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Introduction About CIZASPA X TABLET
CIZASPA X TABLET is a combination of Chlordiazepoxide and Mebeverine which belongs to the group of medicines called Antianxiety drugs and Antispasmodics respectively. It is used in the management of Irritable Bowel Syndrome (IBS) and other digestive problems caused due to excessive stress such as peptic ulcer, Crohn’s disease and Colitis.
It helps in relieving painful stomach cramps, bloating, indigestion and other symptoms of IBS and also reduces the excessive tension and anxiety associated with IBS. CIZASPA X TABLET preferably taken before or with meals.
During the management, follow a fiber-rich diet and drink plenty of water as instructed by your doctor to achieve better results. Restrict the foods that does not suits your gut. If you find that certain foods increase your symptoms, then it makes sense not to eat them.
Before taking CIZASPA X TABLET inform your doctor if you have any lung, liver or kidney problems. You must also inform your doctor if you have any breathing problems, muscle problems, mental illnesses, or an habit of drug abuse or chronic alcoholism as a precaution.
Do not take CIZASPA X TABLET without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of taking CIZASPA X TABLET are tiredness, weakness, headache, dizziness, sleepiness, loss of balance, poor muscle control, problems in passing urine, reduced sex drive and irregular periods. Consult your doctor if any of these side effects trouble you.
Uses Of CIZASPA X TABLET
It is used in the management of:
- Irritable Bowel Syndrome (IBS; painful stomach cramps, bloating, indigestion)
- Peptic ulcer, Crohn’s disease or Colitis
- Excessive tension and anxiety associated with IBS
How CIZASPA X TABLET Works
CIZASPA X TABLET contains two medicines namely chlordiazepoxide and mebeverine. Chlordiazepoxide is an antianxiety medication. It suppresses the abnormal electrical activity within the brain and induces calmness. This helps in the management of anxiety caused due to IBS.
Mebeverine is a smooth muscle relaxant. It reduces stomach cramps by relaxing the smooth muscles present in the stomach and in the intestines. Collectively, these actions reduce stomach cramps, signs of indigestion and nervousness associated with IBS.
How to use CIZASPA X TABLET
Take CIZASPA X TABLET as advised by your physician. It is preferably taken before or with meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking CIZASPA X TABLET unless your doctor advice you to stop.
Side Effects Of CIZASPA X TABLET
Common
- drowsiness and light headedness especially on the next day
- tiredness, dizziness, sleepiness
- loss of balance, unsteadiness or clumsiness
- poor muscle co-ordination
- confusion
- slow or difficulty in speech
Rare
- headache
- vertigo (spinning sensation)
- low blood pressure
- stomach upsets
- skin rashes
- problems with your eyesight
- changes in the level of sexual desire
- problems in passing urine, urge to pee
- impotence
- menstrual irregularities
Stop taking CIZASPA X TABLET and inform your doctor immediately if you experience any of the following side effects such as:
- severe allergic reactions (such as skin rash, itching, swelling of the lips, face or body and difficulty in breathing or swallowing)
- suicidal thoughts or worsening of depression
- behavioural changes
- yellowing of the skin or eyes
- low blood counts causing weakness, pale skin, bleeding problems, sore throat and frequent infections
How To Manage Side Effects
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
Monitoring requiredCIZASPA X TABLET may affect the unborn baby. Therefore, it should be used in pregnant women only if it is considered necessary by the physician. Women of childbearing potential must use an effective contraceptive method to avoid pregnancy while taking this medicine.
Breastfeeding
ContraindicatedCIZASPA X TABLET may pass through the breast milk. Therefore, it is not recommended for use in breastfeeding women. Consult your doctor for advice before taking it.
Driving and Using Machines
Use with CautionCIZASPA X TABLET may induce drowsiness, tiredness and poor muscle control. Therefore, do not drive or handle heavy tools or machines if your ability is affected by CIZASPA X TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking CIZASPA X TABLET, as it could aggravate your existing condition.
Kidney
Use with CautionCIZASPA X TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
Consult your doctorCIZASPA X TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other mild liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take CIZASPA X TABLET if you are allergic to Chlordiazepoxide or to Mebeverine.
Lungs
ContraindicatedCIZASPA X TABLET is not recommended for use in patients with lung diseases or breathing difficulties. Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedCIZASPA X TABLET is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor before taking it.
Use In Geriatrics
Use with CautionCIZASPA X TABLET should be used with caution in the elderly patients (aged 65 years and above). Therefore, consult your doctor before taking it.
Others
CIZASPA X TABLET is not recommended for use if you:
- have myasthenia gravis (severe muscle weakness)
- have any mental illnesses
- have abnormal body movements
Before taking CIZASPA X TABLET inform your doctor if you:
- have depression
- have a previous history of mental illnesses
- have an habit of alcoholism or drug abuse
Interactions
A. Drug-Drug interactions:
Before taking CIZASPA X TABLET inform your doctor if you are taking any of the following medicines such as:
- medicines used to manage psychiatric disorders (such as pimozide, haloperidol, risperidone, thioridazine, fluphenazine, chlorpromazine, clozapine) or selegiline
- medicine used to manage depression like monoamine oxidase inhibitors (Ex. tranylcypromine, moclobemide iproniazid, nialamide, isocarboxazid, toloxatone)
- medicines that reduce anxiety and induces sleep (Ex. diazepam, clonazepam, lorazepam, midazolam)
- medicines used for pain relief (such as tramadol, ibuprofen)
- anesthetics (medicines causing loss of sensation or consciousness) such as sevoflurane, propofol, etc.
- medicines used to manage allergic conditions (such as chlorphenamine)
- medicines used to manage fits (such as phenytoin and phenobarbital)
- rifampicin (an antibiotic used in the management of Tuberculosis)
- cimetidine, omeprazole (medicines used for stomach ulcers)
- medicines used to manage bacterial infections (such as erythromycin)
- disulfiram (a medicine used to quit alcoholism)
- contraceptive agents (birth control pills) Ex. mifepristone
- medicines used to manage viral infections (Ex. ritonavir)
- medicines used to manage high blood pressure (such as atenolol, propranolol, moxonidine)
- medicines used to manage blood clots (such as heparin, warfarin)
- cardiac glycosides (such as digoxin) used to manage abnormal heart rhythm
- levodopa (a medicine used to manage parkinsonism)
- sodium oxybate (a medicine used to manage narcolepsy)
- theophylline (a medicine used to manage asthma)
- opioids (medicines used for pain relief) such as morphine, codeine, pethidine, fentanyl
B. Drug-Food interaction:
Try to take this medicine before or with meals to achieve maximum efficacy.
Overdosage:
If you or anyone else accidentally took more CIZASPA X TABLET, contact your doctor immediately or go to a hospital straight away.
Synopsis
| Drug | : | Chlordiazepoxide, Mebeverine |
| Pharmacological Category | : | Benzodiazepines, Atropine Substitutes |
| Therapeutic Indication | : | Stomach cramps, Psychosomatic disorders |
| Dosage Forms | : | Tablet |
More Information
- Keep CIZASPA X TABLET out of the sight and reach of children
- Store CIZASPA X TABLET at room temperature
FAQs About CIZASPA X TABLET
Q: What is the use of CIZASPA X TABLET?
A: CIZASPA X TABLET is used in the management of Irritable Bowel Syndrome (IBS) and other digestive problems caused due to excessive stress such as peptic ulcer, Crohn’s disease and Colitis. It helps in relieving painful stomach cramps, bloating, indigestion and other symptoms of IBS and also reduces the excessive tension and anxiety associated with IBS.
Q: How CIZASPA X TABLET works in my body?
A: CIZASPA X TABLET suppresses the abnormal electrical activity within the brain and induces calmness. It also relaxes the smooth muscles present in the stomach and in the intestines which reduces stomach cramps.
Q: Can CIZASPA X TABLET be used in children?
A: CIZASPA X TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Q: Can CIZASPA X TABLET be used during pregnancy?
A: CIZASPA X TABLET may affect the unborn baby. Therefore, it should be used in pregnant women only if it is considered necessary by the physician.
Q: Will the use of CIZASPA X TABLET cause sleepiness?
A: Yes, CIZASPA X TABLET can make your feel sleepy, drowsy, or tired. Therefore, do not drive or handle heavy machines or tool if you feel drowsy or sleepy. Avoid consumption of alcohol as it can aggravate your drowsiness.
Q: Can I consume alcohol while taking CIZASPA X TABLET?
A: Avoid consumption of alcohol while taking CIZASPA X TABLET, as it could aggravate your existing condition.
Q: What to do if I forget to take a dose of CIZASPA X TABLET?
A: If you forget to take a dose of CIZASPA X TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of CIZASPA X TABLET to compensate a missed dose, as it could lead to toxicity.
Q: Will taking a higher dose of CIZASPA X TABLET than the prescribed one be beneficial?
A: No, taking a higher dose of CIZASPA X TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I stop taking CIZASPA X TABLET once my symptoms subside?
A: No. Do not stop taking CIZASPA X TABLET without consulting your doctor even if you feel better during the mid-way of the therapy. Sudden discontinuation of therapy may cause withdrawal symptoms such as headaches, muscle pain, tension, restlessness, confusion, mood changes, difficulty in sleeping, irritability, dizziness, tingling sensation, tiredness or weakness, nausea, vomiting and tremors.
Q: Can CIZASPA X TABLET be taken daily?
A: Yes. CIZASPA X TABLET can be taken daily as per your doctor’s instruction. However, if you are doubtful, consult your doctor.
Q: How to take CIZASPA X TABLET?
A: Take CIZASPA X TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It is preferably taken before or along with meals.
Q: What are the common side effects of taking CIZASPA X TABLET?
A: The most common side effects of taking CIZASPA X TABLET are tiredness, weakness, headache, dizziness, sleepiness, loss of balance, poor muscle control, problems in passing urine, reduced sex drive and irregular periods. Consult your doctor if any of these side effects trouble you.
Q: Will CIZASPA X TABLET reduce my sex drive?
A: Yes. CIZASPA X TABLET may affect your sexual life. It may decrease sex drive or cause problems in orgasm, ejaculation or erection. Therefore, consult your doctor if you experience any such symptoms.
References
1. KD. Tripathi. Sedatives and Hypnotics. Antidepressants and Antianxiety drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 401 & 466.
2. Mahnaz Darvish-Damavandi, Shekoufeh Nikfar, and Mohammad Abdollahi. A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. February 2010. [Accessed on 25th February 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816265/
3. Mylan Products Ltd. Librium 5 mg and 10 mg Capsules Chlordiazepoxide hydrochloride. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 25th February 2023] https://www.medicines.org.uk/emc/files/pil.1729.pdf
4. APL Swift Services (Malta) Ltd. Mebeverine 135 mg film-coated tablets. Electronic Medicines Compendium (EMC). [Revised in May 2018] [Accessed on 25th February 2023] https://www.medicines.org.uk/emc/files/pil.2315.pdf
5. La Renon Healthcare Pvt Ltd. Benzip Capsules. [Accessed on 25th February 2023] https://www.larenon.com/wp-content/uploads/2019/12/BENIZEP-LBL.pdf
6. Central Drugs Standard Control Organization. Mebeverine Hcl 135mg + Chlordiazepoxide 5mg tablet. December 2006. [Accessed on 25th February 2023] https://cdscoonline.gov.in/CDSCO/Drugs
7. Leeford Healthcare Pvt Ltd. Mebizid -C. [Accessed on 25th February 2023] https://www.leeford.in/product/725/mebizid-c
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