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Introduction About D FAX PLUS 100 TABLET
D FAX PLUS 100 TABLET is a combination of Clonazepam and Desvenlafaxine which belongs to the group of medicines called Anticonvulsants and Antidepressants respectively. It is used to manage depression. It can also be used in the management of epilepsy (fits), panic disorder and in certain types of phobias (fears).
Before taking D FAX PLUS 100 TABLET, inform your doctor if you have any problems in your liver, kidney or heart. You must also inform your doctor if you have glaucoma, breathing problems, bleeding disorders or any previous history of drug abuse, alcohol abuse or suicide as a precaution.
Talk to your doctor if you have taken any antidepressant (especially monoamine oxidase inhibitor) within the last 14 days before taking this medicine. Do not take D FAX PLUS 100 TABLET without consulting your doctor if you are pregnant or breastfeeding.
The most common side effects of taking D FAX PLUS 100 TABLET are dizziness, drowsiness, tiredness, weak muscles, memory loss, headache, nausea, stomach upset, hair loss, low sex drive, increased sweating, constipation and dry mouth. Consult your doctor if any of these side effect troubles you.
Also, inform your doctor immediately if you experience any worsening of depression, unusual behaviour or have suicidal thoughts after taking D FAX PLUS 100 TABLET.
Uses Of D FAX PLUS 100 TABLET
It is used to manage:
- Depression
- Fits (epilepsy)
- Panic attacks or phobias (fears)
How D FAX PLUS 100 TABLET Works
D FAX PLUS 100 TABLET contains two medicines namely clonazepam and desvenlafaxine. Clonazepam is an anticonvulsant. It suppresses the abnormal electrical activity within the brain and induces calmness which helps in reducing fits.
Desvenlafaxine is an antidepressant medicine. It works by regulating the release and uptake of certain chemical messengers (dopamine, serotonin and norepinephrine) within the brain that affects thoughts, emotions, body movements and behaviour. As a result, it manages seizures, improves your ability to think, controls your emotions and stabilizes your mental health.
How to use D FAX PLUS 100 TABLET
Take D FAX PLUS 100 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine.
Your doctor will decide the correct dose and duration of theray for you depending upon your age, body weight and disease condition.
Do not stop taking D FAX PLUS 100 TABLET without consulting your doctor, even if you feel better during the mid-way of therapy as it could lead to withdrawal symptoms such as depression, nervousness, difficulty in sleeping, irritability, sweating, diarrhea, confusion, mood changes, lack of sleep, hallucinations and/or rapid heartbeats.
Side Effects Of D FAX PLUS 100 TABLET
Common
- dizziness, drowsiness, tiredness
- weak muscles, poor muscle control, loss of balance
- poor concentration, confusion, memory loss, restlessness
- headache
- slow or difficult speech
- urge to pass urine
- blood problems (causing tiredness, bruising, shortness of breath and nose bleeds)
- nausea, stomach upset
- blurred vision
- skin rash or itching
- hair loss
- feeling sleepy or difficulty in sleeping
- increased sweating
- constipation, decreased appetite, dry mouth, diarrhea
- decreased sex drive, delayed ejaculation, problems in erection
- difficulty in passing urine
- weight gain or weight loss
Rare
Stop taking D FAX PLUS 100 TABLET and contact your doctor immediately if you experience any of the following side effects:
- suicidal thoughts and behaviour
- signs of allergic reactions (such as skin rash, itching, swellling of the face, lips, tongue and throat which causes difficulty in breathing or swallowing)
- changes in behavior (such as feeling agitated, restless, aggressive, irritable, violent or angry, false beliefs, nightmares and hallucinations or other inappropriate behavior)
- fits
- signs of heart problems (such as fast or irregular heart rate, chest pain, swollen ankles, fainting, dizziness upon standing)
- signs of serotonin syndrome (feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles, or muscle twitching, loss of coordination, nausea, vomiting, diarrhea, or seizures)
- worsening of hypertension (high blood pressure)
- increased signs of bleeding or bruising
- problems in vision (such as blurred vision, eye swelling or pain, seeing halos around lights and glaucoma)
- low blood sodium levels (causing headache, nausea, difficulty in concentration, memory impairment, confusion, feeling weak or unsteady, hallucinations, fainting or seizures)
- troubled breathing, chest pain or coughing
- severe upper abdominal pain, swollen and tender abdomen, fever
How To Manage Side Effects
Constipation
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Nausea And Vomiting
Take D FAX PLUS 100 TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
Warning & Precautions
Pregnancy
ContraindicatedD FAX PLUS 100 TABLET is generally not recommended for use in pregnant women unless considered necessary by the physician, as it may harm the growing baby. Therefore, inform your doctor before taking D FAX PLUS 100 TABLET if you are pregnant, think you might be pregnant or planning to have a baby.
Breastfeeding
ContraindicatedD FAX PLUS 100 TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk to the nursing infant. Therefore, consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or handle any heavy tools or machines if your ability is affected by D FAX PLUS 100 TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking D FAX PLUS 100 TABLET as it might make you feel dizzier and drowsier.
Kidney
Use with CautionD FAX PLUS 100 TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
Consult your doctorD FAX PLUS 100 TABLET is not recommended for use in patients with severe liver problems (such as liver cirrhosis). It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take D FAX PLUS 100 TABLET if you are allergic to Clonazepam or Desvenlafaxine.
Lungs
Consult your doctorD FAX PLUS 100 TABLET is not recommended for use in patients with severe lung problems (such as pulmonary insufficiency or respiratory insufficiency). It should be used with caution in patients with COPD. Therefore, consult your doctor before taking it.
Heart Disease
Use with CautionD FAX PLUS 100 TABLET should be used with caution in patients with heart problems. Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedD FAX PLUS 100 TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use In Geriatrics
Use with CautionD FAX PLUS 100 TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.
Others
D FAX PLUS 100 TABLET is not recommended for use if you:
- have myasthenia gravis (severe muscle weakness)
- have sleep apnea (breathing stops and starts during sleep)
- have an history of alcoholism or drug abuse
Before taking D FAX PLUS 100 TABLET, inform your doctor if you:
- have previously experienced depression with thoughts of committing suicide
- are an alcoholic
- have poor muscle control caused due to problems in nervous system
- have porphyria (a rare inherited blood disorder)
- are scheduled for any operation in the upcoming days
- have had stroke or any other circulatory disorders
- have or ever had any bleeding problems
- have or have a family history of various mental illness (such as bipolar disorder, mania, and hypomania)
- have high blood cholesterols levels
- have low blood sodium levels (causing tiredness, confusion, and muscle weakness)
- have glaucoma
Interactions
A. Drug - Drug interactions:
Before taking D FAX PLUS 100 TABLET, inform your doctor if you are taking any of the following medicine such as:
- medicines used to manage epilepsy (such as carbamazepine, phenytoin, phenobarbital, sodium valproate, primidone)
- medicines used for pain relief (such as aspirin, celecoxib, tramadol, ibuprofen, diclofenac)
- medicines used to manage high blood pressure (such as ramipril, candesartan, amlodipine, doxazosin)
- medicines used to reduce anxiety and to induce sleep (such as alprazolam, midazolam, lorazepam, nitrazepam)
- muscle relaxants (used for muscle relaxation prior to surgeries) such as tubocurarine
- cimetidine (a medicine used for managing stomach ulcers)
- rifampicin (a medicine used to manage tuberculosis)
- opioid analgesic medications (such as buprenorphine, morphine, codeine or propoxyphene, pethidine, fentanyl etc.)
- other medicines used to manage depression such as monoamine oxidase inhibitors (Ex. moclobemide, isocarboxazid, phenelzine and tranylcypromine), tricyclic antidepressants (Ex. amitriptyline, nortriptyline), lithium, fluoxetine, sertraline, citalopram, escitalopram etc.
- linezolid (an antibiotic used to manage bacterial infection)
- intravenous methylene blue (used to manage abnormal methemoglobin levels in blood)
- medicines used to manage migraine headaches (such as sumatriptan, zolmitriptan)
- tryptophan (an aminoacid used for maintaing mental health)
- buspirone (a medicine used to reduce anxiety)
- amphetamines (used as CNS stimulants) Ex. dexamphetamine and lisdexamphetamine
- dextromethorphan (a cough medicine)
- methadone (a medicine used to manage pain or drug addiction)
- pentazocaine (an anesthetic used to cause numbness before surgeries)
- St. John’s Wort (an herbal medicine used to manage depression)
- medicines that can affect blood clotting (such as aspirin or warfarin)
- medicines used to manage psychotic disorders (Ex. chlorpromazine, prochlorperazine, trihexiphenidyl)
Overdosage:
If you or anyone else accidentally took more D FAX PLUS 100 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include headache, nausea, vomiting, dizziness, drowsiness, low blood pressure, breathing difficulties, feeling agitated, constipation, diarrhea, dry mouth, numbness of body parts and fast heart rate.
Synopsis
| Drug | : | Clonazepam, Desvenlafaxine |
| Pharmacological Category | : | Benzodiazepines, Selective Serotonin and Norepinephrine Reuptake Inhibitor (SNRI) |
| Therapeutic Indication | : | Depression, Fits |
| Dosage Forms | : | Tablet |
More Information
- Keep D FAX PLUS 100 TABLET out of reach of children
- Store D FAX PLUS 100 TABLET at room temperature
FAQs About D FAX PLUS 100 TABLET
Q: What is the use of D FAX PLUS 100 TABLET?
A: D FAX PLUS 100 TABLET is used to manage depression. It can also be used in the management of epilepsy (fits), panic disorder and in certain types of phobias (fears).
Q: How D FAX PLUS 100 TABLET works in my body?
A: D FAX PLUS 100 TABLET suppresses the abnormal electrical activity within the brain and induces sleep. It also regulates the release and uptake of certain chemical messengers within the brain that affects thoughts, emotions, body movements, and behaviour. As a result, it improves your ability to think, controls your emotions and stabilizes your mental health.
Q: Can D FAX PLUS 100 TABLET be used in children?
A: D FAX PLUS 100 TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Q: Can D FAX PLUS 100 TABLET be used during pregnancy?
A: D FAX PLUS 100 TABLET is generally not recommended for use in pregnant women unless considered necessary by the physician, as it may harm the growing baby. Therefore, inform your doctor before taking D FAX PLUS 100 TABLET if you are pregnant, think you might be pregnant or planning to have a baby.
Q: Will the use of D FAX PLUS 100 TABLET cause sleepiness?
A: Yes, D FAX PLUS 100 TABLET can make your feel sleepy, drowsy, or tired. Therefore, do not drive or handle heavy machines or tool if you feel drowsy or sleepy. Avoid consumption of alcohol as it can aggravate your drowsiness.
Q: Can I consume alcohol while taking D FAX PLUS 100 TABLET?
A: Avoid consumption of alcohol while taking this medicine as it may make you feel more dizzy or drowsy.
Q: What to do if I forget to take a dose of D FAX PLUS 100 TABLET?
A: If you forget to take a dose of D FAX PLUS 100 TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of D FAX PLUS 100 TABLET to compensate a missed dose, as it could lead to toxicity.
Q: Will taking a higher dose of D FAX PLUS 100 TABLET than the prescribed one be beneficial?
A: No, taking a higher dose of D FAX PLUS 100 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I stop taking D FAX PLUS 100 TABLET once my symptoms subside?
A: No. Do not stop taking D FAX PLUS 100 TABLET without consulting your doctor even if you feel better during the mid-way of the therapy. Sudden discontinuation of therapy may cause withdrawal symptoms such as headaches, muscle pain, tension, restlessness, confusion, mood changes, difficulty in sleeping, irritability, dizziness, tingling sensation, tiredness or weakness, nausea, vomiting and tremors.
Q: Can D FAX PLUS 100 TABLET be taken daily?
A: Yes. D FAX PLUS 100 TABLET can be taken daily as per your doctor’s instruction. However, if you are doubtful, consult your doctor.
Q: How to take D FAX PLUS 100 TABLET?
A: Take D FAX PLUS 100 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Q: What are the common side effects of taking D FAX PLUS 100 TABLET?
A: The most common side effects of taking D FAX PLUS 100 TABLET are dizziness, drowsiness, tiredness, weak muscles, memory loss, headache, nausea, stomach upset, hair loss, low sex drive, increased sweating, constipation and dry mouth. Consult your doctor if any of these side effect troubles you.
Q: Can D FAX PLUS 100 TABLET cause weight gain?
A: Yes. Weight gain is one of the common side effects of taking D FAX PLUS 100 TABLET. If this side effect bothers you, contact your doctor.
Q: Will D FAX PLUS 100 TABLET reduce my sex drive?
A: Yes. D FAX PLUS 100 TABLET may affect your sexual life. It may decrease sex drive or cause problems in orgasm, ejaculation or erection. Therefore, consult your doctor if you experience any such symptoms.
References
1. KD. Tripathi. Drugs Acting on Central Nervous System. Antiepileptic Drugs. Essentials of Medical Pharmacology. 7th Edition. Page – 418.
2. Barbara G Wells, Joseph T. DiPiro, Terry L. Schwinghammer and Cecily V. DiPiro. Major Depressive Disorder. Pharmacotherapy Handbook. Nineth Edition. Page – 715 & 718.
3. Hajira Basit; Chadi I. Kahwaji. Clonazepam. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. September 2022. [Accessed on 27th February 2023] https://www.ncbi.nlm.nih.gov/books/NBK556010/
4. Michael R. Liebowitz, and Karen A. Tourian. Efficacy, Safety, and Tolerability of Desvenlafaxine 50 mg/d for the Treatment of Major Depressive Disorder: A Systematic Review of Clinical Trials. NIH. National Library of Medicine. National Center of Biotechnology Information. PMC PubMed Central. 2010. [Accessed on 27th February 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947544/
5. Neuraxpharm UK Limited. Clonazepam Neuraxpharm 0.5 mg, 1 mg and 2 mg. Electronic Medicines Compendium. [Revised in October 2021]. [Accessed on 27th February 2023] https://www.medicines.org.uk/emc/files/pil.13633.pdf
6. Pfizer Ltd. U.S. Food & Drug Administration. [Revised in July 2011] [Accessed on 27th February 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021992s030lbl.pdf
7. Pfizer Ltd. MEDICATION GUIDE PRISTIQ® (pris-TEEK) (desvenlafaxine) extended-release tablets. [Revised in January 2022] [Accessed on 27th February 2023] https://labeling.pfizer.com/ShowLabeling.aspx?id=14010
8. Desvenlafaxine + Clonazepam. Erides C 50. Eridanus Healthcare Inc. [Accessed on 27th February 2023] https://www.eridanushealth.com/product/erides-c-50
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