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Introduction About DEXTOP DSR CAPSULE
DEXTOP DSR CAPSULE is a combination of Domperidone and Dexrabeprazole which belongs to the group of medicines called Prokinetic Drugs and Proton pump inhibitors respectively. It is used to manage stomach ulcers (gastric or peptic ulcers) and gastroesophageal reflux disease (GERD; acid reflux causing irritation of food pipe).
It can also be used to reduce the signs of acidity, heartburn, indigestion, burping or bloating. It is typically used among patients who are not responding adequately to therapy with dexrabeprazole alone.
DEXTOP DSR CAPSULE should be taken at least 15-30 minutes before meals. During management with DEXTOP DSR CAPSULE your doctor will closely monitor your kidney functions, liver functions and blood magnesium levels to avoid the risk of unwanted side effects.
Before taking DEXTOP DSR CAPSULE inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any blockage or tears in the gut or have weak bones.
DEXTOP DSR CAPSULE is not recommended for use in patients having bleeding from the gut. It is also not suitable for use in pregnant or breastfeeding women. The most common side effects of taking DEXTOP DSR CAPSULE are dry mouth, cough, sore throat, runny nose, diarrhea, constipation, stomach pain, flatulence and increased signs of infections. Consult your doctor if any of these side effect bothers you.
Uses Of DEXTOP DSR CAPSULE
It is used to manage:
- Stomach ulcers (gastric or peptic ulcers)
- Gastrointestinal Reflux disease (GERD; acid reflux causing irritation of food pipe)
- Nausea and Vomiting
- Acidity, Heartburn
- Signs of indigestion (such as burping, bloating)
How DEXTOP DSR CAPSULE Works
DEXTOP DSR CAPSULE contains two medicines namely domperidone and Dexrabeprazole. Domperidone stimulates the gut and speeds up the movements of food from the stomach into the intestines. This action reduces chances for acid reflux and manages the irritation of food pipe. It also blocks the transmission of nerve signals between the vomiting centers and brain which reduces the onset of nausea and vomiting.
Dexrabeprazole is a proton pump inhibitor. It reduces gastric acid secretion which promotes the healing of ulcers and esophageal lesions. It also provides relief from the unpleasant symptoms of the GI tract (such as acidity, bloating, burping and indigestion).
How to use DEXTOP DSR CAPSULE
Take DEXTOP DSR CAPSULE 15-30 minutes before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking DEXTOP DSR CAPSULE unless your doctor advice you to stop.
Side Effects Of DEXTOP DSR CAPSULE
Common
- benign polyps in the stomach
- dry mouth
- cough, sore throat, runny nose
- diarrhea, constipation, stomach pain, flatulence
- nausea or vomiting
- body pain, back pain
- feeling weak
- sleeplessness
- headache, dizziness
- increased infections
Uncommon
- low sex drive
- drowsiness, sleepiness
- anxiety, nervousness
- blocked sinuses
- breast milk production in men and women
- breast pain or tenderness
- fragile bones (risk of bone fracture)
- indigestion, belching
- skin rash, redness or itching
- muscle pains, joint pains, leg cramps
- urinary tract infection
Rare
- low WBC and platelet counts
- loss of appetite
- depression
- problems in vision
- stomach upset, mouth ulcers, taste disturbance
- weight gain
- kidney problems
Stop taking DEXTOP DSR CAPSULE and inform your doctor immediately if you experience any of the following side effects such as:
- severe allergic reactions (such as skin rash, itching, swelling of the lips, face or body and difficulty in breathing or swallowing)
- severe skin reactions (such as redness, blistering, peeling of skin and bleeding in the lips, eyes, mouth, nose and genitals with fever)
- signs of bleeding in the gut (such as bloody vomits/stools)
- frequent infections, flu-like symptoms, sore throat, mouth ulcers
- increased bleeding tendency
- fast or irregular heartbeat, difficulty in breathing, feeling faint
- fits
- uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture
- signs of kidney problems (such as low urine output, bloody urine, fever, rash and joint stiffness)
- signs of infectious diarrhea (severe persistent watery diarrhea with severe stomach pain and fever)
How To Manage Side Effects
Nausea or vomiting:
Try to take DEXTOP DSR CAPSULE with or just after meals. Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Constipation:
Taking DEXTOP DSR CAPSULE with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Warning & Precautions
Pregnancy
DEXTOP DSR CAPSULE is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
Breastfeeding
DEXTOP DSR CAPSULE is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or handle heavy tools or machines if your ability is affected by DEXTOP DSR CAPSULE.
Alcohol
Avoid consumption of alcohol while taking DEXTOP DSR CAPSULE, as it could aggravate your existing condition.
Kidney
DEXTOP DSR CAPSULE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
DEXTOP DSR CAPSULE should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take DEXTOP DSR CAPSULE if you are allergic to Domperidone, Dexrabeprazole or to any other proton pump inhibitors (such as rabeprazole, omeprazole).
Heart Disease
DEXTOP DSR CAPSULE is not recommended for use in patients with heart problems such as prolongation of QT interval or congestive heart failure. Therefore, consult your doctor before taking it.
Others
DEXTOP DSR CAPSULE is not recommended for use if you:
- have bloody stools or bleeding in the gut
- have blockage or tear in the intestines
- have severe fluid or electrolyte disturbances
- have prolactinoma (a non-cancerous tumor of pituitary gland)
- have low blood potassium or magnesium levels
Before taking DEXTOP DSR CAPSULE inform your doctor if you:
- have osteoporosis
- have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression)
- are going to test Chromogranin A level
- have tumor in the stomach
Use in Pediatrics:
DEXTOP DSR CAPSULE is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use in Geriatrics:
DEXTOP DSR CAPSULE should be used with caution in elderly patients (aged 65 years and above). Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking DEXTOP DSR CAPSULE inform your doctor if you are taking any of the following medicines such as:
- other medicines used to manage gastrointestinal problems (Ex. cisapride, dolasetron, prucalopride, diphemanil)
- medicines used to manage heart problems or hypertension (Ex. digoxin, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
- medicines used to manage HIV infection (Ex. atazanavir, nelfinavir, saquinavir)
- medicines used to manage fungal infections (such as ketoconazole, itraconazole, posaconazole)
- antipsychotics (used to manage mental illness) Ex. haloperidol, pimozide, sertindole
- antidepressants (used to manage depression) Ex. escitalopram or citalopram, fluvoxamine, St John’s wort
- antibiotics (used to manage bacterial infections) Ex. moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin
- medicines used to manage malaria (Ex. halofantrine, lumefantrine)
- antihistamines (used to manage allergies) Ex. mizolastine, mequitazine
- medicines used to manage cancer (Ex. toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib)
- methotrexate (used to manage cancer and auto-immune disease)
- bepridil (used to manage hypertension)
- methadone (used to relieve pain)
- apomorphine (a medicine used to reduce abnormal muscle movements)
Overdosage:
If you or anyone else accidentally took more DEXTOP DSR CAPSULE, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include sleepiness, confusion, uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture.
Synopsis
| Drug | : | Domperidone, Dexrabeprazole |
| Pharmacological Category | : | Dopamine (D2) Receptor antagonists, Proton Pump Inhibitors |
| Therapeutic Indication | : | Peptic ulcer, GERD |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep DEXTOP DSR CAPSULE out of the sight and reach of children
- Store DEXTOP DSR CAPSULE at room temperature
FAQs About DEXTOP DSR CAPSULE
What is DEXTOP DSR CAPSULE used for?
DEXTOP DSR CAPSULE is used to manage peptic ulcers and GERD. It can also be used to manage nausea, vomiting, bloating, burping, acidity and heartburn.
How and when to take DEXTOP DSR CAPSULE?
Take DEXTOP DSR CAPSULE at least 15-30 minutes before meals. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
How long should I take DEXTOP DSR CAPSULE?
You need to take DEXTOP DSR CAPSULE for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
What is the best time to take DEXTOP DSR CAPSULE?
DEXTOP DSR CAPSULE must be taken before meals to avoid gastrointestinal side effects.
What to do if I forgot to take a dose of DEXTOP DSR CAPSULE?
If you forgot to take a dose of DEXTOP DSR CAPSULE, take it as soon as you remember. However, if it is time for the next dose of DEXTOP DSR CAPSULE, skip the missed dose and take the next one regularly. Do not take a double dose of DEXTOP DSR CAPSULE to compensate the missed ones.
What are the most common side effects of taking DEXTOP DSR CAPSULE?
The most common side effects of taking DEXTOP DSR CAPSULE are dry mouth, cough, sore throat, runny nose, diarrhea, constipation, stomach pain, flatulence and increased signs of infections. Consult your doctor if any of these side effect bothers you.
Can I stop taking DEXTOP DSR CAPSULE without consulting your doctor?
No. You should not stop taking DEXTOP DSR CAPSULE without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using DEXTOP DSR CAPSULE, consult your doctor for advice.
Will taking a higher dose of DEXTOP DSR CAPSULE be more effective?
No, taking a higher dose of DEXTOP DSR CAPSULE will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
What precautions do I need to follow while taking DEXTOP DSR CAPSULE?
Make sure to take DEXTOP DSR CAPSULE 30 minutes before meals. Before taking DEXTOP DSR CAPSULE inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any blockage or tears in the gut or have weak bones. Do not take DEXTOP DSR CAPSULE without consulting your doctor if you are pregnant or breastfeeding. Regularly visit your doctor and take all the blood tests recommended by your him/her without fail.
Can I take medication for high blood pressure along with DEXTOP DSR CAPSULE?
It is not advisable to take medicines to control blood pressure while taking DEXTOP DSR CAPSULE without consulting your doctor as they have known interactions with this medicine.
Can DEXTOP DSR CAPSULE be used in pregnant women?
DEXTOP DSR CAPSULE is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
How to take DEXTOP DSR CAPSULE?
You must take DEXTOP DSR CAPSULE as advised by your physician. Try to take DEXTOP DSR CAPSULE 30 minutes before and swallow it with a glass of water. Do not crush or chew the medicine.
How much DEXTOP DSR CAPSULE should I take?
DEXTOP DSR CAPSULE should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Can DEXTOP DSR CAPSULE cause constipation?
Yes. Constipation is a common side effect of using DEXTOP DSR CAPSULE. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.
Can DEXTOP DSR CAPSULE cause dry mouth?
Yes. Dry mouth is a common side effect of using DEXTOP DSR CAPSULE. Contact your doctor if this side effect bothers you.
References
1. KD. Tripathi. Antiemetic, Prokinetic and Digestant drugs & Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page – 666 & 653.
2. Nur Fathurah Zamani, Afifah Sjamun Sjahid, Tuan Hairulnizam Tuan Kamauzaman, Yeong Yeh Lee and Md Asiful Islam. Efficacy and Safety of Domperidone in Combination with Proton Pump Inhibitors in Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Journal of Clinical Medicine. August 2022. [Accessed on 17th December 2022]. https://www.mdpi.com/2077-0383/11/18/5268/htm
3. Balkanpharma Dupnitsa AD. Electronic Medicines Compendium (EMC). [Revised in September 2022]. [Accessed on 17th December 2022]. https://www.medicines.org.uk/emc/files/pil.2842.pdf
4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021]. [Accessed on 17th December 2022]. https://www.medicines.org.uk/emc/files/pil.556.pdf
5. Hetero Healthcare Pvt Ltd. Dirab D 30mg Capsule. [Accessed on 17th December 2022]. https://www.heterohealthcare.com/dirab-d-30-capsule
6. Central Drugs Standard Control Organization. Dexrabeprazole 10mg (EC) + Domperidone 30mg SR Capsules. June 2008. [Accessed on 17th December 2022]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
7. Texas Pharmaceutical Private Limited. Dextop DSR (Dexrabeprazole 10mg+Domperidone 30mg). [Accessed on 17th December 2022]. https://www.texasusa.in/product/dextop-dsr/
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