ENRIFOL H Tablet 28's
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Introduction About ENRIFOL H TABLET
ENRIFOL H TABLET is used in postmenopausal women (with at least 6 months since their last natural period) to manage symptoms that occur after menopause, like hot face, neck, and chest (hot flushes) and osteoporosis (weak bones). It contains Estradiol hemihydrate, which belongs to the group of medicines called Estrogens that helps maintain an adequate level of circulating hormones, thus providing relief from hot flushes and weak bones.
Before you start using ENRIFOL H TABLET, your doctor will ask about your own and your family’s medical history. Your doctor may decide to perform a physical examination (examination of your breasts and/or an internal examination) if necessary.
ENRIFOL H TABLET is not recommended for use in patients allergic to Estradiol or if you have or have had liver disease and the liver function tests have not returned to normal or have lung disease such as pulmonary embolism (blood clots in the lungs), heart disease such as a heart attack, or angina. It is also not recommended for use in patients who have or have suspected breast or endometrial tumour or thrombosis (blood clots in the vein), unusual vaginal bleeding, or unmanageed endometrial hyperplasia (excessive thickening of the womb lining).
Before taking ENRIFOL H TABLET, inform your doctor if you have liver disease (such as a benign liver tumour), lung problems such as asthma, or have high blood pressure, fibroids (non-cancerous growths inside the womb), endometriosis (growth of the womb lining outside the womb) or endometrial hyperplasia (excessive growth of the womb lining), and/or suffer from epilepsy, otosclerosis (disease that affects the eardrum and hearing), and kidney problems.
ENRIFOL H TABLET is not recommended for use in pregnant and breast-feeding women since it is intended to be used only in postmenopausal women. The medicine is also not recommended for use in children and adolescents since it is indicated for use only in postmenopausal women.
The common side effects of taking ENRIFOL H TABLET are headache, nausea, cramps in the legs, abdominal or pelvic pain, unscheduled bleeding or spotting, wind, asthenia (a feeling of weakness), changes in weight, and/or rash or itching. Consult your doctor if any of these symptoms worsen.
Uses Of ENRIFOL H TABLET
- Manages symptoms that occur after menopause in postmenopausal women, like hot faces, neck, and chest (hot flushes)
- Manages osteoporosis in post-menopausal women
How ENRIFOL H TABLET Works
ENRIFOL H TABLET contains precursors of ovarian hormones (responsible for menstruation and reproduction in women), which replace the natural estrogen hormone in the body and help maintain an adequate level of circulating hormones, thus providing relief from vasomotor symptoms (such as hot flashes) in post-menopausal women. It also inhibits bone resorption and helps manage osteoporosis.
How to use ENRIFOL H TABLET
Take ENRIFOL H TABLET as advised by your physician. Swallow the medicine with a glass of water, with or without food. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition. Do not stop taking this medicine without consulting your doctor.
Side Effects Of ENRIFOL H TABLET
Common
- Headache
- Nausea
- Cramps in the legs
- Abdominal/pelvic pain
- Unscheduled bleeding/spotting
- wind
- Asthenia (a feeling of weakness)
- Changes in weight
- Rash/itching
Uncommon
- Signs of hypersensitivity (allergic) reactions such as skin rash, itch, and/or skin redness
- Hives
- Painful red nodules of skin (erythema nodosum)
- Feeling down
- Vaginal thrush (a fungal infection in the vagina caused by Candida albicans)
- Peripheral oedema (swelling of the ankles, feet, or fingers)
- Oedema (water retention)
- Varicose veins (twisted or enlarged veins)
- Gall bladder disorder
- Back pain
- Indigestion
- Nervousness
- Dizziness
- Problems with sight
- Fast heartbeats
- Breast pain/tenderness
Rare
- Intolerance to contact lenses
- Pre-menstrual tension (PMT)
- Feeling anxious
- Migraine
- Vomiting
- Bloating
- Excessive hair growth
- Acne
- Muscle cramps
- Vaginal discharge
- Tiredness
- Swelling of the breasts
- Change in sex drive
Stop taking ENRIFOL H TABLET and consult your doctor immediately if you experience any of the following:
- Signs of blood clots, such as painful swelling and redness of the legs, sudden chest pain, and/or difficulty breathing
- Signs of liver disease, such as yellowing of the skin or whites of the eyes (jaundice),
- Signs of angioedema, such as hives, a swollen face, tongue, or throat, difficulty swallowing, and/or difficulty breathing
- Signs of high blood pressure, such as headaches, tiredness, and/or dizziness
- Migraine-like headaches (happening for the first time)
- Heart attack
- Heavy, irregular, or painful bleeds
How To Manage Side Effects
Headache
If ENRIFOL H TABLET causes headaches, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking ENRIFOL H TABLET. If it lasts more than a week or becomes severe, then consult and inform your doctor.
Indigestion
Try to have smaller and more frequent meals and drink slowly. Reduce your consumption of coffee, cola, tea, or alcohol, and lose weight if you are obese. Try to avoid smoking, and don’t eat rich, fatty, or spicy foods. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Take ENRIFOL H TABLET with or just after a meal. Stick to simple meals. Avoid eating oil-rich or spicy foods, sugary snacks, and drinks. Avoid drinking too much liquid along with your meals, and drink slowly in between meals. Consult your doctor if the condition worsens.
Skin rash Or Itching
Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Consult and inform your doctor if the symptom gets worse.Try to pat or tap your skin instead of scratching it. Hold a damp towel to cool your skin. Wear loose clothing and avoid tight clothes or clothes made from wool or synthetic fabrics. Avoid using perfumed soaps, deodorants, or moisturizers, and use a skin softener regularly.
Tiredness
Make sure you take a rest and drink plenty of fluids. Avoid or limit the consumption of alcohol. Try to take one ENRIFOL H TABLET at a time and sit down (or lie down) when the symptoms are at their worst. Avoid driving or using tools or machinery until you feel well.
Warning & Precautions
Pregnancy
ContraindicatedENRIFOL H TABLET is not recommended for use during pregnancy. It is used in peri- and postmenopausal women only. Stop taking ENRIFOL H TABLET if you become pregnant and contact your doctor.
Breastfeeding
ContraindicatedENRIFOL H TABLET is not recommended for use in breastfeeding women, as it is intended to be used only in postmenopausal women. Consult your doctor before taking ENRIFOL H TABLET.
Kidney
Use with CautionENRIFOL H TABLET should be used with caution in patients with kidney problems. Consult your doctor before taking ENRIFOL H TABLET.
Liver
Consult your doctorENRIFOL H TABLET is not recommended for use if you have or have had liver disease and the liver function tests have not returned to normal. It should be used with caution in patients with liver disease (such as a benign liver tumour). Consult your doctor before taking ENRIFOL H TABLET.
Allergy
ContraindicatedDo not take ENRIFOL H TABLET if you are allergic to Estradiol, and/or any other ingredients in this medicine.
Lungs
Consult your doctorENRIFOL H TABLET is not recommended for use in patients with lung disease such as pulmonary embolism (blood clots in the lungs). It should be used with caution in patients with other lung problems, such as asthma. Consult your doctor before taking ENRIFOL H TABLET.
Heart Disease
Consult your doctorENRIFOL H TABLET is not recommended for use in patients with heart disease such as heart attack or angina. Inform your doctor if you have high blood pressure before taking the medicine.
Use In Pediatrics
ContraindicatedENRIFOL H TABLET is not recommended for use in children since it is intended to be used only in postmenopausal women.
Use In Geriatrics
Consult your doctorThere is no information on the use of ENRIFOL H TABLET on elderly women (aged 65 years and older). Consult your doctor before taking ENRIFOL TABLET.
Others
ENRIFOL H TABLET is not recommended for use if you:
- Have, had, or suspected breast cancer
- Have or suspect endometrium cancer
- Have unusual vaginal bleeding
- Suffer from unmanageed endometrial hyperplasia (excessive thickening of the womb lining)
- Have or have had thrombosis (blood clots in a vein), such as in the legs (deep venous thrombosis) or the lungs (pulmonary embolism)
- Have a blood clotting disorder (such as protein C, protein S, or antithrombin deficiency)
- Have recently had blood clots in the arteries, such as stroke
- Suffer from porphyria (a rare inherited blood disorder)
Before taking ENRIFOL H TABLET, inform your doctor if you:
- Have fibroids (non-cancerous growths) inside womb
- Suffer from endometriosis (growth of the womb lining outside the womb) or have a history of endometrial hyperplasia (excessive growth of the womb lining)
- Have an increased risk of developing blood clots
- Have an increased risk of developing estrogen-sensitive cancer, such as a mother, sister, or grandmother who has or has had breast cancer
- Suffer from diabetes, gallstones, migraines, or severe headaches
- Suffer from systemic lupus erythematosus (a disease of the immune system that affects many organs of the body)
- Suffer from epilepsy
- Suffer from otosclerosis (a disease affecting the eardrum and hearing)
- Have a very high level of fat in your blood (triglycerides)
- Have hereditary and acquired angioedema
- have had your womb removed (a hysterectomy)
- Are scheduled for any surgery
- Are planning to have a lab test
- Have intolerance to sugars
Interactions
A. Drug-Drug Interactions:
- Anticoagulants (Ex. warfarin)
- Antiepileptic (Ex. phenobarbital, phenytoin, carbamazepine, lamotrigine)
- Anti tubercular agents (Ex. rifampicin, rifabutin)
- Anti-retroviral medicines (Ex. nevirapine, efavirenz, ritonavir, and nelfinavir)
- Anti-depressants (St. John’s Wort)
- Anti-hepatitis (Ex. ombitasvir, paritaprevir, ritonavir, and dasabuvir)
- Immunosuppressive agents (Ex. tacrolimus, cyclosporin)
- Analgesics (Ex. fentanyl)
- Xanthine’s (Ex. theophylline)
Overdosage:
If you or anyone else accidentally takes too much of ENRIFOL TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose may include nausea, vomiting, sleepiness, dizziness, and/or withdrawal bleeding.
Synopsis
| Drug | : | Estradiol |
| Pharmacological Category | : | Estrogens |
| Therapeutic Indication | : | Provides relief from symptoms after menopause |
| Dosage Forms | : | Tablet, Cream, Gel, Transdermal Patch |
More Information
Storage
- Keep ENRIFOL TABLET out of reach of children
- Store ENRIFOL TABLET at room temperature
FAQs About ENRIFOL H TABLET
Q: What is ENRIFOL TABLET used for?
A: ENRIFOL TABLET is used in postmenopausal women (with at least 6 months since their last natural period) to provide relief from symptoms that occur after menopause. It is also used to manage osteoporosis (a condition marked by weak and fragile bones), which occurs after menopause in a few women.
Q: What are the side effects of taking ENRIFOL TABLET?
A: The most common side effects of taking ENRIFOL TABLET are headache, nausea, cramps in the legs, abdominal or pelvic pain, unscheduled bleeding or spotting, wind, asthenia (a feeling of weakness), changes in weight, and/or rash or itching. Consult your doctor if any of these symptoms worsen.
Q: How is ENRIFOL TABLET taken?
A: Take ENRIFOL TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Q: What happens if ENRIFOL TABLET is taken more than its required dosage?
A: If you or anyone else accidentally takes too much of ENRIFOL TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose may include nausea, vomiting, sleepiness, dizziness, and/or withdrawal bleeding.
Q: How does ENRIFOL TABLET work?
A: ENRIFOL H TABLET contains precursors of ovarian hormones (responsible for menstruation and reproduction in women), which replace the natural estrogen hormone in the body and help maintain an adequate level of circulating hormones, thus providing relief from vasomotor symptoms (such as hot flashes) in post-menopausal women. It also inhibits bone resorption and helps manage osteoporosis.
Q: How quickly does ENRIFOL TABLET work to relieve menopausal symptoms?
A: The onset of symptom relief can vary from person to person. Some women may experience improvement in symptoms like hot flashes and vaginal dryness within a few weeks of starting ENRIFOL TABLET therapy. However, it may take several weeks to months for the full benefits to be realized. Your healthcare provider can give you a better idea of what to expect based on your individual circumstances.
Q: What should I do if I miss a dose of ENRIFOL TABLET?
A: If you miss a dose of ENRIFOL TABLET, take it as soon as you remember, unless it's almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. Bleeding or spotting may occur if you miss a dose.
Q: Can ENRIFOL TABLET be used for birth control?
A: No, ENRIFOL TABLET are not designed or approved for use as a method of birth control. They do not contain progesterone, which is necessary for contraceptive purposes. If you're looking for birth control options, speak to your healthcare provider about appropriate methods such as combination birth control pills, contraceptive patches, intrauterine devices (IUDs), or other forms of contraception.
Q: Can I undergo surgery while using ENRIFOL H TABLET?
A: If you are going to have surgery, tell the doctor that you are taking ENRIFOL H TABLET. You may need to stop taking ENRIFOL H TABLET about 4 to 6 weeks before the operation to reduce the risk of a blood clot. Consult your doctor when you can start taking ENRIFOL H TABLET.
Q: Are there any lifestyle changes I should make while taking ENRIFOL TABLET?
A: While taking ENRIFOL TABLET, it's beneficial to maintain a healthy lifestyle that includes a balanced diet, regular exercise, adequate sleep, and stress management. These lifestyle factors can contribute to overall well-being and may complement the effects of hormone replacement therapy. Avoiding smoking and excessive alcohol consumption is also recommended for general health and to minimize certain risks associated with hormone therapy.
Q: What are the long-term risks associated with ENRIFOL TABLET therapy?
A: Long-term use of ENRIFOL TABLET, especially at higher doses or for extended periods, may be associated with increased risks of certain conditions such as breast cancer, heart disease, stroke, and blood clots. However, the actual risks can vary based on factors such as age, health status, family history, and the specific regimen of hormone therapy. Your healthcare provider will assess these factors and monitor your health closely while you're on management.
Q: Can ENRIFOL TABLET cause weight gain?
A: Weight changes, including weight gain, are possible side effects of ENRIFOL TABLET therapy. However, not everyone experiences this side effect, and the degree of weight change can vary widely among individuals. Factors such as diet, exercise, hormonal changes, and metabolism can influence weight while taking hormone replacement therapy. If you're concerned about weight changes, discuss them with your healthcare provider for guidance and support.
Q: Does ENRIFOL TABLET cause bleeding?
A: Yes, ENRIFOL TABLET may cause some irregular bleeding or light bleeding (spotting) during the first few months of usage. If the bleeding is troublesome or continues beyond the first few months of management, you should discuss this with your doctor.
Q: How should I buy ENRIFOL H TABLET from an online pharmacy?
A: If you wish to buy a ENRIFOL H TABLET on Netmeds, you need a prescription from a Registered Medical Practitioner. Netmeds has made buying online medicines more easy for consumers and is one of India's leading Online Pharmacy.
References
1. K.D. Tripathi. Estrogens, Progestins and Contraceptives. Essentials of Medical Pharmacology. seventh edition. 2013. Page – 306.
2. Nosek, M., Kennedy, H.P. and Gudmundsdottir, M. Distress during the menopause transition: a rich contextual analysis of midlife women’s narratives. Sage Open. 2012. [Accessed on 12th April 2024] https://journals.sagepub.com/doi/pdf/10.1177/2158244012455178#:~:text=The%20women%20reported%20a%20range,%3B%20see%20also%20Table%201)
3. Estradiol. NIH National Library of Medicine. National center for biotechnology information. PubChem. July 2022. [Accessed on 12th April 2024] https://pubchem.ncbi.nlm.nih.gov/compound/Estradiol
4. Cipla Ltd. Estova Tablet. [Revised in February 2021] [Accessed on 12th April 2024] https://www.ciplamed.com/product-index/estova-tablets
5. TTK Healthcare Limited. Primiwal Tablet. [Revised in February 2021] [Accessed on 12th April 2024] https://ttkhealthcare.com/ethical-products/
6. Abbott Biologicals BV. Electronic Medicines Compendium (EMC) [Revised in September 2023] [Accessed on 12th April 2024] https://www.medicines.org.uk/emc/files/pil.1174.pdf
7. Drug bank. Estradiol. [Accessed on 12th April 2024].https://go.drugbank.com/drugs/DB00783
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