Name: GEMER 2 Tablet 15's
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Introduction About GEMER 2 TABLET

GEMER 2 TABLET is used to manage type 2 diabetes mellitus when diet, exercise and the single agent does not result in adequate glycemic control. It is a combination of Glimepiride and Metformin which belongs to a group of medicines called Antidiabetic agents. Glimepiride lowers blood sugar by causing the pancreas to produce more insulin and helps the body to use insulin efficiently. Metformin reduces the total amount of sugar released into the blood by the liver.

Along management with GEMER 2 TABLET follow regular exercise and diet plan as advised by your doctor to achieve better results. Before taking GEMER 2 TABLET inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, acute heart problems. Inform your doctor if you are pregnant or breastfeeding. It is not suitable for use in children and adolescents under 18 years of age.

Avoid consumption of alcohol during management with GEMER 2 TABLET as it may increase or decrease the blood sugar lowering action of GEMER 2 TABLET and increases the risk of lactic acidosis. The most common side effects of taking GEMER 2 TABLET are taste disturbance, diarrhea or stomach ache. Contact your doctor if any of the symptoms worsen.

Uses Of GEMER 2 TABLET

Used to manage type 2 diabetes mellitus

Benefits of GEMER 2 TABLET

Controls blood sugar levels in Type 2 Diabetes patients: It combines Glimepiride (2mg) and Metformin (500mg) to help manage blood glucose levels effectively.
Reduces insulin resistance and improves glucose utilization – Glimepiride stimulates the pancreas to release insulin, while Metformin improves insulin sensitivity, reducing insulin resistance.
Prevents Diabetes Complications – Proper control of blood sugar reduces the risk of kidney damage, nerve issues, eye problems, and cardiovascular diseases.
Weight Management – Metformin in GEMER 2 Tablet helps control weight gain often associated with diabetes treatment.
Comprehensive Diabetes Management – It works best when combined with a healthy diet, regular exercise, and lifestyle modifications to maintain stable blood sugar levels?
Decreases the risk of diabetic complications like neuropathy and retinopathy

How GEMER 2 TABLET Works

GEMER 2 TABLET controls blood glucose levels, where Glimepiride works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin works by lowering glucose production in the liver, delaying glucose absorption from intestine, and increasing the body's sensitivity to insulin.

How to use GEMER 2 TABLET

Take GEMER 2 TABLET as advised by your physician.
Swallow GEMER 2 TABLET with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Do not stop taking GEMER 2 TABLET without informing your doctor.

Can I take Gemer 2 twice a day?

Yes, Gemer 2 Tablet can be taken twice a day, but it should be done under the supervision and guidance of your healthcare provider. Typically, Gemer 2 (which contains Glimepiride and Metformin) is started with one tablet per day, but depending on how well your blood sugar levels are controlled, your doctor may adjust the dosage.

For patients with specific needs, such as higher blood glucose levels, the doctor may recommend two doses per day. This is often split between the morning and evening meals to help maintain consistent blood sugar levels throughout the day.

What is the recommended dosage of Gemer 2 for type 2 diabetes?

Adults (Type 2 Diabetes): The typical starting dose for Gemer 2 (combination of Glimepiride 2mg + Metformin 500mg) is 1 tablet daily, usually taken with food to reduce the risk of gastrointestinal side effects such as nausea and upset stomach.
Adjustment of Dosage: Your doctor may increase the dose if required, based on the blood glucose levels. The dose may be gradually adjusted based on your response and tolerance.
Maximum Dosage: The maximum recommended dose is generally 2 tablets per day (depending on your doctor’s assessment).

Can Gemer 2 be taken before or after meals?

Take with Food: To minimize gastrointestinal discomfort, it's recommended to take Gemer 2 Tablet with meals, typically during breakfast or the main meal of the day.

What if I forgot to take GEMER 2 TABLET

Missed Dose: If you miss a dose, do not double the dose. Take the next dose at the usual time. If you have missed multiple doses, consult your healthcare provider for further guidance.

Overdose

If you or anyone else takes too much of GEMER 2 TABLET, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of GEMER 2 TABLET includes risk of low blood sugar levels. Symptoms of lactic acidosis include vomiting, bellyache with muscle cramps, general feeling of not being well with severe tiredness, reduced body temperature, low heartbeat, and difficulty in breathing.

Side Effects Of GEMER 2 TABLET

Like all medicines, Gemer 2 Tablet may cause certain side effects in some individuals, although not everybody gets them.

What are the common side effects of Gemer 2 Tablet?

taste disturbance
diarrhea
stomach pain
loss of appetite

Stop taking GEMER 2 TABLET and contact your doctor immediately if you experience any of the following side effects:

lactic acidosis
inflammation of the liver which may result in jaundice (yellowing of skin or eyes)
severe allergic reactions (such as skin rash, hives, and increased sensitivity to sun, inflammation of blood vessels which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock)
severe low blood sugar levels

1. Does Gemer 2 cause hypoglycemia (low blood sugar)?

Yes, Gemer 2 Tablet can cause hypoglycemia (low blood sugar), especially due to the presence of Glimepiride, which is a sulfonylurea that stimulates the pancreas to release insulin. This can lower blood sugar levels more than desired, particularly if the patient skips meals, does not eat enough carbohydrates, or takes alcohol with the medication.

Signs of hypoglycemia may include sweating, shaking, dizziness, headache, or feeling lightheaded. It is important to monitor blood sugar regularly to prevent hypoglycemia and know how to address low blood sugar episodes, such as consuming a quick source of glucose (e.g., fruit juice or glucose tablets).

2. Is dizziness a side effect of Gemer 2?

Yes, dizziness can be a side effect of Gemer 2 Tablet, particularly during the initial phase of treatment or when the dosage is increased. Dizziness may occur due to low blood sugar (hypoglycemia) or as a result of the medication's impact on the body's insulin production and glucose regulation.

If you experience persistent or severe dizziness, it's important to consult your healthcare provider, as it may require dosage adjustment or additional management.

3. Can Gemer 2 be stopped suddenly or does it require tapering?

It is generally not recommended to suddenly stop taking Gemer 2, especially due to its Metformin and Glimepiride components. Abruptly stopping the medication can cause blood sugar levels to spike, which can lead to hyperglycemia or other complications.

Gemer 2 should be discontinued only under the guidance of a healthcare provider, who may gradually reduce the dosage if necessary, especially when switching to other treatment options. Tapering may not be specifically required, but close monitoring of blood glucose levels is essential during any change in treatment.
If a patient is switching from oral medications to insulin or other therapies, the transition should be done cautiously and under medical supervision to avoid significant changes in blood sugar levels?

Long-term Effects of Using Gemer 2?

Positive Effects:

Better Blood Sugar Control: Both medications work synergistically to help control type 2 diabetes by improving insulin sensitivity and glucose utilization.
Reduced Risk of Complications: Proper blood glucose control can lower the risk of long-term complications such as cardiovascular disease, nerve damage, and kidney disease.

Possible Adverse Effects:

Lactic Acidosis: Long-term use of Metformin can lead to a rare but serious condition called lactic acidosis, particularly in patients with renal or hepatic dysfunction. Regular kidney function monitoring is essential to detect any signs of impaired function early?
Vitamin B12 Deficiency: Long-term use of Metformin may impair the absorption of Vitamin B12, which can lead to peripheral neuropathy and other issues. Periodic screening for Vitamin B12 levels is advisable.
Weight Gain: Glimepiride, being a sulfonylurea, may cause weight gain in some patients, which is a concern for diabetes management. Patients should monitor their weight regularly and work with their healthcare provider on weight management strategies?

How To Manage Side Effects

Diarrhea

Diarrhea can cause dehydration, so drink plenty of fluids such as oral rehydration solutions (ORS), broth, and clear soups.
Follow the BRAT diet (bananas, rice, applesauce, and toast) which is gentle on the stomach.
Avoid dairy, high-fat, or spicy foods which could aggravate diarrhea.
Probiotics may help restore gut flora, especially after an episode caused by an infection or antibiotics.
Like stomach pain, diarrhea can be aggravated by stress and fatigue, so resting is essential.
If diarrhea persists for more than 48 hours, or if it's accompanied by fever, blood, or severe dehydration, contact a healthcare provider immediately.

Hypoglycemia

Taking Gemer 2 (which contains Glimepiride and Metformin) can lead to hypoglycemia (low blood sugar) because Glimepiride stimulates your body to produce more insulin. This can lower blood sugar too much, especially if you:

Skip meals or eat irregularly
Exercise without adjusting your medication or food intake
Drink alcohol on an empty stomach
Take certain other diabetes medications at the same time

How to Manage Hypoglycemia caused by Gemer 2 Tablet:

If you feel symptoms of low blood sugar, consume a fast-acting sugar source like Glucose tablets (15 grams), Fruit juice or regular soda (about 1/2 cup) and Honey or sugar (1 tablespoon)
After eating sugar, check your blood glucose to ensure it’s back to normal. After raising blood sugar, eat a snack with carbohydrates (like crackers) to stabilize your levels. Don’t skip meals.
In severe cases (e.g., unconsciousness), you may need an emergency glucagon injection or medical attention.

Stomach Pain

Antacids (e.g., Tums, Maalox) can relieve acid-related stomach pain or discomfort.
Drink warm water or herbal teas like ginger or chamomile tea to soothe the stomach lining and reduce inflammation.
Avoid caffeine, alcohol, and spicy foods that can irritate the stomach further.
Resting and lying down in a comfortable position can sometimes help relieve stomach pain, especially if caused by gas or indigestion.
Avoid heavy or greasy foods. Opt for light meals like bananas, applesauce, and plain rice (BRAT diet) to soothe the stomach.

GEMER 2 TABLET is not recommended for use in elderly patients (aged 75 years or above) and it should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may assess your kidney function more frequently during management with GEMER 2 TABLET.

Other Warnings for GEMER 2 TABLET

Before taking GEMER 2 TABLET inform your doctor if you:

are recovering from injury, operation, infections with fever, or from other forms of stress
have glucose-6-phosphate dehydrogenase (G6PD) deficiency
have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take [GBNKEYWORD

GEMER 2 TABLET is not recommended for use, if you have:

type 1 diabetes mellitus
diabetic ketoacidosis
uncontrolled diabetes or ketoacidosis
dehydration
severe infection

Diet and Lifestyle Advice

1. Foods to Avoid While Taking Gemer 2 Tablet:

Refined Sugars & Processed Carbs: Foods like sugary beverages, white bread, pastries, and candies can cause a spike in blood sugar levels. Avoid foods with a high glycemic index (GI) as they can interfere with Gemer 2’s effectiveness.
Fried & Fatty Foods: High-fat foods (fried foods, fatty cuts of meat, and fast food) can contribute to insulin resistance, making it harder for the medication to work efficiently.
Alcohol: Alcohol can lower blood sugar and increase the risk of hypoglycemia, especially when taking Gemer 2, due to the combination of Glimepiride and Metformin. It’s advisable to limit alcohol intake and monitor blood sugar levels?

2. Best Dietary Practices for Controlling Blood Sugar:

Balanced Meals: Focus on a diet rich in whole grains, lean proteins, and healthy fats. Include vegetables, legumes, nuts, and seeds in meals.
Fiber-Rich Foods: Foods such as leafy greens, oats, beans, and berries help regulate blood sugar levels and improve insulin sensitivity.
Portion Control: Eating smaller meals more frequently can help avoid drastic blood sugar fluctuations.
Low Glycemic Index Foods: Incorporate foods with a low glycemic index, such as non-starchy vegetables (spinach, kale), nuts, seeds, and whole grains, which help in maintaining stable blood sugar levels?

3. How Carbohydrate Intake Affects Diabetes Medication Effectiveness:

Carbohydrates directly affect blood glucose levels. Consuming too many carbs can overwhelm the body’s ability to regulate blood sugar, making it harder for Gemer 2 to control glucose levels.
Carb counting is an essential part of diabetes management. Diabetic patients are often advised to limit their intake of simple carbohydrates and focus on complex carbs (like whole grains, vegetables) that are absorbed more slowly, preventing sharp rises in blood sugar.
Balanced Carbohydrate Intake is essential to ensure Gemer 2 works effectively. Rapid spikes in blood sugar require more insulin to control, which could stress the body and lead to inefficient glucose management

4. Best Exercises for People with Diabetes:

Aerobic Exercise: Regular walking, cycling, swimming, and jogging can help improve blood sugar control by increasing insulin sensitivity.
Strength Training: Weight lifting and resistance exercises help build muscle mass, which can enhance glucose uptake and reduce insulin resistance.
Yoga & Pilates: These are beneficial for both physical health and stress management, as stress can raise blood sugar levels.

5. How Physical Activity Affects Blood Sugar and Medication Needs:

Exercise lowers blood glucose levels by increasing insulin sensitivity. It can reduce the need for insulin or other blood sugar-lowering medications in some cases.
Exercise helps maintain a healthy weight, which can lead to more stable blood sugar levels.
Adjustments to medication may be necessary if blood sugar levels drop too low during or after exercise, so it's crucial to monitor blood glucose levels and discuss exercise plans with a healthcare provider?

6. Can People with Diabetes Safely Do High-Intensity Workouts?

High-intensity workouts (HIIT) can be safe for people with diabetes if they are properly managed. However, it is important to consult a doctor beforehand, especially if blood sugar levels are not well-controlled.
HIIT has been shown to improve insulin sensitivity, muscle mass, and cardiovascular health, which are important for managing diabetes. However, these workouts can cause a drop in blood sugar, so it is important to monitor levels closely and adjust food or medication intake if needed?

Drug - Drug interaction

Does Gemer 2 interact with other diabetes medications?

Increased Risk of Hypoglycemia (Low Blood Sugar):

Sulfonylureas (like Glimepiride, present in Gemer 2) can interact with other antidiabetic medications, increasing the risk of hypoglycemia. Combinations with other oral antidiabetic agents (such as insulin or other sulfonylureas) can lead to more pronounced blood sugar drops.
Beta-blockers (e.g., Metoprolol) may mask symptoms of hypoglycemia (e.g., shaking, heart palpitations).

Increased Risk of Lactic Acidosis:

Metformin, one of the key components of Gemer 2, can interact with cimetidine, increasing its blood concentration, which may elevate the risk of lactic acidosis.
Diuretics (e.g., Furosemide) and certain anti-hypertensive medications can increase Metformin levels in the blood and may require close monitoring.

Reduced Effectiveness of Gemer 2:

Drugs like diuretics, corticosteroids, phenothiazines, and estrogens can increase blood glucose and may reduce the effectiveness of Gemer 2.
Thyroid products (e.g., levothyroxine) and oral contraceptives may also interfere with the blood glucose control achieved by Gemer 2.

Toxicity Risks:

Cationic drugs like Digoxin, Morphine, Quinidine, and Vancomycin can compete with Metformin for renal excretion, increasing the risk of side effects or toxicity?

Drug - Food interaction

Are there any food interactions with Gemer 2?

Alcohol: Alcohol intake can increase the risk of lactic acidosis when taking Metformin and may also lead to hypoglycemia. Drinking alcohol excessively can hinder the effectiveness of Gemer 2, leading to dangerous fluctuations in blood glucose levels?

Foods High in Sugar: Foods with a high glycemic index (such as sugary drinks, white bread, and processed snacks) can increase blood sugar levels rapidly, undermining the effectiveness of Gemer 2. It’s important to consume whole foods (whole grains, vegetables, legumes) and avoid refined sugars to maintain stable blood sugar.

Vitamin B12 Deficiency: Long-term use of Metformin (in Gemer 2) can interfere with the absorption of Vitamin B12, leading to deficiency. Foods high in B12, such as meat, dairy, and fortified cereals, can help mitigate this. Regular screening for vitamin levels is recommended?

Foods with Fiber: Fiber-rich foods such as vegetables, oats, beans, and whole grains help improve insulin sensitivity. They also help in slowing down the absorption of sugar from the intestines, which may help in blood glucose management?

Synopsis

Drug	:	Glimepiride, Metformin
Pharmacological Category	:	Sulfonylureas, Biguanides
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet

More Information

Differences between oral diabetes medications and insulin therapy:

Aspect	Oral Diabetes Medications	Insulin Therapy
Purpose	Helps manage blood sugar levels in people with type 2 diabetes.	Regulates blood sugar levels, especially in type 1 diabetes and type 2 diabetes if oral meds are insufficient.
Mechanism of Action	Varies by medication: improves insulin sensitivity, decreases glucose production, or stimulates insulin release (e.g., Metformin, Glimepiride).	Insulin is directly injected to replace or supplement the body's insulin.
Type of Treatment	Pills taken by mouth.	Injected via syringe or insulin pump, or inhaled (rapid-acting forms).
Administration	Taken orally, typically once or twice a day.	Typically injected multiple times daily, or via a continuous insulin pump.
Used For	Primarily for type 2 diabetes.	Used for type 1 diabetes and sometimes for type 2 diabetes when oral meds are ineffective.
Risk of Hypoglycemia	Generally lower risk of hypoglycemia (low blood sugar) compared to insulin. However, some medications like sulfonylureas can cause it.	Higher risk of hypoglycemia, especially with long-acting or rapid-acting insulin.
Flexibility with Meals	May require meal planning (e.g., sulfonylureas), but generally offers more flexibility than insulin.	Requires more precise timing with meals and snacks, as insulin doses are closely linked to carbohydrate intake.
Common Side Effects	Gastrointestinal issues, weight gain, hypoglycemia (with some), and Vitamin B12 deficiency (with Metformin).	Injection site reactions, weight gain, hypoglycemia, and potential long-term complications (e.g., lipohypertrophy).
Cost	Generally lower cost compared to insulin.	Insulin therapy can be expensive, especially without insurance coverage.
Monitoring	Blood sugar monitoring may be required, but typically less frequent than with insulin therapy.	Requires frequent blood sugar monitoring to adjust insulin doses based on readings and food intake.

Comparisons with similar medicines such as Glimestar M2, Glycomet GP2, Gluconorm G2, Amaryl M2 table

Brand Name	Active Ingredients	Mechanism of Action	Common Side Effects	Dosing Frequency	Usage
Glimestar M2	Metformin & Glimepiride	Metformin reduces glucose production by the liver. Glimepiride stimulates insulin release.	Hypoglycemia, Gastrointestinal issues, Weight gain	Usually once or twice daily with meals	Used to manage blood sugar in type 2 diabetes
Glycomet GP2	Metformin & Glimepiride	Similar to Glimestar M2. Works by reducing liver glucose production and increasing insulin release.	Gastrointestinal problems, Hypoglycemia, Weight gain	Typically once or twice daily with meals	Used for controlling blood sugar levels in type 2 diabetes
Gluconorm G2	Metformin & Glimepiride	Same mechanism as the others. Metformin reduces glucose absorption, while Glimepiride boosts insulin production.	Nausea, Vomiting, Hypoglycemia	Usually twice a day with meals	Used to control high blood sugar in type 2 diabetes
Amaryl M2	Metformin & Glimepiride	Metformin helps the body use insulin more effectively, while Glimepiride stimulates insulin secretion.	Hypoglycemia, Dizziness, Weight gain	Taken once or twice daily	Helps lower blood sugar in type 2 diabetes

Alternatives to GEMER 2 Tablet

Janumet (Sitagliptin + Metformin)
Amaryl M (Glimepiride + Metformin)
Voglibose

FAQs About GEMER 2 TABLET

Q: What are the Precautions for Elderly Patients Taking Gemer 2?

A: Kidney function: Elderly patients may have decreased kidney function, increasing the risk of lactic acidosis. Kidney function should be monitored. Hypoglycemia risk: Older adults are more susceptible to low blood sugar, especially when they skip meals or are more physically active. Regular blood sugar monitoring is advised

Q: Is Gemer 2 an Insulin Substitute?

A: No, Gemer 2 is not an insulin substitute. It helps manage blood sugar by combining Glimepiride (which stimulates insulin release) and Metformin (which improves insulin sensitivity). Insulin may still be required for some patients

Q: Can I Take Gemer 2 with Metformin or Insulin?

A: With Metformin: Since Gemer 2 already contains Metformin, you should not take additional Metformin without consulting your doctor to avoid an overdose. With Insulin: Gemer 2 can be taken with insulin, but there is an increased risk of hypoglycemia, so close blood sugar monitoring is needed

Q: Can Gemer 2 Be Taken with Blood Pressure Medications?

A: Yes, Gemer 2 can generally be taken with blood pressure medications. However, some medications like diuretics or beta-blockers may affect blood sugar control. It’s important to monitor blood sugar and kidney function regularly when combining these treatments

Q: Can I take GEMER 2 Tablet twice a day?

A:Only if prescribed by your doctor. Typically, it is taken once daily with food.

Q: Does GEMER 2 cause hypoglycemia?

A: Yes, if not taken with food or combined with other diabetes medications.

Q: Is it safe to drink alcohol while taking GEMER 2?

A: No, alcohol may increase the risk of lactic acidosis and hypoglycemia.

Q: What is the use of Gemer 2 Tablet?

A: GEMER 2 TABLET is used to manage type 2 diabetes mellitus in adults. This combination helps regulate blood sugar levels effectively in individuals whose blood sugar is not adequately controlled by diet, exercise, or a single diabetes medication. It helps reduce the risk of diabetes-related complications such as heart disease, nerve damage, or kidney issues.

Q: How does Gemer 2 work to control blood sugar?

A: GEMER 2 TABLET contains a combination of two medicines namely, glimepiride and metformin. Glimepiride stimulates the pancreas to release more insulin, a hormone that lowers blood sugar levels. It also improves the body’s response to insulin. Metformin decreases the amount of sugar produced by the liver and reduces sugar absorption in the intestines. It also enhances the body’s ability to use insulin more effectively, making it a comprehensive treatment for blood sugar control.

Q: What is the best time to take GEMER 2 TABLET?

A: It is usually recommended to take GEMER 2 TABLET with meals to minimize the risk of gastrointestinal side effects such as nausea or upset stomach. Following your doctor’s instructions regarding the timing is essential, as they might tailor the dose to suit your lifestyle and blood sugar patterns.

Q: How many doses of GEMER 2 TABLET can be taken in a day?

A: The dosage depends on the individual’s medical condition, blood sugar levels, and response to treatment. Typically, it is taken once or twice daily with meals, but the exact dose should be determined by a doctor. Taking more than the prescribed dose can lead to hypoglycemia (low blood sugar), so it’s crucial to stick to the recommended schedule.

Q: Can pregnant women take Gemer 2?

A: The combination of Glimepiride + Metformin is generally not recommended during pregnancy due to the potential risk of harming the unborn baby. Instead, insulin is preferred for controlling blood sugar levels in pregnant women with diabetes. If you are pregnant or planning to conceive, consult your doctor for a safe treatment plan.

Q: Can GEMER 2 TABLET control blood sugar levels?

A: Yes, this medicine is highly effective in controlling blood sugar levels in people with type 2 diabetes especially when diet, lifestyle changes and treatment with single agents does not yield optimum blood sugar control. However, its effectiveness also depends on maintaining a healthy lifestyle, including regular exercise and a balanced diet. Regular monitoring of blood sugar is essential to ensure the medication works optimally.

Q: Who should not use GEMER 2 TABLET?

A: GEMER 2 TABLET is not suitable for individuals with severe kidney or liver disease, type 1 diabetes or diabetic ketoacidosis, known allergies to glimepiride, metformin, or any other ingredients in the medicine, or a history of lactic acidosis. Therefore, always inform your doctor about any pre-existing conditions or medications you are taking to avoid adverse effects.

Q: What are the common side effects of GEMER 2 TABLET?

A: The most common side effects of GEMER 2 TABLET include nausea, vomiting, diarrhea, stomach pain, dizziness, or low blood sugar (hypoglycemia. Consult your doctor if any of these side effects worsens.

Q: Is GEMER 2 TABLET safe?

A: Yes, GEMER 2 TABLET is generally safe when taken as prescribed. However, regular monitoring of kidney and liver function is necessary, as prolonged use can affect these organs. Additionally, following the recommended dose and schedule minimizes the risk of side effects.

Q: Can GEMER 2 TABLET be taken on an empty stomach or before food?

A: No, it is best taken with food to reduce the risk of stomach upset and hypoglycemia. Food helps slow down the absorption of glimepiride, preventing a sudden drop in blood sugar levels, which can cause dizziness or weakness.

Q: Is Gemer 2 safe for people with kidney disease?

A: GEMER 2 TABLET is not suitable for individuals with severe kidney disease, as it can increase the risk of lactic acidosis, a potentially life-threatening condition. Mild to moderate kidney impairment requires dose adjustment and close monitoring. Always consult your doctor before starting or continuing this medication.

Q: How long will it take for GEMER 2 TABLET to control blood sugar levels?

A: GEMER 2 TABLET begins to lower blood sugar within a few hours of taking a dose. However, achieving optimal blood sugar control may take a few weeks, depending on individual response and adherence to the prescribed regimen, diet, and exercise plan.

Q: Can I stop taking Gemer 2 suddenly?

A: No, stopping the medication without your doctor’s advice can cause your blood sugar levels to rise again, leading to complications. Diabetes is a chronic condition requiring ongoing management. Your doctor may adjust the dose or switch medications based on your progress, but self-discontinuation is not recommended.

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on March 4th 2025]

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on March 4th 2025]

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on March 4th 2025]

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on March 4th 2025]

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Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 18 Mar 2025 | 04:19 PM(IST)

Lab updated