Bactrim DS Tablet 10'S
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Introduction About BACTRIM DS TABLET
Bactrim DS Tablet is a combination of Sulfamethoxazole and Trimethoprim belonging to the antibacterial group of medicines. It helps inhibit the growth of bacteria responsible for infections in the urinary tract, respiratory tract, and other body parts. BACTRIM DS TABLET is suitable for use both in adults and in adolescents (aged 12 years or older).
Take BACTRIM DS TABLET for the stipulated duration as instructed by your doctor even if you feel better during the midway of the therapy to achieve better results. Failing to complete the full course of the therapy or skipping doses in between the therapy may not result in adequate infection control.
Before taking BACTRIM DS TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have asthma, any allergic conditions, genetic disorders, blood-related disorders, folic acid deficiency, high blood potassium levels or if you are malnourished as a precaution.
Consult your doctor before taking this medicine if you are pregnant or breastfeeding. Common side effects of taking BACTRIM DS TABLET are headaches, nausea, diarrhea, high blood potassium levels, fungal infections of the mouth or vagina, and skin rashes. Consult your doctor if any of these side effects trouble you.
Key Composition
- Sulfamethoxazole – 800mg
- Trimethoprim – 160mg
- Excipients: povidone, sodium starch glycolate, magnesium stearate
Uses Of BACTRIM DS TABLET
Manages:
- Lung infections (Ex. Pneumonia or Pneumocystis jiroveci pneumonia) are caused by a bacteria called Pneumocystis jirovecii
- Toxoplasmosis (an infection with the Toxoplasma gondii parasite)
- Urinary tract infections
- Respiratory tract infections (Ex. bronchitis)
- Ear infections (Ex. otitis media)
- Nocardiosis (a bacterial infection that affects the lungs, skin, and brain)
Benefits of BACTRIM DS TABLET
- Combines Sulfamethoxazole and Trimethoprim, a synergistic antibacterial pair that works by blocking two steps in bacterial folic acid synthesis, offering broad-spectrum action.
- Helps control bacterial growth responsible for urinary tract, respiratory, intestinal, and ear infections under professional supervision.
- Provides a dual-phase advantage - Sulfamethoxazole inhibits bacterial folate formation while Trimethoprim prevents its conversion to active DNA compounds, supporting faster microbiological recovery.
- Known for its wide efficacy range, targeting both Gram-positive and Gram-negative organisms that cause common infections.
- Designed to assist physicians in managing infection outbreaks effectively while reducing recurrence due to combined action on bacterial metabolism.
- Offers cost-effective therapy with well-established global clinical usage and flexible administration options under medical advice.
How BACTRIM DS TABLET Works
- Sulfamethoxazole:
This sulfonamide derivative structurally resembles para-aminobenzoic acid (PABA) and competitively blocks the enzyme dihydropteroate synthase.
As a result, it prevents the bacterial conversion of PABA to dihydrofolic acid, leading to folate deficiency inside bacterial cells and a bacteriostatic effect. - Trimethoprim:
This antifolate agent selectively inhibits dihydrofolate reductase (DHFR), an enzyme necessary to convert dihydrofolic acid into tetrahydrofolic acid.
Without tetrahydrofolic acid, bacteria cannot synthesize the nucleic acids required for replication, resulting in growth inhibition. - Synergistic Bactericidal Effect:
Both drugs together create a sequential blockade that makes the combination bactericidal rather than just bacteriostatic.
Resistance develops more slowly in this dual form than with either agent alone.
How to use BACTRIM DS TABLET
How to Take Bactrim DS Tablet
Take Bactrim DS Tablet exactly as prescribed by your doctor. It is usually taken by mouth with a full glass of water, either with or without food. Taking it after meals may help reduce stomach discomfort.
Always read the prescription label carefully and follow the exact dosing schedule given by your healthcare provider.
Quick Tips for Proper Use:
- Take your doses at the same time each day to maintain steady levels in the body.
- Swallow the tablet whole; do not crush or chew it.
- Drink plenty of fluids throughout the day to support kidney health and prevent crystal formation.
- Complete the full course even if your symptoms improve early.
Recommended Dosage Schedule
Adults:
- Typical dose: 1 Bactrim DS tablet (Sulfamethoxazole 800 mg+Trimethoprim 160mg) every 12 hours for 5 to 14 days depending on infection severity and site.
- Take only the prescribed number of days—stopping early may lead to recurrence.
Children (2 months and older):
- Dosage is based on body weight – 20mg/kg of Sulfamethoxazole +4mg/kg of Trimethoprim every 12 hours for 5 to 10days.
- Always use the pediatric dose formulation or liquid suspension when prescribed.
- Bactrim DS is not recommended for infants younger than 2 months.
Special Populations:
- Kidney Impairment: For creatinine clearance 15–30mL/min, doctors may recommend half the standard dose; avoid with clearance<15 mL/min unless under supervision.
Step-by-Step Administration Instructions
- Check your dose on the prescription label before each use.
- Swallow the tablet with a full glass (200–250mL) of water.
- If it causes stomach upset, take it immediately after food or milk.
- Hydrate adequately to prevent kidney issues.
- Keep a consistent schedule – set a reminder to take it morning and evening.
Oral Administration and Hydration Advice
- Take the medicine orally with water; avoid lying down immediately after taking it.
- Hydration is crucial during Bactrim therapy—aim for adequate daily fluid intake to protect kidneys and reduce crystalluria risk.
- Limit caffeine and alcohol, which may contribute to dehydration.
What if I forgot to take BACTRIM DS TABLET
- If you miss a dose, take it as soon as you remember.
- If it is almost time for the next dose, skip the missed dose and resume the regular schedule.
- Do not double the dose to make up for one you missed, as it may increase side-effect risks.
- If you miss multiple doses or are unsure what to do, consult your doctor or pharmacist.
Overdose
Taking more than the recommended amount may cause nausea, vomiting, dizziness, or confusion. In such cases, seek medical help immediately or contact a local poison control center.
Side Effects Of BACTRIM DS TABLET
Common
- high potassium levels in blood causing abnormal heartbeats
- fungal infection (thrush or candidiasis) of mouth or vagina
- headache, nausea, diarrhoea
- skin rashes
When to consult your doctor?
- severe allergic reactions (such as skin rashes, itching, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing, chest pain and fainting)
- severe skin reactions (such as generalised skin redness with pustules accompanied by fever, ulcers in the mouth, throat, nose, genitals, red, swollen eyes, severe skin rash with blistering and peeling of skin, red pinpoint targets under the skin)
- signs of abnormal WBC count (such as fever, swollen glands, weakness, light-headedness, shortness of breath, bruising with or without skin rash)
- unexpected worsening of cough and shortness of breath
Warning & Precautions
Pregnancy
Use with CautionBACTRIM DS TABLET should be used with caution in pregnant women. Therefore, consult your doctor for advice before taking it.
Breastfeeding
Use with CautionBACTRIM DS TABLET should be used with caution in breastfeeding women. Therefore, consult your doctor for advice before taking it.
Driving and Using Machines
ContraindicatedDo not drive or operate any heavy tools or machines if your ability is affected by BACTRIM DS TABLET.
Alcohol
ContraindicatedAvoid consumption of alcohol while taking BACTRIM DS TABLET.
Kidney
Consult your doctorBACTRIM DS TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
Liver
ContraindicatedBACTRIM DS TABLET is not recommended for use in patients with severe liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take BACTRIM DS TABLET if you are allergic to Sulphamethoxazole, trimethoprim, sulphonamide medicines (such as gliclazide, glibenclamide) or to thiazide diuretics (such as Bendroflumethiazide).
Lungs
Use with CautionBACTRIM DS TABLET should be used with caution in patients with asthma. Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedBACTRIM DS TABLET is not recommended for use in children and adolescents (aged below 12 years). However, consult your doctor for advice before taking it.
Use In Geriatrics
Use with CautionBACTRIM DS TABLET should be used with caution in elderly patients. Therefore, consult your doctor for advice before taking it.
Other Warnings for BACTRIM DS TABLET
Before taking BACTRIM DS TABLET, consult your doctor if you:
- Have any allergic conditions (such as watery eyes, an itchy nose, or repeated sneezing)
- Have anemia or a vitamin B9 (folic acid) deficiency
- Have G6PD deficiency (a genetic disorder that affect metabolism)
- Have phenylketonuria (the buildup of an amino acid called phenylalanine in the body)
- Are underweight or malnourished
- Have high blood potassium levels
- Have very low RBC, WBC, and platelet counts in the blood
Who should not take BACTRIM DS TABLET
BACTRIM DS TABLET is not recommended for use if you:
- Ever had bleeding problems (such as thrombocytopenia)
- Have porphyria (a rare blood disorder)
Diet and Lifestyle Advice
Maintaining healthy lifestyle habits while taking Bactrim DS Tablet supports the body’s ability to recover efficiently and helps lower the risk of side effects. The following guidance includes diet, hydration, daily habits, and sun exposure tips to complement safe antibiotic use.
Hydration and Kidney Health
- Drink plenty of water (8–10 glasses daily) unless your doctor advises otherwise.
Bactrim increases the concentration of certain crystals in urine that may irritate the kidneys or bladder; proper hydration minimizes this risk. - Avoid dehydration from caffeine, alcohol, or vigorous workouts during illness. Replace lost fluids with clear water or electrolyte-balanced drinks.
Sun Exposure and Skin Care
- Limit exposure to direct sunlight, tanning lamps, and UV beds while on the medication.
The sulfamethoxazole component can hei - Use SPF 30+sunscreen, wear full-sleeve clothing, and reapply protection when outdoors.
- Avoid tanning products and use mild, soothing moisturizers if dryness or redness occurs.
Balanced Nutrition and Gut Health
- Take Bactrim with or after a light meal (toast, boiled rice, banana, or yogurt) to reduce stomach discomfort.
- Include probiotic or fermented foods (curd, kefir, buttermilk, pickled vegetables) to restore healthy gut flora depleted by antibiotics.
- Eat soft, bland meals instead of rich or spicy foods if nausea or cramps appear.
- Prioritize lean proteins, fruits, whole grains, and cooked vegetables for steady energy and faster recovery.
Sleep and Rest Routine
- Ensure adequate sleep (7–8 hours daily) to strengthen immunity during treatment.
- Avoid skipping rest, strenuous exercise, or late-night habits that can slow recovery.
- Gentle stretching or short walks can support circulation if tolerated.
Medication Timing and Consistency
- Take Bactrim at the same time every day to maintain a balanced antibiotic level in your body.
- Do not skip or double doses; consistent dosing ensures optimal infection control.
- Use reminders or pill organizers to stay on schedule.
Supplements and Vitamins
- Avoid unnecessary vitamin C, vitamin D, or folic acid supplements unless prescribed, as they may interfere with how Bactrim works.
- Discuss all herbal products and over-the-counter items (especially potassium supplements) with your healthcare provider before starting them.
Hygiene and Infection Control
- Maintain good personal hygiene: wash hands frequently, sanitize personal items, and keep wounds clean and dry.
- Replace or disinfect toothbrushes and towels after the antibiotic course to lower reinfection risks.
Drug - Drug interaction
1. Blood Thinners (Warfarin, Jantoven):
- Bactrim DS can increase warfarin levels, raising the risk of bleeding.
- Recommendation: Monitor INR/prothrombin time regularly and adjust warfarin dosage as advised.
2. Diuretics (Water Pills):
- Examples: hydrochlorothiazide, furosemide, spironolactone.
- May cause low platelet count or hyperkalemia (high potassium levels) when used together.
3. Blood Pressure Medicines (ACE Inhibitors and ARBs):
- Examples: lisinopril, enalapril, losartan, valsartan.
- Combination may result in dangerously high potassium levels, especially in elderly patients.
4. Diabetes Medicines (Hypoglycemics):
- Examples: glipizide, glyburide, pioglitazone, metformin.
- Bactrim enhances their glucose-lowering effect, leading to low blood sugar (hypoglycemia).
- Frequent blood sugar monitoring is recommended.
5. Antiarrhythmics:
- Examples: dofetilide (Tikosyn), procainamide.
- Can cause life-threatening heart rhythm disturbances due to raised plasma drug levels.
- Concurrent use is contraindicated.
6. Immunosuppressants:
- Example: cyclosporine.
- May increase risk of temporary kidney toxicity; use only under close medical supervision.
7. Methotrexate
- Bactrim may increase methotrexate concentration, enhancing toxicity risk (blood and liver effects).
- Avoid co-administration unless under specialist guidance.
8. Digoxin:
- Levels of this heart medicine can increase, especially in older adults.
- Doctors may recommend periodic blood level monitoring.
9. Phenytoin (Anti-seizure medicine):
- Bactrim slows phenytoin metabolism, increasing risk of drowsiness or toxicity.
10. Pyrimethamine (Anti-malarial):
- Combined use can cause megaloblastic anemia due to folate depletion.
- Avoid high doses or combine cautiously.
11. Indomethacin and NSAIDs:
- May increase Bactrim levels in the body, raising side-effect potential.
12. Zidovudine (Antiretroviral):
- Concurrent use can heighten risk of anemia or low white cell count.
Drug - Food interaction
1. Acidic Foods (Citrus & Vinegar-Based Items):
- Foods such as oranges, lemons, grapefruit, and tomatoes can increase stomach acidity and worsen nausea or heartburn associated with Bactrim DS.
- If the medicine causes stomach upset, avoid highly acidic foods until symptoms settle.
2. High-Potassium Foods:
- Bactrim can raise blood potassium levels (hyperkalemia) because trimethoprim reduces potassium excretion in the kidneys.
- Limit high-potassium foods like bananas, avocados, spinach, tomatoes, dried apricots, and potassium-enriched salt substitutes.
- The risk increases in elderly individuals and those with kidney problems, diabetes, or concurrent use of ACE inhibitors/diuretics.
3. Alcohol:
- Alcohol places extra load on the liver and may cause serious nausea, dizziness, and flushing due to a “disulfiram-like” reaction when combined with Bactrim.
- It can also weaken the immune system and worsen dehydration, so it’s best avoided until recovery is complete.
4. Caffeine:
- Bactrim has a mild diuretic effect; excess caffeine (coffee, tea, or energy drinks) may increase dehydration and intensify its side effects.
- Moderation is advised—combine medication with sufficient water intake.
5. Greasy, Spicy, or Processed Foods:
- High-fat or spicy foods can irritate the stomach and aggravate antibiotic-related discomfort (e.g., nausea, diarrhea, or cramping).
- Opt for mild, low-fat meals such as oatmeal, porridge, toast, banana, or boiled vegetables while taking Bactrim.
Synopsis
| Drug | : | Sulphamethoxazole, Trimethoprim |
| Pharmacological Category | : | Sulphonamides, Diaminopyrimidine |
| Therapeutic Indication | : | Bacterial Infections |
| Dosage Forms | : | Tablet, Syrup, Suspension, Injection, Infusion, Eye drops |
More Information
Did you know
- Bactrim DS Stands for Double Strength:
“DS” means the tablet contains double the standard amount of active ingredients Sulfamethoxazole 800 mg+Trimethoprim 160mg providing an optimized ratio for better bacterial control. - It Targets Two Metabolic Steps at Once:
Bactrim DS blocks two consecutive stages of bacterial folic acid production, making it more effective than single-agent antibiotics in stopping bacterial growth. - Clinically Active Since 1973:
Approved by the FDA in 1973, Bactrim DS is still widely used across the world due to its proven combination therapy against bacterial infections like urinary tract, respiratory, and gastrointestinal infections. - Helps Manage Traveler’s Diarrhea:
It’s among the few oral antibiotics that can be used to control bacterial infections causing traveler’s diarrhea, mainly due to E.coli contamination in food or water. - Gluten- and Lactose-Free Formulation:
Bactrim DS tablets do not contain gluten or lactose, making them suitable for patients with dietary restrictions or sensitivities. - Generic Availability:
The generic form of Bactrim DS (co-trimoxazole) is equally effective but typically more cost-efficient than the branded version, allowing better access for patients. - Works Best With Hydration Support:
Maintaining adequate water intake helps your kidneys flush medicine efficiently and reduces the risk of crystal formation, especially during prolonged courses. - Photosensitivity Alert:
Sunlight may cause mild skin reactions while on Bactrim DS. Using sunscreen and protective clothes can minimize this effect a practical example of antibiotic awareness in daily life.
FAQs About BACTRIM DS TABLET
Q: What is BACTRIM DS TABLET used for?
A: BACTRIM DS TABLET is used to manage severe bacterial infections, including lung infections, toxoplasmosis (infection with the Toxoplasma gondii parasite), urinary tract infections, respiratory tract infections (such as bronchitis), ear infections (such as otitis media), and an infection called nocardiosis, which can affect the lungs, skin, and brain.
Q: How does BACTRIM DS TABLET work in my body?
A: BACTRIM DS TABLET is used to manage severe bacterial infections, including lung infections, toxoplasmosis (infection with the Toxoplasma gondii parasite), urinary tract infections, respiratory tract infections (such as bronchitis), ear infections (such as otitis media), and an infection called nocardiosis, which can affect the lungs, skin, and brain.
Q: How should I take BACTRIM DS TABLET?
A: Take BACTRIM DS TABLET as advised by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Q: For how long should I take BACTRIM DS TABLET?
A: Take BACTRIM DS TABLET for the stipulated duration as prescribed by your doctor. Do not skip the medicine or stop taking it on your own, as it can cause the infection to reappear.
Q: Can BACTRIM DS TABLET be given to pregnant women?
A: BACTRIM DS TABLET should be used with caution in pregnant women. Therefore, consult your doctor for advice before taking it.
Q: What precautions should I follow while taking BACTRIM DS TABLET?
A: Before taking BACTRIM DS TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have asthma, any allergic conditions, genetic disorders, blood-related disorders, or if you are malnourished, as a precaution. Consult your doctor before taking this medicine if you are pregnant or breastfeeding. Regularly visit your doctor for a check-up and perform all medical tests recommended by your doctor without fail. Take BACTRIM DS TABLET for the stipulated duration recommended by your doctor to achieve better results. Failing to do so may cause the symptom to reoccur.
Q: What are the side effects of taking BACTRIM DS TABLET?
A: The most common side effects of taking BACTRIM DS TABLET are headache, nausea, diarrhea, high blood potassium levels, fungal infections of the mouth or vagina, and skin rashes. Consult your doctor if any of these side effects trouble you.
Q: Can I stop taking BACTRIM DS TABLET once my symptoms subside?
A: Do not stop taking this medicine once your symptom subsides. It is important to take the full course of BACTRIM DS TABLET to achieve better results. Failing to complete the full course of the therapy or skipping doses in between may not result in adequate infection control. It may also cause your symptoms to reappear.
Q: Can the use of BACTRIM DS TABLET cause diarrhea?
A: BACTRIM DS TABLET may cause diarrhea in some individuals. If you experience diarrhea, drink plenty of fluids, such as water or fruit juice, to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens, contact your doctor immediately.
Q: What should I do if I forget to take a dose of BACTRIM DS TABLET?
A: If you forgot to take a dose of BACTRIM DS TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose to compensate for the forgotten dose.
Q: Is it safe to purchase BACTRIM DS TABLET from online pharmacies like Netmeds?
A: Yes. Generally, it is safe to purchase BACTRIM DS TABLET from reputable online pharmacies like Netmeds in India. Netmeds adheres to strict regulations to ensure the quality and authenticity of the medications. If you wish to buy BACTRIM DS TABLET on Netmeds, you need a prescription from a registered medical practitioner. Netmeds has made buying online medicines easier for consumers and is one of India’s leading online pharmacies.
References
1. KD. Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 689, 705 & 706.
2. Tyler R. Kemnic, Meghan Coleman. Trimethoprim Sulfamethoxazole. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2022. [Accessed on 25th October 2025]. 
3. Erwin L. van der Veen, Anne G. M. Schilder, Tim K. Timmers, Maroeska M. Rovers, Ad C. Fluit, Marc J. Bonten, Maurine A. Leverstein-van Hall. Effect of long-term trimethoprim/sulfamethoxazole treatment on resistance and integron prevalence in the intestinal flora: a randomized, double-blind, placebo-controlled trial in children. Journal of Antimicrobial Chemotherapy. Oxford Academic. May 2009. [Accessed on 25th October 2025]. 
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4. Aspen Pharma Trading Limited. Co-Trimoxazole 160 mg/800 mg Forte Tablets. Electronic Medicines Compendium. [Revised in September 2022]. [Accessed on March 25th October 2025].
5. Aspen Pharma Trading Limited. Co-Trimoxazole 80 mg/400 mg Tablets. Electronic Medicines Compendium. [Revised in July 2021]. [Accessed on 25th October 2025].
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