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Introduction About EMVOID I.V INJECTION
EMVOID I.V INJECTION contains Fosaprepitant which belongs to the group of medicines called Antiemetics. It is used to manage nausea and vomiting caused due to chemotherapy. It is mostly used in combination with other medicines and when the management with cancer medicines has a strong or moderate potential to trigger nausea and vomiting.
EMVOID I.V INJECTION should be used under careful medical supervision. It is suitable for use in adults, adolescents and in children (aged 6 months or older).
Before receiving EMVOID I.V INJECTION, inform your doctor if you are allergic to aprepitant or fosaprepitant or have any liver problems. It should not be used in pregnant or breastfeeding women unless considered necessary by the physician.
Women of childbearing age must consult their doctor for a suitable birth control method to avoid pregnancy while undergoing therapy with this medicine. The most common side effect of receiving EMVOID I.V INJECTION are constipation, indigestion, headache, tiredness, loss of appetite, hiccups and pain, redness, swelling or inflammation at the site of injection. Consult your doctor if any of these side effect worsens.
Uses Of EMVOID I.V INJECTION
- Manage nausea and vomiting caused due to chemotherapy
How EMVOID I.V INJECTION Works
EMVOID I.V INJECTION is an antiemetic medicine. It works by blocking the transmission of nerve signals between the vomiting centres and the brain. This controls the onset of vomiting among patients who undergo chemotherapy.
How to use EMVOID I.V INJECTION
EMVOID I.V INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of EMVOID I.V INJECTION
Common
- constipation, indigestion
- headache, tiredness
- loss of appetite
- hiccups
- liver problems
Uncommon
- dizziness, sleepiness
- acne, skin rash, skin redness, hot flushes
- anxiety
- burping, nausea, vomiting
- heartburn, stomach pain, dry mouth, flatulence
- pain or burning sensation while passing urine
- weakness
- faster or irregular heartbeats
- high blood pressure
- fever with increased risk of infection
- low RBC count in blood
- injection site reactions (pain, redness, itching and inflammation)
Rare
- difficulty in thinking
- taste disturbance
- skin sensitivity, excessive sweating, sores on skin
- euphoria (feeling of extreme happiness), disorientation
- bacterial infection, fungal infection
- stomach ulcer, inflammation of the small intestine and colon, oral sores, bloating
- increased or frequent urination
- presence of sugar or blood in urine
- cough with mucus, throat irritation
- sneezing, excessive thirst
- eye discharge and itching, ringing in the ear
- muscle spasms
- slow heartbeat
- low WBC in blood
- low blood sodium levels
- weight loss
Contact your doctor immediately if you experience any of the following side effects after receiving EMVOID I.V INJECTION:
- severe allergic reaction (such as skin rash, itching, swelling of the face, eyes, lips, tongue, throat, difficulty in breathing, low blood pressure)
- severe pain, swelling, redness, burning or blistering, necrosis at the site of injection
How To Manage Side Effects
Constipation
Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Injection Site Reactions
Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor.
Warning & Precautions
Pregnancy
Monitoring requiredEMVOID I.V INJECTION should not be used in pregnant women unless considered necessary by the physician. Therefore, inform your doctor if you are pregnant or think you may be pregnant before receiving EMVOID I.V INJECTION. Women of childbearing age must consult their doctor for a suitable birth control method to avoid pregnancy while undergoing therapy with this medicine.
Breastfeeding
ContraindicatedIt is not whether EMVOID I.V INJECTION is excreted through breast milk. Therefore, it is not recommended for use in breastfeeding women. Consult your doctor for advice.
Driving and Using Machines
Use with CautionEMVOID I.V INJECTION may cause dizziness and sleepiness. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by this medicine.
Alcohol
Consult your doctorAvoid consumption of alcohol before receiving EMVOID I.V INJECTION.
Liver
Use with CautionEMVOID I.V INJECTION should be used with caution in patients with liver problems. Therefore, inform your doctor before receiving it.
Allergy
ContraindicatedInform your doctor before receiving EMVOID I.V INJECTION if you are allergic to Fosaprepitant or aprepitant.
Use In Pediatrics
Consult your doctorEMVOID I.V INJECTION should be used with caution in children and adolescents (aged 6 months or older). It is not recommended for use in babies aged below 6 months and in babies with body weight less than 6 kg due to lack of safety data. Therefore, consult your doctor before administration.
Use In Geriatrics
Use with CautionEMVOID I.V INJECTION should be used with caution in elderly patients. Therefore, consult your doctor before receiving it.
Interactions
A. Drug-Drug interactions:
Before receiving EMVOID I.V INJECTION, inform your doctor if you are taking any of the following medicines:
- pimozide (a medicine used to manage psychiatric conditions)
- medicines used to manage hay fever (such as terfenadine and astemizole)
- cisapride (a medicine used to manage digestive problems)
- certain birth control pills and intrauterine devices may not work adequately, therefore, consult your doctor
- medicines used to suppress immune function (such as ciclosporin, tacrolimus, sirolimus, everolimus)
- medicines used for pain management (such as alfentanil, fentanyl)
- quinidine (used to manage an irregular heartbeat)
- medicines used to manage cancer (such as irinotecan, etoposide, vinorelbine, ifosfamide)
- ergot alkaloid derivatives (used for migraine headache) such as ergotamine and diergotamine
- medicines used for blood thinning (such as warfarin, acenocoumarol)
- medicines used to manage bacterial infections (such as rifampicin, clarithromycin, telithromycin)
- medicines used to manage epilepsy (such as phenytoin, carbamazepine)
- medicines used to induce calmness and sleep (Ex. alprazolam, midazolam, triazolam, phenobarbital)
- St. John’s Wort (an herbal preparation used to manage depression)
- medicines used to manage HIV infections (such as ritonavir, nelfinavir etc.)
- medicines used to manage fungal infection (such as itraconazole, voriconazole, Posaconazole, ketoconazole (except shampoo))
- nefazodone (a medicine used to manage depression)
- diltiazem (a medicine used to manage high blood pressure)
- corticosteroids (such as dexamethasone) used to manage autoimmune conditions
- tolbutamide (a medicine used to manage diabetes)
Overdosage:
EMVOID I.V INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, contact your doctor if you experience any unusual side effects.
Synopsis
| Drug | : | Fosaprepitant |
| Pharmacological Category | : | NK1 Receptor Antagonists |
| Therapeutic Indication | : | Chemotherapy induced emesis |
| Dosage Forms | : | Injection |
More Information
- Keep EMVOID I.V INJECTION out of reach of children
- Store EMVOID I.V INJECTION in a refrigerator between 2-8°C
FAQs About EMVOID I.V INJECTION
Q: Is EMVOID I.V INJECTION a chemo drug?
A: No. EMVOID I.V INJECTION is an antiemetic medicine used to manage nausea and vomiting caused due to chemotherapy.
Q: What class does EMVOID I.V INJECTION belongs to?
A: EMVOID I.V INJECTION belongs to NK1 receptor antagonists which works by blocking the transmission of nerve signals between brain and vomiting centers, thereby reducing vomiting caused by chemotherapy.
Q: Is foraprepitant same as aprepitant?
A: Fosaprepitant is a prodrug of aprepitant. Following administration, fosaprepitant gets converted into the body as aprepitant and exerts its effects.
Q: How long does it take for EMVOID I.V INJECTION to start working?
A: It may take around 2 days for EMVOID I.V INJECTION to exert its effects. However, this time period may vary from person-to-person based on the dose administered by the doctor.
Q: What are the common side effects of EMVOID I.V INJECTION?
A: The most common side effects of receiving EMVOID I.V INJECTION are constipation, indigestion, headache, tiredness, loss of appetite, hiccups and pain, redness, swelling or inflammation at the site of injection. Consult your doctor if any of these side effect worsens.
Q: What is the use of EMVOID I.V INJECTION?
A: EMVOID I.V INJECTION is used to manage nausea and vomiting caused due to chemotherapy. It is mostly used in combination with other medicines and when the management with cancer medicines has a strong or moderate potential to trigger nausea and vomiting.
Q: How EMVOID I.V INJECTION controls vomiting?
A: EMVOID I.V INJECTION works by blocking the transmission of nerve signals between the vomiting centres and the brain. This controls the onset of vomiting among patients who undergo chemotherapy.
Q: Can EMVOID I.V INJECTION be used to manage vomiting due to motion sickness?
A: No. EMVOID I.V INJECTION should only be used to manage nausea and vomiting caused due to chemotherapy. It should be used under proper medical supervision and not recommended for use in motion sickness.
References
1. KD. Tripathi. Antiemetic, Prokinetic and Digestant Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 670.
2. Semjon Willier, Karin Melanie Cabanillas Stanchi, Martina von Have, Vera Binder, Franziska Blaeschke, Judith Feucht, Tobias Feuchtinger and Michaela Döring. Efficacy, safety and feasibility of fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting in pediatric patients receiving moderately and highly emetogenic chemotherapy – results of a non-interventional observation study. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2019. [Accessed on 8th November 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858739/
3. Merck Sharp & Dohme (UK) Limited. IVEMEND® 150 mg powder for solution for infusion. Fosaprepitant. Electronics Medicines Compendium. [Revised in June 2022]. [Accessed on 8th November 2023] https://www.medicines.org.uk/emc/files/pil.5947.pdf
4. Merck Sharp & Dohme Corp. EMEND (fosaprepitant) for injection, for intravenous use. U.S. Food and Drug Administration. [Revised in April 2018]. [Accessed on 8th November 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/022023s017lbl.pdf
5. Central Drugs Standard Control Organization. Fosaprepitant (as dimeglumine) for injection 150mg. December 2011. [Accessed on 8th November 2023] https://cdscoonline.gov.in/CDSCO/Drugs
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