabetes management solution.

Glyciphage SR for Diabetes:

• Glyciphage SR is widely prescribed for type 2 diabetes as it lowers elevated blood sugar levels by decreasing hepatic glucose production and improving peripheral insulin sensitivity.
• The sustained-release formula ensures long-lasting control, reduces post-meal sugar spikes, and lowers the risk of hypoglycemia.
• With regular use and a proper diet, Glyciphage SR supports better HbA1c control and long-term diabetes management.

Glyciphage for PCOS:

• Metformin is sometimes prescribed off-label to manage symptoms of Polycystic Ovary Syndrome (PCOS), especially in women with insulin resistance.
• While not officially approved for PCOS, many doctors use it to reduce elevated insulin and androgen levels in women in PCOS.
• By enhancing insulin sensitivity, Glyciphage may support hormonal balance and help address symptoms like irregular periods, acne, and unwanted hair growth.
• It may also assist in weight management when combined with diet and lifestyle changes.

Glyciphage SR for Weight Loss:

• Although not a weight-loss drug, Glyciphage SR may aid weight reduction in individuals with insulin resistance or PCOS by improving insulin function and lowering appetite.
• It helps prevent fat storage triggered by high insulin levels and promotes better metabolic health.
• When combined with a balanced diet and exercise, it can contribute to gradual and sustained weight loss.

Glyciphage for Insulin Resistance:

• Glyciphage improves how the body uses insulin, making it especially useful in managing insulin resistance—a key factor in type 2 diabetes, PCOS, and metabolic syndrome.
• It reduces glucose production in the liver and increases insulin sensitivity in muscle and fat tissues, helping the body maintain normal blood sugar levels more efficiently.

How GLYCIPHAGE SR 1GM TABLET Works

Glyciphage SR 1gm Tablet contains Metformin in a sustained-release form, which helps manage type 2 diabetes by lowering blood sugar levels in multiple ways.

It works by reducing the amount of glucose produced by the liver, decreasing the absorption of sugar from the intestines, and improving the body’s response to insulin.

The sustained-release (SR) formulation ensures the medicine is released slowly over time, providing consistent blood sugar control throughout the day while reducing stomach-related side effects.

It helps lower fasting and post-meal blood sugar levels and improves long-term glycemic control when used with a healthy diet and exercise.

How to use GLYCIPHAGE SR 1GM TABLET

• Take Glyciphage SR 1gm Tablet exactly as prescribed by your doctor.
• Swallow the tablet whole with water—do not crush, chew, or break it. It’s usually taken once or twice daily, depending on your blood sugar levels and your doctor’s instructions.
• Always follow a consistent schedule and combine it with proper diet and exercise for best results.

Best Time to Take Glyciphage SR:

The best time to take Glyciphage SR is with your evening meal or as advised by your doctor. Taking it with food helps reduce the chances of stomach upset, a common side effect when starting Metformin.

Glyciphage SR Dosage for Diabetes:

The usual starting dose of Glyciphage SR for diabetes is 500 mg once daily with food, which may be gradually increased by your doctor based on your blood sugar response. The maximum recommended dose can go up to 2000 mg per day in divided doses. Do not self-adjust the dosage without medical supervision.

Glyciphage SR Before or After Food:

Glyciphage SR should be taken after food, preferably with or immediately after a meal. This helps reduce the risk of gastrointestinal side effects like nausea, bloating, or stomach cramps.

How Long to Take Glyciphage SR?

Glyciphage SR is usually taken long-term for managing type 2 diabetes or insulin resistance, unless advised otherwise by your doctor. Regular monitoring of blood sugar and periodic health check-ups are important to assess how well the treatment is working.

What if I forgot to take GLYCIPHAGE SR 1GM TABLET

If you miss a dose of Glyciphage SR, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed one and resume your regular schedule. Do not double the dose to make up for a missed one.

Overdose

Taking too much Glyciphage SR can lead to a serious condition called lactic acidosis, which is rare but life-threatening. Symptoms include severe weakness, breathing difficulty, stomach pain, dizziness, or irregular heartbeat. In case of overdose, seek immediate medical help.

Side Effects Of GLYCIPHAGE SR 1GM TABLET

Like all medicines, Glyciphage SR 1gm Tablet may cause certain side effects in some individuals, although not everyone gets them.

Common Side Effects of Glyciphage SR 1gm Tablet are:

• Nausea or vomiting
• Stomach pain or bloating
• Loss of appetite
• Metallic taste in the mouth
• Diarrhea, loss of appetite

Glyciphage SR Tablet Adverse Effects:

Stop taking GLYCIPHAGE SR 1GM TABLET and consult your doctor immediately if you experience any of the following side effects:

• serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
• signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)
• signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)

Glyciphage SR Long-Term Side Effects:

When used over the long term, Glyciphage SR (Metformin sustained-release) is generally considered safe and well-tolerated. However, some individuals may experience certain side effects with prolonged use.

• One of the most common concerns is vitamin B12 deficiency, which can lead to symptoms like fatigue, nerve problems (tingling or numbness), or anemia if not monitored.
• Other rare but serious long-term risks include lactic acidosis, a rare buildup of lactic acid in the blood, especially in those with kidney or liver issues.

Some users may also report mild digestive discomfort, though this usually improves over time. Regular blood tests and medical checkups can help detect and manage any long-term effects early.

Warning & Precautions

Pregnancy

Monitoring required

Glyciphage SR is not recommended during pregnancy unless absolutely necessary, particularly in the first trimester. For pregnant women with gestational diabetes or type 2 diabetes, insulin is usually preferred due to its better safety profile. Metformin may be used in some cases under strict medical supervision, especially in the second and third trimesters, but only when the potential benefits outweigh the risks.

Breastfeeding

Monitoring required

Glyciphage SR is excreted in breast milk, but there have been no reports of harm to nursing infants. However, it should only be used during breastfeeding if the potential benefits to the mother outweigh the risks to the baby. It's crucial to consult with a healthcare provider before using Metformin SR while breastfeeding.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if your ability is affected by the medicine.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking GLYCIPHAGE SR 1GM TABLET as it may increase the risk of unwanted side effects.

Kidney

Consult your doctor

In patients with kidney disease, the use of Glyciphage SR must be approached with caution. Metformin can cause lactic acidosis in individuals with impaired kidney function, which can be life-threatening. Kidney function should be monitored regularly, and the dosage may need to be reduced or adjusted based on glomerular filtration rate (GFR). If kidney function is significantly impaired (e.g., GFR < 30 mL/min), Glyciphage SR should generally be avoided.

Liver

Consult your doctor

Glyciphage SR should be used with caution in individuals with liver problems, particularly liver disease or hepatic dysfunction, as Metformin is metabolized in the liver. Patients with liver disease may have a higher risk of lactic acidosis. Before starting treatment, liver function should be assessed, and if there is severe liver impairment, Glyciphage SR may be contraindicated.

Allergy

Contraindicated

Do not take GLYCIPHAGE SR 1GM TABLET if you are allergic to Metformin or any other ingredients of this medicine.

Lungs

Contraindicated

Glyciphage SR 1gm Tablet is not recommended for use in patients with severe infection of lungs or respiratory tract.

Heart Disease

Contraindicated

Glyciphage SR 1gm Tablet is not recommended for use in patients with heart problems (such as acute heart failure or a recent heart attack).

Use In Pediatrics

Consult your doctor

Glyciphage SR is generally not recommended for children under 10 years of age. For pediatric patients aged 10-18, the use of Metformin may be considered for type 2 diabetes, but it should be under strict medical supervision. Dosage adjustments may be needed based on the child’s weight, age, and renal function.

Use In Geriatrics

Monitoring required

In elderly patients, Glyciphage SR can be used, but renal function should be closely monitored because kidney function tends to decline with age, increasing the risk of lactic acidosis. The dosage may need to be reduced, and any signs of renal impairment should prompt immediate medical review. The elderly are also more prone to other side effects, such as gastrointestinal discomfort, so adjustments may be required.

Other Warnings for GLYCIPHAGE SR 1GM TABLET

Before taking Glyciphage SR 1gm Tablet, inform your doctor if you:

• are about to have any X-ray or scan
• are about a have a major surgery
• are in fasting

Who should not take [GBNKEYWORD

Glyciphage SR 1gm Tablet is not recommended for use if you:

• have severe, uncontrollable diabetes
• have lactic acidosis or ketoacidosis  
• are dehydrated  
• have any systemic infection  
• have shock or problems in blood circulation
• have breathing problems
• are an alcoholic

Safety Advice

Expert Advice to Follow while Taking Glyciphage SR 1gm Tablet:

• Monitor Kidney Function: Regularly check kidney function through blood tests, as Metformin is processed by the kidneys. Do not use if you have severe kidney problems.
• Stay Hydrated: Drink plenty of water to avoid dehydration, which can affect kidney function and medication effectiveness.
• Limit Alcohol Consumption: Excessive alcohol increases the risk of lactic acidosis and may interfere with blood sugar control. Drink in moderation.
• Watch for Lactic Acidosis Symptoms: Seek immediate medical attention if you experience symptoms like muscle pain, difficulty breathing, or unusual tiredness, as these may indicate lactic acidosis.
• Monitor Blood Sugar: Regularly check your blood sugar levels to ensure proper medication management and prevent hypoglycemia or hyperglycemia.
• Avoid During Pregnancy: Discuss alternatives with your doctor if you're pregnant, as Glyciphage SR may not be recommended during pregnancy.
• Inform Your Doctor of Other Medications: Inform your doctor about all medications, including over-the-counter drugs, as Glyciphage SR may interact with other drugs.

Diet and Lifestyle Advice

1. Follow a Balanced Diet
A well-balanced diet is key in managing type 2 diabetes. Focus on whole foods, such as:

• Non-starchy vegetables (e.g., leafy greens, broccoli, and peppers) for fiber and low carbs.
• Whole grains like oats, quinoa, and brown rice instead of refined grains (e.g., white bread and pasta) to prevent blood sugar spikes.
• Lean proteins such as chicken, fish, tofu, and legumes to stabilize blood sugar.
• Healthy fats from sources like olive oil, avocados, and nuts, which can improve insulin sensitivity.

2. Carbohydrate Management
Carbohydrates have the greatest effect on blood sugar. Control your carbohydrate intake by:

• Choosing complex carbs (e.g., whole grains, vegetables) over simple sugars and refined carbs.
• Using portion control to limit carbohydrate-rich foods at each meal.
• Avoiding sugary snacks, beverages, and foods high in added sugars (e.g., soda, desserts).

3. Fiber-Rich Foods
Fiber slows down the absorption of sugars and helps control blood sugar levels. Include plenty of:

• Vegetables, fruits (like berries), legumes (beans, lentils), and whole grains.
• Aiming for about 25-30 grams of fiber per day helps with both blood sugar regulation and digestive health.

4. Consistent Meal Timing
Eating meals at regular intervals helps prevent extreme blood sugar fluctuations. Aim for:

• 3 balanced meals and 2-3 snacks throughout the day.
• Eating meals around the same time each day to regulate blood sugar levels.
• Avoid skipping meals as it can lead to overeating or a spike in blood sugar later.

5. Portion Control
Managing portion sizes is essential to avoid excess calorie intake and maintain a healthy weight. Use methods like:

• Plate method: Fill half your plate with vegetables, a quarter with lean protein, and a quarter with whole grains or starchy vegetables.
• Mindful eating: Pay attention to portion sizes and eat slowly to avoid overeating.

6. Regular Physical Activity
Exercise helps lower blood sugar levels by improving insulin sensitivity. Aim for:

• 150 minutes of moderate exercise per week, such as brisk walking, swimming, or cycling.
• Include both aerobic exercises (e.g., walking, jogging) and strength training (e.g., weightlifting or bodyweight exercises) for maximum benefits.
• Exercise helps with weight loss, reduces the risk of heart disease, and improves overall well-being.

7. Maintain a Healthy Weight
Losing even a small amount of weight (5-10% of your total body weight) can significantly improve blood sugar control. Focus on:

• A combination of a balanced diet and regular physical activity to lose weight gradually.
• Avoid fad diets or drastic weight loss plans, as they can be unsustainable and harmful to long-term health.

8. Stay Hydrated
Drinking enough water is essential for blood sugar control and overall health. Aim to:

• Drink at least 8 cups (2 liters) of water per day to stay hydrated.
• Avoid sugary drinks and sodas, which can cause blood sugar spikes.

9. Manage Stress
Stress can cause blood sugar levels to rise. Practice stress-reducing techniques such as:

• Deep breathing, yoga, or meditation to manage stress levels.
• Adequate sleep: Ensure 7-8 hours of restful sleep to help regulate hormone levels that affect blood sugar.

10. Avoid Smoking and Limit Alcohol
Smoking can increase the risk of complications associated with diabetes, while excessive alcohol can affect blood sugar control. Therefore:

• Quit smoking and seek support or professional help if needed.
• Limit alcohol intake to moderate levels (1 drink per day for women, 2 for men), and always consume alcohol with food to prevent hypoglycemia.

What is the difference between Glyciphage and Glyciphage SR?

Drug - Drug interaction

• Insulin and other oral antidiabetic drugs: Combining Glyciphage SR with other antidiabetic medications (like insulin or sulfonylureas) may increase the risk of hypoglycemia (low blood sugar). Blood sugar levels should be monitored frequently.
• Diuretics (water pills): Some diuretics, particularly loop diuretics (e.g., furosemide) and thiazides, may affect kidney function and increase the risk of lactic acidosis when taken with Metformin.
• Corticosteroids and corticosteroid creams: These can raise blood sugar levels, potentially decreasing the effectiveness of Glyciphage SR.
• Other medications affecting kidney function: Drugs that can impair kidney function, like NSAIDs (e.g., ibuprofen) or certain blood pressure medications, may increase the risk of lactic acidosis when combined with Metformin.
• Iodine-containing contrast agents: If you're undergoing a CT scan or MRI with contrast, inform your healthcare provider, as Metformin should be temporarily stopped before and after the procedure to avoid kidney damage

More Information

FAQs About GLYCIPHAGE SR 1GM TABLET

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.
2. Calette Corcoran; Tibb F. Jacobs. Metformin. StatPearls. NIH. National Library of Medicine. National center for biotechnology information. PMC. PubMed Central. [Revised on May 2022]. [Accessed on 18th April 2025] 
3. Shuyan Gu, Jihao Shi, Zhiliu Tang, Monika Sawhney, Huimei Hu, Lizheng Shi, Vivian Fonseca, Hengjin Dong. Comparison of Glucose Lowering Effect of Metformin and Acarbose in Type 2 Diabetes Mellitus: A Meta-Analysis. PLOS ONE. May 2015. [Accessed on 18th April 2025] 
4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 18th April 2025] 
5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 18th April 2025] 
6. Merck Santé S.A.S. U.S. Food & Drug Administration. [Revised in April 2017] [Accessed on 18th April 2025] 
7. Franco Indian Pharmaceuticals Pvt Ltd. GLYCIPHAGE® GLYCIPHAGE 850® GLYCIPHAGE 250®TABLETS. (ORAL ANTI-HYPERGLYCEMIC AGENT). [Accessed on 18th April 2025] 

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 19 Apr 2025 | 11:04 AM(IST)