DERIPHYLLIN Tablet 30's

Introduction About DERIPHYLLIN TABLET

DERIPHYLLIN TABLETcontains a combination of Etofylline and Theophylline which belongs to the group of medicines called Bronchodilators. It is used in the management of asthma (in which airways narrow and swell and may produce extra mucus, coughing and shortness of breath), chronic bronchitis (inflammation of the lining of bronchial tubes, which carry air to and from lungs causing cough and thick mucus), and chronic obstructive pulmonary disorder.

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include breathing difficulty, cough, mucus (sputum) production, and wheezing.

Before taking DERIPHYLLIN TABLET, inform your doctor if you have porphyria, liver, heart, or thyroid problems; worsening of chest symptoms; a stomach ulcer; cystic fibrosis; a high fever; a viral infection; fits; difficulty passing urine (in men); are a smoker; are diabetic; or are going to have an operation. Avoid consuming alcohol during this management.

Inform your doctor if you are pregnant or breastfeeding before taking DERIPHYLLIN TABLET. DERIPHYLLIN TABLET is not recommended for children under the age of six. The most common side effects of taking DERIPHYLLIN TABLET are nausea, vomiting, headache, restlessness, and dizziness. Consult your doctor if your symptoms do not improve. 

Uses Of DERIPHYLLIN TABLET

To manage:

• Asthma
• Chronic Bronchitis
• Chronic Obstructive Pulmonary Disease (COPD)

How DERIPHYLLIN TABLET Works

DERIPHYLLIN TABLET works by relaxing the smooth muscles in the airway, in which etofylline works by dilating and relaxing the airway muscles, and theophylline relaxes the smooth muscles located in the bronchial airways and pulmonary blood vessels, reducing the airway's responsiveness to allergens and thereby reducing inflammation.

How to use DERIPHYLLIN TABLET

Take DERIPHYLLIN TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will determine the right dose and duration depending upon your age, body weight, and disease condition.

Side Effects Of DERIPHYLLIN TABLET

How To Manage Side Effects

Diarrhea

Drink lots of or fruit juice to keep yourself hydrated. If the symptom does not show improvement, consult your doctor.

Headache

Avoid bright lights, drink more water, and take rest. If the symptom does not show improvement, consult your doctor.

Nausea And Vomiting

Stick to simple meals. Avoid eating rich or spicy food. If the symptom does not show improvement, consult your doctor.

Stomach Pain

Try to rest and relax and have smaller and frequent meals. Keep a heat pad on stomach. If the symptom does not show improvement, consult your doctor.

Warning & Precautions

Pregnancy

Monitoring required

DERIPHYLLIN TABLET is not recommended for use in pregnant women or women planning to be pregnant uncles clearly necessary. Consult your doctor before taking DERIPHYLLIN TABLET.

Breastfeeding

Monitoring required

DERIPHYLLIN TABLET is excreted in breastmilk so it will be given to you only if the benefits overweight the risk causing to the child. Consult your doctor before taking it.

Driving and Using Machines

Safe

DERIPHYLLIN TABLET has no or negligible effect on your ability to drive or use machines.

Alcohol

Consult your doctor

Do not consume alcohol while taking DERIPHYLLIN TABLET as it can alter the way this medicine works.

Kidney

Use with Caution

DERIPHYLLIN TABLET should be used with caution if you are male and have difficulty in passing urine (can be due to an enlarged prostate gland). Consult your doctor before taking it.

Liver

Use with Caution

DERIPHYLLIN TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take DERIPHYLLIN TABLET if you are allergic to Etofylline or Theophylline or any other ingredients of this medicine.

Lungs

Use with Caution

DERIPHYLLIN TABLET should be used with caution in patients with worsening of chest symptoms like breathlessness or cough. Consult your doctor before taking it.

Heart Disease

Use with Caution

DERIPHYLLIN TABLET should be used with caution in patients with an irregular heartbeat, high blood pressure or any other heart problems. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

DERIPHYLLIN TABLET is not recommended for use in children below 6 years of age. Consult your doctor before taking it.

Use In Geriatrics

Consult your doctor

Dose will be adjusted by your doctor depending on your age, body weight and disease condition. Consult your doctor before taking DERIPHYLLIN TABLET.

Interactions

A. Drug - Drug interactions:

Before taking DERIPHYLLIN TABLET, inform your doctor if you are taking any of the following medicine:

• certain other medicines to manage asthma or breathing conditions that contain theophylline, aminophylline, salbutamol, terbutaline, or salmeterol, steroids (Ex. prednisolone, hydrocortisone)
• diuretics (to increase urine production)
• oral contraceptives
• St John’s Wort, fluvoxamine or lithium (for depression)
• aminoglutethimide, methotrexate or lomustine (to manage cancer)
• carbamazepine or phenytoin (for seizures, fits or convulsions)
• medicines known as barbiturates to help in sleeping
• adenosine, diltiazem, isoprenaline, mexiletine, propafenone, propranolol, verapamil or beta blockers, regadenoson or dipyridamol (for high blood pressure and other heart problems)
• pentoxifylline (for diseased blood vessels)
• benzodiazepines (to manage anxiety)
• aciclovir to manage Herpes viruses
• sulphinpyrazone or allopurinol (for gout)
• carbimazole (for problems of thyroid gland)
• cimetidine or nizatidine (to manage stomach ulcers, indigestion or heartburn)
• antibiotics (Ex. ciprofloxacin, clarithromycin, erythromycin, enoxacin)
• fluconazole (manage fungal infections)
• rifampicin or isoniazid (manage tuberculosis)
• ritonavir to manage HIV
• interferons (manage conditions such as herpes, cancer, leukaemia or hepatitis)
• thiabendazole to manage worms like threadworms
• doxapram to stimulate breathing
• disulfiram (manages alcoholism)
• cough medicine containing ephedrine.
• certain anesthetics such as halothane and ketamine
• you have recently had, or are going to have a flu injection

B. Drug - Food interaction:

• avoid caffeinated drinks during this management.

Overdosage:

If you or anyone else accidentally take too much of DERIPHYLLIN TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are stomach pains, feel or be sick (possibly vomiting blood), fast or irregular heartbeat, low blood pressure, restlessness, or unusual muscle stiffness, have a fit or even go into a coma.

Synopsis

More Information

• Keep DERIPHYLLIN TABLET out of reach from children
• Do not store above 25°C

FAQs About DERIPHYLLIN TABLET

Q: What is DERIPHYLLIN TABLET used for?

A: DERIPHYLLIN TABLET is used in the management of asthma, chronic bronchitis, and chronic obstructive pulmonary disorder. Consult your doctor for more information.

Q: Can DERIPHYLLIN TABLET be used by pregnant women?

A: DERIPHYLLIN TABLET should not be used in pregnant women or women planning to become pregnant unless absolutely necessary.Consult your doctor before taking it.

Q: Can DERIPHYLLIN TABLET be used in patients with heart problems?

A: DERIPHYLLIN TABLET should be used with caution in patients with an irregular heartbeat, high blood pressure, or any other heart problems. Consult your doctor before taking it.

Q: What if I accidentally take more of DERIPHYLLIN TABLET?

A: If you or anyone else accidentally takes too much DERIPHYLLIN TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are stomach pains, feeling or being sick (possibly vomiting blood), a fast or irregular heartbeat, low blood pressure, and restlessness.

Q: How does DERIPHYLLIN TABLET work?

A: DERIPHYLLIN TABLET works by relaxing the smooth muscles in the airway, in which etofylline works by dilating and relaxing the airway muscles, and theophylline relaxes the smooth muscles located in the bronchial airways and pulmonary blood vessels, reducing the airway's responsiveness to allergens and thereby reducing inflammation.

References

1. KD Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Eighth Edition. 2019. Page –243-247.

2. Peter J. Barnes. Theophylline. [Accessed on 8th August 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033977/

3. J Zuidema, J Verhoeven, F W Merkus. Pharmacokinetics of etofylline after intravenous and oral administration to humans. [Accessed on 8th August 2021] https://pubmed.ncbi.nlm.nih.gov/7263108/

4. Napp Pharmaceuticals Limited. Electronic Medicines Compendium (EMC). [Revised in January 2019] [Accessed on 8th August 2021] https://www.medicines.org.uk/emc/files/pil.1021.pdf, https://www.medicines.org.uk/emc/product/1021/smpc

5. Pubchem. Etofylline. [Revised on August 2022] [Accessed on 8th August 2021] https://pubchem.ncbi.nlm.nih.gov/compound/etofylline

6. NIH. Etofylline. [Accessed on 8th August 2021] https://drugs.ncats.io/drug/L164909TBI

7. Etofylline, Theophylline. Mayoclinic. [Revised in April 2020] [Accessed on 8th August 2021] https://www.mayoclinic.org/diseases-conditions/copd/symptoms-causes/syc-20353679

Useful Diagnostic Tests

• Lung function test
• Chest X-ray
• CT scan

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)

Last updated on 15 Feb 2023 | 05:06 PM(IST)