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INTRODUCTION
ZIPSYDON contains Ziprasidone which belongs to the group of medicines called Antipsychotics. It is used in the treatment of Schizophrenia (a mental disorder characterized by seeing, hearing and feeling things that does not exist, believing in something that do not exist, unusual suspicion, remaining absent, difficulty in being social, nervousness, depression and anxiety. Also, it is used for the treatment of manic or mixed episodes of moderate severity in bipolar disorder (in people of age 10 to 17 years). Mania is a disease that is characterized by elated behaviour, exaggerated self-esteem, increase in energy, decreased need for sleeping, lack of concentration or hyperactivity and repeated high risk-taking behaviour.
ZIPSYDON is not recommended for use in patients with heart diseases or those who recently had heart attack or heart rhythm problems. Before taking ZIPSYDON inform your doctor if you have any liver or blood clot problems (including family history), had fits, low-resting heart rate or salt depletion as a result of severe diarrhoea or vomiting.
ZIPSYDON should be used in pregnant women only if clearly advised by the doctor. It is not recommended for use in breast-feeding women. Consult with your doctor before taking ZIPSYDON if you are pregnant or breast feeding. ZIPSYDON should be used with caution in children (aged 10 -17 years) and elderly patients (above 65 years of age). Consult with your doctor before taking ZIPSYDON. The most common side effects of taking ZIPSYDON are sleepiness, headache and dizziness. Consult with your doctor if the symptoms do not improve.
USES OF ZIPSYDON
Treats,
- schizophrenia
- manic episodes (a symptom of bipolar disorder)
HOW ZIPSYDON WORKS
ZIPSYDON works in the brain to improve thinking, mood and behavior by restoring the balance of certain natural substances in the brain such as dopamine and serotonin, which helps to treat manic episodes of bipolar disorder and symptoms of schizophrenia.
DIRECTIONS FOR USE
Take ZIPSYDON as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF ZIPSYDON
COMMON
- restlessness
- abnormal movements that include involuntary movements, muscular stiffness and rigidity, slow movements, shaking, general weakness and tiredness
- sleepiness
- headache
- dizziness
- constipation
- nausea, vomiting, digestive problems, dry mouth, more salivation
- blurred vision
UNCOMMON
- increased appetite
- agitation or anxious, tightness of throat, nightmares
- seizures, involuntary movement of the eyes into a fixed position, clumsiness, speech disorder, numbness, tingling and pricking sensation, decreased ability to concentrate, drooling, excessive daytime sleepiness, exhaustion
- palpitation, fainting feel while getting up, breathlessness
- light sensitive, buzzing in the ears
- sore throat, swallowing difficulties, swollen tongue, diarrhoea, wind, stomach discomfort.
- itchy skin rash, acne
- muscle cramp, stiff or swollen joints
- thirst, pain, chest discomfort, abnormal walk
RARE
- runny nose
- signs of decreased calcium levels in the blood (fatigue, cramping, muscle weakness)
- panic attack, depression, thinking becomes slow, emotionless
- unusual position of head (wry-neck or torticollis), paralysis, restless legs
- partial or complete vision loss in one eye, itchy and dry eyes, disturbances in vision
- pain in the ear
- hiccups
- acid reflux
- loss of hair, face swelling, irritations in the skin
- inability to open mouth
- urinary incontinence, pain and difficulties while urinating
- decreased or increased erection, decreased orgasm, abnormal breast milk production
- enlargement of breast in both men and women
- hot feeling, fever
- signs of decreased or increased white blood cells (fatigue, wheezing, night sweats)
- signs of abnormal liver function (abdominal pain, dark urine, yellowish skin and eyes)
- high blood pressure
- psoriasis (patches of raised or red and inflamed skin covered with white scales)
Stop taking ZIPSYDON and consult with your doctor if you experience any of the following side effects:
- irregular heartbeat, dizziness while standing up which indicates abnormal functioning of the heart. This can be a symptom of a condition called postural hypotension
- involuntary/unusual movements, especially in face and tongue
- signs of serious allergic reactions (angioedema) such as face, lips, tongue or throat swelling, swallowing or breathing problems and a nettle rash
- signs of neuroleptic malignant syndrome such as fever, breathing rapidly, sweating, muscle stiffness, shaking, difficulty swallowing and reduced consciousness
- signs of serotonin syndrome such as feeling confused, agitated, increased temperature, sweating, lack of muscle co-ordination and muscle twitching
- signs of torsade’s de pointes such as fast, irregular heartbeat and fainting
HOW TO MANAGE SIDE EFFECTS
Nausea and Vomiting:
ZIPSYDON can be taken with or after meals. Simple meals are preferred. Oil rich or spicy foods should be avoided. Contact your doctor if the symptom did not improve.
Headache:
Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Apply pain-relieving balm on your forehead if required. If there is no improvement, consult your doctor.
Constipation:
Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Contact your doctor if the symptom did not improve.
Dizziness:
Lie down until dizziness passes away and then move slowly and carefully. Take plenty amount of rest and drink plenty of fluids. Contact your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
ZIPSYDON should be used in pregnant women only when considered clearly necessary. Contact your doctor before taking ZIPSYDON.
BREASTFEEDING
ZIPSYDON is not recommended for use in breast feeding women since it may pass into the breast milk. Consult with your doctor before taking ZIPSYDON if you are breast-feeding.
DRIVING AND USING MACHINES
Do not take drive or use machines after taking ZIPSYDON as it may make you feel drowsy.
ALCOHOL
Consumption of alcohol is not recommended while taking ZIPSYDON, as this may increase the risk of side effects.
LIVER
ZIPSYDON should be used with caution in patients with liver problems. Consult with your doctor before taking ZIPSYDON.
ALLERGY
Do not take ZIPSYDON if you are allergic to Ziprasidone or any other ingredients of this medicine.
LUNGS
ZIPSYDON should be used with caution in patients with pulmonary embolism. Consult with your doctor before taking ZIPSYDON.
HEART DISEASE
ZIPSYDON is not recommended for use in patients with heart diseases or those who recently had heart attack, heart rhythm problems and used with caution in patients with low resting heartrate. Contact your doctor before taking ZIPSYDON.
OTHERS
Before taking ZIPSYDON, inform your doctor if you have:
- history of blood clots (including family history)
- suffered from seizures (fits)
- salt depletion which resulted from a prolonged severe diarrhoea and vomiting
- dementia
- stroke
- laboratory test (such as blood, urine, or liver function test)
Use in pediatrics:
ZIPSYDON should be used with caution in children (aged 10-17 years). Consult child’s doctor for advice.
Use in geriatrics:
ZIPSYDON should be used with caution in elderly patients (above 65 years of age). Consult your doctor before taking ZIPSYDON.
INTERACTIONS
A. Drug - Drug interactions:
Before taking ZIPSYDON inform your doctor if you are taking any of the following medicines:
- class IA and III antiarrhythmics (such as procainamide, quinidine, disopyramide and amiodarone) (used in the treatment of arrythmia)
- arsenic trioxide (used in the treatment of certain type of cancer)
- halofantrine, mefloquine (used in the treatment of malaria)
- levomethadyl acetate (used for treating narcotic dependence)
- mesoridazine, thioridazine, sertindole (used in the treatment of schizophrenia)
- pimozide (used to control motor or verbal tics)
- sparfloxacin, gatifloxacin, moxifloxacin and macrolides like erythromycin, clarithromycin (used in the treatment of certain type of bacterial infections)
- dolasetron mesilate (used to prevent nausea and vomiting caused by chemotherapy)
- cisapride (used to treat heart burn)
- rifampin (used to treat tuberculosis)
- lithium, carbamazepine, valproate (used in the treatment of bipolar disorder)
- fluoxetine, paroxetine, sertraline (used in the treatment of depression)
- st. john ´s wort (used in the treatment of depression and menopausal symptoms)
- phenytoin, phenobarbital, carbamazepine, ethosuximide (used in the treatment of epilepsy)
- levodopa, bromocriptine, ropinirol, pramipexole (used in the treatment of parkinson’s disease)
- verapamil (used in the treatment of high blood pressure and chest pain)
- itraconazole (used in the treatment of fungal infections)
- ritonavir (used in the treatment of HIV infection)
Over dosage:
If you or anyone else accidentally take too much of ZIPSYDON, contact your doctor or visit the nearby hospital immediately. Symptoms of overdose of ZIPSYDON includes drowsiness, shaking, fits and involuntary movements of the head and neck.
SYNOPSIS
| Drug | : | Ziprasidone |
| Pharmacological Category | : | Antipsychotics |
| Therapeutic Indication | : | Schizophrenia, Manic disorder |
| Dosage Forms | : | Capsule |
MORE INFORMATION
- Keep the medicine out of reach of children
- Store at room temperature
FAQs ABOUT ZIPSYDON
What are the common side effects of ZIPSYDON?
The common side effects of ZIPSYDON are restlessness, abnormal movements which includes involuntary movements, muscular stiffness and rigidity, slow movements, shaking, general weakness and tiredness, sleepiness, headache, dizziness, constipation, nausea, vomiting and digestion problems, dry mouth, more salivation and blurred vision. Consult with your doctor if the symptom gets worse.
What should I do if I forgot to take a dose of ZIPSYDON?
It is important for you to take ZIPSYDON regularly at the same time of each day. If you forget to take a dose of ZIPSYDON, take it immediately when you remember unless it is time for your next dose. In that case, just take the next dose of ZIPSYDON. Do not take double dose to make up for the forgotten dose.
Can ZIPSYDON be used in breast-feeding women?
ZIPSYDON is not recommended for use in breast feeding women since it may pass into the breast milk. Consult with your doctor before taking ZIPSYDON if you are breast-feeding.
Is ZIPSYDON safe to use in patients with heart problems?
ZIPSYDON is not recommended for use in patients with heart diseases or those who recently had heart attack, heart rhythm problems and used with caution in patients with low resting heartrate. Contact your doctor before taking ZIPSYDON.
Can ZIPSYDON be used in elderly patients?
ZIPSYDON should be used with caution in elderly patients (above 65 years of age). Your doctor may adjust the dose depending upon vital organ functions and general health condition of the patient. Consult your doctor before taking ZIPSYDON.
REFERENCES
1. K.D. Tripathi. Ziprasidone. Drugs acting on central nervous system. Essentials of medical pharmacology. Seventh edition. 2013. Page – 442.
2. Bouchette D, Fariba KA, Marwaha R. Ziprasidone. National Institute of Health. NLM. National Centre for Biotechnology Information. May 2022. [Accessed on June 2nd, 2022] https://www.ncbi.nlm.nih.gov/books/NBK448157/
3. Greenberg WM, Citrome L. Ziprasidone for Schizophrenia and Bipolar Disorder: A Review of the Clinical Trials. National Institute of Health. NLM. National Centre for Biotechnology Information. PMC. Pubmed Central. June 2007. [Accessed on June 2nd 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494156/
4. R-Pharm Germany GmbH, Heinrich-Mack-Str. Zeldox capsules (Ziprasidone). Health products regulatory authority (HPRA). October 2012. [Accessed on June 2nd 2022] https://www.hpra.ie/img/uploaded/swedocuments/1-3-1-common-pl-capsules-clean%20Zeldox-2154406-25022015160018-635604768383911250.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood count
PRODUCT DETAILS
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