Gluconorm G2D Tablet 10'S

Introduction About GLUCONORM G2D TABLET

GLUCONORM G2D TABLET is a combination of Cholecalciferol, Glimepiride, and Metformin, which belongs to a group of medicines called Antidiabetic agents. GLUCONORM G2D TABLET is used to manage type 2 diabetes in adults along with diet and exercise.

During management with GLUCONORM G2D TABLET, your doctor will check your kidney function at least once a year or more frequently if you are elderly and/or if you have worsening kidney function.

GLUCONORM G2D TABLET is not recommended for use in patients with severe kidney problems, kidney stones, or a tendency to form kidney stones, liver problems, acute heart failure or have recently had a heart attack, severe problems with your circulation (such as shock), or have breathing difficulties. Therefore, consult your doctor before taking it.

GLUCONORM G2D TABLET is not recommended for use by pregnant women or breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.

The most common side effects of taking GLUCONORM G2D TABLET are nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and change in taste. Consult your doctor if any of the side effects worsen.

Uses Of GLUCONORM G2D TABLET

• To manage type II diabetes mellitus

How GLUCONORM G2D TABLET Works

GLUCONORM G2D TABLET helps to control the blood sugar level, where cholecalciferol improves insulin resistance, promotes insulin secretion, and helps manage blood sugar levels. Glimepiride works by increasing the amount of insulin released by the pancreas and lowering blood sugar levels. Metformin works by decreasing glucose production in the liver and the amount of glucose absorbed by the stomach and intestine. It also helps to restore the body’s response to insulin.

How to use GLUCONORM G2D TABLET

Always take GLUCONORM G2D TABLET as directed by your physician. Swallow the medicine as a whole, and do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you, depending on your age and health condition. Do not stop taking GLUCONORM G2D TABLET without informing your doctor.

Side Effects Of GLUCONORM G2D TABLET

How To Manage Side Effects

Constipation

Include fiber-rich foods in your diet, such as fresh fruits, vegetables, and whole-grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Contact your doctor if constipation persists.

Diarrhea

Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling drowsy. Do not consume excessive amounts of alcohol. Consult your doctor if your drowsiness worsens.

Loss Of Appetite

Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack that is rich in calories and protein, such as dried fruit and nuts.

Nausea And Vomiting

Take GLUCONORM G2D TABLET, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting do not improve.

Skin rash Or Itching

Avoid hot baths because hot water can irritate your skin further. Do not scratch the affected area. Use sunscreen and wear protective clothing while going outside. Use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if your rashes worsen.

Stomach Pain

Try to have smaller meals but take them frequently. Keep a heat pad on your stomach. Do not self-manage and contact your doctor if the stomach pain does not improve.

Warning & Precautions

Pregnancy

Contraindicated

GLUCONORM G2D TABLET is not recommended for use by pregnant women. Consult your doctor before taking it.

Breastfeeding

Contraindicated

GLUCONORM G2D TABLET is not recommended for use by breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if you have symptoms of low blood sugar, such as weakness, dizziness, increased sweating, a fast heartbeat, vision disorders, or difficulty in concentration after taking GLUCONORM G2D TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking GLUCONORM G2D TABLET, as it may increase the risk of unwanted side effects.

Kidney

Contraindicated

GLUCONORM G2D TABLET is not recommended for use in patients with severe kidney problems, who have kidney stones, or who have a tendency to form kidney stones. Consult your doctor before taking it.

Liver

Contraindicated

GLUCONORM G2D TABLET is not recommended for use in patients with liver problems. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take GLUCONORM G2D TABLET if you are allergic to cholecalciferol, glimepiride, metformin, or any of the other ingredients of the medicine.

Heart Disease

Consult your doctor

GLUCONORM G2D TABLET is not recommended for use in patients with acute heart failure, who have recently had a heart attack, have severe problems with their circulation (such as shock), or have breathing difficulties. It should be used with caution in patients with narrowing of the arteries. Therefore, consult your doctor before taking it.

Use In Pediatrics

Contraindicated

GLUCONORM G2D TABLET is not recommended for use in children or adolescents (aged below 18 years) as safety and efficacy have not been established. Therefore, consult your doctor before taking it.

Use In Geriatrics

Use with Caution

GLUCONORM G2D TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug Interactions:

Before taking GLUCONORM G2D TABLET, inform your doctor if you are taking any of the following medicines:

• other medicines used to manage diabetes mellitus (such as insulin or metformin)
• medicines used to manage pain and inflammation (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azapropazone, and oxyphenbutazone)
• medicines used to manage urinary infections (amikacin, nitrofurantoin, sulfamethoxazole)
• medicines used to manage bacterial and fungal infections (such as tetracyclines, chloramphenicol, trimethoprim, ciprofloxacin, clarithromycin, fluconazole, miconazole, ketoconazole, itraconazole, and isavuconazole)
• medicines used to manage blood clotting (Ex. warfarin)
• medicines used for muscle buildup (Ex. nandrolone, oxymetholone)
• medicines used for male sex hormone replacement therapy (Ex. testosterone)
• medicines used to manage depression (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, and fluoxetine)
• medicines used to manage high blood cholesterol levels (Ex. fenofibrate, nicotinic acid, colesevelam)
• medicines used to manage high blood pressure and heart conditions (Ex. enalapril, lisinopril, ramipril, verapamil, ranolazine, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine, hydrochlorothiazide, disopyramide, digoxin, digitoxin, bendroflumethiazide, and reserpine)
• medicines used to manage gout (Ex. allopurinol, probenecid, sulfinpyrazone)
• medicines used to manage cancer (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib, and olaparib)
• fenfluramine (a medicine used to manage obesity)
• pentoxifylline (a medicine that can improve blood flow in the body)
• medicines used to manage allergic rhinitis (Ex. tritoqualine)
• sympatholytics (medicines used to manage high blood pressure, heart failure, or prostate problems) (Ex. prazosin, doxazosin, clonidine)
• medicines containing female sex hormones (Ex. estradiol, progesterone)
• levothyroxine (a medicine used to manage thyroid problems)
• medicines to manage mental illness (such as chlorpromazine, prochlorperazine, and lithium)
• corticosteroids (used to manage pain and inflammatory conditions) (Ex. prednisolone, betamethasone, and hydrocortisone)
• medicines used to manage asthma (Ex. salbutamol, terbutaline)
• medicines used to raise heartbeat, to manage asthma or nasal congestion, coughs and colds, to reduce weight, or in life-threatening emergencies (adrenaline and sympathomimetics)
• medicines used to manage constipation (Ex. lactulose, liquid paraffin)
• medicines used to manage epilepsy (Ex. carbamazepine, phenobarbital, phenytoin, primidone)
• medicines to manage nervousness and sleep problems (barbiturates) (Ex. phenobarbital)
• medicines used to reduce increased pressure in the eye (Ex. acetazolamide)
• glucagon, diazoxide (medicines used to manage signs of low blood sugar levels)
• rifampicin, isoniazid (medicines used to manage tuberculosis)
• medicines to manage stomach ulcers (H2 antagonists) (Ex. cimetidine)
• other vitamin D-containing medicines, including multi-vitamins
• calcium supplements
• medicines leading to fat malabsorption (Ex. orlistat, cholestyramine, liquid paraffin)
• actinomycin (a medicine used to manage some forms of cancer)
• beta-2 agonists such as salbutamol or terbutaline (used to manage asthma)
• dolutegravir (a medicine used to manage HIV infection)

Overdosage:

If you or anyone else accidentally took more GLUCONORM G2D TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, a fast heartbeat, and confusion). Overdosage may also cause lactic acidosis, and symptoms include vomiting, abdominal pain, muscle cramps, a general feeling of not being well with severe tiredness, and difficulty breathing. Further symptoms include reduced body temperature and heartbeat.

Synopsis

More Information

• Keep GLUCONORM G2D TABLET out of reach of children
• Store GLUCONORM G2D TABLET at room temperature

FAQs About GLUCONORM G2D TABLET

Q: Is GLUCONORM G2D TABLET safe during pregnancy?

A: GLUCONORM G2D TABLET is not recommended for use by pregnant women. Inform your doctor if you are pregnant, think you may be pregnant, or plan to become pregnant before taking this medicine.

Q: What are the side effects of taking GLUCONORM G2D TABLET?

A: The most common side effects of taking GLUCONORM G2D TABLET are nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and change in taste. Consult your doctor if any of the side effects worsen.

Q: What precautions have to be taken while using GLUCONORM G2D TABLET?

A: Before taking GLUCONORM G2D TABLET, inform your doctor if you are recovering from an injury, operation, infections with fever, or any forms of stress, or have G6PD deficiency, disorders of the thyroid glands, pituitary gland, or adrenal cortex, have undernourishment, irregular meal time, missed or delayed meal or period of fasting, have high levels of calcium in your blood (hypercalcaemia) or urine (hypercalciuria), have sarcoidosis (an inflammatory condition that affects your lungs, heart, and kidneys), or are on prolonged fasting.

Q: What should I do if I forget to take a dose of GLUCONORM G2D TABLET?

A: If you forgot to take a dose of GLUCONORM G2D TABLET, take it as soon as you remember. However, if it is time for the next dose of GLUCONORM G2D TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of GLUCONORM G2D TABLET to compensate for the missed ones.

Q: How long should I take GLUCONORM G2D TABLET?

A: You need to take GLUCONORM G2D TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Q: How do you manage the side effects of GLUCONORM G2D TABLET?

A: Low blood sugar is a common side effect of taking GLUCONORM G2D TABLET. Try to have sugar-rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If you have not reached your optimum level, take another sugary snack or drink and check your blood sugar levels once again. If your condition does not improve, consult your doctor immediately.

References

1. KD. Tripathi. Insulin, oral antidiabetic drugs, and glucagon. Essentials of medical pharmacology. Eighth edition, 2019. Page – 299.

2. Nakashima A, Yokoyama K, Yokoo T, Urashima M. Role of vitamin D in diabetes mellitus and chronic kidney disease. World J Diabetes. 2016. [Accessed on 24th January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781904/

3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 24th January 2024] https://www.medicines.org.uk/emc/files/pil.10743.pdf

4. Colonis Pharma Limited.. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 24th January 2024] https://www.medicines.org.uk/emc/files/pil.7247.pdf

5. Brown & Burk UK Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 24th January 2024] https://www.medicines.org.uk/emc/files/pil.10760.pdf

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin-Fasting
• Insulin Postprandial (PP)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 24 Jan 2024 | 06:13 PM(IST)