Aromasin 25mg Tablet 15'S
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Introduction About AROMASIN 25MG TABLET
AROMASIN 25MG TABLET contains Exemestane which belongs to the group of medicines called Aromatase inhibitors. It is used for advanced breast cancer in post-menopausal women whose disease has progressed following Tamoxifen therapy. It is also used for hormone-dependent advanced breast cancer in postmenopausal women when management with different hormonal drug management has not worked well enough.
Breast cancer is a disease in which cells in the breast grow out of control. There are different kinds of breast cancer. The kind of breast cancer depends on which cells in the breast turn into cancer. Breast cancer can begin in different parts of the breast.
Before taking AROMASIN 25MG TABLET, inform your doctor if you have liver or kidney problem, a history or are suffering from any condition which affects the strength of your bones. AROMASIN 25MG TABLET is not recommended for use among pregnant and breastfeeding women. Consult your doctor before taking it. The most common side effects of taking AROMASIN 25MG TABLET are depression, headache, muscle, and joint pain, hair loss, and abdominal pain. Consult your doctor if any of the side effects worsen or persists for a longer duration.
Uses Of AROMASIN 25MG TABLET
It is used for:
- advanced breast cancer in post-menopausal women whose disease has progressed following Tamoxifen therapy
- hormone-dependent advanced breast cancer in postmenopausal women when management with different hormonal drug management has not worked well enough
How AROMASIN 25MG TABLET Works
AROMASIN 25MG TABLET belongs to aromatase inhibitor which blocks the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink. It works by reducing the amount of oestrogen made in the body.
How to use AROMASIN 25MG TABLET
Take AROMASIN 25MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct duration for you depending upon your age, body weight, and disease condition.
Side Effects Of AROMASIN 25MG TABLET
Common
- skin rash, hives, itchiness, swollen hands, and feet
- hot flushes, difficulty sleeping and increased sweating (menopausal symptoms)
- reduction in the number of white blood cells, platelets, liver enzymes, blood enzymes, and hemoglobin
- carpal tunnel syndrome (combination of pins and needles, pain and numbness affecting all the hand except the little finger) or tingling/prickling of the skin
- depression
- headache
- musculoskeletal pain (bone, muscle, or joint pain)
- dizziness
- tiredness
- abdominal pain
- loss of appetite
- vomiting
- constipation
- indigestion
- diarrhea
- hair loss
- thinning of bones which might decrease their strength (osteoporosis), leading to bone fractures (breaks or cracks)
- weakness
Rare
- breaking out of small blisters
- drowsiness
Stop taking AROMASIN 25MG TABLET and contact your doctor immediately if you experience any of the following side effects;
- hypersensitivity
- inflammation of the liver (hepatitis) and bile ducts which cause yellowing of the skin (cholestatic hepatitis)
- feeling unwell, nausea, jaundice (yellowing of the skin and eyes), itching, right-sided abdominal pain, and loss of appetite
How To Manage Side Effects
Diarrhea
Drink a lot of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Nausea And Vomiting
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods.
Warning & Precautions
Pregnancy
ContraindicatedAROMASIN 25MG TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.
Breastfeeding
ContraindicatedAROMASIN 25MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel drowsy, dizzy or weak after taking AROMASIN 25MG TABLET.
Kidney
Use with CautionAROMASIN 25MG TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking it.
Liver
Use with CautionAROMASIN 25MG TABLET should be used with caution in patients with liver problems. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take AROMASIN 25MG TABLET if you are allergic to Exemestane or any of the other ingredients of this medicine.
Use In Pediatrics
ContraindicatedAROMASIN 25MG TABLET is not recommended for use in children. Consult your doctor before taking it.
Use In Geriatrics
Use with CautionAROMASIN 25MG TABLET should be used with caution in elderly patients. Consult your doctor before taking it.
Others
AROMASIN 25MG TABLET is not recommended if you have:
- not already been through the menopause (still having a monthly period)
Before taking AROMASIN 25MG TABLET, inform your doctor if you:
- have a history or are suffering from any condition which affects the strength of the bones
Interactions
A. Drug-Drug interactions:
Before taking AROMASIN 25MG TABLET, inform your doctor if you are taking any of the following medicine:
- Rifampicin (used to manage infection)
- Carbamazepine or phenytoin (used for epilepsy)
- St. John wort (Hypericum perforatum)
Overdosage:
If you or anyone else accidentally takes too much of AROMASIN 25MG TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Exemestane |
| Pharmacological Category | : | Aromatase inhibitors |
| Therapeutic Indication | : | Hormone dependent early and advanced breast cancer in postmenopausal women |
| Dosage Forms | : | Tablet |
More Information
- Keep AROMASIN 25MG TABLET out of reach of children
- Store at room temperature
FAQs About AROMASIN 25MG TABLET
Q: How to take AROMASIN 25MG TABLET?
A: Take AROMASIN 25MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Q: Is it safe to use AROMASIN 25MG TABLET in older people?
A: AROMASIN 25MG TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.
Q: Is there any food restriction while taking AROMASIN 25MG TABLET?
A: AROMASIN 25MG TABLET to be taken after meals, there is no food restriction as such. Consult your doctor before taking it.
Q: Who should consult the doctor before taking AROMASIN 25MG TABLET?
A: Patients having liver and kidney problems or having a history or suffering from any condition which affects the strength of the bones, consult your doctor before taking AROMASIN 25MG TABLET.
Q: Can I take AROMASIN 25MG TABLET along with Anti-epileptics?
A: No. Anti-epileptics like carbamazepine and phenytoin should not be taken along with AROMASIN 25MG TABLET.
References
1. Claudine Isaacs, Anton Wellstein, and Anna T. Riegel. Hormones and Related Agents in the Therapy of Cancer. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 1237-1247.
2. Giorgia Zucchini, Elena Geuna, Andrea Milani, Caterina Aversa, Rossella Martinello, and Filippo Montemurro. Clinical utility of exemestane in the treatment of breast cancer. International Journal of women’s health. May 2015. [Accessed on 14th May] https://pubmed.ncbi.nlm.nih.gov/26064072/
3. Caroline Lohrisch. Exemestane as third and fourth line hormonal therapy for metastatic breast cancer. December 2000. [Accessed on 14th May] https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr-2000-66684
4. Muaiad Kittaneh, Stefan Gluck. Exemestane in the Adjuvant Treatment of Breast Cancer in Postmenopausal Women. October 2011. [Accessed on 2022] https://journals.sagepub.com/doi/10.4137/BCBCR.S6234
5. Glenmark Pharmaceuticals limited. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 14th May] https://www.medicines.org.uk/emc/files/pil.9952.pdf
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