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INTRODUCTION ABOUT BIOVORIN 15MG TABLET
BIOVORIN 15MG TABLET contains Leucovorin Calcium, which belongs to the group of medicines called Folic acid analogs. BIOVORIN 15MG TABLET is used to increase folic acid levels in the body, whereas methotrexate (medicine) lowers folic acid levels in the body. It is therefore used to counteract this and support the maintenance of folic acid levels. This is known as Leucovorin rescue. This medicine is also used to manage a form of anaemia (megaloblastic) which results from low levels of folic acid.
Your doctor may advise to do routine blood tests to evaluate and monitor your health condition. BIOVORIN 15MG TABLET is generally not recommended for use in patients with pernicious anaemia or other megaloblastic anaemia caused by vitamin B12 deficiency. BIOVORIN 15MG TABLET should be used with caution in pregnant and breastfeeding women.
BIOVORIN 15MG TABLET is generally safe medicine to use with no common side effects if taken in the right amount. Contact your doctor if you experience any unusual side effects.
USES OF BIOVORIN 15MG TABLET
It is used:
- to increase folic acid levels in the body, whereas methotrexate (medicine) lowers folic acid levels in the body. It is therefore used to counteract this and support the maintenance of folic acid levels
- to manage a form of anaemia (megaloblastic) which results from low levels of folic acid
HOW BIOVORIN 15MG TABLET WORKS
Leucovorin Calcium is an active metabolite of folic acid and an essential coenzyme for nucleic acid synthesis. It can be used to selectively rescue cells from the adverse effects of methotrexate. Methotrexate inhibits nucleic acid synthesis by blocking the activation of folic acid. Leucovorin is folic acid in its active (reduced) form, so it allows nucleic acid synthesis to proceed even in the presence of methotrexate.
DIRECTIONS FOR USE
Take BIOVORIN 15MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Depending on your age, body weight, and disease condition. Your doctor will determine the appropriate dose and duration for you.
SIDE EFFECTS OF BIOVORIN 15MG TABLET
UNCOMMON
- urticaria
- dermatitis
Stop taking BIOVORIN 15MG TABLET and contact your physician immediately if you experience any of the following side effects:
- serious allergic reactions such as swelling of the face, eyelids, and lips, causing sudden wheezing, difficulty in breathing, rash or itching particularly those that cover your entire body
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredBIOVORIN 15MG TABLET should be used with caution during pregnancy only if clearly needed, as it is not known whether it may cause harm to the unborn baby. Contact your doctor before taking BIOVORIN 15MG TABLET.
BREASTFEEDING
Use with CautionBIOVORIN 15MG TABLET should be used with caution in breastfeeding women. It is not known whether the medicine is excreted through breast milk. Contact your doctor before taking BIOVORIN 15MG TABLET.
DRIVING AND USING MACHINES
Use with CautionBIOVORIN 15MG TABLET does not affect your ability to drive or operate a machine.
ALLERGY
ContraindicatedDo not take BIOVORIN 15MG TABLET if you are allergic (hypersensitive) to Leucovorin calcium or have an intolerance to lactose or other ingredients in this medicine.
OTHERS
BIOVORIN 15MG TABLET is not recommended if you have:
- pernicious anaemia or other megaloblastic anaemia caused by vitamin B12 deficiency
INTERACTIONS
A. Drug-Drug interactions:
Tell your doctor if you have recently taken any other medicines, including medicines obtained without a prescription, vitamin supplements, herbal products or the following:
- antibiotics (used to manage bacterial infections) ex. chloramphenicol, trimethoprim-sulfamethoxazole
- antiepileptics (used to manage epilepsy) ex. phenobarbital, phenytoin, or primidone
- fluorouracil (used for cancer)
Overdosage:
If you or anyone else have accidentally taken too much of BIOVORIN 15MG TABLET, consult your doctor immediately or visit the nearby hospital. Contact your physician if you experience any unusual symptoms.
SYNOPSIS
| Drug | : | Leucovorin Calcium |
| Pharmacological Category | : | Folic acid analogs |
| Therapeutic Indication | : | Used to increase folic acid levels with methotrexate combination |
| Dosage Forms | : | Injection, Tablet |
MORE INFORMATION
- Keep BIOVORIN 15MG TABLET out of the sight and reach from children
- Store BIOVORIN 15MG TABLET below 25°C
FAQs ABOUT BIOVORIN 15MG TABLET
Q: What is BIOVORIN 15MG TABLET used for?
A: BIOVORIN 15MG TABLET is used to increase folic acid levels in the body, whereas methotrexate (medicine) lowers folic acid levels in the body. It is therefore used to counteract this and support the maintenance of folic acid levels. This is known as Leucovorin rescue. This medicine is also used to manage a form of anaemia (megaloblastic) which results from low levels of folic acid.
Q: Can I take BIOVORIN 15MG TABLET to manage folic acid deficiency caused by other medicines?
A: BIOVORIN 15MG TABLET is an active form of folic acid. It can be used to manage methotrexate's harmful effects (which reduce folic acid levels). BIOVORIN 15MG TABLET increases folic acid levels. It is used to reverse this and help to maintain folic acid levels.
Q: Can I take BIOVORIN 15MG TABLET while breastfeeding?
A: BIOVORIN 15MG TABLET should be used with caution by breastfeeding women. It is not known whether the medicine is excreted through breast milk. Contact your doctor before taking BIOVORIN 15MG TABLET.
Q: When BIOVORIN 15MG TABLET is not recommended?
A: BIOVORIN 15MG TABLET is generally not recommended for use in patients with pernicious anaemia or other megaloblastic anaemia caused by vitamin B12 deficiency.
Q: Is BIOVORIN 15MG TABLET a chemo drug?
A: BIOVORIN 15MG TABLET is not a chemotherapy medication, but it is given in conjunction with chemotherapy medications such as fluorouracil (5-FU) to enhance the effects of fluorouracil and to make the medicine work better.
Q: Can BIOVORIN 15MG TABLET cause serious side effects?
A: BIOVORIN 15MG TABLET may cause serious side effects such as swelling of the face, eyelids, and lips, causing sudden wheezing, difficulty in breathing, and rash or itching over the entire body. Stop taking BIOVORIN 15MG TABLET and contact your physician immediately if you experience the following effects.
Q: Should BIOVORIN 15MG TABLET be taken with food?
A: Take BIOVORIN 15MG TABLET with or without food, as advised by your physician. Depending on your age, body weight, and disease state, your doctor will determine the appropriate dose and duration for you.
REFERENCES
1. Robert J. Kizior, Keith J. Hodgson. Leucovorin. Saunders Nursing Drug handbook 2021. 29th edition. 2021. Page-681.
2. Hegde VS, Nagalli S. Leucovorin. National Institute of Health. NLM. National centre for biotechnology information. Stat Pearls. January 2022. [Accessed on 8th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK553114/
3. Orion Corporation. Electronic Medicines Compendium (EMC). [Revised in May 2020] [Accessed on 10th August 2022] https://www.medicines.org.uk/emc/files/pil.1369.pdf
4. West-Ward Pharmaceuticals Corp. Leucovorin calcium. [Revised in October 2020] [Accessed on 10th August 2022] https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=33663425-4731-4977-9127-9e59b6b91497&type=pdf
USEFUL DIAGNOSTIC TESTS
- Vitamin B12
- Vitamin Screening
- Vitamin Basic Package
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