AMARYL M 2mg Tablet 20's

Introduction About AMARYL M 2MG TABLET

AMARYL M 2mg Tablet 20's is a fixed-dose combination of glimepiride (2mg) and metformin, designed for adults managing type 2 diabetes mellitus. This dual-ingredient formulation is ideal for patients who have not achieved adequate blood sugar control with diet, exercise, or monotherapy alone. By leveraging two complementary mechanisms—glimepiride’s stimulation of insulin release from pancreatic beta cells and metformin’s reduction of hepatic glucose production with enhanced insulin sensitivity—AMARYL M provides a robust, data-backed solution for glycemic management, demonstrated to effectively lower HbA1c and fasting/post-meal blood sugar levels in comparative studies. 

The medicine is recommended particularly for newly diagnosed type 2 diabetes patients and those with comorbidities such as hypertension and dyslipidemia who require efficient, cost-effective glucose control. Patients should take AMARYL M 2mg Tablet once daily with meals—preferably the first main meal—to minimize gastrointestinal side effects and hypoglycemia risk. Consistent meal timing, regular monitoring of blood sugar, and adherence to prescriber instructions are crucial for safety and effectiveness. Patients must avoid skipping doses or doubling up after missed doses and consult their healthcare provider prior to making any changes to their routine.

Precautions for use include monitoring for low blood sugar (especially in elderly and those with kidney impairment), avoiding alcohol, and informing healthcare providers of all concurrent medications to prevent interactions. AMARYL M is not recommended for type 1 diabetes, those with severe kidney or liver disease, or in cases of diabetic ketoacidosis. In pregnancy and breastfeeding, safety is not well established; alternative treatments should be discussed with a physician. Common side effects include gastrointestinal upset (nausea, diarrhea, abdominal pain), mild hypoglycemia, headache, and dizziness. Rare side effects may include lactic acidosis or allergic reactions—prompt medical attention is needed if severe symptoms occur.

Patients receiving AMARYL M 2mg Tablet benefit from a well-tolerated and accessible therapy, with flexible dosing and strong evidence for lowering both fasting and postprandial glucose, making it a preferred option for a wide range of adults with type 2 diabetes seeking reliable long-term control and reduced complications.

Uses Of AMARYL M 2MG TABLET

• Treatment of type 2 diabetes mellitus in adults.
• Helps reduce the risk of diabetes complications such as kidney, eye, nerve, and heart problems

Benefits of AMARYL M 2MG TABLET

Effective Control of Blood Sugar in Type 2 Diabetes

AMARYL M 2mg Tablet combines glimepiride and metformin to provide a powerful approach to managing blood sugar levels in adults with type 2 diabetes. Glimepiride stimulates the pancreas to release insulin, which facilitates glucose uptake by cells, while metformin reduces glucose absorption in the intestines and decreases hepatic glucose production. This complementary mechanism helps achieve better glycemic control, lowering both fasting and post-meal blood sugar levels effectively when diet and exercise alone are insufficient. Consistent use as prescribed supports maintaining target blood glucose and reducing spikes that can cause long-term damage.

Combination Therapy Enhances Insulin Production & Sensitivity

The dual action of AMARYL M’s ingredients enhances the body’s ability to both produce insulin and respond to it efficiently. Glimepiride increases insulin secretion from pancreatic beta cells, providing an essential boost where endogenous insulin is inadequate. Meanwhile, metformin improves insulin sensitivity at the cellular level and reduces excess sugar production by the liver. This synergy not only improves blood sugar regulation but also mitigates the progression of insulin resistance commonly seen in type 2 diabetes, contributing to sustained therapeutic benefits and fewer complications.

Reduces Risk of Diabetes-Related Complications

Proper glycemic control with AMARYL M 2mg Tablet lowers the risk of serious diabetes complications including kidney damage, nerve problems, eye disorders, and cardiovascular diseases. By maintaining blood sugar levels within the recommended range, the medication helps minimize the harmful effects of chronic hyperglycemia on vital organs and blood vessels. Combined with lifestyle modifications such as diet and exercise, AMARYL M supports long-term health outcomes and reduces hospitalization risks associated with uncontrolled diabetes.

How AMARYL M 2MG TABLET Works

How Does Amaryl M 2mg Tablet Work?

Amaryl M 2mg Tablet is a combination medication containing Glimepiride and Metformin, designed to effectively lower blood glucose levels in patients with Type 2 Diabetes Mellitus. Glimepiride works by stimulating the pancreas to release more insulin, while Metformin reduces glucose production in the liver and improves the body’s response to insulin. Together, these two mechanisms help increase insulin availability, reduce excessive glucose production, and enhance glucose uptake by muscles and other tissues. This dual action helps control both fasting and postprandial blood sugar levels, making Amaryl M more effective than either drug used alone.

How glimepiride increases insulin release?

Glimepiride, a sulfonylurea class drug, increases insulin secretion from pancreatic β-cells. It binds to sulfonylurea receptors (SUR1) on the β-cell membrane, leading to the closure of ATP-sensitive potassium channels. This closure causes depolarization of the cell, which opens voltage-gated calcium channels. The resulting influx of calcium triggers the release of stored insulin into the bloodstream. By increasing insulin availability, glimepiride helps lower blood glucose levels effectively. However, it is only effective in patients whose pancreatic β-cells are functioning, which is why it is not suitable for Type 1 diabetes.

Metformin liver glucose production inhibition mechanism

Metformin, a biguanide, primarily acts on the liver to reduce glucose output. It inhibits gluconeogenesis, the process by which the liver produces glucose, by activating AMP-Activated Protein Kinase (AMPK), a key regulator of cellular energy. This reduces hepatic glucose production and improves insulin sensitivity, resulting in lower blood glucose levels, especially during fasting. Additionally, Metformin increases peripheral glucose uptake by muscles and decreases intestinal glucose absorption. Unlike sulfonylureas, it does not stimulate insulin release, which contributes to a lower risk of hypoglycemia when used alone.

How to use AMARYL M 2MG TABLET

How should I take Amaryl M 2mg tablet?

• Take the tablet by mouth with a full glass of water.
• Best taken with breakfast or the first main meal to reduce the risk of hypoglycemia.
• Do not crush, chew, or break the tablet; swallow it whole.
• Take it at the same time each day to maintain consistent blood sugar control.
• Do not skip meals after taking the tablet to avoid low blood sugar episodes.
• If prescribed twice daily, take the second dose with your evening meal.

Recommended Dosage of Amaryl M 2mg Tablet

• Starting dose (typical adult): 1 tablet once daily with breakfast.
• Dose may be adjusted every 1–2 weeks based on blood glucose response.
• Maximum recommended dose: Usually 1–2 tablets per day, depending on formulation and individual response.
• Elderly or renal-impaired patients: Start at lowest possible dose and monitor closely.
• Always follow the doctor’s instructions; do not adjust the dose yourself.

Special Instructions for Amaryl M in Type 2 Diabetes:

• Monitor blood sugar regularly to track effectiveness and prevent hypoglycemia.
• Carry a quick source of sugar (juice, glucose tablets) in case of low blood sugar.
• Avoid alcohol, as it increases the risk of lactic acidosis from metformin.
• Inform your doctor about all other medications, supplements, or herbal products.
• Maintain dietary and exercise routines; the medication works best alongside lifestyle modifications.
• Report symptoms such as dizziness, excessive sweating, or confusion promptly.
• Periodic kidney and liver function tests may be recommended, especially in elderly patients.

What if I forgot to take AMARYL M 2MG TABLET

If you forget to take your Amaryl M tablet at the scheduled time, take it as soon as you remember, provided it is not too close to your next meal or dose. If it is nearly time for your next dose, skip the missed tablet and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of hypoglycemia (low blood sugar). Always try to take the medication at the same time each day to maintain stable blood sugar levels.

Overdose

Taking more than the prescribed dose of Amaryl M can lead to severe hypoglycemia, which may present as dizziness, sweating, trembling, confusion, or even loss of consciousness. Overdose of the metformin component may rarely cause lactic acidosis, a serious condition characterized by rapid breathing, unusual weakness, fatigue, and abdominal discomfort. In case of suspected overdose, seek immediate medical attention. Treatment may involve administration of glucose for hypoglycemia, supportive care, and monitoring of vital signs, blood sugar, and renal function.

Side Effects Of AMARYL M 2MG TABLET

Common side effects of AMARYL M 2mg TABLET:

• taste disturbance
• diarrhea
• stomach pain
• loss of appetite

When to Seek Medical Attention?

Stop taking AMARYL M 2mg TABLET and contact your doctor immediately if you experience any of the following side effects:

• lactic acidosis
• inflammation of the liver which may result in jaundice (yellowing of skin or eyes)
• severe allergic reactions (such as skin rash, hives, and increased sensitivity to sun, inflammation of blood vessels which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock)
• severe low blood sugar levels

How To Manage Side Effects

Diarrhea

• Drink plenty of clean, boiled or filtered water to prevent dehydration.
• Use Oral Rehydration Solution (ORS) to replace lost fluids and electrolytes.
• Take clear liquids like coconut water, rice water, or mild soups for hydration.
• Eat a light BRAT diet – Bananas, Rice, Applesauce, and Toast – to be gentle on the stomach.
• Avoid oily, spicy, high-fiber, or dairy-rich foods until digestion improves.
• Rest well and avoid strenuous activities to help your body recover.
• Seek medical advice if diarrhoea lasts more than 2–3 days or if you notice signs of dehydration.

Loss Of Appetite

• Drink a glass of warm lemon water with honey in the morning to stimulate digestion.
• Eat small, frequent meals instead of large portions to avoid feeling overwhelmed.
• Include ginger tea or fresh ginger slices in your diet, as ginger helps boost hunger naturally.
• Add mild spices like cumin, black pepper, or fennel to meals to enhance taste and improve appetite.
• Take light physical activity, such as a short walk, to help trigger natural hunger signals.
• Avoid excess caffeine, alcohol and processed foods, which can suppress appetite.
• If loss of appetite persists for more than a week or is accompanied by weight loss, consult a doctor.

Warning & Precautions

Pregnancy

Contraindicated

AMARYL M 2MG TABLET should not be taken during pregnancy. Consult your doctor before taking AMARYL M 2MG TABLET if you are planning to become pregnant.     

Breastfeeding

Contraindicated

AMARYL M 2MG TABLET should not be taken during breastfeeding as it may pass through breast milk. 

Driving and Using Machines

Use with Caution

Do not drive or handle any machines if you experience low or high blood sugar levels (symptoms include dizziness, tiredness, shaking or trembling) or if you develop visual problems due to altered blood sugar levels. 

Alcohol

Consult your doctor

Avoid consumption of alcohol during management with AMARYL M 2MG TABLET as it may increase or decrease the blood sugar lowering action of AMARYL M 2MG TABLET and increases the risk of lactic acidosis. 

Kidney

Consult your doctor

AMARYL M 2MG TABLET is not recommended for use in patients with severe kidney disease and it should be used with caution in patients with kidney disease and your dose will be adjusted if needed depending upon kidney function. 

Liver

Consult your doctor

AMARYL M 2MG TABLET is not recommended if you have severe liver disease and it should be used with caution in patients with liver disease and your dose will be adjusted if needed depending upon liver function.

Allergy

Contraindicated

Do not take AMARYL M 2MG TABLET if you are allergic (hypersensitive) to Glimepiride or Metformin or other sulfonylureas (such as glipizide, glibenclamide) or sulfonamides (such as sulfamethoxazole).

Heart Disease

Contraindicated

AMARYL M 2MG TABLET is not recommended for use in patients with acute heart problems or recently had a heart attack or have severe circulatory problems or breathing difficulties (signs of heart failure).

Use In Pediatrics

Contraindicated

AMARYL M 2MG TABLET is not recommended for use in children and adolescents (under 18 years of age).

Use In Geriatrics

Consult your doctor

AMARYL M 2MG TABLET is not recommended for use in elderly patients (aged 75 years or above) and it should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may assess your kidney function more frequently during management with AMARYL M 2MG TABLET.  

Other Warnings for AMARYL M 2MG TABLET

Before taking AMARYL M 2MG TABLET inform your doctor if you:

• are recovering from injury, operation, infections with fever, or from other forms of stress
• have glucose-6-phosphate dehydrogenase (G6PD) deficiency
• have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take [GBNKEYWORD

AMARYL M 2MG TABLET is not recommended for use, if you have:

• type 1 diabetes mellitus
• diabetic ketoacidosis
• uncontrolled diabetes or ketoacidosis
• dehydration
• severe infection

Safety Advice

• Take With Food: Always take the tablet with breakfast or the first main meal to reduce the risk of hypoglycemia (low blood sugar).
• Monitor Blood Sugar: Regularly monitor your blood glucose levels to ensure the medicine is effective and to prevent both hypoglycemia and hyperglycemia.
• Hypoglycemia Awareness: Be aware of symptoms of low blood sugar such as dizziness, sweating, tremors, confusion, or palpitations. Carry a quick sugar source (glucose tablets or juice) at all times.
• Alcohol Avoidance: Avoid or limit alcohol intake, as it can increase the risk of lactic acidosis from metformin and exacerbate hypoglycemia.
• Kidney and Liver Function: Periodic monitoring of renal and hepatic function is recommended, especially in elderly patients or those with pre-existing conditions.
• Drug Interactions: Inform your doctor of all medications, supplements, and herbal products, as several drugs can increase or decrease the effects of Amaryl M.
• Missed Dose: If a dose is missed, take it as soon as remembered unless it is near the next scheduled dose. Do not double the dose.
• Lifestyle Measures: Continue a balanced diet and regular exercise, as medication alone is not sufficient to control blood glucose.
• Allergic Reactions: Stop use and seek medical attention if you notice rash, itching, swelling, or difficulty breathing.

Diet and Lifestyle Advice

1. Balanced Diet:

• Follow a diabetic-friendly diet rich in vegetables, whole grains, lean proteins, and fruits.
• Limit simple sugars, sugary beverages, and refined carbohydrates to prevent blood sugar spikes.
• Include high-fiber foods (like oats, beans, and vegetables) to improve blood sugar control.
• Monitor portion sizes and avoid overeating, which can affect glucose levels.

2. Regular Meals:

• Take Amaryl M with breakfast or the first main meal.
• Avoid skipping meals, as missing food while on glimepiride can increase the risk of hypoglycemia.

3. Physical Activity:

• Engage in regular exercise such as walking, cycling, swimming, or yoga.
• Physical activity helps improve insulin sensitivity and control blood glucose.
• Start slowly and gradually increase intensity, especially if you have not exercised regularly.

4. Weight Management:

• Maintain a healthy body weight, as obesity can worsen insulin resistance.
• Combine dietary control and physical activity for effective weight management.

5. Hydration:

• Drink adequate water throughout the day.
• Avoid excessive consumption of alcohol or sugary drinks.

6. Blood Sugar Monitoring:

• Keep a log of blood glucose readings before and after meals.
• Adjust diet and activity based on blood sugar patterns in consultation with your healthcare provider.

7. Lifestyle Habits:

• Avoid smoking, which can increase cardiovascular risk.
• Manage stress through relaxation techniques like meditation, deep breathing, or light physical activity.
• Get adequate sleep, as poor sleep can affect blood sugar control.

1. How does Amaryl M 2mg Tablet compare to Glimepiride alone?

2. Is Amaryl M 2mg more effective than other combination antidiabetic medications?

Drug - Drug interaction

1. NSAIDs, Aspirin, Sulfonamides

• Interaction: These drugs may enhance the effect of glimepiride, increasing the risk of hypoglycemia.
• Management: Monitor blood glucose closely. Educate the patient on signs of low blood sugar. Adjust glimepiride dose if necessary.

2. Beta-Blockers, Clonidine, Reserpine

• Interaction: These medications can mask symptoms of hypoglycemia, such as rapid heartbeat or tremors.
• Management: Monitor blood glucose regularly. Instruct the patient to watch for atypical hypoglycemia symptoms.

3. Other Hypoglycemic Agents (Insulin, Meglitinides)

• Interaction: Additive effect may increase the risk of hypoglycemia.
• Management: Start combination therapy at lower doses and monitor blood glucose frequently. Adjust therapy as needed.

4. Oral Antifungals (e.g., Miconazole)

• Interaction: May inhibit glimepiride metabolism, causing severe, prolonged hypoglycemia.
• Management: Avoid concurrent use if possible. If unavoidable, monitor blood glucose closely and adjust glimepiride dose.

5. Thiazide Diuretics, Corticosteroids (e.g., Prednisolone)

• Interaction: Can reduce glimepiride’s effect, potentially causing hyperglycemia.
• Management: Monitor blood glucose and adjust Amaryl M dose if needed.

6. CYP2C9 Inducers (e.g., Rifampin, Phenytoin)

• Interaction: May increase glimepiride metabolism, leading to reduced glucose-lowering effect.
• Management: Monitor blood glucose closely. Dose adjustment may be required. Reassess after discontinuing the inducer.

7. Colesevelam (Bile Acid Sequestrants)

• Interaction: May reduce absorption of glimepiride, decreasing efficacy.
• Management: Take Amaryl M at least 4 hours before colesevelam. Monitor blood glucose and adjust dose if needed.

8. Iodinated Contrast Agents

• Interaction: Can impair kidney function, causing metformin accumulation and increased risk of lactic acidosis.
• Management: Temporarily stop metformin before the procedure. Resume only after kidney function is confirmed normal.

9. Drugs Affecting Kidney Function (NSAIDs, ACE Inhibitors, Diuretics)

• Interaction: May reduce renal clearance of metformin, increasing the risk of lactic acidosis.
• Management: Monitor kidney function regularly. Adjust or temporarily discontinue Amaryl M if necessary.

Drug - Food interaction

1. Alcohol

• Interaction: Alcohol can increase the risk of lactic acidosis from metformin and may potentiate hypoglycemia due to glimepiride.
• Management: Avoid excessive alcohol intake. Monitor for symptoms such as dizziness, unusual fatigue, rapid breathing, or muscle pain.

2. Grapefruit Juice

• Interaction: Although not a major concern with glimepiride or metformin, grapefruit juice can potentially affect drug metabolism of some oral hypoglycemics.
• Management: Limit consumption of grapefruit juice. Monitor blood glucose for any unusual changes.

3. High-Carbohydrate Meals / Sugary Foods

• Interaction: High sugar intake can reduce the effectiveness of Amaryl M by causing postprandial hyperglycemia.
• Management: Follow a balanced, diabetic-friendly diet. Avoid excessive intake of sweets and refined carbohydrates. Monitor blood sugar after meals.

4. Very Low-Calorie or Fasting Diets

• Interaction: Skipping meals or very low-calorie diets while on glimepiride may increase the risk of hypoglycemia.
• Management: Take Amaryl M with meals. Do not skip meals, and maintain regular eating patterns. Adjust dose only under medical supervision.

5. Fiber-Rich Foods / Whole Grains (Large Amounts)

• Interaction: High-fiber foods can sometimes reduce absorption of metformin, slightly decreasing its effectiveness.
• Management: Maintain a consistent diet. Monitor blood glucose, but no major restriction is usually needed.

6. Caffeine

• Interaction: Caffeine may slightly increase blood glucose levels in some individuals.
• Management: Moderate caffeine intake. Monitor glucose levels and adjust diet or medication under guidance if needed.

Synopsis

More Information

FAQs About AMARYL M 2MG TABLET

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on 22nd October 2025] 

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on 22nd October 2025]  

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on 22nd October 2025]  

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on 22nd October 2025] 

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 27 Oct 2025 | 12:50 PM(IST)