Gluconorm G 2mg Tablet 15'S

Introduction About GLUCONORM G 2MG TABLET

Gluconorm G 2mg Tablet is formulated to help individuals manage type 2 diabetes effectively. It is particularly suitable for patients who are not able to control blood sugar with diet and exercise alone. The tablet combines Glimepiride and Metformin, providing a dual mechanism to regulate blood sugar. Glimepiride stimulates the pancreas to release insulin, while Metformin reduces glucose production in the liver and improves insulin sensitivity. This combination makes it an ideal choice for patients needing both fasting and post-meal glucose control.      

The tablet is most effective when taken with meals, usually once or twice daily as prescribed by a doctor. Regular intake at the same time each day, along with a balanced diet and moderate physical activity, helps maintain stable blood sugar levels. It is essential for patients to monitor their blood glucose levels regularly to ensure optimal control and to help their doctor make any necessary dose adjustments. Missing doses or taking extra doses can lead to low blood sugar (hypoglycaemia) or reduced effectiveness.

Patients should follow several precautions while taking Gluconorm G. Avoid alcohol, maintain hydration, and inform your doctor about any existing kidney, liver, or heart problems. Use with caution when driving or operating machinery as dizziness or low blood sugar may occur. The medicine is not recommended during pregnancy or breastfeeding, as it may affect the baby. Patients planning pregnancy should consult their doctor to discuss safer alternatives for blood sugar management.

Common side effects may include nausea, stomach upset, diarrhoea, mild dizziness, or low blood sugar. Rare but serious complications, such as lactic acidosis, may present as extreme tiredness, muscle cramps, vomiting, or difficulty breathing. Immediate medical attention is required if these symptoms occur. Overall, Gluconorm G 2mg Tablet provides an effective and convenient option for patients needing comprehensive blood sugar control, when used responsibly under medical guidance.

Uses Of GLUCONORM G 2MG TABLET

• Used to manage type 2 diabetes mellitus (when diet, exercise and the single agent does not result in adequate glycaemic control)

Benefits of GLUCONORM G 2MG TABLET

Gluconorm G 2mg Tablet for Sugar Management:

Gluconorm G 2mg Tablet helps manage type 2 diabetes by controlling blood sugar levels. It combines Glimepiride, which boosts insulin release, and Metformin, which reduces sugar production in the liver. This dual action helps keep both fasting and post-meal glucose in check.  

How GLUCONORM G 2MG TABLET Works

Gluconorm G 2mg Tablet Mechanism of Action

Gluconorm G 2mg Tablet works through a dual mechanism to help manage blood sugar levels in type 2 diabetes: 

1. Glimepiride: Stimulates the pancreas to release more insulin. This helps the body use glucose from the blood efficiently, lowering post-meal sugar levels.
2. Metformin: Reduces glucose production in the liver and improves insulin sensitivity in body tissues. This helps lower fasting blood sugar and supports long-term glucose control.

How to use GLUCONORM G 2MG TABLET

How to Take Gluconorm G 2mg Tablet

• Take the tablet exactly as prescribed by your doctor.
• Usually taken once or twice daily, depending on your blood sugar levels and doctor’s instructions.
• Always take with meals to reduce the risk of low blood sugar and stomach upset.
• Swallow the tablet whole with water; do not crush, break, or chew it.
• If you miss a dose, take it as soon as you remember, but skip it if it’s almost time for your next dose. Do not double the dose.
• Maintain a consistent schedule to help control blood sugar more effectively.
• Combine with a healthy diet, regular exercise, and blood sugar monitoring for best results.

What if I forgot to take GLUCONORM G 2MG TABLET

• If you forget to take your Gluconorm G 2mg tablet, take it as soon as you remember.
• If it is nearly time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take two doses at the same time to make up for the forgotten one.
• Missing doses frequently may reduce the effectiveness of the medicine in maintaining blood sugar control.
• To avoid missing doses, try to take your tablet at the same time each day and set reminders if needed.

Overdose

If you or someone else has accidentally taken more than the recommended dose of Gluconorm G 2mg tablet, seek medical help immediately or visit the nearest hospital without delay. Taking an overdose may lead to low blood sugar (hypoglycaemia). Signs of lactic acidosis may include vomiting, stomach pain with muscle cramps, extreme tiredness, feeling unwell, slow heartbeat, low body temperature, and breathing difficulty.

Side Effects Of GLUCONORM G 2MG TABLET

Common side effects of Gluconorm G 2mg tablet:

• taste disturbance
• diarrhoea
• stomach pain
• bloating
• loss of appetite

When to Seek Medical Attention?

Stop taking Gluconorm G 2mg tablet and contact your doctor immediately if you experience any of the following side effects:

• lactic acidosis
• inflammation of the liver which may result in jaundice (yellowing of skin or eyes)
• severe allergic reactions (such as skin rash, hives, and increased sensitivity to sun, inflammation of blood vessels which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock)
• severe low blood sugar levels

How To Manage Side Effects

Loss Of Appetite

• Eat small, frequent meals: Instead of three large meals, have smaller portions throughout the day to stimulate hunger gradually.
• Stay hydrated: Drink enough water but avoid drinking large amounts right before meals to prevent feeling full too quickly.
• Ginger: Consuming fresh ginger or ginger tea before meals may help boost digestion and appetite.
• Lemon and honey water: Drinking warm water with lemon and honey before meals can help activate digestive juices.
• Herbal teas: Peppermint or chamomile tea can calm the stomach and improve appetite.
• Engage in light physical activity: A short walk or mild exercise before meals can naturally stimulate hunger.
• Avoid stress and get adequate sleep: Stress and tiredness can reduce appetite, so ensure proper rest and relaxation.

Stomach Pain

• Warm compress: Place a heating pad or hot water bag on your stomach for 15–20 minutes to relax muscles and reduce cramps.
• Ginger tea: Drinking warm ginger tea can help soothe the stomach and ease discomfort caused by indigestion or gas.
• Peppermint: Peppermint tea or a few drops of peppermint oil in warm water may help relax digestive muscles and relieve pain.
• Drink plenty of fluids: Staying hydrated helps flush out toxins and supports digestion. Avoid carbonated or sugary drinks.
• Eat light foods: Opt for bland foods like bananas, rice, toast, or yogurt until your stomach feels better.
• Avoid spicy and oily foods: These can worsen irritation and discomfort in the stomach lining.
• Rest: Give your body time to recover and avoid heavy physical activity until the pain eases.

Warning & Precautions

Pregnancy

Contraindicated

Gluconorm G 2mg Tablet should not be used during pregnancy. Consult your doctor if you are planning to become pregnant before starting this medication.   

Breastfeeding

Contraindicated

This medicine should not be taken while breastfeeding, as it may pass into breast milk and affect the baby.   

Driving and Using Machines

Use with Caution

Avoid driving or using machines if you experience low or high blood sugar symptoms, such as dizziness, fatigue, shaking, or visual disturbances.  

Alcohol

Contraindicated

Alcohol may increase or decrease the blood sugar-lowering effect of Gluconorm G and raise the risk of lactic acidosis. Discuss alcohol consumption with your doctor. 

Kidney

Consult your doctor

Patients with severe kidney disease should avoid this medicine. For those with kidney concerns, the dosage may need adjustment based on kidney function. 

Liver

Consult your doctor

Gluconorm G is not recommended in severe liver disease. Patients with liver issues should use it cautiously, and dosage adjustments may be required depending on liver function.  

Allergy

Contraindicated

Do not take Gluconorm G if you are allergic to Glimepiride, Metformin, other sulfonylureas (e.g., glipizide, glibenclamide), or sulfonamides (e.g., sulfamethoxazole).  

Heart Disease

Contraindicated

This medicine is not recommended for patients with recent heart attack, acute heart problems, severe circulatory issues, or breathing difficulties. 

Use In Pediatrics

Contraindicated

GLUCONORM G 2MG TABLET is not recommended for use in children and adolescents (under 18 years of age). 

Use In Geriatrics

Consult your doctor

For patients 65 years and older, Gluconorm G should be used with caution, particularly in those with impaired kidney function. Doctors may monitor kidney function more frequently, and it is generally not recommended for patients aged 75 years or above.

Other Warnings for GLUCONORM G 2MG TABLET

Before taking Gluconorm G 2mg tablet inform your doctor if you:  

• are recovering from injury, operation, infections with fever, or from other forms of stress
• have glucose-6-phosphate dehydrogenase (G6PD) deficiency
• have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take [GBNKEYWORD

Gluconorm G 2mg tablet is not recommended for use, if you have:

• type 1 diabetes mellitus
• diabetic ketoacidosis
• uncontrolled diabetes or ketoacidosis
• dehydration
• severe infection

Safety Advice

• Dehydration: Avoid getting dehydrated. Drink enough water, especially during exercise or in hot weather, as dehydration can increase the risk of lactic acidosis.
• Surgery or medical tests: Inform your doctor if you are scheduled for surgery or medical imaging that uses contrast dye, as this medicine may need to be temporarily stopped.
• Infections or illness: If you experience fever, vomiting, or severe infection, contact your doctor, as these conditions can affect blood sugar control.
• Avoid skipping meals: Missing meals while taking this medicine can increase the risk of hypoglycaemia. Eat regular, balanced meals.
• Medication changes: Always inform your doctor about all other medicines, supplements, or herbal products you are taking to avoid possible interactions.
• Unexplained symptoms: Report unusual tiredness, muscle pain, breathing difficulty, or stomach discomfort immediately, as these could be signs of lactic acidosis.

Diet and Lifestyle Advice

• Balanced diet: Eat a well-balanced diet that includes whole grains, vegetables, lean proteins, and fibre-rich foods to help maintain steady blood sugar levels.
• Regular meals: Do not skip meals. Eat at regular intervals to avoid sudden drops in blood sugar.
• Limit sugar intake: Reduce consumption of sugary foods, desserts, and sweetened beverages to help control glucose levels.
• Stay hydrated: Drink plenty of water throughout the day to prevent dehydration and support overall health.
• Physical activity: Engage in regular moderate exercise such as brisk walking, cycling, or yoga, as recommended by your doctor.
• Avoid alcohol and smoking: These can interfere with blood sugar control and increase the risk of side effects.
• Monitor blood sugar: Check your blood glucose levels regularly and maintain a record to track your progress.
• Stress management: Practice relaxation techniques like meditation or deep breathing, as stress can affect blood sugar balance.
• Adequate sleep: Ensure you get sufficient rest each night to help your body manage blood sugar effectively.

1. Gluconorm G 2mg Tablet compares with Glimepiride 2mg Tablet in controlling blood sugar

2. Gluconorm G 2mg Tablet compares with other common antidiabetic drugs

Drug - Drug interaction

1. Insulin and other antidiabetic medicines

• Interaction: Combining Gluconorm G 2mg tablet with insulin or other antidiabetic drugs (e.g., gliclazide, pioglitazone) can increase the risk of hypoglycaemia.
• Management: Regularly monitor blood sugar levels; your doctor may adjust the dose of one or more medicines accordingly.

2. Beta-blockers (e.g., propranolol, atenolol, metoprolol)

• Interaction: These medicines can mask symptoms of low blood sugar, such as tremors and rapid heartbeat.
• Management: Be cautious; monitor blood glucose frequently and recognize other signs like sweating or dizziness.

3. Corticosteroids (e.g., prednisolone, dexamethasone)

• Interaction: May reduce the blood sugar–lowering effect of Gluconorm G 2mg tablet.
• Management: Your doctor may need to adjust your diabetes medication or monitor blood sugar more closely.

4. Diuretics (e.g., furosemide, hydrochlorothiazide)

• Interaction: Can reduce metformin effectiveness and increase the risk of lactic acidosis or high blood sugar.
• Management: Use with caution and monitor kidney function and blood sugar levels regularly.

5. Antibiotics (e.g., rifampicin, chloramphenicol)

• Interaction: Rifampicin may reduce, while chloramphenicol may enhance the effect of glimepiride, leading to unstable blood sugar levels.
• Management: Blood sugar monitoring is essential; dose modification may be required.

6. Non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, diclofenac)

• Interaction: May enhance the glucose-lowering effect and increase the risk of hypoglycaemia.
• Management: Monitor blood glucose regularly and report symptoms like sweating, dizziness, or confusion.

7. Thyroid hormones (e.g., levothyroxine)

• Interaction: May reduce the effectiveness of Gluconorm G 2mg tablet in controlling blood sugar.
• Management: Blood glucose levels should be monitored, and your doctor may adjust the diabetes medication dose.

8. Antifungal medicines (e.g., fluconazole, miconazole)

• Interaction: May increase the effect of glimepiride, leading to a higher risk of low blood sugar.
• Management: Monitor blood sugar closely and watch for symptoms of hypoglycaemia.

9. ACE inhibitors (e.g., enalapril, ramipril)

• Interaction: These may enhance the blood sugar–lowering effect of Gluconorm G 2mg tablet.
• Management: Monitor blood sugar levels and adjust dosage if hypoglycaemia occurs.

10. Oral contraceptives and hormone replacement therapy

• Interaction: May reduce the blood sugar–lowering effect of Gluconorm G 2mg
• Management: Blood glucose should be checked regularly, and medication may need to be modified.

Drug - Food interaction

1. High-fat or fried foods

• Interaction: Fatty or greasy meals may slow the absorption of the medicine and worsen blood sugar control.
• Management: Choose balanced meals with moderate fat content and avoid frequent consumption of fried or oily foods.

2. Refined carbohydrates and sugary foods

• Interaction: Foods high in sugar or refined carbs (such as sweets, white bread, or pastries) can increase blood glucose and counteract the effect of the medicine.
• Management: Limit sugary foods and opt for whole grains, vegetables, and fibre-rich foods to maintain stable blood sugar levels.

3. Caffeine (coffee, tea, soft drinks)

• Interaction: High caffeine intake may cause blood sugar fluctuations or enhance symptoms of low blood sugar such as anxiety and palpitations.
• Management: Limit caffeine consumption and monitor how your body responds after taking the medicine.

4. Grapefruit or grapefruit juice

• Interaction: Grapefruit may interfere with drug metabolism, potentially altering the blood sugar–lowering effect of glimepiride.
• Management: Avoid or limit grapefruit products while on this medicine, unless advised otherwise by your doctor.

5. Fiber-rich foods (in excess)

• Interaction: Extremely high fibre intake can reduce the absorption of glimepiride and metformin, decreasing their effectiveness.
• Management: Maintain a balanced intake of fibre adequate but not excessive to ensure proper drug absorption.

Synopsis

More Information

FAQs About GLUCONORM G 2MG TABLET

Q: What is Gluconorm G 2mg Tablet used for?

A: Gluconorm G 2mg Tablet is a medicine that helps control blood sugar in people with type 2 diabetes. It contains Glimepiride and Metformin, which work together to lower glucose levels. Glimepiride helps your body use insulin better, while Metformin reduces sugar production in the liver. This medicine is used along with a healthy diet and regular exercise to maintain steady blood sugar levels.

Q: Can I take Gluconorm G 2mg Tablet on an empty stomach?

A: It is recommended to take this medicine with or just after a meal. Taking it on an empty stomach can increase the risk of low blood sugar (hypoglycaemia) and stomach upset. Eating with the tablet also helps the body absorb it more evenly.

Q: What are the common side effects of Gluconorm G 2mg Tablet?

A: Some common side effects include nausea, stomach upset, diarrhoea, or mild dizziness. Low blood sugar may occur, especially if you skip meals or exercise more than usual. Most side effects are mild and temporary, but you should report severe or persistent symptoms to your doctor.

Q: Do I need to monitor blood sugar while taking Gluconorm G 2mg Tablet?

A: Yes, regular monitoring of blood sugar is essential. It helps you and your doctor know how well the medicine is working and allows for timely adjustments in dosage or diet. Keep a record of your readings for follow-up visits.

Q: Can Gluconorm G 2mg Tablet be taken with other medicines?

A: Some medicines can affect how Gluconorm G works, such as insulin, corticosteroids, or blood pressure medicines. Always inform your doctor about all medicines, supplements, or herbal products you use. Dose adjustments may be required.

Q: Can food affect Gluconorm G 2mg Tablet?

A: Yes, taking it with meals helps reduce stomach upset and prevents low blood sugar. Avoid excessive sugary foods, high-fat meals, or alcohol, as they can affect blood sugar control or the medicine effectiveness.

Q: Can I exercise while taking Gluconorm G 2mg Tablet?

A: Moderate exercise is recommended but monitor your blood sugar closely. Overexertion or skipping meals before exercise can increase the risk of low blood sugar. Adjust your routine or food intake as advised by your doctor.

Q: Can I take other herbal supplements?

A: Some herbal supplements can affect blood sugar or interact with this medicine. Always consult your doctor before starting any herbal or over-the-counter products while taking Gluconorm G.

Q: How long does Gluconorm G 2mg Tablet take to work?

A: The medicine usually starts lowering blood sugar within a few hours, but consistent improvement may take several days to weeks. Continue your diet, exercise, and follow-up appointments to achieve the best results.

Q Can I stop taking Gluconorm G 2mg Tablet suddenly?

A: No, do not stop Gluconorm G suddenly without your doctor’s advice. Stopping abruptly can lead to high blood sugar and worsen diabetes control. Your doctor may guide a gradual reduction if needed.

Q: Can I take Gluconorm G 2mg Tablet with food supplements or vitamins?

A: Most vitamins are safe, but some supplements may affect blood sugar. Always check with your doctor or pharmacist before combining them with Gluconorm G.

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on 4th October 2025]

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on 4th October 2025] 

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on 4th October 2025] 

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on 4th October 2025]

Useful Diagnostic Tests

• Random blood sugar
• Fasting blood sugar
• Post prandial blood sugar
• Sugar risk package
• HbA1C also known as glycated haemoglobin, glycosylated haemoglobin

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 19 Nov 2024 | 10:35 AM(IST)