AZATEND O 200mg Tablet 14's

Introduction About AZATEND O 200MG TABLET

AZATEND O 200MG TABLET contains Azacitidine, which belongs to the group of medicines called Anticancer agents. It is used in adults in the management of acute myeloid leukaemia (AML). AML is a type of blood cancer where the bone marrow releases an excess amount of immature white blood cells into the bloodstream. It is characterized by recurrent infections, fever, tiredness, and increased bleeding or bruising.

AZATEND O 200MG TABLET also helps in controlling AML when the disease is less severe or not active. Before taking AZATEND O 200MG TABLET, inform your doctor if you have any liver problems.

AZATEND O 200MG TABLET is not recommended for use by pregnant or breastfeeding women. Both men and women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with this medicine. Men may seek advice on sperm preservation, if necessary, prior to therapy with this medicine.

The most common side effects of receiving AZATEND O 200MG TABLET are constipation, stomach pain, infections of the nose, sinuses, and throat, pneumonia, tiredness, weakness, generalized pain, stiff joints, back pain, flu, hay fever, and weight loss. Consult your doctor if any of these side effects trouble you.

AZATEND O 200MG TABLET may cause severe nausea, vomiting, and diarrhea. To manage this, your doctor will prescribe suitable anti-emetic and antidiarrheal medicines along with this medicine. However, inform your doctor immediately if these side effects worsen.

Uses Of AZATEND O 200MG TABLET

• Management of acute myeloid leukaemia (blood cancer) in adults

How AZATEND O 200MG TABLET Works

AZATEND O 200MG TABLET is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the tumour cells that are required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it manages abnormal cell division within the body, slows down the growth of tumour cells, and helps the bone marrow produce normal blood cells.

How to use AZATEND O 200MG TABLET

Take AZATEND O 200MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. AZATEND O 200MG TABLET can be taken with or without food.

Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Do not stop taking this medicine without consulting your doctor.

Side Effects Of AZATEND O 200MG TABLET

How To Manage Side Effects

Constipation

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.

Warning & Precautions

Pregnancy

Contraindicated

AZATEND O 200MG TABLET is not recommended for use in pregnant women as it may harm the growing baby. Therefore, consult your doctor before taking it. Women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with AZATEND O 200MG TABLET and until 6 months after stopping the therapy. If you accidentally became pregnant while receiving AZATEND O 200MG TABLET, inform your doctor immediately.

Breastfeeding

Contraindicated

AZATEND O 200MG TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

AZATEND O 200MG TABLET may cause tiredness, weakness and problems in concentration. Therefore, do not drive or operate any machines if your ability is affected by AZATEND O 200MG TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking AZATEND O 200MG TABLET as it may make you feel drowsier.

Liver

Use with Caution

AZATEND O 200MG TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.

Use In Pediatrics

Contraindicated

AZATEND O 200MG TABLET is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor for advice before taking it.

Use In Geriatrics

Use with Caution

AZATEND O 200MG TABLET should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

Interactions

A. Drug- Drug interactions:

Before taking AZATEND O 200MG TABLET, inform your doctor if you are taking any of the following medicines, such as:

• other anticancer medicines (such as cisplatin, methotrexate, 5-flurouracil, etc.)
• omeprazole (a medicine used to manage stomach ulcers)

Overdosage:

If you or anyone else accidentally took more AZATEND O 200MG TABLET, consult your doctor immediately or visit the nearby hospital straight away.

Synopsis

More Information

• Keep AZATEND O 200MG TABLET out of reach of children
• Store AZATEND O 200MG TABLET at room temperature

FAQs About AZATEND O 200MG TABLET

Q: What is the use of AZATEND O 200MG TABLET?

A: AZATEND O 200MG TABLET is used in the management of acute myeloid leukaemia (AML).

Q: How does AZATEND O 200MG TABLET work?

A: AZATEND O 200MG TABLET is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that are required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it manages abnormal cell division within the body, slows down the growth of cancer cells, and helps the bone marrow produce normal blood cells.

Q: Can I take AZATEND O 200MG TABLET during breastfeeding?

A: No. AZATEND O 200MG TABLET is not recommended for use in breast-feeding women. Therefore, consult your doctor before taking it.

Q: Can AZATEND O 200MG TABLET increase the risk of infection?

A: AZATEND O 200MG TABLET may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while taking AZATEND O 200MG TABLET. To avoid this, your doctor will regularly monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection, such as a fever.

Q: Can the use of AZATEND O 200MG TABLET make me feel tired?

A: Yes. AZATEND O 200MG TABLET may make you feel tired easily. This is because it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after taking AZATEND O 200MG TABLET. Tiredness can also occur if you have any pre-existing disease conditions, such as liver or kidney impairment, while taking this medicine.

Q: Can I drive a car after taking AZATEND O 200MG TABLET?

A: AZATEND O 200MG TABLET may make you feel tired or weak. Therefore, do not drive or operate any heavy tools or machines if your abilities are affected by AZATEND O 200MG TABLET.

Q: How do I take AZATEND O 200MG TABLET?

A: Take AZATEND O 200MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. AZATEND O 200MG TABLET can be taken with or without food.

Q: What should I do if I forget to take a dose of AZATEND O 200MG TABLET?

A: If you forget to take a dose of AZATEND O 200MG TABLET or vomit immediately after taking the dose, take it as soon as you remember. Do not take the medicine twice to make up for the forgotten dose.

Q: How do you control nausea caused by AZATEND O 200MG TABLET?

A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them, along with AZATEND O 200MG TABLET. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-manage nausea.

References

1. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. Cytotoxic agents. Chemotherapy of Neoplastic Diseases. 12th Edition. Page – 1700.

2. Lesley J Scott. Azacitidine: A Review in Myelodysplastic Syndromes and Acute Myeloid Leukaemia. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2016. [Accessed on 21st March 2023] https://pubmed.ncbi.nlm.nih.gov/27193945/

3. Bristol-Myers Squibb Pharma EEIG. Azacitidine. Onureg 200 and 300mg mg film-coated tablets. European Medicines Compendium. [Revised in September 2021]. [Accessed on 21st March 2023] https://www.medicines.org.uk/emc/files/pil.14218.pdf

4. ONUREG (azacitidine) tablets, for oral use. U.S. Food and Drug Administration. [Revised in September 2020]. [Accessed on 21st March 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/214120s000lbl.pdf

5. Bristol-Myers Squibb Pharma EEIG. Azacitidine. Onureg 200 and 300mg mg film-coated tablets. European Medical Agency. [Accessed on 21st March 2023] https://www.ema.europa.eu/en/documents/product-information/onureg-epar-product-information_en.pdf

Useful Diagnostic Tests

• Bone marrow smear microscopy examination
• Complete Blood Count
• Peripheral Smear Examination

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)

Last updated on 31 Oct 2023 | 06:05 PM(IST)