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Introduction About AMITRIP 25MG TABLET
AMITRIP 25MG TABLET is used in the management of depression, neuropathic pain and tension type headache or migraine in adults. It contains a medicine called Amitriptyline which is an antidepressant medicine. It enhances your mood by boosting the levels of a chemical called serotonin in your brain.
AMITRIP 25MG TABLET must be used under medical supervision. Take this medicine for the duration exactly as advised by your doctor. Do not stop therapy abruptly or overuse this medicine for prolonged periods without consulting your doctor. Regularly visit your doctor and perform the medical tests suggested by your doctor to achieve better results.
Avoid concomitant usage of AMITRIP 25MG TABLET with other antidepressants like MAOIs to avoid potential drug-drug interactions. Do not take if you have taken any MAOIs within the last 14 days without consulting your doctor. It should not be used in patients with severe liver problems, recent heart attack, or heart problems.
Before taking AMITRIP 25MG TABLET, inform your doctor if you have imbalances of potassium and magnesium levels in the body and other mental illness like bipolar disorder and schizophrenia. You must also inform your doctor if you are scheduled for any surgery in the upcoming days, have diabetes, thyroid disorders, epilepsy, narrow angle glaucoma, enlarged prostate and blockage or stenosis in the gut as a precaution.
AMITRIP 25MG TABLET should be used during pregnancy and breastfeeding only if it is considered clearly necessary by the physician.
The most common side effects of taking AMITRIP 25MG TABLET are excessive sleepiness/drowsiness, dizziness, headache, tiredness, dry mouth, constipation, excessive thirst, excessive sweating, weight gain, changes in taste, confusion, lack of attention, unable to walk properly, low sex-drive, problems with erection, tingling and numbness of arms or legs and problems in urination. Consult your doctor if they trouble you.
Also, patients or caregivers must close monitor the patients and inform the doctor immediately if the patients develop suicidal thoughts, mania or mood changes after taking AMITRIP 25MG TABLET.
Uses Of AMITRIP 25MG TABLET
- Management of depression, neuropathic pain and tension type headache or migraine in adults
How AMITRIP 25MG TABLET Works
AMITRIP 25MG TABLET is a tricyclic antidepressant. It works by increasing the levels of certain neurotransmitters in the brain, primarily serotonin and norepinephrine by inhibiting their reuptake into nerve cells, which helps to improve mood and relieve symptoms of depression.
How to use AMITRIP 25MG TABLET
- Take AMITRIP 25MG TABLET as advised by your physician.
- Swallow the medicine with a glass of water.
- Do not crush or chew the medicine.
- Do not stop taking AMITRIP 25MG TABLET without consulting your doctor.
- Your doctor will decide the correct dosage and duration of therapy based on your age, body weight and health condition.
Side Effects Of AMITRIP 25MG TABLET
Like all medicines, AMITRIP 25MG TABLET may cause few side effects although not everybody gets them
Common side effects of AMITRIP 25MG TABLET:
- sleepiness/drowsiness
- shivering or shakiness of hands or other body parts
- dizziness, headache, tiredness
- irregular heartbeat
- dizziness while standing up or changing posture
- dry mouth, constipation, nausea, excessive thirst
- excessive sweating
- weight gain, changes in taste,
- slurred or slow speech
- vision problems, nasal congestion, dilated pupils
- confusion, lack of attention, unable to walk properly
- sexual disturbances (low sex-drive, problems with erection)
- tingling and numbness of arms or legs
- problems in urination
Stop taking AMITRIP 25MG TABLET and consult your doctor immediately if you experience any of the following side effects:
- suicidal thoughts (thoughts of harming or killing themselves), anxiety
- mania (profuse and rapidly changing ideas, exaggerated gaiety and excessive physical activity)
Warning & Precautions
Pregnancy
Monitoring requiredAMITRIP 25MG TABLET should be used during pregnancy only if it is considered clearly necessary by the physician. Your doctor will prescribe this medicine only if it benefits the mother and justifies the risk to the fetus.
Breastfeeding
Consult your doctorAMITRIP 25MG TABLET may pass through breast milk. Therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Driving and Using Machines
Use with CautionAMITRIP 25MG TABLET may cause dizziness and drowsiness. Therefore, do not drive or handle any heavy tools or machineries until your concentration becomes clear after taking this medicine.
Alcohol
Consult your doctorIt is advised to avoid alcohol consumption while undergoing therapy with AMITRIP 25MG TABLET as it could increase your drowsiness.
Liver
ContraindicatedAMITRIP 25MG TABLET is not recommended for use in patients with severe liver disease.
Allergy
ContraindicatedDo not take AMITRIP 25MG TABLET if you are allergic to Amitriptyline or any other ingredients of this medicine.
Heart Disease
Consult your doctorAMITRIP 25MG TABLET is not recommended for use in patients who suffered a recent heart attack or have heart problems such as disturbances in heart rhythm, or coronary artery disease. It should be used with caution in patients with heart problems such as slow heart rate or difficulty in pumping blood, etc.
Use In Pediatrics
Consult your doctorAMITRIP 25MG TABLET is generally not recommended for use in children and adolescents (aged below 18 years). However, your doctor may prescribe it to you after considering the risks and benefits.
Use In Geriatrics
Monitoring requiredAMITRIP 25MG TABLET should be used with extreme caution in elderly patients as it could increase of fall due to its tendency to cause dizziness and hypotension. Therefore, caregivers should closely monitor the elderly patients.
Others
AMITRIP 25MG TABLET is not recommended for use if you have:
- taken other antidepressants called MAOIs within the last 14 days
- moclobemide the day before
Before taking AMITRIP 25MG TABLET, inform your doctor if you:
- have any underlying health condition that causes low potassium or magnesium levels in the body
- have a high level of potassium in your blood
- are scheduled for any surgery in the upcoming days
- have an overactive thyroid gland or take thyroid medication
- have bipolar disorder
- have narrow angle glaucoma
- have epilepsy or a previous history of fits
- have difficulty in passing urine
- have an enlarged prostate
- have disorders of thyroid gland
- have schizophrenia
- have pylorus stenosis (narrowing of the gastric outlet) and paralytic ileus (blocked intestine)
- have diabetes
Interactions
A. Drug-Drug interactions:
- Monoamine oxidase inhibitors (such as isocarboxazid, phenelzine, selegiline, and tranylcypromine, moclobemide)
- Cisapride (used for gastric ulcers)
- Selegiline (an antiparkinsonian drug)
- Sympathetic agents (such as adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine present in cough or cold medicine)
- Antihypertensive medicines (such as diltiazem, verapamil, guanethidine, betanidine, clonidine reserpine and methyldopa)
- Anticholinergic drugs (such as atropine, hyoscyamine)
- Thioridazine (an antipsychotic agent for schizophrenia)
- Tramadol (a painkiller)
- Antifungal agents (such as fluconazole, terbinafine, ketoconazole, and itraconazole)
- Sedatives and hyponotics
- Other antidepressants (such as SSRIs (fluoxetine, paroxetine, fluvoxamine), duloxetine and bupropion)
- Buprenorphine/Opioids, methadone (pain killers)
- Cardiac drugs (such as beta blockers and antiarrhythmics)
- Cimetidine (used for stomach ulcers)
- Methylphenidate (used for ADHD)
- Ritonavir (an anti-HIV agent)
- Oral contraceptives (birth control pills)
- Rifampicin (used for infections)
- Antiepileptic agents (such as phenytoin, carbamazepine, valproic acid)
- St. John´s Wort (hypericum perforatum) an herbal antidepressant
- Thyroid medication
- Anti-allergic medicines (such as astemizole and terfenadine)
- Medicines used for some mental illnesses (such as pimozide and sertindole)
- Halofantrine (an antimalarial agent)
- Diuretics (such as furosemide)
Overdosage:
If you or anyone else accidentally taken too much of AMITRIP 25MG TABLET consult your doctor immediately or visit the nearby hospital straight away. Symptoms of overdosage might include dilated pupils, fast or irregular heartbeats, difficulties in passing urine, dry mouth, fits, fever, agitation, confusion, hallucinations, uncontrolled movements, weak pulse, pallor, blue discolouration of the skin, slow heart rate, extreme drowsiness and abnormal heart rhythm.
Synopsis
| Drug | : | Amitriptyline |
| Pharmacological Category | : | Tricyclic Antidepressants |
| Therapeutic Indication | : | Depression, Neuropathic pain, Headache |
| Dosage Forms | : | Tablet, Injection |
More Information
Storage
- Keep AMITRIP 25MG TABLET out of reach of children
- Store AMITRIP 25MG TABLET at room temperature
FAQs About AMITRIP 25MG TABLET
Q: What is AMITRIP 25MG TABLET used for?
A: AMITRIP 25MG TABLET is used in the management of depression, neuropathic pain and tension type headache or migraine in adults. It contains a medicine called Amitriptyline which is an antidepressant medicine. It enhances your mood by boosting the levels of a chemical called serotonin in your brain.
Q: How AMITRIP 25MG TABLET works?
A: AMITRIP 25MG TABLET is a tricyclic antidepressant. It works by increasing the levels of certain neurotransmitters in the brain, primarily serotonin and norepinephrine by inhibiting their reuptake into nerve cells, which helps to improve mood and relieve symptoms of depression.
Q: Can AMITRIP 25MG TABLET be used in children?
A: AMITRIP 25MG TABLET is generally not recommended for use in children and adolescents (aged below 18 years). However, your doctor may prescribe it to you after considering the risks and benefits. Therefore, consult your doctor for advice.
Q: Can AMITRIP 25MG TABLET be used during pregnancy?
A: AMITRIP 25MG TABLET should be used during pregnancy only if it is considered clearly necessary by the physician. Your doctor will prescribe this medicine only if it benefits the mother and justifies the risk to the fetus. Therefore, inform your doctor if you are pregnant, think you may be pregnant or planning for a baby before starting therapy with this medicine.
Q: Can AMITRIP 25MG TABLET cause weight gain?
A: Amitriptyline can cause weight gain as a side effect. This is relatively common with tricyclic antidepressants, including amitriptyline. The weight gain may be due to increased appetite, changes in metabolism, or fluid retention. If you are concerned about weight gain while taking amitriptyline, it is important to discuss this with your healthcare provider. They can offer strategies to manage weight, such as dietary changes, increased physical activity, or potentially adjusting the medication regimen.
Q: Can AMITRIP 25MG TABLET cause hair loss?
A: Amitriptyline is not commonly associated with hair loss, but it can occur as a rare side effect. Hair loss, or alopecia, is listed as a potential side effect of many medications, including some antidepressants. If you experience hair loss while taking AMITRIP 25MG TABLET, it is important to discuss this with your healthcare provider. They can determine whether the medication is the likely cause and discuss possible alternatives or treatments to manage this side effect.
Q: Can AMITRIP 25MG TABLET cause sexual problems?
A: AMITRIP 25MG TABLET can cause sexual problems as a side effect. These issues may include decreased libido, difficulty achieving orgasm, or erectile dysfunction. These side effects are due to the drug's impact on neurotransmitters, which can affect sexual function. If you experience sexual problems while taking AMITRIP 25MG TABLET, it is important to talk to your doctor.
Q: When will I start feeling better after taking AMITRIP 25MG TABLET?
A: The time it takes to start feeling better after beginning amitriptyline can vary. Typically, some people may start to notice improvements in their symptoms within 1 to 2 weeks. However, it often takes 4 to 6 weeks to experience the full therapeutic effects. It's important to continue taking the medication as prescribed and to be patient, as antidepressants can take time to work. If you have any concerns about your progress or side effects, consult your healthcare provider for guidance.
Q: Can AMITRIP 25MG TABLET cause problems in urination?
A: AMITRIP 25MG TABLET can cause problems in urination. It may lead to urinary retention, difficulty starting urination, or a decreased ability to empty the bladder completely. These side effects occur because amitriptyline has anticholinergic properties, which can affect the bladder muscles and the signals that control urination. If you experience any urinary issues while taking amitriptyline, it is important to discuss them with your doctor at the earliest.
Q: Can I consume alcohol while taking AMITRIP 25MG TABLET?
A: It is generally advised to avoid consuming alcohol while taking amitriptyline. Alcohol can increase the sedative effects of amitriptyline, leading to enhanced drowsiness, dizziness, and difficulty concentrating.
Q: What precautions must be followed while taking AMITRIP 25MG TABLET?
A: GBNKEYWORD] must be used under medical supervision. Take this medicine for the duration exactly as advised by your doctor. Do not stop therapy abruptly or overuse this medicine for prolonged periods without consulting your doctor. Regularly visit your doctor and perform the medical tests suggested by your doctor to achieve better results. Avoid concomitant usage of AMITRIP 25MG TABLET with other antidepressants like MAOIs to avoid potential drug-drug interactions. Before taking AMITRIP 25MG TABLET, inform your doctor about your current and previous medical history, presence of neurological and other mental disorders, pregnancy and breastfeeding. Patients or caregivers must close monitor the patients and inform the doctor immediately if the patients develop suicidal thoughts, mania or mood changes after taking AMITRIP 25MG TABLET.
References
- KD. Tripathi. Essentials of Medical Pharmacology. 7th Edition. 2013. Chapter 33. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Page – 454, 455-460
- Amitriptyline. StatPearls. NIH. National Library of Medicine. National Center For Biotechnology Information. July 2023. [Accessed on 22nd June 2024]. click here
- Amitriptyline 10 mg, 25 mg, and 50 mg Film-Coated Tablets. EMC. UK. Brown & Burk UK Ltd. [Revised in January 2022]. [Accessed on 22nd June 2024]. click here
- AMITRIPTYLINE HYDROCHLORIDE tablet, film coated. Dailymed.com. [Revised in March 2024]. [Accessed on 22nd June 2024]. click here
- Amitriptyline for depression. NHS. UK. [Revised in September 2021]. [Accessed on 22nd June 2024]. click here
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