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Introduction About ACYLOVIR 400 TABLET
ACYLOVIR 400 TABLET contains Acyclovir, which belongs to the group of medicines called Antivirals. It is used for chickenpox, shingles, cold sores, genital herpes and other herpes simplex infections to manage infections in people with a weakened immune system. Cold sores, (a virus causing contagious sores, most often around the mouth or on the genitals), genital herpes (a common sexually transmitted infection caused by the herpes simplex virus and symptoms include genital pain and sores, pain, itching and small sores).
Before taking ACYLOVIR 400 TABLET inform your doctor if you have kidney problems. ACYLOVIR 400 TABLET should be used with caution among pregnant or breastfeeding women. Consult your doctor before taking ACYLOVIR 400 TABLET.
The most common side effects of taking ACYLOVIR 400 TABLET are headache, dizziness, feeling or being sick, diarrhea, stomach pain and rashes. Contact your doctor if the symptom persists.
Uses Of ACYLOVIR 400 TABLET
ACYLOVIR 400 TABLET is used in the following conditions:
- chickenpox and Herpes zoster (shingles)
- cold sores, genital herpes
- herpes simplex infections
- problems in those people infected with a virus
- infections in low immunity patients
How ACYLOVIR 400 TABLET Works
ACYLOVIR 400 TABLET works against or stopping the growth of viruses (herpes virus). It has a higher affinity for viral DNA cells than human DNA cells and incorporates into the viral DNA and causes DNA chain termination and inactivation, leading to the death of cells.
How to use ACYLOVIR 400 TABLET
Take ACYLOVIR 400 TABLET as advised by your physician. Swallow the medicine by mouth with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Side Effects Of ACYLOVIR 400 TABLET
Common
- headache
- dizziness
- nausea
- vomiting
- diarrhea
- stomach pain
- skin reaction after exposure to light (photosensitivity), itchy skin
- feeling tired
- fever
Uncommon
- itchy, hive-like rash
- hair loss
Rare
- effects on blood and urine tests
- increase in liver enzymes
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water or fruit juice to keep you hydrated. Do not consume any medicine on your own without consulting your doctor.
Dizziness Or Drowsiness
If ACYLOVIR 400 TABLET makes you feel dizzy, take rest until you feel better. Do not drive or operate any machines.
Headache
Take rest and drink plenty of fluids. If not subsided. Consult your doctor if your symptom gets worse or persist.
Nausea And Vomiting
Take simple meals and do not eat rich or spicy food.
Skin rash Or Itching
Try to use an unscented moisturiser. If the symptom does not improve, contact your doctor.
Stomach Pain
Try to rest and relax. Eat smaller meals but take them frequently. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.
Warning & Precautions
Pregnancy
Use with CautionACYLOVIR 400 TABLET should be used with caution in pregnant women. Consult your doctor before taking it.
Breastfeeding
Use with CautionACYLOVIR 400 TABLET should be used with caution in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy, drowsiness or asleep after taking ACYLOVIR 400 TABLET.
Kidney
Consult your doctorACYLOVIR 400 TABLET is not recommended for use if you have renal failure. It should be used with caution in patients with kidney problems. Consult your doctor before taking ACYLOVIR 400 TABLET.
Allergy
ContraindicatedDo not take ACYLOVIR 400 TABLET if you are allergic to Acyclovir, valacyclovir, or any of the other ingredients of this medicine.
Use In Geriatrics
Use with CautionACYLOVIR 400 TABLET should be used with caution in elderly patients (aged above 75 years). Consult your doctor before taking ACYLOVIR 400 TABLET.
Others
ACYLOVIR 400 TABLET is not recommended for use if you:
- have thrombotic thrombocytopenic purpura/haemolytic uremic syndrome (TTP/HUS)
Before taking ACYLOVIR 400 TABLET, inform your doctor:
- if you have a low resistance to disease (immune deficiency)
- if you are taking nephrotoxic medicines (Ex. amphotericin B and aminoglycoside antibiotics)
Interactions
A. Drug-Drug interactions:
Before taking ACYLOVIR 400 TABLET, inform your doctor if you are taking any of the following medicine:
- probenecid (used to manage gout)
- cimetidine (used to manage stomach ulcers)
- drugs acting on the immune system (Ex. mycophenolate mofetil)
- amikacin, amphotericin B, atovaquone, lumefantrine, mefloquine, azithromycin, capreomycin, caspofungin, clarithromycin, clindamycin, doxycycline, erythromycin (used to manage infections)
- antivirals Ex. valacyclovir, valganciclovir, ganciclovir, tenofovir, cidofovir (used to manage viral infections)
- albendazole (used to manage parasitic infections)
- dapsone, isoniazid (used to manage mycobacterial infections)
- antifungals Ex. fluconazole, itraconazole
Overdosage:
If you or anyone else accidentally takes too much of ACYLOVIR 400 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are agitation, seizures, lethargy.
Synopsis
| Drug | : | Acyclovir |
| Pharmacological Category | : | Antivirals |
| Therapeutic Indication | : | Chickenpox, shingles, herpes simplex virus |
| Dosage Forms | : | Tablet, Suspension, Syrup, Infusion, Injection, Cream, Ointment, Eye- ointment |
More Information
Storage
- Keep ACYLOVIR 400 TABLET out of the sight and reach from children
- Store ACYLOVIR 400 TABLET below 25°C
FAQs About ACYLOVIR 400 TABLET
Q: Can ACYLOVIR 400 TABLET be used to manage Urinary Tract Infections?
A: Yes. ACYLOVIR 400 TABLET used to manage cystitis caused by the herpes simplex virus. Consult your doctor before taking ACYLOVIR 400 TABLET.
Q: What precautions do I need to follow while taking ACYLOVIR 400 TABLET?
A: Patients taking ACYLOVIR 400 TABLET must inform their doctor about their pre-existing disease conditions like kidney, heart, or liver problems and if they are elderly above 65 years of age.
Q: Can ACYLOVIR 400 TABLET be used on pregnancy?
A: Yes. ACYLOVIR 400 TABLET should be used with caution in pregnant women. Consult your doctor before taking ACYLOVIR 400 TABLET.
Q: Who should avoid taking ACYLOVIR 400 TABLET?
A: ACYLOVIR 400 TABLET is not recommended for patients having kidney diseases or elderly above 65 years and patients with allergic history to acyclovir. Consult your doctor before taking ACYLOVIR 400 TABLET.
Q: How long does it take for ACYLOVIR 400 TABLET to show its effects?
A: ACYLOVIR 400 TABLET works within 24-48 hours of administration.
Q: Can ACYLOVIR 400 TABLET manage a bacterial infection?
A: No. ACYLOVIR 400 TABLET is an antiviral medicine used to manage herpes simplex virus, chicken pox, and shingles. Talk to your doctor before taking ACYLOVIR 400 TABLET.
References
1. KD Tripathi. Antiviral drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page-799.
2. Laurence L. Brunton, Randa Hilal-Dandan, Bjorn C. Knollman, Antiviral agents (Non-retroviral), Goodman & Gillman’s: The pharmacological basics of therapeutics, 13th edition. 2018. Page-1105.
3. Terapia S.A & Sun Pharmaceutical Industries Europe BV. Electronic Medicines Compendium (EMC). [Revised in October 2019] [Accessed on 18th April 2022] https://www.medicines.org.uk/emc/files/pil.4336.pdf
4. Terapia S.A. & Sun Pharmaceutical Industries Europe BV. Electronic Medicines Compendium (EMC). [Revised in October 2019] [Accessed on 18th April 2022] https://www.medicines.org.uk/emc/files/pil.4335.pdf
5. GlaxoSmithKline. U.S. Food & Drug Administration. [Revised in June 2005] [Accessed on 18th April 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/018828s030,020089s019,019909s020lbl.pdf
6. Acyclovir. CDSCO. [Revised in September 2010] [Accessed on 18th April 2022] https://cdscoonline.gov.in/CDSCO/Drugs
7. Significant drug interactions for drugs used to treat or prevent opportunistic infections. https://clinicalinfo.hiv.gov/en/guidelines/pediatric-opportunistic-infection/table-5-significant-drug-interactions-drugs-used-treat
8. Drugbank. Mechanism of action of acyclovir. https://go.drugbank.com/drugs/DB00787
Useful Diagnostic Tests
- Herpes Simplex Virus 1 DNA PCR
- Herpes Simplex Virus 1 IgG
- Herpes Simplex Virus 2 DNA PCR
- Herpes Simplex Virus 2 IgG
- Herpes Simplex Virus 2 IgM
- Varicella Zoster IgG
- Varicella Zoster IgM
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