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Introduction About DROTIN M TABLET
DROTIN M TABLET is a combination of Drotaverine and Mefenamic acid which belongs to the group of medicines called Anti-spasmodic agents and Non-Steroidal Anti-inflammatory drugs (NSAIDs). It is used to manage pain in the stomach, intestine, urinary tract and pain due to irritable bowel syndrome, pain due to gall stones or kidney stones or liver and kidney disease, pain after surgery or child birth, painful periods (dysmenorrhea), heavy bleeding during periods (menorrhagia). It is also used for fever, muscle pain, inflammation, and migraine headache.
DROTIN M TABLET is not recommended for use in patients with severe kidney, liver or heart diseases and asthma. Contact your doctor before taking.
DROTIN M TABLET is not recommended for use in pregnancy. Contact your doctor before taking. DROTIN M TABLET is not recommended for use in breast feeding women as it may pass through the breast milk. Contact your doctor before taking.
DROTIN M TABLET should be used with caution in children. Contact your doctor before taking. DROTIN M TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking.
The most common side effects of this medicine are nausea, vomiting, diarrhea, stomach pain, constipation, dry mouth, lack of appetite, feeling thirsty and heartburn, dizziness and sleepiness. Contact your doctor if any of the above symptoms worsen.
Uses Of DROTIN M TABLET
Used to manage:
- muscle pain
- migraine headache
- functional bowel disorders
- fever
- heavy bleeding during periods
- abdominal pain
- pain after surgery
- pain in renal colic
- pain during periods
How DROTIN M TABLET Works
DROTIN M TABLET is a combination of two medicines, Drotaverine and Mefenamic acid, which relieves abdominal pain and cramps. Drotaverine relieves contractions (spasms) associated with smooth muscles in the abdomen. Mefenamic acid works by blocking the release of certain chemical messengers that cause abdominal pain and inflammation (swelling).
How to use DROTIN M TABLET
Take DROTIN M TABLET as advised by your physician.
For Tablet: Swallow DROTIN M TABLET with a glass of water. Do not crush or chew the medicine.
For Dispersible Tablet: Disperse DROTIN M TABLET in the specified quantity of water as mentioned in the label. Consume the mixture immediately after reconstitution.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Continue to take DROTIN M TABLET for the stipulated duration prescribed by your doctor to achieve better results.
Side Effects Of DROTIN M TABLET
Common
- nausea
- vomiting
- diarrhea
- stomach pain
- heartburn
- constipation
- dry mouth
- feeling thirsty
- rashes and itching
- sweating
- hypotension
- headache
- tachycardia
- dizziness
- sleep disorders
- flushing
- allergic dermatitis
Rare
Stop taking DROTIN M TABLET and contact your doctor immediately if you experience any of the following side effects:
- appearance of blood clots in the body
- allergic reactions such as swelling of face and lips causing difficulty in breathing
- skin discolouration on the face or neck
How To Manage Side Effects
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.
Nausea or Vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the symptom did not improve.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals. and drink plenty of water. Exercise more regularly.
Stomach pain:
Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the symptom did not improve.
Dizziness:
Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.
Itchy skin:
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if the symptom did not improve.
Warning & Precautions
Pregnancy
DROTIN M TABLET is not recommended for use in pregnant women. Contact your doctor before taking.
Breastfeeding
DROTIN M TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you feel dizziness or sleepiness after taking [GBNEYWORD].
Alcohol
Avoid consumption of alcohol while taking DROTIN M TABLET as it increases the risk of stomach bleeding.
Kidney
DROTIN M TABLET is not recommended for use in patients with severe kidney disease. Contact your doctor before taking.
Liver
DROTIN M TABLET is not recommended for use in patients with severe liver disease. Contact your doctor before taking.
Allergy
Do not take DROTIN M TABLET if you are allergic to Drotaverine, Mefenamic acid or to any other ingredients of this medicine.
Lungs
DROTIN M TABLET is not recommended for use in patients with lung diseases such as asthma. Contact your doctor before taking.
Heart Disease
DROTIN M TABLET is not recommended for use in patients with severe heart diseases. Contact your doctor before taking.
Others
DROTIN M TABLET is not recommended for use if you have:
- peptic ulcers
- porphyria
- active bleeding disorders
- to undergo surgery
- bedridden for a long time or immobility
- depression
- diabetes
Use in geriatrics:
DROTIN M TABLET should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking.
Interactions
A. Drug-Drug interactions:
Before taking DROTIN M TABLET inform your doctor if you are taking the following medicines:
- analgesics (medicines used for pain Ex. diclofenac, celecoxib)
- medicines used to manage diabetes mellitus (Ex. glipizide, glibenclamide)
- atropine (medicine used to manage bradycardia and used during eye examination)
- alprazolam, clobazam, diazepam (medicines used to manage seizures, anxiety and insomnia)
- medicine used to manage high blood pressure (Ex. captopril)
- cyclosporine (medicines acting on the immune system)
- medicine used to manage Parkinson’s disease (Ex. levodopa)
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdose are nausea, vomiting, severe stomach pain, tiredness, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, difficulty in breathing, confusion and severe headache.
Synopsis
| Drug | : | Drotaverine, Mefenamic acid |
| Pharmacological Category | : | Phosphodiesterase 4 inhibitors, NSAIDs |
| Therapeutic Indication | : | Manages Pain |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep out of reach of children
- Store DROTIN M TABLET below 25°C
FAQs About DROTIN M TABLET
Q: For what conditions DROTIN M TABLET is used?
A: DROTIN M TABLET is used for the management of pain in stomach, intestine, urinary tract, pain due to irritable bowel syndrome, pain due to gall stones or kidney stones or liver and kidney disease, pain after surgery or childbirth, painful periods (dysmenorrhea) or heavy bleeding during periods (menorrhagia). It is also used to manage fever, muscle pain, inflammation, and migraine headache.
Q: Can I drink alcohol while taking DROTIN M TABLET?
A: No. Avoid consumption of alcohol while taking DROTIN M TABLET as it increases the risk of stomach bleeding.
Q: Can I take DROTIN M TABLET during pregnancy?
A: No. DROTIN M TABLET is not recommended for use in pregnant women. Contact your doctor before taking the medicine.
Q: Can I use DROTIN M TABLET if I have asthma?
A: No. DROTIN M TABLET is not recommended for use in patients with lung diseases such as asthma. Contact your doctor before taking the medicine.
Q: Does DROTIN M TABLET cause sleepiness?
A: Yes. DROTIN M TABLET may cause sleepiness. Avoid driving or operate any machines while you are feeling sleepy. Do not consume alcohol, as it can aggravate your dizziness or sleepiness. Contact your doctor if the symptom did not improve.
Q: How does DROTIN M TABLET work?
A: DROTIN M TABLET contains Drotaverine, which is a smooth muscle relaxant. It works by inhibiting the enzyme phosphodiesterase-IV and increasing the levels of cyclic adenosine monophosphate (cAMP) in smooth muscles, leading to relaxation of the muscles. Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) which works by reducing the production of certain chemicals in the body that cause inflammation and pain.
Q: Who should not take DROTIN M TABLET?
A: DROTIN M TABLET is contraindicated in individuals with known hypersensitivity to Drotaverine, Mefenamic Acid, or any other components of the medicine. It should also be avoided in patients with severe hepatic impairment, severe renal impairment, or a history of gastrointestinal bleeding or ulceration.
Q: Can DROTIN M TABLET be taken with other medications?
A: It is essential to inform your healthcare professional about all the medications, supplements, and herbal products you are currently taking, as they may interact with DROTIN M TABLET. Certain medications, such as other NSAIDs, anticoagulants, and corticosteroids, may interact with DROTIN M TABLET and may increase the risk of side effects or reduce its effectiveness.
Q: What should I do if I miss a dose of DROTIN M TABLET?
A: If you miss a dose of DROTIN M TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
Q: What should I do in case of overdose with DROTIN M TABLET?
A: In case of an overdose with DROTIN M TABLET consult your doctor immediately. Overdose symptoms may include nausea, vomiting, stomach pain, dizziness, drowsiness, and even liver damage in severe cases.
References
1. KD. Tripathi. Drugs acting on the ANS. Essentials of medical pharmacology. Seventh edition. 2013. Page- 118.
2. J. B. Sharma, j. Aruna, Praveen kumar, kallol kumar roy, Neena malhotra, Sunesh kumar. Uses of Drotaverine and Mefenamic acid. Indian Journal of Medical sciences. June 2009. [Accessed on 31st May 2022] https://www.researchgate.net/publication/26671355_Comparison_of_efficacy_of_oral_drotaverine_plus_mefenamic_acid_with_paracervical_block_and_with_intravenous_sedation_for_pain_relief_during_hysteroscopy_and_indometrial_biopsy
3. Bethesda (MD). Mechanism of Drotaverine. National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2004. [Accessed on 31st May 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Drotaverine
4. Bethesda (MD). Mechanism of Mefenamic acid. National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2004. [Accessed on 31st May 2022] https://pubchem.ncbi.nlm.nih.gov/compound/4044
5. Lelypharma B.V. Electronic Medicines Compendium (EMC). [Revised on April 2020] [Accessed on 31st May 2022] https://www.medicines.org.uk/emc/files/pil.12890.pdf
6. Opella Healthcare Hungary Ltd. Drotaverine. [Revised on December 2021] [Accessed on 31st May 2022] https://www.ravimiregister.ee/Data/PIL_ENG/PIL_11232_ENG.pdf
7. Drotaverine and Mefenamic acid. Bionova. [Accessed on 31st May2022] https://www.bionova.co.in/drotafix-tablet.html
8. Drotaverine and Mefenamic acid. Innovexia life sciences Pvt Ltd. [Accessed on 31st May2022] https://www.innovexia.com/drotaverine-hydrochloride-and-mefenamic-acid-tablets
9. Drotaverine and Mefenamic acid. Solitaire Pharmacia Pvt Ltd. [Accessed on 31st May2022] https://www.solitaireexpo.com/antispasmodic-drugs.html
10. Drotaverine and Mefenamic acid. Vibcare. [Accessed on 31st May 2022] https://vibcare.co.in/drotaverine-mefenamic-acid/
11. Drotaverine and Mefenamic acid. Mkmedicine. [Accessed on 31st May 2022] https://www.mkmedicine.in/drotaverine-80-mg-mefenamic-acid-250-mg-tablet.html
12. Drotaverine and Mefenamic acid. Medixbiocare. [Accessed on 31st May 2022] https://m.medixbiocare.net/drotaverine-hcl-mefenamic-acid-tablet-6270850.html
13. Drotaverine and Mefenamic acid. Alviziahealthcare. [Accessed on 31st May 2022] https://alviziahealthcare.com/ATMODROT-MF.html
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