DEGATIDE 120 Injection 1's
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Introduction About DEGATIDE 120 INJECTION
DEGATIDE 120 INJECTION is used to manage adult patients with advanced hormone dependent prostate cancer. It contains Degarelix which belongs to the group of medicines called Gonadotrophin-releasing hormone antagonist or GnRH blocker. DEGATIDE 120 INJECTION works by blocking messages from a part of the brain called the hypothalamus that tells the pituitary gland to produce luteinising hormone. Luteinising hormone tells the testicles to produce testosterone. So degarelix stops the testicles making testosterone. Prostate cancer depends on testosterone to grow. Hormone therapy blocks or lowers the amount of testosterone in the body.
DEGATIDE 120 INJECTION should be used with caution in patients have low bone density, glucose intolerance, diabetes mellitus, liver, kidney or cardiovascular diseases. DEGATIDE 120 INJECTION is not recommended for use in pregnant women. It is not recommended for use in children and adolescents. Consult your doctor before receiving the medicine.
DEGATIDE 120 INJECTION should be used with caution in elderly patients, therefore consult your doctor before receiving. The most common side effects after receiving DEGATIDE 120 INJECTION are hot flushes and inflammation around the injection site, dizziness, weight gain, headache, diarrhoea. Consult your doctor immediately in case any of the side effects worsen or you experience an allergic reaction after receiving DEGATIDE 120 INJECTION.
Uses Of DEGATIDE 120 INJECTION
- It is used to manage adult patients with advanced hormone dependent prostate cancer
How DEGATIDE 120 INJECTION Works
DEGATIDE 120 INJECTION contains Degarelix which works by blocking messages from a part of the brain called the hypothalamus that tells the pituitary gland to produce luteinising hormone. Luteinising hormone tells the testicles to produce testosterone. So degarelix stops the testicles making testosterone.
How to use DEGATIDE 120 INJECTION
DEGATIDE 120 INJECTION will be administered by a healthcare professional only. It is for subcutaneous administration only and is not to be administered intravenously. DEGATIDE 120 INJECTION is for subcutaneous administration to the abdominal region only. As with other medicines administered by subcutaneous injection, the injection site should vary periodically. Injections should be given in areas of the abdomen that will not be exposed to pressure. (e.g., not close to waistband or belt nor close to the ribs. It should be reconstituted before use.
Side Effects Of DEGATIDE 120 INJECTION
Common
- hot flushes and inflammation around the injection site
- a drop in red blood cells that can cause breathlessness, tiredness and looking pale
- weight gain
- difficulty sleeping or getting to sleep
- headaches
- feeling dizzy
- diarrhoea
- feeling sick
- excessive sweating including night sweats
- rash
- discomfort or pain in muscles, bones, or joints
- growth of breast tissue
- problems getting or maintaining an erection (erectile dysfunction)
- high temperature
- chills
- tiredness
- flu like symptoms such as high temperature, feeling achy, cough, sore throat, and headache
How To Manage Side Effects
Diarrhea
Drink plenty of water or fruit juices to keep yourself hydrated. Don’t take any medicine on your own for managing diarrhoea however, contact your doctor if your diarrhoea worsens.
Dizziness Or Drowsiness
Lie down until the dizziness is gone and get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and medicine, however, consult your doctor if the symptom gets worse.
Headache
Drink lots of water and avoid skipping meals. Try to be relaxed and avoid stress. Apply pain relieving balm on your forehead if necessary and consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
ContraindicatedDEGATIDE 120 INJECTION is not indicated in women. In addition, due to its pharmacological effects can cause fetal harm when administered to a pregnant woman. Consult your doctor before receiving the medicine.
Breastfeeding
Consult your doctorThere is no relevant indication for use of DEGATIDE 120 INJECTION in women. Consult your doctor before receiving the medicine.
Driving and Using Machines
Use with CautionThere is no relevant indication for use of DEGATIDE 120 INJECTION in women. Consult your doctor before receiving the medicine.
Kidney
Use with CautionDEGATIDE 120 INJECTION should be used with caution in patient with kidney problems, therefore consult your doctor before receiving.
Liver
Use with CautionDEGATIDE 120 INJECTION should be used with caution in patient with liver problems, therefore consult your doctor before receiving.
Allergy
ContraindicatedDo not receive DEGATIDE 120 INJECTION if you are allergic or hypersensitive to Degarelix or any of the ingredients of this medicine.
Heart Disease
Use with CautionDEGATIDE 120 INJECTION should be used with caution in patients with cardiovascular disease such as stroke and myocardial infarction therefore consult your doctor before receiving the medicine.
Use In Pediatrics
ContraindicatedDEGATIDE 120 INJECTION is not recommended for use in children and adolescents. Consult your doctor before receiving the medicine.
Use In Geriatrics
Use with CautionThere is no need to adjust the dose for the elderly or in patients with mild or moderate liver or kidney function impairment. Consult your doctor before receiving the medicine.
Others
Before receiving DEGATIDE 120 INJECTION inform your doctor if you have:
- have changes in bone density
- have glucose intolerance
- have diabetes mellitus
Interactions
A. Drug-Drug interactions:
Before receiving DEGATIDE 120 INJECTION, inform your doctor if you are taking any of the following medicine:
- Antiarrhythmic agents (Ex. Quinidine, procainamide, amiodarone and sotalol)
- Opiate (narcotic) analgesics (Ex. Methadone)
- Antibiotics (Ex. Moxifloxacin)
- Antipsychotics
Overdosage:
There is no clinical experience with the effects of an acute overdose with DEGATIDE 120 INJECTION. In the event of an overdose the patient should be monitored and appropriate supportive treatment should be given, if considered necessary.
Synopsis
| Drug | : | Degarelix |
| Pharmacological Category | : | Gonadotrophin-Releasing Hormone Antagonist or GnRH blocker |
| Therapeutic Indication | : | Used to manage adult patients with advanced hormone dependent prostate cancer |
| Dosage Forms | : | Injection |
More Information
Storage
- Keep DEGATIDE 120 INJECTION out of reach of children
- Store at temperature between 2°C to 8°C
FAQs About DEGATIDE 120 INJECTION
Q: What happens if I stop my management with DEGATIDE 120 INJECTION suddenly?
A: Patients who are receiving DEGATIDE 120 INJECTION for a longer duration should not stop the management with DEGATIDE 120 INJECTION suddenly or without consulting your doctor. Your doctor will slowly reduce your dosage, to avoid withdrawal symptoms.
Q: What are the precautions need to be followed while receiving DEGATIDE 120 INJECTION?
A: DEGATIDE 120 INJECTION should be used with caution in patients have low bone density, glucose intolerance, diabetes mellitus, liver, kidney or cardiovascular diseases.
Q: What are the methods of after reconstitution of DEGATIDE 120 INJECTION?
A: The reconstituted solution must be clear liquid free from any undissolved matter. Chemical and physical in-use stability of the reconstituted solution has been demonstrated for 2 hours at 25°C after solvent addition. From a microbiological point of view, once reconstituted, the product should be administered immediately.
Q: What are the common side effects while receiving DEGATIDE 120 INJECTION?
A: The most common side effects after receiving DEGATIDE 120 INJECTION are hot flushes and inflammation around the injection site, dizziness, weight gain, headache, diarrhoea. Consult your doctor immediately in case any of the side effects worsen or you experience an allergic reaction after receiving DEGATIDE 120 INJECTION.
Q: What DEGATIDE 120 INJECTION is used for?
A: DEGATIDE 120 INJECTION is used to manage adult patients with advanced hormone dependent prostate cancer.
Q: Can DEGATIDE 120 INJECTION be used during pregnancy?
A: DEGATIDE 120 INJECTION is not recommended for use in pregnant women, as it may cause harm to the growing baby.
Q: Who should avoid taking DEGATIDE 120 INJECTION?
A: DEGATIDE 120 INJECTION is not recommended for use if you are allergic or hypersensitive to Degarelix or any other ingredients of this medicine.
Q: What is advanced prostate cancer?
A: Prostate cancer is considered advanced when it breaches the prostate's border. As it advances, the cancer may also spread (metastasize) to other areas of the body. Men with advanced prostate cancer typically start treatment with hormone therapy.
Q: Should I follow any special diet if I have advanced prostate cancer?
A: Small changes in your diet can lead to healthier living and maintaining overall health. Fruits and vegetables, especially dark, leafy greens, are recommended. Try to reduce fats from red meat and dairy. Instead, choose fish, lean poultry, or plant-based proteins from nuts and beans. Before making changes to your diet, be sure to talk to your doctor.
References
1. CDSCO. [Accessed on September 11th 2024] https://cdscoonline.gov.in/CDSCO/Drugs
2. Ferring Pharmaceuticals. [Revised on March 18, 2016] [Accessed on September 11th 2024] https://pdf.hres.ca/dpd_pm/00034229.PDF
3. FIRMAGON. [Accessed on September 11th 2024] https://firmagon.com/hcp/
4. Ferring Pharmaceuticals A/S. Food and Drug Administration. [Revised on November 13, 2013] [Accessed on September 11th 2024] https://www.ema.europa.eu/en/documents/product-information/firmagon-epar-product-information_en.pdf
Useful Diagnostic Tests
- Prostate Specific Antigen - Psa (Total)
- Healthians Prostate Cancer Package
- Prostate Specific Antigen - Psa (Free)
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