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Introduction About DOXIVERGE INJECTION
DOXIVERGE INJECTION contains Doxycycline which belongs to the groups of medicines called Antibiotics. It is used for the management of various bacterial infections like that of respiratory tract, urinary tract, skin, eyes, digestive system, bones, blood, etc. DOXIVERGE INJECTION is also used to manage sexually transmitted infections (Ex. syphilis, gonorrhoea, chlamydia), plague (spreads through rats), cholera (spreads through contaminated water), brucellosis (spreads from animals to human by eating raw dairy products), anthrax (spreads from sheep or cattle), etc.
DOXIVERGE INJECTION can also be used to manage malaria in short-term travellers (<4 months) to areas with chloroquine- and/or pyrimethamine sulphadoxine-resistant strains. It is advised to reduce sun exposure and to use fully covering clothes and sunscreen while going out as there is a chance of getting light sensitivity during management with DOXIVERGE INJECTION.
Before receiving DOXIVERGE INJECTION, inform your doctor if you have myasthenia gravis, systemic lupus erythematosus, history of intracranial hypertension or oral candidiasis, liver or kidney problems, porphyria or if you are an overweight woman of childbearing age.
There are no adequate and well-controlled studies on the use of DOXIVERGE INJECTION in pregnant women. DOXIVERGE INJECTION should be used in breastfeeding women only if your doctor finds it necessary. DOXIVERGE INJECTION should be used in children (8 years of age or less) only if the potential benefits outweigh the risks.
Avoid consumption of alcohol during DOXIVERGE INJECTION management. The most common side effects of receiving DOXIVERGE INJECTION are mild diarrhea, nausea, vomiting, light sensitivity, skin rash or itching, headaches and tooth discoloration. Consult your doctor if any of the symptoms worsen with time.
Uses Of DOXIVERGE INJECTION
Used to
- manage various bacterial infections like that of respiratory tract, urinary tract, skin, eyes, digestive system, bones, blood, etc
- manage sexually transmitted infections (Ex. syphilis, gonorrhoea, chlamydia), plague, cholera, brucellosis, anthrax, etc
- prevent malaria in short-term travellers (<4 months) to areas with chloroquine- and/or pyrimethamine sulphadoxine-resistant strains
How DOXIVERGE INJECTION Works
DOXIVERGE INJECTION reduces bacterial infection by blocking protein synthesis of bacteria and thus managing its growth.
How to use DOXIVERGE INJECTION
DOXIVERGE INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Do not try to self-administer the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of DOXIVERGE INJECTION
Common
- mild diarrhea, nausea, vomiting
- light sensitivity
- skin rash or itching
- headaches
- tooth discoloration
Rare
- bloody diarrhea
- low blood cell count
- migraines
- throat irritation or trouble swallowing
- chest pain, shortness of breath, irregular or fast heart rate
- worsening of systemic lupus erythematosus
- painful urination
- high blood pressure in the head
- ulcers in food pipe if taken without water
Stop receiving DOXIVERGE INJECTION and contact doctor if you experience any of the following side effects:
- Clostridium difficile-associated diarrhoea (blood in stool, stomach pain, watery stools, dehydration, fever)
- Steven – Johnson syndrome (skin with rashes, blisters, pain along with fever)
- overgrowth of nonsusceptible organisms, including fungi
- acute generalized exanthematous pustulosis (areas with redness and swelling on body along with fever)
- toxic epidermal necrolysis (painful red area without blister formation which spreads quickly and causes skin to peel, fever, chills)
- drug reaction with eosinophilia and systemic symptoms (DRESS)
- intra cranial hypertension (headache, blurred or double vision, loss of vision)
- angioedema (swelling in face, lips, mouth, throat with difficulty in swallowing and breathing)
- anaphylactic shock (increased heart rate, over sweating, fall in blood pressure, fainting)
How To Manage Side Effects
Nausea and Vomiting:
Avoid eating fried and greasy food. Take simple, light, small meals at frequent intervals. Drink plenty of fluids and stay hydrated always. If symptom persists, contact your doctor.
Diarrhea:
Drink plenty of water, fluids and electrolytes such as ORS and stay hydrated. If symptom persists, contact your doctor.
Headache:
Drink plenty of fluids and stay hydrated. Try to be tension free and relaxed. Take adequate sleep and rest. Avoid consumption of alcohol. Apply pain balm if required. If symptom persists, contact your doctor.
Light sensitivity:
Reduce exposure to sunlight. While going out, wear fully covering clothes and apply sunscreen with high SPF. If symptom persists, contact your doctor.
Skin rashes:
Do not scratch on rashes. Apply mild moisturizers if needed and avoid hot showers. Take an oatmeal bath. If symptom persists, contact your doctor.
Warning & Precautions
Pregnancy
There are no adequate and well-controlled studies on the use of DOXIVERGE INJECTION in pregnant women. Consult your doctor before receiving it.
Breastfeeding
DOXIVERGE INJECTION should be used in breastfeeding women only if your doctor finds it necessary. Consult your doctor before receiving it.
Alcohol
Avoid consumption of alcohol while receiving DOXIVERGE INJECTION, as it may reduce the efficacy of this medicine.
Kidney
DOXIVERGE INJECTION should be used with caution in patients with kidney problems. Consult your doctor before receiving it.
Liver
DOXIVERGE INJECTION should be used with caution in patients with liver impairment. Consult your doctor before receiving it.
Allergy
Do not receive DOXIVERGE INJECTION if you are allergic to doxycycline, minocycline, tetracycline or any of the other ingredients of this medicine. Consult your doctor before receiving it.
Others
Before receiving DOXIVERGE INJECTION, inform your doctor if you have:
- a history of yeast infections
- porphyria (rare blood disease)
- myasthenia gravis (autoimmune disorder)
- a history of lupus (autoimmune disease)
- recent colitis (inflammation of digestive tract) due to antibiotics use
- intracranial hypertension (high pressure in the head)
Use in pediatrics:
DOXIVERGE INJECTION should be used in children (8 years of age or less) only if the potential benefits outweigh the risks. Consult your child’s doctor for advice.
Interactions
A. Drug – Drug interactions:
Before receiving DOXIVERGE INJECTION inform your doctor if you are taking any of the following medicines:
- medicines used to manage blood clotting (Ex. heparin, warfarin)
- penicillin (used to manage bacterial infection)
- medicines used to manage or manage acidity (Ex. aluminium hydroxide, magnesium carbonate, calcium carbonate)
- bismuth subsalicylate (used to manage diarrhoea)
- medicines used to manage mood disorders and depression (Ex. phenobarbitone, pentobarbital)
- medicines used to manage fits (Ex. phenytoin, carbamazepine)
- methoxyflurane (used to relieve pain associated with trauma)
- medicine used to manage pregnancy (Ex. ethinylestradiol, norethindrone)
Overdosage:
DOXIVERGE INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms after receiving DOXIVERGE INJECTION.
Synopsis
| Drug | : | Doxycycline |
| Pharmacological Category | : | Tetracyclines |
| Therapeutic Indication | : | Bacterial infections in different parts of body |
| Dosage Forms | : | Injection, Combipack injection, Tablet, Capsule |
More Information
- Keep DOXIVERGE INJECTION out of reach of children
- Store DOXIVERGE INJECTION at room temperature
FAQs About DOXIVERGE INJECTION
What precautions have to be followed when receiving DOXIVERGE INJECTION?
Use of DOXIVERGE INJECTION may result in overgrowth of nonsusceptible organisms, including fungi. If this occurs, it should be discontinued. Before you take DOXIVERGE INJECTION, tell your doctor if you are using, have recently used or might use any other medicines. Before receiving DOXIVERGE INJECTION, tell your doctor if you are allergic to doxycycline, minocycline, tetracycline, other medications or any of the other ingredients of this medicine.
Can DOXIVERGE INJECTION cause diarrhea?
Diarrhea is a common problem caused by DOXIVERGE INJECTION, which usually ends when the medicine is discontinued. Sometimes after starting the management, you might develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of DOXIVERGE INJECTION. If this occurs, you should tell the doctor as soon as possible.
Does DOXIVERGE INJECTION cause tooth problems?
Yes. The use of DOXIVERGE INJECTION during last half of pregnancy, infancy and childhood up to the age of 8 years (tooth development phases) may cause permanent discolouration of the teeth (yellow-grey-brown). Enamel hypoplasia (thin or absent enamel) has also been reported. Consult your doctor for further queries.
Can DOXIVERGE INJECTION be used to manage syphilis?
Yes. DOXIVERGE INJECTION can be used to manage sexually transmitted diseases like syphilis. The dose and duration of management will be determined by your doctor according to your age, body weight and severity of infection.
Does DOXIVERGE INJECTION cause sensitivity to light?
Yes. Photosensitivity (light sensitivity) manifested by a worsening sunburn reaction has been observed in some patients receiving DOXIVERGE INJECTION. Patients prone to be exposed to direct sunlight or ultraviolet light should know that this reaction can occur with DOXIVERGE INJECTION or similar medicines and management should be discontinued at the first evidence of skin redness.
References
1. KD Tripathi. Autocoids and related drugs. Tetracyclines and Chloramphenicol (Broad Spectrum Antibiotics). Eighth edition. 2019. Page 786.
2. Reema S. Patel; Mayur Parmar. Doxycycline Hyclate. NIH National Library of Medicine, National center for biotechnology information. StatPearls [Internet]. July 2022. [Accessed on 10th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK555888/
3. Doxycycline. NIH National Library of Medicine, National center for biotechnology information. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. January 2019. [Accessed on 10th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK548353/#:~:text=Doxycycline%20has%20been%20associated%20with,is%20probably%20most%20commonly%20mixed
4. BDR PHARMACEUTICALS INTERNATIONAL PVT.LTD. Doxicip for injection (Doxycycline for Injection USP 100 mg). Ciplamed. [Revised in February 2022] [Accessed on 10th November 2022] https://ciplamed.com/content/doxicip-for-injection
5. MIMS. Doxycycline. [Accessed on 10th November 2022] https://www.mims.com/singapore/drug/info/doxycycline?mtype=generic
Useful Diagnostic Tests
- Complete Blood Count
- Peripheral smear examination
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