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Introduction About ETOSPAZ MR 4 TABLET
ETOSPAZ MR 4 TABLET is a combination of Etoricoxib and Thiocolchicoside which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs (NSAID) and Muscle relaxants. It is used to reduce pain and swelling in the joints and muscles in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout and muscle spasm. This medicine is also used for the short-term management after dental surgery for moderate pain. Muscle spasm is the rapid spontaneous contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses are damaged or interrupted that control muscle movement, it could lead to muscle spasms. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty in moving and pain in affected muscles and joints.
ETOSPAZ MR 4 TABLET is not recommended for use in patients having inflammatory bowel disease, severe congestive heart failure, peptic ulcer or cerebrovascular disease. Consult your doctor for advice. Before taking ETOSPAZ MR 4 TABLET, inform your doctor if you have blood disorders, kidney problems, liver problems or heart problems.
ETOSPAZ MR 4 TABLET is not recommended to use among pregnant and breastfeeding women. The most common side effects of this medicine are stomach pain, dry socket, edema, dizziness, headache, palpitations, arrhythmia, constipation, diarrhea, indigestion, gastritis, nausea and vomiting. Consult your doctor if the above side effects worsens or persist for a longer duration.
Uses Of ETOSPAZ MR 4 TABLET
- Used to reduce pain, swelling in the joints and muscles in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout and muscle spasm
How ETOSPAZ MR 4 TABLET Works
ETOSPAZ MR 4 TABLET reduces pain and swelling in the joints and muscles, whereas Etoricoxib works by blocking the release of certain chemical messengers that cause pain and inflammation and Thiocolchicoside works on the centers in the brain and spinal cord to relieve muscle stiffness or spasm and improves pain and movement of muscles.
How to use ETOSPAZ MR 4 TABLET
ETOSPAZ MR 4 TABLET reduces pain and swelling in the joints and muscles, whereas Etoricoxib works by blocking the release of certain chemical messengers that cause pain and inflammation and Thiocolchicoside works on the centers in the brain and spinal cord to relieve muscle stiffness or spasm and improves pain and movement of muscles.
Side Effects Of ETOSPAZ MR 4 TABLET
Common
- stomach pain
- dry socket
- edema
- dizziness
- headache
- palpitations
- uneven heart rhythm (arrhythmia)
- increase in blood pressure
- wheezing or shortness of breath
- constipation
- gastritis
- flatulence
- diarrhea
- heartburn
- indigestion
- nausea
- vomiting
- inflammation of the esophagus
- mouth ulcers
- changes in blood tests
- bruising
- weakness and fatigue, flu-like illness
- drowsiness
Uncommon
- anorexia
- unusual dark urine
- itching
- fever
- fatigue
Rare
- confusion
- restlessness
- liver problems
- low blood levels of sodium
- liver failure
- severe skin reactions
- urticaria
Stop taking ETOSPAZ MR 4 TABLET and contact your doctor immediately if you experience the following side effects:
- shortness of breath, chest pain, ankle swelling
- yellowing of the skin and eyes
- severe or continual stomach pain or stools become black
- allergic reaction (symptoms include ulcers or blistering, swelling of the face, lips, tongue or throat which may cause difficulty in breathing)
How To Manage Side Effects
Constipation
Eat plenty of fiber-rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly.
Diarrhea
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Loss Of Appetite
Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack that is rich in calories and protein, such as dried fruit and nuts.
Nausea And Vomiting
Take this medicine with or just after meals. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor for advice if you experience nausea for a long time.
Stomach Pain
Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.
Warning & Precautions
Pregnancy
ContraindicatedETOSPAZ MR 4 TABLET is not recommended for use in pregnant women. Consult your doctor for advice.
Breastfeeding
ContraindicatedETOSPAZ MR 4 TABLET is not recommended for use in breastfeeding women. Consult your doctor for advice.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you experience dizziness or sleepiness. Consult your doctor for advice.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking this medicine because it can aggravate your existing condition.
Kidney
ContraindicatedETOSPAZ MR 4 TABLET is not recommended for use in patients having severe kidney disease. Consult your doctor for advice.
Liver
ContraindicatedETOSPAZ MR 4 TABLET is not recommended for use in patients having severe liver problems. Consult your doctor for advice.
Allergy
ContraindicatedDo not take ETOSPAZ MR 4 TABLET if you are allergic to Etoricoxib, Thiocolchicoside or to any of the other ingredients of this medicine.
Heart Disease
Consult your doctorETOSPAZ MR 4 TABLET is not recommended for use if you have or had high blood pressure that has not been controlled by management, heart problems (heart failure), angina (chest pain), heart attack or bypass surgery. It should be used with caution if you have any mild to moderate heart problems. Consult your doctor for advice.
Use In Pediatrics
ContraindicatedETOSPAZ MR 4 TABLET is not recommended for use in children and adolescents (below 16 years of age). Consult your doctor before taking the medicine.
Use In Geriatrics
Use with CautionETOSPAZ MR 4 TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking it.
Others
ETOSPAZ MR 4 TABLET is not recommended for use if you:
- have stomach ulcer or bleeding in the stomach or intestines
- have Crohn’s disease, Ulcerative colitis, or Colitis (inflammatory bowel disease)
- have any kind of stroke, and muscles problems
- have peripheral arterial disease
Tell your physician before taking this medicine if you:
- had dehydration (a prolonged bout of vomiting or diarrhea)
- had swelling due to fluid retention
- have being managed for an infection
- have high cholesterol, diabetes
- are a smoker
- have epilepsy
Interactions
A. Drug-Drug interactions:
Inform your physician, if you are taking:
- medicines used to thin blood (Ex. warfarin)
- medicines used to manage infections (Ex. rifampicin)
- medicine used for suppressing the immune system, and often used in rheumatoid arthritis (Ex. methotrexate, ciclosporin, or tacrolimus)
- medicine used to manage depression (Ex. lithium)
- medicines used to control high blood pressure and heart failure (Ex. enalapril, ramipril, losartan, valsartan)
- medicine used as diuretics
- medicine used to manage heart failure and irregular heart rhythm (Ex. digoxin)
- medicine used to manage asthma (Ex. salbutamol)
- birth control pills
- hormone replacement therapy
- medicine used to relieve pain and reduce the risk of serious problems like heart attacks and strokes (Ex. aspirin)
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately.
Synopsis
| Drug | : | Etoricoxib, Thiocolchicoside |
| Pharmacological Category | : | Non-steroidal anti-inflammatory drugs (NSAID), Muscle relaxants |
| Therapeutic Indication | : | Manages inflammatory musculoskeletal disorders associated with painful muscle spasm |
| Dosage Forms | : | Tablet, Capsule, Soft Gel Capsules |
More Information
Storage
- Keep out of reach of children
- Store at room temperature
FAQs About ETOSPAZ MR 4 TABLET
Q: Does ETOSPAZ MR 4 TABLET cause any dizziness?
A: Yes. This medicine can cause dizziness in some people. Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Avoid consumption of alcohol as it can aggravate your dizziness. If the symptom persists for a longer time, contact your doctor for advice.
Q: What precaution to be taken if I miss a dose of ETOSPAZ MR 4 TABLET?
A: If a dose of ETOSPAZ MR 4 TABLET is missed, then take the next dose at the usual time. Do not take a double dose to make up for a forgotten missed dose.
Q: Can I stop ETOSPAZ MR 4 TABLET if I feel well?
A: Do not stop taking ETOSPAZ MR 4 TABLET without consulting with your doctor, even if you feel better. Stopping may worsen the condition.
Q: How to take ETOSPAZ MR 4 TABLET?
A: Take ETOSPAZ MR 4 TABLET as advised by your doctor. Swallow the medicine as a whole and do not crush or chew the medicine.
Q: Is it safe to use ETOSPAZ MR 4 TABLET during pregnancy?
A: ETOSPAZ MR 4 TABLET is generally not recommended to use in pregnant women. Consult your doctor before taking it.
References
1. Tilo Grosser, Emer M. Smyth, and Garret A. FitzGerald. Pharmacotherapy of Inflammation, Fever, Pain, and Gout. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page-687-709.
2. Priyanka S, Manju J and Girish K. A Comparative Study of Efficacy and Tolerability of Fixed-Dose Combination of Etoricoxib and Thiocolchicoside versus Thiocolchicoside alone in Patients with Painful Muscle Spasms. Biomedical and Pharmacology Journal. February 2022. [Accessed on 1st June 2022] https://biomedpharmajournal.org/vol15no1/a-comparative-study-of-efficacy-and-tolerability-of-fixed-dose-combination-of-etoricoxib-and-thiocolchicoside-versus-thiocolchicoside-alone-in-patients-with-painful-muscle-spasms/
3. Dam Kim1, Soo-Kyung Cho, Seoung Wan Nam, Hyuk Hee Kwon, Sun-Young Jung, Chan Hong Jeon, Seul Gi Im, Dalho Kim, Eun Jin Jang, Yoon-Kyoung Sung. Cardiovascular and Gastrointestinal Effects of Etoricoxib in the Treatment of Osteoarthritis: A Systematic Review and Network Meta-analysis. Journal of Rheum. October 2017. [Accessed on 1st June 2022] https://synapse.koreamed.org/articles/1064345
4. DM Pharma. Etoricoxib, Thiocolchicoside Tablet. [Accessed on 1st June 2022] http://www.dmpharma.co.in/Etoricoxibthiocolchicoside.html
5. Mylan UK Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised on September 2020] [Accessed on 1st June 2022] https://www.medicines.org.uk/emc/files/pil.8537.pdf
6. European Medicinal Agency. November 2013. [Accessed on 1st June 2022] https://www.ema.europa.eu/en/documents/referral/thiocolchicoside-article-31-referral-annex-iii_en.pdf
7. Taj Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Accessed on 1st June 2022] http://pro.tajpharma.com/pdf/thiocolchicoside-capsules-pil-taj-pharmaceuticals.pdf
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