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Introduction About CIPREMI INJECTION
CIPREMI INJECTION contains Remdesivir which belongs to the group of medicines called Antiviral drugs. It is used in adults and children (older than 28 days and weighing at least 3 kg) for the management of coronavirus disease 2019 (COVID-19) who have pneumonia, need extra oxygen to help them breathe, but who are not on artificial ventilation.
It also manages adults and children (weighing at least 40 kg) who do not need extra oxygen to breathe and are at increased risk for progressing to severe COVID-19. Coronavirus causes short-term, mild upper respiratory infection (common cold), with symptoms like nasal obstruction, sneezing, runny nose, and sometimes cough.
Prior to the management, your doctor may want you to take several blood tests to understand your existing condition. Before receiving CIPREMI INJECTION, inform your doctor if you have any liver, kidney problems, or if you are immunocompromised.
CIPREMI INJECTION should be used with caution among pregnant or breastfeeding women, therefore consult your doctor before receiving. CIPREMI INJECTION is not recommended for children younger than 28 days of age or weighing less than 3 kg.
CIPREMI INJECTION should be used with caution in elderly patients above 65 years of age. The most common side effects of receiving CIPREMI INJECTION are nausea, headache, or rash. Contact your doctor if any of the symptoms worsen.
Uses Of CIPREMI INJECTION
- It is used in adults and children (older than 28 days and weighing at least 3 kg) for the management of coronavirus disease 2019 (COVID-19)
- It also manages adults and children (weighing at least 40 kg) who do not need extra oxygen to breathe and are at increased risk for progressing to severe COVID-19
How CIPREMI INJECTION Works
CIPREMI INJECTION stops the viral RNA (converts information in DNA to proteins) synthesis which in turn works by stopping the virus multiplication in cells and even the virus multiplication in the body. Thus, helping your body to overcome the virus infection.
How to use CIPREMI INJECTION
CIPREMI INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Side Effects Of CIPREMI INJECTION
Common
- nausea
- headache
- rash
Rare
Stop receiving CIPREMI INJECTION and contact your doctor immediately if you experience any of the following side effects:
- allergic reactions (changes in your blood pressure or heart rate, high temperature, rash, fever, nausea, breathlessness, wheezing, sweating, swelling of the lips, face, or throat, shaking, low oxygen level in blood, vomiting)
How To Manage Side Effects
Nausea:
Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if symptoms do not improve.
Headache:
Drink an ample amount of water. Get adequate rest. Try to be relaxed and stress-free. Ask your doctor before taking any medicine for headaches. Avoid bright lights. Consult your doctor if symptoms do not improve.
Warning & Precautions
Pregnancy
CIPREMI INJECTION should be received with caution in pregnant women or women planning to have a baby as it is not known if it can harm your unborn baby. It will only be given if the potential benefits of management outweigh the potential risks to the mother and the unborn child.
You must use effective contraception during this> management. Consult your doctor before receiving it.
Breastfeeding
CIPREMI INJECTION should be received with caution in breastfeeding women as it is not known if it can pass into breast milk. Your doctor will help you decide whether to continue breastfeeding or to start the> management. Consult your doctor before receiving it.
Driving and Using Machines
CIPREMI INJECTION is not likely to affect your ability to drive or use machines.
Kidney
CIPREMI INJECTION should be received with caution in patients with kidney problems. Consult your doctor before receiving it.
Liver
CIPREMI INJECTION should be received with caution in patients with liver problems. Consult your doctor before receiving it.
Allergy
Do not receive CIPREMI INJECTION if you are allergic to Remdesivir or any of the other ingredients of this medicine.
Others
Before receiving CIPREMI INJECTION, inform your doctor if you:
- are immunocompromised (immune system is not working properly)
Use in pediatrics:
CIPREMI INJECTION is not recommended for use in children younger than 28 days of age or weighing less than 3 kg. Consult your doctor before receiving it.
Use in geriatrics:
CIPREMI INJECTION should be received with caution in elderly patients aged above 65 years. Consult your doctor before receiving it.
Interactions
A. Drug - Drug interactions:
Before receiving CIPREMI INJECTION, inform your doctor if you are taking any of the following medicine:
- chloroquine phosphate (used to manage malaria)
- hydroxychloroquine sulfate (used to manage joint inflammation)
- midazolam (used to induce sleep)
- pitavastatin (used to reduce blood cholesterol)
- theophylline (used to manage symptoms of asthma, bronchitis, or other lung diseases)
- rifampicin (used to manage infections like tuberculosis)
Overdosage:
CIPREMI INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so you are unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Remdesivir |
| Pharmacological Category | : | Nucleoside analog |
| Therapeutic Indication | : | Covid 19 |
| Dosage Forms | : | Injection |
More Information
- Keep CIPREMI INJECTION out of reach of children
- Store at 30°C
FAQs About CIPREMI INJECTION
What is CIPREMI INJECTION used for?
CIPREMI INJECTION is used in adults and children (older than 28 days and weighing at least 3 kg) for the management of coronavirus disease 2019 (COVID-19) who have pneumonia, need extra oxygen to help them breathe, but who are not on artificial ventilation. It also manages adults and children (weighing at least 40 kg) who do not need extra oxygen to help them breathe and are at increased risk for progressing to severe COVID-19.
Do I need to take any tests while receiving CIPREMI INJECTION?
Yes. You will be given blood tests before and during management with CIPREMI INJECTION as determined by your doctor. These tests are to check for kidney or liver problems, and the time taken by your blood to clot.
Is CIPREMI INJECTION safe in pregnancy?
CIPREMI INJECTION should be received with caution in pregnant women or women planning to have a baby as it is not known if it can harm your unborn baby. It will only be given if the potential benefits of management outweigh the potential risks to the mother and the unborn child. You must use effective contraception during this management. Consult your doctor before receiving it.
How does CIPREMI INJECTION work?
CIPREMI INJECTION stops the viral RNA (converts information in DNA to proteins) synthesis which in turn works by stopping the virus multiplication in cells and even the virus multiplication in the body. Thus, helping your body to overcome the virus infection.
Can CIPREMI INJECTION cause a headache?
Yes. Headache is a common side effect of CIPREMI INJECTION. In such cases, drink ample amount of water and get adequate rest. Try to be relaxed and stress-free. Avoid bright lights. Ask your doctor before taking any medicine for headaches.
References
1. KD Tripathi. Drugs for cough and bronchial asthma. Essentials of Medical Pharmacology. 8th edition. 2019. Page – 237.
2. Richard T. Eastman, Jacob S. Roth, Kyle R. Brimacombe, Anton Simeonov, Min Shen, Samarjit Patnaik, and Matthew D. Hall. Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19. NIH, National library of medicine, National center for biotechnology information. Pubmed Central. May 2020. [Accessed on 1st June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202249/
3. Abdul Aleem, Jiten P. Kothadia. Remdesivir. NIH, National library of medicine, National center for biotechnology information. Pubmed.gov. September 2022. [Accessed on 1st June 2022] https://pubmed.ncbi.nlm.nih.gov/33085408/
4. Gilead Sciences Ireland UC. Electronic Medicines Compendium (EMC). [Revised in September 2022] [Accessed on 1st June 2022] https://www.medicines.org.uk/emc/files/pil.11597.pdf
5. Gilead Sciences, Inc. U.S. Food & Drug Administration. [Revised in October 2020] [Accessed on 1st June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/214787Orig1s000lbl.pdf
Useful Diagnostic Tests
- RT-PCR test
- Antigen test
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