ACTIDE 100mcg Injection 1ml
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Introduction About ACTIDE 100MCG INJECTION
ACTIDE 100MCG INJECTION is used in the management of acromegaly (a condition where body produces more amount of growth hormones), certain types of tumours of gastrointestinal tract (such as carcinoid tumours, VIPomas, glucagonomas, gastrinomas, insulinomas), pituitary tumours that produce too much thyroid-stimulating hormone when other types of treatment (surgery or radiotherapy) are not working and other pituitary hormone imbalances.
It can also be used to reduce complications like abscess in abdomen and inflammation following surgery of the pancreas and to stop bleeding from ruptured gastro-oesophageal varices in patients suffering from cirrhosis (chronic liver disease).
Octreotide mimics somatostatin, controlling the release of growth hormone, insulin, and gut hormones by binding to specific receptors. It reduces intestinal fluid secretion, slows gut movement, and tightens abdominal blood vessels, making it effective for managing acromegaly, hormone-secreting tumors, and certain bleeding conditions.
ACTIDE 100MCG INJECTION should be used under medical supervision. During therapy with ACTIDE 100MCG INJECTION, your doctor will periodically monitor your gall bladder, heart rate, liver functions, thyroid functions, pancreas function and vitamin B12 levels as a precaution.
Before receiving ACTIDE 100MCG INJECTION, inform your doctor if you are pregnant, breastfeeding, have gall stones, diabetes or low blood sugar levels as a precaution. The most common side effects of receiving ACTIDE 100MCG INJECTION are gall stone formation and inflammation, diabetes, low blood sugar levels, irregular heartbeat, underactive thyroid, headache, dizziness, gastric problems, tiredness, weakness, dark urine and feces, pain at injection site. Consult your doctor if they trouble you.
Also, inform your doctor immediately if you experience fever, yellowing of skin and whites of eyes, chills, stomach pain, sudden pain of upper abdomen with nausea, vomiting, diarrhea or light-coloured urine after receiving ACTIDE 100MCG INJECTION.
Uses Of ACTIDE 100MCG INJECTION
Management of pituitary gland related hormone abnormalities such as:
- Acromegaly
- Certain types of tumours of gastrointestinal tract (such as carcinoid tumours, VIPomas, glucagonomas, gastrinomas, insulinomas)
- Pituitary tumours that produce too much thyroid-stimulating hormone
- Reduce complications following surgery of the pancreas
- Stop bleeding from ruptured gastro-oesophageal varices in patients suffering from cirrhosis
How ACTIDE 100MCG INJECTION Works
ACTIDE 100MCG INJECTION contains Octreotide works by mimicking a natural hormone called somatostatin, which helps control the release of several other hormones in the body. It attaches to specific receptors on cells, mainly in the digestive system and hormone-producing glands, and slows down the release of growth hormone, insulin, and certain gut hormones. It also reduces fluid secretion in the intestines and slows down gut movement. Additionally, it tightens blood vessels in the abdomen, which helps reduce bleeding in certain conditions. These effects make octreotide useful for managing acromegaly, and other problems caused due to excessive growth hormone, hormone-secreting tumors, and certain types of bleeding.
How to use ACTIDE 100MCG INJECTION
ACTIDE 100MCG INJECTION will be given to you only by a doctor or a nurse into your vein as an intravenous infusion. Alternatively, it can also be self-administered beneath the skin, if advised by your physician.
Your doctor will clearly explain you how to self-administer this medicine. Skin beneath your thighs, upper arms, and abdomen are ideal for self-administration. While self-administration, it is advisable to avoid eating meals around the time of injection to reduce stomach problems. It is recommended to inject Octreotide between meals or at bedtime.
Your doctor will decide the correct dose and duration of therapy for you based on your age, body weight and health condition.
Side Effects Of ACTIDE 100MCG INJECTION
Common
- Gallstone formation causing sudden back pain
- Gallstone inflammation causing pain in the upper right abdomen, fever, nausea, yellowing of the skin and eyes (jaundice)
- Too high or low blood sugar levels
- Slow heart rate, low appetite
- Underactive thyroid gland (hypothyroidism) causing changes in appetite, heart rate, body weight, feeling tired, swelling of front side of neck
- Diarrhoea, abdominal pain, nausea, vomiting, constipation, flatulence, stomach discomfort after meals, feeling fullness of stomach
- Headache, dizziness
- Pain at the injection site
- Fatty stools, loose stools, discolouration of faeces
- Change in liver function tests
- Hair loss
- Shortness of breath, weakness
Uncommon
- Feeling thirsty, low urine output
- Dark urine
- Dry flushed skin
- Fast heartbeat
Inform your doctor immediately if you experience any of the following side effects after receiving ACTIDE 100MCG INJECTION:
- Signs of gall stone formation (such as fever, yellowing of skin and whites of eyes, chills, stomach pain)
- Allergic reactions (causing skin rashes, itching, difficulty in swallowing or breathing, swelling and tingling, possibly with a drop in blood pressure with dizziness or loss of consciousness)
- Inflammation of pancreas (symptoms include sudden pain of upper abdomen, nausea, vomiting, diarrhea, yellowing of skin and whites of the eye, loss of appetite, light coloured urine)
- Abnormal heartbeat
- Low platelet counts which results in increased risk of bleeding
How To Manage Side Effects
Dizziness Or Drowsiness
To manage dizziness at home, sit or lie down immediately to prevent falls, and avoid sudden movements or standing up quickly. Stay hydrated by drinking water, as dehydration can cause or worsen dizziness. Focus on a stable object to help regain your balance, and avoid bright lights, excessive screen time, or noisy environments. Eating small, regular meals can prevent low blood sugar, which may contribute to dizziness. If dizziness is persistent, recurrent, or accompanied by other symptoms, seek medical advice.
Headache
To manage a headache at home, start by resting in a quiet, dark room and applying a cold or warm compress to your forehead or neck. Stay hydrated by drinking plenty of water, as dehydration can worsen headaches. Practicing relaxation techniques such as deep breathing, meditation, or gentle neck and shoulder stretches can reduce tension. Limiting screen time and avoiding bright lights, loud noises, and strong smells may also help. If headaches persist or worsen, consult a healthcare provider for further evaluation.
Warning & Precautions
Pregnancy
Monitoring requiredACTIDE 100MCG INJECTION should be used during pregnancy only if considered clearly necessary. Therefore, consult your doctor for advice. Women of childbearing potential must use a suitable contraceptive while receiving ACTIDE 100MCG INJECTION to avoid pregnancy.
Breastfeeding
Monitoring requiredIt is not known whether Octreotide passes into the breast milk. Therefore, it is not recommended for use in breastfeeding women unless considered necessary by the physician.
Driving and Using Machines
Use with CautionDo not drive or handle heavy machinery if you experience headache, tiredness or any other side effects that can affect you concentration and attention after receiving ACTIDE 100MCG INJECTION.
Allergy
ContraindicatedBefore receiving ACTIDE 100MCG INJECTION, inform your doctor if you are allergic to Octreotide or any other ingredients of this medicine.
Use In Pediatrics
Consult your doctorThere is only limited experience available with the use of octreotide in children. Therefore, your doctor will prescribe ACTIDE 100MCG INJECTION after overweighing risks and benefits of therapy to the child.
Use In Geriatrics
Use with CautionACTIDE 100MCG INJECTION should be used with caution in elderly patients. Therefore, consult your doctor before usage.
Others
Before taking ACTIDE 100MCG INJECTION, inform your doctor if you:
- have diabetes or low blood sugar levels
- have or previously had gall stones
- have vitamin B12 deficiency
Interactions
A. Drug-Drug interactions:
- Cimetidine (a medicine used for stomach ulcer)
- Ciclosporin (an immunosuppressants)
- Bromocriptine (a medicine used to reduce prolactin production)
- Quinidine (an antiarrhythmic agent)
- Terfenadine (an antifungal agent)
- Antihypertensive medicines (such as beta blocker or a calcium channel blocker)
- Insulin (antidiabetic agent)
- Radiotherapy (such as lutetium (177Lu) oxodotreotide)
Overdosage:
If you or anyone else accidentally received too much of ACTIDE 100MCG INJECTION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include low blood pressure, slow or irregular heart rate, severe upper stomach pain, yellow skin and eyes, nausea, loss of appetite, diarrhoea, weakness, tiredness, weight loss and abdominal swelling.
Synopsis
| Drug | : | Octreotide |
| Pharmacological Category | : | Somatostatin analogs |
| Therapeutic Indication | : | Pituitary hormone imbalance |
| Dosage Forms | : | Injection |
More Information
Storage
- Keep ACTIDE 100MCG INJECTION out of reach of children
- Store ACTIDE 100MCG INJECTION in a refrigerator between 2-8°C
FAQs About ACTIDE 100MCG INJECTION
Q: What is ACTIDE 100MCG INJECTION used for?
A: ACTIDE 100MCG INJECTION is used in the management of acromegaly, certain types of tumours of gastrointestinal tract (such as carcinoid tumours, VIPomas, glucagonomas, gastrinomas, insulinomas), pituitary tumours that produce too much thyroid-stimulating hormone when other types of treatment (surgery or radiotherapy) are not working and other pituitary hormone imbalances. It can also be used to reduce complications like abscess in abdomen and inflammation following surgery of the pancreas and to stop bleeding from ruptured gastro-oesophageal varices in patients suffering from cirrhosis (chronic liver disease).
Q: How ACTIDE 100MCG INJECTION works?
A: ACTIDE 100MCG INJECTION contains Octreotide works by mimicking a natural hormone called somatostatin, which helps control the release of several other hormones in the body. It attaches to specific receptors on cells, mainly in the digestive system and hormone-producing glands, and slows down the release of growth hormone, insulin, and certain gut hormones. It also reduces fluid secretion in the intestines and slows down gut movement. Additionally, it tightens blood vessels in the abdomen, which helps reduce bleeding in certain conditions. These effects make octreotide useful for managing acromegaly, and other problems caused due to excessive growth hormone, hormone-secreting tumors, and certain types of bleeding.
Q: Can ACTIDE 100MCG INJECTION be self-administered?
A: ACTIDE 100MCG INJECTION can be self-administered beneath the skin, if advised by your physician. Your doctor will clearly explain you how to self-administer this medicine. Skin beneath your thighs, upper arms, and abdomen are ideal for self-administration. Do not self-administer this medicine into your veins.
Q: Will ACTIDE 100MCG INJECTION turn my urine dark?
A: Dark or light discoloration of urine is one of the common side effects of receiving ACTIDE 100MCG INJECTION. If dark urine is associated with severe stomach pain, tiredness, nausea, vomiting, yellowing of skin, consult your doctor immediately.
Q: Is ACTIDE 100MCG INJECTION safe?
A: ACTIDE 100MCG INJECTION is safe when used under medical supervision. Your doctor will closely monitor your health condition and adjust the dose according to avoid unwanted side effects.
Q: How long can we use ACTIDE 100MCG INJECTION?
A: The duration of therapy with ACTIDE 100MCG INJECTION will be decided by your physician based on the severity of your health condition. Therefore, continue using octreotide injection as far as your doctor suggests it to you.
Q: What precautions should I follow while on therapy with ACTIDE 100MCG INJECTION?
A: ACTIDE 100MCG INJECTION should be used under medical supervision. During therapy with ACTIDE 100MCG INJECTION, your doctor will periodically monitor your gall bladder, heart rate, liver functions, thyroid functions, pancreas function and vitamin B12 levels as a precaution. Before receiving ACTIDE 100MCG INJECTION, inform your doctor if you are pregnant, breastfeeding, have gall stones, diabetes or low blood sugar levels as a precaution.
Q: Can ACTIDE 100MCG INJECTION increase my weight?
A: ACTIDE 100MCG INJECTION may increase weight in some individuals, as it is shown to alter thyroid functions, appetite levels, etc. If you experience weight gain after using ACTIDE 100MCG INJECTION and it troubles you, check with your doctor for advice.
Q: Can ACTIDE 100MCG INJECTION be used in children?
A: There is only limited experience available with the use of octreotide in children. Therefore, your doctor will prescribe ACTIDE 100MCG INJECTION after overweighing risks and benefits of therapy to the child.
Q: Can ACTIDE 100MCG INJECTION be used in pregnancy?
A: ACTIDE 100MCG INJECTION should be used during pregnancy only if considered clearly necessary. Therefore, consult your doctor for advice. Women of childbearing potential must use a suitable contraceptive while receiving ACTIDE 100MCG INJECTION to avoid pregnancy.
Q: What are the common side effects of receiving ACTIDE 100MCG INJECTION?
A: The most common side effects of receiving ACTIDE 100MCG INJECTION are gall stone formation and inflammation, diabetes, low blood sugar levels, irregular heartbeat, underactive thyroid, headache, dizziness, gastric problems, tiredness, weakness, dark urine and feces, pain at injection site. Consult your doctor if they trouble you.
Q: When should I consult the doctor while on therapy with ACTIDE 100MCG INJECTION?
A: Inform your doctor immediately if you experience fever, yellowing of skin and whites of eyes, chills, stomach pain, sudden pain of upper abdomen with nausea, vomiting, diarrhea or light-coloured urine after receiving ACTIDE 100MCG INJECTION.
References
1. KD. Tripathi. Essentials of Medical Pharmacology. 7th edition. Hormones and related drugs. Page-238.
2. Octreotide. StatPearls. National Center for biotechnology information. National Library of Medicine. [Revised in May 2023]. [Accessed on 20th August 2024] https://www.ncbi.nlm.nih.gov/books/NBK544333/
3. Octreotide 50,100,200,500mcg solution for injection. EMC.UK. Sun Pharmaceutical Industries Europe B.V. [Revised in June 2022]. [Accessed on 20th August 2024] https://www.medicines.org.uk/emc/files/pil.6310.pdf
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