CRAL ORAL Gel 200ml

Introduction About CRAL ORAL GEL

CRAL ORAL GEL contains Sucralfate, which belongs to the group of medicines called Anti-ulcer agents. It is used for the short-term (up to 8 weeks) management of active duodenal ulcers (part of the small intestine), prophylaxis of gastrointestinal haemorrhage due to stress ulceration in critically ill patients, gastric and benign ulcers.

CRAL ORAL GEL should be used with caution in patients with chronic renal failure, dialysis patients and diabetes. CRAL ORAL GEL should be used with caution in pregnant and breastfeeding women. The safety and effectiveness of CRAL ORAL GEL for use in children have not been established.

CRAL ORAL GEL should be used with caution in elderly patients above 65 years of age. The most common side effect of taking CRAL ORAL GEL is constipation. Consult your doctor if any of your symptoms get worse or persist.

Uses Of CRAL ORAL GEL

• Management of active duodenal ulcer, benign and gastric ulcers
• Prophylaxis management of gastrointestinal haemorrhage

How CRAL ORAL GEL Works

CRAL ORAL GEL works by forming a protective layer around the ulcer saving it from the further attack of acid, pepsin or bile. It increases growth factor production, promoting tissue growth, regeneration, thereby facilitating repair.

How to use CRAL ORAL GEL

Take CRAL ORAL GEL as advised by your physician. Shake well before each use. Take CRAL ORAL GELon an empty stomach at least 1 hour before or 2 hours after a meal for best results. Your doctor will determine the correct dose and duration for you based on your age, body weight and disease condition.

Side Effects Of CRAL ORAL GEL

How To Manage Side Effects

Constipation:

Consume fiber-rich foods such as fresh fruits, vegetables and cereals. Consume lots of water and exercise more regularly. Contact your doctor if your symptom doesn’t improve.

Warning & Precautions

Pregnancy

CRAL ORAL GEL should be used with caution in pregnant women or women planning to have a baby. It will be given to you by the doctor only if clearly needed. Contact your doctor before taking CRAL ORAL GEL.

Breastfeeding

CRAL ORAL GEL should be used with caution in breastfeeding women as it is not known whether it passes into breast milk. Contact your doctor before taking CRAL ORAL GEL.

Driving and Using Machines

Do not drive or operate any machines if you feel any unusual effects after taking CRAL ORAL GEL.

Kidney

CRAL ORAL GEL should be used with caution in patients with chronic kidney failure and patients undergoing dialysis. Contact your doctor before taking CRAL ORAL GEL.

Allergy

Do not take CRAL ORAL GEL if you are allergic to Sucralfate or any of the other ingredients in this medicine.

Interactions

A. Drug-Drug interactions:

Before taking CRAL ORAL GEL, inform your doctor if you are taking any of the following medicine:

• ranitidine, cimetidine (medicine used to manage stomach acidity and peptic ulcer)
• digoxin (a medicine used to manage heart failure), quinidine (a medicine used to manage irregular heart rate)
• antibiotics like fluoroquinolone, ciprofloxacin, norfloxacin, ofloxacin, ketoconazole and tetracycline (medicines used to manage bacterial infections)
• l-thyroxine (a medicine used to manage low thyroid hormone)
• phenytoin (a medicine used to manage epilepsy)
• theophylline (medicine used to manage wheezing, shortness of breath and chest tightness)
• warfarin (to manage blood clots)

Overdosage:

If you or anyone else accidentally take too much of CRAL ORAL GEL, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are nausea, vomiting, indigestion and abdominal pain.

Synopsis

More Information

• Keep CRAL ORAL GEL out of reach from children
• Store CRAL ORAL GEL below 30°C

FAQs About CRAL ORAL GEL

What is CRAL ORAL GEL used for?

CRAL ORAL GEL is used for the short-term (up to 8 weeks) management of active duodenal ulcer (part of the small intestine), prophylaxis of gastrointestinal haemorrhage due to stress ulceration in critically ill patients, gastric and benign ulcers.

Is CRAL ORAL GEL safe in pregnancy?

CRAL ORAL GEL should be used with caution in pregnant women or women planning to have a baby. It will be given to you by the doctor only if clearly needed. Contact your doctor before taking CRAL ORAL GEL.

Can CRAL ORAL GEL be used in elderly patients?

CRAL ORAL GEL should be used with caution in elderly patients aged 65 years or above, especially with decreased liver, kidney and cardiac function or other diseases. Contact your doctor before taking CRAL ORAL GEL.

How CRAL ORAL GEL work?

CRAL ORAL GEL works by forming a protective layer around the ulcer, saving it from further attack by acid, pepsin or bile. It increases growth factor production, promoting tissue growth, regeneration, thereby facilitating repair.

Can CRAL ORAL GEL be used in patients with kidney problems?

CRAL ORAL GEL should be used with caution in patients with chronic kidney failure and patients undergoing dialysis. Contact your doctor for more information before taking it.

References

1. KD Tripathi. Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of Medical Pharmacology. Seventh Edition, 2013. Page - 656.

2. Wallace JL, Sharkey KA. Pharmacotherapy of Gastric Acidity, Peptic Ulcers and Gastroesophageal Reflux Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 1315.

3. Kudaravalli P, John S. Sucralfate. StatPearls [Internet]. NIH National Library of Medicine. National Center for Biotechnology Information. [Revised in February 2022] [Accessed on 18th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK551527/

4. R N Brogden, R C Heel, T M Speight, G S Avery. Sucralfate. A review of its pharmacodynamic properties and therapeutic use in peptic ulcer disease. NIH National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov 1984. [Accessed on 18th October 2022] https://pubmed.ncbi.nlm.nih.gov/6368184/#:~:text=Sucralfate%20is%20a%20basic%20aluminium%20salt%20of%20sulphated,effects%20of%20pepsin%2C%20acid%20and%20possibly%20bile%20salts.

5. Aptalis Pharma US, Inc. U.S. Food & Drug Administration. [Revised in March 2013] [Accessed on 18th October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/018333s034,019183s016lbl.pdf

6. Sucralfate. Pharmaceutical Associates, Inc. [Revised in January 2022] [Accessed on 18th October 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=fa6e4661-1bee-4a64-b982-9d44dbdb8498&type=display

7. Sucralfate. Amneal Pharmaceuticals LLC. [Revised in February 2021] [Accessed on 18th October 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4350b771-76a9-4e00-93f0-a18c71288f83

8. Sucralfate. Aptalis Pharma Canada Inc. [Revised in September 2013] [Accessed on 18th October 2022] https://allerganwebcdnprod.azureedge.net/allergancanadaspecialty/allergancanadaspecialty/media/actavis-canada-specialty/en/products/pms/sulcrate_pm_12sep2013_eng.pdf

9. Zuventus Healthcare Ltd. Ancool SF (Sucralfate 500mg). [Accessed on 18th October 2022] http://www.zuventus.co.in/patient_wise_products_selected.aspx?Medi_Id=256

10. Fourrts India Laboratories Pvt Ltd. Sucralfate. [Accessed on 18th October 2022] https://www.fourrts.com/sucrafil/

11. Wellona Pharma. Sucralfate. [Accessed on 18th October 2022] https://wellonapharma.com/product/finished/sucralfate-suspension

Useful Diagnostic Tests

• Kidney function test

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 27 Oct 2022 | 10:44 AM(IST)