Zobilan 4mg Injection 5ml

Bone Metabolism Rx required
OUT OF STOCK

Best Price* ₹ 2,691.00 MRP ₹ 2,990.00
(Inclusive of all taxes) * Mkt: Mylan Pharmaceuticals Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

ZOBILAN contains Zoledronic Acid which belongs to the group of medicines called Bisphosphonates. It is used to prevent bone complications such as fractures, bone metastases (cancer that has spread from the original (primary) tumor to the bone) in adult patients and helps to reduce the amount of calcium in the blood in adult patients (tumour-induced hypercalcaemia (TIH)).

Along treatment with ZOBILAN your doctor might ask you to make some lifestyle changes such as eating balanced diet rich in calcium and vitamin D. Prior to starting the treatment with ZOBILAN your doctor might want you to take some diagnostic tests to understand the existing condition.

Before receiving ZOBILAN inform your doctor if you had or have pain, swelling or numbness of the jaw, feeling of heaviness in the jaw or loosening of teeth, kidney disease, are having dental treatment or due to undergo dental surgery.

ZOBILAN is not recommended for use in pregnant and breast-feeding women. ZOBILAN is not recommended for use in children and adolescents (under 18 years of age) and should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving ZOBILAN.

The most common side effects of receiving ZOBILAN are headache, nausea, vomiting, loss of appetite, conjunctivitis and anaemia (low number of red blood cells). Inform your doctor if any of the symptom worsens.

USES OF ZOBILAN

Used in adult patients to:

  • prevent bone complications such as fractures and bone metastases
  • helps to reduce the amount of calcium in the blood (tumour-induced hypercalcaemia (TIH))

HOW ZOBILAN WORKS

ZOBILAN works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bones and minimizes the risk of fractures.

DIRECTIONS FOR USE

ZOBILAN will be given to you only by a doctor or a nurse into a vein (intravenously). Your doctor will decide the correct dose and duration of ZOBILAN for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ZOBILAN

COMMON

  • headache
  • flu-like symptoms such as fever, fatigue, weakness, drowsiness, chills and bone, joint or muscle pain
  • gastrointestinal reactions such as nausea, vomiting, loss of appetite
  • conjunctivitis
  • low level of phosphate in blood
  • low level of red blood cells (anaemia)

UNCOMMON

  • allergic reactions
  • high or low blood pressure, chest pain
  • rash, itching, redness and swelling at the infusion site
  • shortness of breath
  • dizziness, anxiety
  • sleep disturbances
  • taste disturbances
  • trembling
  • tingling or numbness of the hands or feet
  • diarrhoea, constipation, abdominal pain
  • dry mouth
  • weight gain
  • increased sweating
  • sleepiness
  • blurred vision, tearing of the eye, eye sensitivity to light
  • sudden coldness with fainting, limpness or collapse
  • difficulty in breathing with wheezing or coughing
  • urticaria

RARE

  • slow heartbeat
  • confusion
  • unusual fracture of the thigh bone (symptoms such as pain, weakness or discomfort in thigh, hip, or groin)
  • interstitial lung disease (inflammation of the tissue around the air sacs of the lungs)
  • joint swelling
  • painful redness and/or swelling of the eye

Consult your doctor if you experience any of the following side effects after receiving ZOBILAN:

  • severe kidney impairment (signs include nausea, vomiting, fluid retention, decreased or increased urination)
  • low levels of calcium in blood (hypocalcademia) (symptoms such as muscle cramps, dry skin, burning sensation, irregular heartbeat, seizures, spasm and twitching (tetany))
  • bone damage in jaw (osteonecrosis) (symptoms such as pain in the mouth, teeth and/or jaw, swelling or non-healing sores inside the mouth or jaw, discharge, numbness or feeling of heaviness in jaw or loosening of a tooth)
  • irregular heart rhythm (atrial fibrillation)
  • severe allergic reaction (symptoms such as shortness of breath, swelling mainly of the face and throat)

HOW TO MANAGE SIDE EFFECTS

Headache:

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.

Nausea or vomiting:

Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.

Dizziness:

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Inform your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and drink plenty of water. If this does not help, inform your doctor for receiving alternate treatment for constipation.

Abdominal pain:

Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, inform your doctor.

WARNING & PRECAUTIONS

PREGNANCY

ZOBILAN is not recommended for use in pregnant women. Consult your doctor before receiving ZOBILAN.

BREASTFEEDING

ZOBILAN is not recommended for use in breastfeeding women. Consult your doctor before receiving ZOBILAN.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel drowsiness and sleepiness after receiving ZOBILAN.

KIDNEY

ZOBILAN should be used with caution in patients with kidney problem. Consult your doctor before receiving ZOBILAN.

ALLERGY

Do not receive ZOBILAN if you are allergic to Zoledronic Acid or other bisphosphonate (such as alendronate) or any of the other ingredients of this medicine.

OTHERS

Before receiving ZOBILAN inform your doctor if you:

  • had or have pain, swelling or numbness of the jaw, feeling of heaviness in the jaw or loosening of teeth
  • are having dental treatment or are due to undergo dental surgery

Use in paediatrics:

ZOBILAN is not recommended for use in children and adolescents (under 18 years of age). Consult child’s doctor for advice.

Use in geriatrics:

ZOBILAN should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving ZOBILAN.

INTERACTIONS

A. Drug – Drug interactions:

Before receiving ZOBILAN inform your doctor if you have received or receiving or taking any of the following medicines:

  • aminoglycosides such as gentamicin (used to treat severe bacterial infections)
  • calcitonin (used to treat post-menopausal osteoporosis and hypercalcaemia)
  • loop diuretics such as chlorthalidone, indapamide (used to treat high blood pressure or oedema)
  • other calcium-lowering medicines
  • thalidomide (used to treat certain type of blood cancer involving the bone)
  • other medicines (used to treat osteoporosis and other non-cancer diseases of the bone)
  • any other bisphosphonates such as risedronate (used to treat bone problems such as osteopenia or osteoporosis)
  • anti-angiogenic medicines such as bevacizumab, axitinib (used to treat cancer)

Overdosage:

ZOBILAN will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms such as serum electrolyte abnormalities (Ex. abnormal levels of calcium, phosphorus, and magnesium) and/or changes in kidney function including severe kidney impairment, consult your doctor immediately.

SYNOPSIS

Drug :  

Zoledronic Acid

Pharmacological Category :  

Bisphosphonates

Therapeutic Indication :  

Prevents fractures and bone metastases, Reduces the amount of calcium in the blood

Dosage Forms :  

Injection, Infusion

MORE INFORMATION

  • Keep ZOBILAN out of reach in children
  • Store at a temperature not exceeding 30°C

FAQs ABOUT ZOBILAN

How long should I receive ZOBILAN?

ZOBILAN should be received in the dose and duration as advised by your doctor. The medicine takes around 6 months to show its maximum benefits on bones. However, in some cases, the doctor may suggest ZOBILAN for a longer duration. The exact duration will depend on the condition you are being treated for.

How is ZOBILAN administered?

ZOBILAN will be given to you only by a doctor or a nurse into a vein (intravenously). Your doctor will decide the correct dose and duration of ZOBILAN for you depending upon your age, body weight and disease condition.

What are the lifestyle changes should I follow while receiving ZOBILAN?

To get maximum benefit from this medicine, there are certain lifestyle changes that you must adhere to. Include some calcium or vitamin D rich foods for bone strength. Try to spend more time in sunlight to get natural vitamin D. Quit smoking and reduce alcohol consumption as they may harm your bones. You can take up an exercise regime such as walking and low-impact aerobics as they are good for your bones. Similarly, you can try strength-training exercises where you use your own body weight which in turn improve bone health.

Can ZOBILAN cause constipation?

Yes, ZOBILAN may cause constipation in some individuals. To manage this effect, try to eat more high-fiber foods such as fresh fruit, vegetables, cereals and drink plenty of water. If this does not help, inform your doctor for receiving alternate treatment for constipation.

Is ZOBILAN safe to use in pregnant or breast-feeding women?

ZOBILAN is not recommended for use in pregnant and breast-feeding women. Consult your doctor before receiving ZOBILAN if you are pregnant or planning to pregnant or breast-feeding.

REFERENCES

1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 4229-4231.

2. J R Berenson. Zoledronic acid in cancer patients with bone metastases: results of Phase I and II trials. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. April 2001. [Accessed on 7th June 2022] https://pubmed.ncbi.nlm.nih.gov/11346862/

3. Ali Haidar, Morten Jonler, Troels B Folkmar, Lars Lund. Bisphosphonate (zoledronic acid)-induced osteonecrosis of the jaw. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 2009. [Accessed on 7th June 2022] https://pubmed.ncbi.nlm.nih.gov/19903091/

4. Seacross Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 7th June 2022] https://www.medicines.org.uk/emc/files/pil.7205.pdf

USEFUL DIAGNOSTIC TESTS

  • Calcium Test
  • Intact Parathyroid Hormone

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    20 g
    Ingredient
    ZOLEDRONIC ACID 4MG
    Hsn Code
    30049099
ALTERNATE BRANDS View All
ZORRENT 4mg Injection 1's
Prescription Bone Metabolism Rx required
Rs.2,500.00
Zoldonat 4mg Injection 1's
Prescription Bone Metabolism Rx required
Rs.2,990.00
Zobone 4mg Injection 1's
Prescription Bone Metabolism Rx required
Rs.3,398.66
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Copyright© 2023. All Rights Reserved.